Patents Examined by R. Clarke
-
Patent number: 11591561Abstract: Transfer of genetic and other materials to cells is conducted in a hands-free, automated and continuous process that includes flowing the cells between electroporation electrodes to facilitate delivery of a payload into the cells, while acoustophoretically focusing the cells. Also described is a control method for the acoustophoretic focusing of cells that includes detecting locations of cells flowing through a channel, such as with an image analytics system, and modulating a drive signal to an acoustic transducer to change the locations of the cells flowing in the channel. Finally, an electroporation driver module is described that uses a digital to analog converter for generating an electroporation waveform and an amplifier for amplifying the electroporation waveform for application to electroporation electrodes.Type: GrantFiled: October 23, 2018Date of Patent: February 28, 2023Assignee: The Charles Stark Draper Laboratory, Inc.Inventors: Vishal Tandon, Charles A. Lissandrello, Ryan A. Dubay, Rebecca Christianson, Jenna Leigh Balestrini, Peter Hsi, Jason Fiering
-
Patent number: 11591574Abstract: Methods to form a surface coating and surface pattern, which are based on adsorption of hydrocarbon chains that can be used with imaging optics to visualize macrophage fusion and multinucleated giant cell formation with living specimens are described.Type: GrantFiled: October 5, 2020Date of Patent: February 28, 2023Assignees: ARIZONA BOARD OF REGENTS ON BEHALF OF ARIZONA STATE UNIVERSITY, UNIVERSITY OF NOTRE DAME DU LACInventors: James Faust, Tatiana Ugarova, Robert Ros, Wayne Christenson, Kyle Doudrick
-
Patent number: 11591565Abstract: The present application discloses a cell culture media for growth, maintenance and induction of reversion to a less mature state of a cell comprising a MUC1* activating ligand.Type: GrantFiled: April 16, 2014Date of Patent: February 28, 2023Assignee: MINERVA BIOTECHNOLOGIES CORPORATIONInventors: Cynthia Bamdad, Benoit Smagghe
-
Patent number: 11582967Abstract: An aqueous storage solution for the storage of red blood cells, comprising an aqueous solution and at least one lipid, wherein the at least one lipid is effective in suppressing hemolysis in red blood cells and wherein the at least one lipid is emulsified within the aqueous solution.Type: GrantFiled: August 11, 2016Date of Patent: February 21, 2023Assignee: Fenwal, Inc.Inventor: Craig L. Sandford
-
Patent number: 11583519Abstract: A nasal composition is provided comprising or consisting of a first composition part in the form of a liquid for nasal application to a patient in use, and a second composition part in the form of a powder for nasal application to the patient in use. The first and second composition parts are applied to the patient separately or together as required.Type: GrantFiled: October 18, 2019Date of Patent: February 21, 2023Assignee: Nasaleze Patents LimitedInventor: Todor A. Popov
-
Patent number: 11555157Abstract: A method of producing liquid fuel and/or chemicals from a carbonaceous material entails combusting a conditioned syngas in pulse combustion heat exchangers of a steam reformer to help convert carbonaceous material into first reactor product gas which includes carbon monoxide, hydrogen, carbon dioxide and other gases. A portion of the first reactor product gas is transferred to a hydrogen reformer into which additional conditioned syngas is added and a reaction carried out to produce an improved syngas. The improved syngas is then subject to one or more gas clean-up steps to form a new conditioned syngas. A portion of the new conditioned syngas is recycled to be used as the conditioned syngas in the pulse combustion heat exchangers and in the hydrocarbon reformer. A system for carrying out the method include, a steam reformer, a hydrocarbon reformer, first and second gas-cleanup systems, a synthesis system and an upgrading system.Type: GrantFiled: March 10, 2020Date of Patent: January 17, 2023Assignee: ThermoChem Recovery International, Inc.Inventors: Ravi Chandran, Dave G. Newport, Daniel A. Burciaga, Daniel Michael Leo, Justin Kevin Miller, Brian Christopher Attwood
-
Patent number: 11535880Abstract: Described herein are engineered organelles comprising multi-component proteins from different species incorporated into a membrane structure with interior and exterior aspects. In one embodiment the artificial organelle incorporates one or more protein complexes that absorb optical energy and catalyze electron transfer in biochemical reactions that can be used to reduce NAD+ to NADH or analogues thereof.Type: GrantFiled: January 7, 2021Date of Patent: December 27, 2022Assignee: ENSOVI, INC.Inventors: Kyle A. Minor, Carlo D. Montemagno, David W. Wendell
-
Patent number: 11448644Abstract: The invention relates generally to compositions and methods for the detection of zinc. In particular, compositions and methods are provided to detect changes in cellular zinc concentration and to correlate them to cellular phenomena.Type: GrantFiled: July 16, 2019Date of Patent: September 20, 2022Assignee: Northwestern UniversityInventors: Teresa K. Woodruff, Thomas V. O'Halloran, Alison M. Kim, Emily Que, Betty Kong, Miranda Bernhardt
-
Patent number: 11434466Abstract: The present invention provides a process of cultivating microalgae and a joint method of same jointed with denitration. During the microalgae cultivation, EM bacteria is added into the microalgae suspension. In the nutrient stream for cultivating microalgae, at least one of the nitrogen source, phosphorus source and carbon source is provided in the form of a nutrient salt. During the cultivation, the pH of the microalgae suspension is adjusted with nitric acid and/or nitrous acid. The joint method includes (1) a step of cultivating microalgae; (2) a separation step of separating a microalgae suspension obtained from step (1) into a wet microalgae (microalgae biomass) and a residual cultivation solution; and (3) a NOx absorbing/immobilizing step of denitrating an industrial waste gas with the residual cultivation solution obtained from step (2). The nutrient stream absorbed with NOx obtained from step (3) is used to provide nitrogen source to the microalgae cultivation of step (1).Type: GrantFiled: March 17, 2015Date of Patent: September 6, 2022Assignees: CHINA PETROLEUM & CHEMICAL CORPORATION, RESEARCH INSTITUTE OF PETROLEUM PROCESSING, SINOPECInventors: Junfeng Rong, Xuhua Zhou, Lin Cheng, Junying Zhu, Xugeng Huang, Baoning Zong
-
Patent number: 11433108Abstract: Therapeutic methods for administering gut microbiota and oncolytic viruses to a subject are provided. The gut microbiota serve to pre-condition, the subject's immune system to antitumor responses and augments anticancer activity of the oncolytic vims. Combinations of the gut. microbiota and viruses and uses thereof for treating and preventing cancer are provided. The present disclosure also provides methods for building elite responder selection platforms through hierarchical clustering analysis of genomic profiles for human gut microbiome.Type: GrantFiled: March 28, 2017Date of Patent: September 6, 2022Assignee: SUZHOU PRAJNA BIOTECH CO., LTD.Inventors: Minjie Hu, Yu Li, Xiaoling Liu, Rebecca Hu
-
Patent number: 11389565Abstract: Described herein are molded dehydrated placental tissue compositions, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the molded dehydrated placental tissue compositions are also described herein.Type: GrantFiled: May 21, 2018Date of Patent: July 19, 2022Assignee: MiMedx Group, Inc.Inventors: Thomas J. Koob, Guilhem Denoziere, Rebeccah J. C. Brown
-
Patent number: 11332771Abstract: The specification describes an improved serum-free animal cell culture medium, which can used for the production of a protein of interest. Ornithine, or a combination of ornithine and putrescine can be added to serum-free media or chemically defined media to improve viable cell density, to reduce cell doubling time, and to increase the production of a protein of interest.Type: GrantFiled: January 14, 2020Date of Patent: May 17, 2022Assignee: Regeneron Pharmaceuticals, Inc.Inventors: Shadia Abike Oshodi, Amy S. Johnson, Shawn M. Lawrence
-
Patent number: 11332768Abstract: A method for producing a partially hydrolysed lignocellulosic material is provided including treating a lignocellulosic material with an acid and/or an alkali and then a polyol. Also provided are methods of producing a fermentable sugar, or a fermentable sugar and a fermentation product from said partially hydrolysed lignocellulosic material. A partially hydrolysed lignocellulosic material, a fermentable sugar, and fermentation product produced by such methods are also provided. Also provided is an apparatus for producing a partially hydrolysed lignocellulosic material, such as by the aforementioned method.Type: GrantFiled: July 10, 2015Date of Patent: May 17, 2022Assignee: LEAF SCIENCES PTY LTDInventors: Alex Baker, Leslie Alan Edye
-
Patent number: 11291161Abstract: Systems and methods for growing vegetation are provided. The disclosed systems (100) and methods (1100, 1200) use rotating growth mats (102) and a cutting device (112). The rotating growth mats and cutting device can be coupled to an anaerobic digester (402) to generated methane gas using vegetation grown on the growth mats. The systems and methods may further use C artificial light sources (108) and a nutrients delivery system (110) to assist growth.Type: GrantFiled: February 16, 2017Date of Patent: April 5, 2022Assignee: BENNAMANN SERVICES LTDInventors: Christopher Mann, Michael Bennett, Derek William Kenneth Jenkins, Thomas William Bradshaw, Matthew Charles Seabrook Heritage
-
Patent number: 11291686Abstract: The present disclosure relates to human facilitating cells (hFC), and methods of isolating, characterizing, and using such hFCs.Type: GrantFiled: February 5, 2019Date of Patent: April 5, 2022Assignee: University of Louisville Research Foundation, Inc.Inventors: Suzanne T. Ildstad, Mary Jane Elliott
-
Patent number: 11274277Abstract: The present invention provides a production method of a cell aggregate containing an anterior eye segment tissue or a partial structure thereof, or a precursor tissue thereof, including culturing pluripotent stem cell aggregates in suspension in the presence of a bone morphogenic factor signal transduction pathway activating substance to induce self-organization of an anterior eye segment tissue or a partial structure thereof, or a precursor tissue thereof. In one embodiment, the bone morphogenic factor signal transduction pathway activating substance is BMP4. In one embodiment, the suspension culture is performed entirely or partially in the presence of a fibroblast growth factor. The produced cell aggregate can further contain a neural retinal tissue.Type: GrantFiled: August 6, 2014Date of Patent: March 15, 2022Assignees: RIKEN, Sumitomo Chemical Company, LimitedInventors: Yoshiki Sasai, Chikafumi Ozone, Yuko Maruyama
-
Patent number: 11253818Abstract: A method of producing cellulase includes steps (1) to (3): (1) subjecting an aqueous solution of cellulase derived from filamentous fungi to filtration through an ultrafiltration membrane with a molecular weight cut off of 100,000 to 200,000 to obtain a filtrate and concurrently obtain a concentrated enzyme liquid as a retentate; (2) further subjecting the filtrate obtained in step (1) to filtration through a second ultrafiltration membrane with a molecular weight cut off of 5,000 to 50,000 to obtain a second concentrated enzyme liquid as a retentate; and (3) mixing the concentrated enzyme liquid obtained in steps (1) and (2) to obtain cellulase derived from filamentous fungi.Type: GrantFiled: November 21, 2012Date of Patent: February 22, 2022Assignee: Toray Industries, Inc.Inventors: Hiroyuki Kurihara, Katsushige Yamada
-
Patent number: 11253554Abstract: Disclosed herein are compositions and methods for diagnosing fungal dysbiosis in the gut of a subject with cirrhosis that involves assaying a sample from the subject for bacterial taxa. These compositions and methods are based on the discovery that there is significant correlation between fungal and bacterial diversity in gut microbiota of cirrhotic patients. Therefore, disclosed herein is a method for treating a subject with liver cirrhosis that involves assaying a gut sample from the subject for bacterial taxa to generate a bacterial profile, comparing the bacterial profile to control profiles to predict fungal dysbiosis; and treating the subject for fungal dysbiosis.Type: GrantFiled: October 5, 2017Date of Patent: February 22, 2022Assignees: Virginia Commonwealth University, George Mason UniversityInventors: Jasmohan Bajaj, Patrick M. Gillevet
-
Patent number: 11241461Abstract: Provided herein are methods and compositions related to Blautia Strain A useful as therapeutic agents.Type: GrantFiled: August 29, 2018Date of Patent: February 8, 2022Assignee: Evelo Biosciences, Inc.Inventors: Brian Goodman, Peter Sandy, Jacqueline Papkoff, Humphrey Gardner, Holly Ponichtera
-
Patent number: 11220667Abstract: A Kurthia gibsonii strain EO-06 with Deposit Number of CGMCC No. 18436, a Clostridium kogasensis strain EO-08 with Deposit Number of CGMCC No. 18438 and a Clostridium acidisoli strain EO-09 with Deposit Number of CGMCC No. 18439 are provided. The above strains can be used to treat pollution, for example, to treat industrial gas or wastewater containing ethylene oxide, which greatly improves the decontamination disposal capacity of ethylene oxide in industrial production. The present disclosure also provides a degradation agent for degrading ethylene oxide and a method for biodegrading ethylene oxide.Type: GrantFiled: September 4, 2020Date of Patent: January 11, 2022Assignees: CHiO KANG MEDICAL, INC., QIAOKANG BIOTECH (GUANGDONG) CO., LTD.Inventors: Shengwei Hu, Dongxin Hou, Jianlong Xue, Weiguo Wang, Yecheng He, Xiuling Zhong, Xin Yin, Liqing Zhu, Jiali Lin, Lixiong Feng