Patents Examined by Quang Nguyen
  • Patent number: 10143760
    Abstract: Described herein are constructs used for liver-specific expression of a transgene.
    Type: Grant
    Filed: July 13, 2016
    Date of Patent: December 4, 2018
    Assignee: Sangamo Therapeutics, Inc.
    Inventors: Brigit E. Riley, Gary K. Lee
  • Patent number: 10138495
    Abstract: The present disclosure provides a method of generating a stable producer cell line. The generation of stable producer cell lines, such as those provided in accordance with the present invention, increases the reproducibility and ease of creating high titer lentiviral stocks while easing biosafety concerns and the variation in expressed envelope proteins defines the tropism of the generated virus. The present disclosure also provides for a novel lentiviral transfer vector plasmid.
    Type: Grant
    Filed: November 2, 2017
    Date of Patent: November 27, 2018
    Assignee: Calimmune, Inc.
    Inventors: Chi-Lin Lee, Jeffrey S Bartlett
  • Patent number: 10138486
    Abstract: The present invention provides methods of treatment using inhibitors of DEK protein and DEK activity. Such methods include, but are not limited to, methods of preventing, treating, and/or ameliorating inflammatory diseases, infections, autoimmune diseases, malignant diseases, and other diseases or conditions in which DEK has been implicated. Such inhibitors of DEK protein include, but are not limited to, pharmaceutical compositions including single stranded DNA or RNA aptamers capable of binding to DEK. In some embodiments, such aptamers are useful for diagnosing DEK related diseases or conditions. Related kits and compositions are further provided.
    Type: Grant
    Filed: March 11, 2016
    Date of Patent: November 27, 2018
    Assignee: THE REGENTS OF THE UNIVERSITY OF MICHIGAN
    Inventors: David Markovitz, Nirit Mor-Vaknin, Maureen Legendre, David Engelke, Kristine Benford, Dave Pai
  • Patent number: 10106816
    Abstract: A synthetic lentiviral vector construct comprises a genomic RNA packaging enhancer (GRPE) element and lentiviral nucleic acid sequences sufficient for reverse transcription and packaging in a host cell.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: October 23, 2018
    Assignee: Case Western Reserve University
    Inventor: Eric J. Arts
  • Patent number: 10082803
    Abstract: A method and a system for establishing a route of an unmanned aerial vehicle are provided. The method includes identifying an object from surface scanning data and shaping a space, which facilitates autonomous flight, as a layer, collecting surface image data for a flight path from the shaped layer, and analyzing a change in image resolution according to a distance from the object through the collected surface image data and extracting an altitude value on a flight route.
    Type: Grant
    Filed: February 27, 2017
    Date of Patent: September 25, 2018
    Assignee: Thinkware Corporation
    Inventors: Young-Kuk Ham, Tae Kyu Han
  • Patent number: 10082798
    Abstract: A system for autonomously navigating a vehicle may include at least one processor. The processor may be programmed to receive a first navigational map associated with a first road segment and a second navigational map, different from the first navigational map, associated with a second road segment. The first road segment and the second road segment may overlap one another at an overlap segment. The processor may be programmed to determine at least a first autonomous navigational response for the vehicle along the first road segment based on analysis of the first navigational map; at least a second autonomous navigational response for the vehicle along the second road segment based on analysis of the second navigational map; and at least a third autonomous navigational response for the vehicle in the overlap segment based on at least one of the first navigational map and the second navigational map.
    Type: Grant
    Filed: August 9, 2017
    Date of Patent: September 25, 2018
    Assignee: MOBILEYE VISION TECHNOLOGIES LTD.
    Inventors: Amnon Shashua, Yoram Gdalyahu, Ofer Springer, Aran Reisman, Daniel Braunstein
  • Patent number: 10074270
    Abstract: In one embodiment, a cluster application generates navigation-related data based on observations received from vehicles. In operation, the cluster application computes an oriented distance between two observed object positions based on a heading, where each observed object position is associated with a different one of two observations. The cluster application then generates a cluster that includes the two observations based on the oriented distance. Subsequently, the cluster application computes an object position that is associated with the cluster based on the two observations. The cluster application transmits the object position and at least one characteristic associated with the observations to a update application that generates an update to a road database. Because the cluster application computes the object position based on multiple observations that are likely of a single object, the object position associated with the cluster may be more reliable than the observed object positions.
    Type: Grant
    Filed: July 18, 2017
    Date of Patent: September 11, 2018
    Assignee: HARMAN BECKER AUTOMOTIVE SYSTEMS GMBH
    Inventors: Volodymyr Ivanov, Alexey Pryakhin, Ievgenii Borshch
  • Patent number: 10071132
    Abstract: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
    Type: Grant
    Filed: April 11, 2016
    Date of Patent: September 11, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lisa Gunaydin, Peter Hegemann, Andre Berndt
  • Patent number: 10064912
    Abstract: Stimulation of target cells using light, e.g., in vivo or in vitro, is implemented using a variety of methods and devices. One example involves a vector for delivering a light-activated molecule comprising a nucleic acid sequence that codes for light-activated molecule. The light-activated molecule includes a modification to a location near the all-trans retinal Schiff base, e.g., to extends the duration time of the open state. Other aspects and embodiments are directed to systems, methods, kits, compositions of matter and molecules for ion channels or pumps or for controlling currents in a cell (e.g., in in vivo and in vitro environments).
    Type: Grant
    Filed: November 29, 2016
    Date of Patent: September 4, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Karl Deisseroth, Ofer Yizhar, Lisa Gunaydin, Peter Hegemann, Andre Berndt
  • Patent number: 10066240
    Abstract: There are disclosed nucleic acid vectors for use in both gram positive and gram negative bacteria. In embodiments the vectors comprise a prokaryotic expression cassette and in embodiments comprise a eukaryotic expression cassette. In embodiments the vectors encode a hybrid protein comprising a DNA binding domain, a CPP domain and a signal sequence.
    Type: Grant
    Filed: February 12, 2015
    Date of Patent: September 4, 2018
    Assignee: Symvivo Corporation
    Inventors: Herbert Alexander Graves, Mark Andrew Fox, Sheetal Raithatha, Umesh Ramachandran
  • Patent number: 10047365
    Abstract: The present invention relates to the production and use of covalently closed circular (ccc) recombinant DNA molecules such as plasmids, cosmids, bacterial artificial chromosomes (BACs), bacteriophages, viral vectors and hybrids thereof, and more particularly to vector modifications that improve expression of these DNA molecules.
    Type: Grant
    Filed: November 18, 2013
    Date of Patent: August 14, 2018
    Assignee: NATURE TECHNOLOGY CORPORATION
    Inventor: James A. Williams
  • Patent number: 10029637
    Abstract: A method for triggering a plurality of actuators of a safety system of a motor vehicle from an energy source, wherein, by using sensor signals, the requirement for triggering and the desired triggering time period are determined and a maximum group size of actuators to be triggered within a time window is predefined. For successive time windows, individual, at least partly different, maximum group sizes are respectively predefined and the maximum group size for the respective time window is determined adaptively by using the actuators already actually triggered in preceding time windows. Here, it is preferably also possible to take account of the situation in which different triggering time periods are predefined for actuators.
    Type: Grant
    Filed: December 17, 2014
    Date of Patent: July 24, 2018
    Assignee: Continental Automotive GmbH
    Inventor: Ludwig Ertl
  • Patent number: 10006189
    Abstract: A control system controls a construction machine that includes a work machine including a bucket having a plurality of tilting mechanisms. The control system includes: a tilt angle sensor that is provided in the bucket so as to detect tilt angle data including a rotation angle of the bucket about the tilt shaft, the tilt angle sensor being capable of detecting an inclination angle with respect to a horizontal plane; a data acquisition unit to which the tilt angle data is output from the tilt angle sensor; a data fixing unit that fixes the tilt angle data output to the data acquisition unit based on a fixing command to generate fixed data; and a work machine control unit that controls the work machine based on the fixed data until the fixing command is disabled.
    Type: Grant
    Filed: May 9, 2017
    Date of Patent: June 26, 2018
    Assignee: Komatsu Ltd.
    Inventor: Jin Kitajima
  • Patent number: 9999685
    Abstract: The present invention provides an isolated nucleic acid molecule comprising, or consisting of, the nucleic acid sequence of SEQ ID NO: 1 or a nucleic acid sequence of at least 200 bp having at least 70% identity to the sequence of SEQ ID NO: 1, wherein the isolated nucleic acid molecule specifically leads to the expression in retinal amacrine bipolar cells of a gene when operatively linked to a nucleic acid sequence coding for the gene.
    Type: Grant
    Filed: February 9, 2015
    Date of Patent: June 19, 2018
    Assignee: FRIEDRICH MIESCHER INSTITUTE FOR BIOMEDICAL RESEARCH
    Inventors: Botond Roska, Josephine Juettner
  • Patent number: 9987347
    Abstract: An aspect of the present invention is related to nucleic acid constructs capable of expressing a polypeptide, such as a consensus dengue prME that elicits an immune response in a mammal against more than one subtype of dengue virus, and methods of use thereof. Additionally, there are DNA plasmid vaccines capable of generating in a mammal an immune response against a plurality of dengue virus subtypes, comprising a DNA plasmid and a pharmaceutically acceptable excipient, and methods of use thereof. The DNA plasmid is capable of expressing a consensus dengue antigen in a cell of the mammal in a quantity effective to elicit an immune response in the mammal that is cross reactive against all 4 dengue subtypes.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: June 5, 2018
    Assignees: THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA, INOVIO PHARMACEUTICALS, INC.
    Inventors: David B. Weiner, Jian Yan, Niranjan Sardesai
  • Patent number: 9970024
    Abstract: A method of altering a eukaryotic cell is provided including transfecting the eukaryotic cell with a nucleic acid encoding RNA complementary to genomic DNA of the eukaryotic cell, transfecting the eukaryotic cell with a nucleic acid encoding an enzyme that interacts with the RNA and cleaves the genomic DNA in a site specific manner, wherein the cell expresses the RNA and the enzyme, the RNA binds to complementary genomic DNA and the enzyme cleaves the genomic DNA in a site specific manner.
    Type: Grant
    Filed: December 16, 2013
    Date of Patent: May 15, 2018
    Assignee: President and Fellows of Harvard College
    Inventors: George M. Church, Prashant Mali, Luhan Yang
  • Patent number: 9970030
    Abstract: Methods for use with Type II CRISPR-Cas9 systems for increasing Cas9-mediated genome engineering efficiency are disclosed. The methods can be used to decrease the number of off-target nucleic acid double-stranded breaks and/or to enhance homology-directed repair of a cleaved target nucleic acid.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: May 15, 2018
    Assignee: Caribou Biosciences, Inc.
    Inventors: Peter Sean Cameron, Rachel E. Haurwitz, Andrew P. May, Christopher H. Nye, Megan van Overbeek
  • Patent number: 9955676
    Abstract: The present invention provides an in vivo platform for identifying and determining therapeutic or prophylactic activity of test compounds in delay-type hypersensitivity (DTH) and other inflammatory or cancerous diseases mediated by activation of IKK-?C46A mutants. The in vivo platform of the present invention is a non-human transgenic mammal, e.g., a mouse model, with a site directed mutagenesis at a cysteine residue replaced by alanine in IKK-? protein kinase. The site directed mutagenesis is introduced by a specially designed targeting vector containing a transversion in exon 3 of the Ikbkb genes encoding the IKK-?. The present invention also provides methods for generating the transgenic mammal and for determining and identifying compounds that can inhibit activation of IKK-?C46A mutants.
    Type: Grant
    Filed: February 11, 2015
    Date of Patent: May 1, 2018
    Assignee: Macau University of Science and Technology
    Inventors: Liang Liu, Ting Li, Kam Wai Wong, Zhihong Jiang, Hua Zhou
  • Patent number: 9937233
    Abstract: Provided are compositions and methods for delivering biological moieties such as modified nucleic acids into cells to modulate protein expression. Such compositions and methods include the use of modified messenger RNAs, and are useful to treat or prevent diseases, disorders or conditions, or to improve a subject's heath or wellbeing.
    Type: Grant
    Filed: August 26, 2016
    Date of Patent: April 10, 2018
    Assignee: ModernaTX, Inc.
    Inventors: Jason P. Schrum, Stephane Bancel, Noubar B. Afeyan, Kenechi Ejebe
  • Patent number: 9932572
    Abstract: The technology relates in part to compositions comprising modified Caspase-9 polypeptides, compositions comprising nucleic acids coding for modified Caspase-9 polypeptides, chimeric modified Caspase-9 polypeptides, and methods of use thereof, including methods for cell therapy. Methods for cell therapy include modifying transfused cells to express an inducible modified Caspase-9 protein, with reduced basal activity in the absence of the inducer.
    Type: Grant
    Filed: July 29, 2016
    Date of Patent: April 3, 2018
    Assignee: Bellicum Pharmaceuticals, Inc.
    Inventors: David Spencer, Wei-Chun Chang