Abstract: N-(4-Imidazolyl)propyl-N'-heterocyclomethylthioethyl guanidines which are selective histamine H.sub.2 -receptor agonists.

Abstract: This invention relates to substituted indolobenzoxazepines which show neuroleptic activity.

Abstract: The new compound N-(1,2,2,2-tetrachloroethyl)-formimide chloride of the formula ##STR1## is produced by reacting a substituted formamide of the formula ##STR2## wherein X is OH or Cl,With approximately the stoichiometrically required amount of a highly reactive inorganic acid chloride, e.g. phosphorus pentachloride. The compound (I) can be reacted with sulfur at about 150.degree. to 250.degree. C to produce trichlorothiazole of the formula ##STR3## which is known to have insecticidal activity.

Abstract: Compounds of the formula ##STR1## in which R is lower alkyl; R.sub.1 is lower alkyl or lower alkoxy; X is thio or sulfonyl; R.sub.2 is alkyl, benzothiazol-2-yl, benzyl, naphthyl, benzimidazol-2-yl, thiazol-2-yl, phenyl or substituted phenyl wherein said substituents are chloro, bromo, methyl or methoxy and the use of these compounds as insecticides.

Abstract: Novel 1-alkylideneaminouracil compounds of the formula ##STR1## in which R.sup.1 is optionally substituted hydrocarbyl which may contain hetero-atoms.R.sup.2 is hydrogen or halogen; andR.sup.3 is hydrogen or alkyl; orR.sup.2 and R.sup.3 together represent a multi-membered methylene bridge which forms, with the two carbon atoms in the 5- and 6-position of the heterocyclic structure, a fused ring which is optionally substituted by alkyl.R.sup.4 is alkyl, cycloalkyl, cycloalkenyl, optionally substituted 5-membered or 6-membered heteroaryl with the hetero-atoms O, N or S; andR.sup.5 is hydrogen, alkyl or optionally substituted aryl; advantageously employ the selective herbicides in crops, e.g., in cotton or cereal crops.

Abstract: Amine salts of substituted benzimidazoles with a carboxymethyleneamino group at the 1-position have been discovered to possess a markedly enhanced stability in aqueous solutions when compared with other salts. The improved salts are di- and tri-loweralkylamine salts.

Abstract: Carbostyril derivatives useful as coccidiostats are prepared by reacting an ortho-halo benzaldehyde with a 2-alkyl-2-oxazoline, then heating at above about 200.degree. C thereby forming the carbostyril.

Abstract: Nitroimidazolyl-s-triazolo[4,3-b]pyridazines of the formula: ##STR1## wherein R is hydrogen or lower alkyl optionally substituted in the 2-position by hydroxyl or by lower acyloxy or lower alkoxy;A is hydrogen, halogen, azido, cyano; lower alkyl alkoxy, alkylthio, alkylsulfonyl, carboxyl; lower alkoxycarbonyl, lower alkoxycarbonimidoyl; or hydrazino, carbamoyl, amidino or a carboximidohydrazide group optionally substituted by one or two lower acyl, alkyl or cycloalkyl radicals; orA is a radical of the formula: ##STR2## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or a number of organic radicals or, taken together, can be an alkylene bridge; andR.sub.3 is hydrogen or lower alkyl; or, together with R.sub.2, R.sub.3 can form an alkylene bridge;n is 0 or 1;And the pharmaceutically compatible thereof, possess high in vivo effectiveness as antimicrobials.

Abstract: 2-ACYL-5-NITROTHIAZOLES OF THE FORMULA ##STR1## wherein A' is furyl, thienyl or pyrrolyl substituted by halo, or phenyl substituted by 3 to 5 of halo, hydroxy, alkyl or alkoxy of 1-4 carbon atoms, possess antifungal activity, e.g., against Candida albicans, Trichophyton metagrophytes and Trichophyton rubrum.

Abstract: Metal complexes of azolyl ethers of the formula ##STR1## in which M is a metal,X is halogen, nitro, nitrile, optionally substituted alkyl, optionally substituted aryl, cycloalkyl, amino, carboxyl, alkoxycarbonyl, alkylcarbonyloxy, alkoxy, alkylthio, halogenoalkoxy, halogenoalkylthio, aryloxy, arylcarbonyloxy, benzoyl, halogenobenzoyl, alkylcarbonylamino, dialkylamino, alkylsulfonyl, alkylsulfonyloxy, arylsulfonyl or arylsulfonyloxy,Az is an imidazolyl radical, a 1,2,4-triazolyl-(1) radical or a 1,2,4-triazolyl-(4) radical,B is CO or CH(OH),R is alkyl or optionally substituted aryl,A is an anion of an inorganic acid,a is an integer from 0 to 5,n is 0 or 1,m is an integer from 1 to 4,p is an integer from 1 to 6, andk is an integer from 0 to 12, which possess fungicidal, bactericidal and plant growth-regulating properties.

Abstract: 8-(.beta.-AMINOETHYL)ERGOLINES-I of the general formula ##STR1## wherein R.sup.1 is a hydrogen atom or an acyl group of the general formula R.sup.3 --CO, R.sup.3 being a hydrogen atom, an alkyl group having from 1-5 carbon atoms, a phenyl group, a phenylalkyl group or a pyridyl group or substituents thereof, and R.sup.2 is a hydrogen atom or a methyl group. Acid addition salts of the described ergolines evidence pharmacological activity in the anti-inflammation and hypotensive fields.

Abstract: The compounds are aryl-pyridazinone derivatives, e.g., 1-methyl-5-(2'-fluoro-5'-trifluoromethylphenyl)-1H-pyrazolo [4,3-c]pyridazin-6(5H)-one. They are useful as antihypertensives and are prepared by treating a hydrazinopyridazinone with a dialkylamino dialkyl-acetal.

Abstract: New perfluoroalkylalkylcarboxylic acids of the formula ##EQU1## are provided, wherein R.sub.f is an unbranched or branched perfluoroalkyl radical with 3 to 18 carbon atoms, R.sub.1 is hydrogen or fluorine and m is a whole number from 1 to 3.The new compounds are suitable for producing water and oil-repellent finishes, soil-release and antisoiling effects on porous and non-porous substrates. They are further valuable intermediates for the manufacture of fluorinated compounds which may be used in the same field as the inventive compounds.

Abstract: 2-Amino-1,4-dihydropyridines bearing a carbonyl function in the 5-position and being optionally substituted by lower alkyl or phenyl in the 6-position, and the corresponding 2-amino-1,4,5,6,7,8-hexahydro-5-oxoquinolines, which derivatives are further substituted by a carbonyl group in the 3-position and optionally substituted in the 4-position by lower alkyl, phenyl, substituted phenyl or a heterocyclic group are antihypertensive agents and coronary vessel dilators. The compounds, of which 2-amino-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylic acid 3,5-diethyl ester is a representative embodiment, are prepared through condensation of an ylideneacetoacetic acid ester and an amidine.

Abstract: 1-Cycloalkylmethyl-3a-(substituted-phenyl) decahydroisoquinolines, useful as analgetic agonists or analgetic antagonists.

Abstract: Macrocyclic polyamines containing 3-7 nitrogen atoms in the ring and destablized to complex formation by (1) an asymmetric ring and/or (2) provision of nitrogen atoms in excess of that required for complex formation are described. The compounds can be used to extract metal ions from solution. The metal complexes are thermally activated curing agents for epoxy resins.

Abstract: 2-Acyl-4-oxo-hexahydro-4H-pyrazino[2,1-a]isoquinoline derivatives of the formula ##STR1## wherein COR is the acyl radical of an up to 26 carbon atom acid and their physiologically acceptable acid addition and quaternary ammonium salts, are anthelmintics and can be produced by reacting 4-oxo-1,2,3,6,7,11b-hexahydro-4H-pyrazino[2,1-a]isoquinoline with an acid or a reactive functional derivative thereof.

Abstract: 1-Aryl-3,4-dihydro-2(1H)-isoquinolinecarbonyl chlorides, useful in the preparation of the corresponding carboxamides, are described herein. The subject compounds can be prepared by reacting an 1-aryl-3,4-dihydro-2(1H)-isoquinoline with phosgene.

Abstract: New N-substituted 1-amino-3-phenoxy-propan-2-ol compounds of the formula: ##EQU1## wherein R.sub.1 and R.sub.2 are, individually, hydrogen or, taken together, represent a sulfur linkage, an ethylene radical or a valency bond;B is straight or branched chain alkylene or hydroxyalkylene of from 2 to 5 carbon atoms; andR.sub.3 is hydrogen or alkyl of up to 3 carbon atoms;And the physiologically compatible salts thereof; possess valuable cardiac and circulatory activity.

Abstract: 2,1-Benzisothiazolyl N-lower alkyl- or N,N-di-lower alkylcarbamates are prepared from novel hydroxy-2,1-benzisothiazoles and alkoxy-2,1-benzisothiazoles. 2,1-Benzisothiazol-4-yl N-methylcarbamate is an effective insecticide.