Patents Examined by Raymond K. Covington
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Patent number: 6686481Abstract: The present invention relates to a process to prepare semi synthetic statins, to intermediates formed during said process and to highly purified simvastatin produced by the process.Type: GrantFiled: July 26, 2001Date of Patent: February 3, 2004Assignee: Plus Chemicals, B.V.Inventors: Szabo Csaba, Ferenc Korodi, Melczer Istvan, Szabolcs Salyi, David Leonov
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Patent number: 4770818Abstract: There is disclosed a process for the preparation of 1-aminoanthraquinones from 5-nitro-1,4,4a,9a-tetrahydroanthraquinones with a basic reducing agent, which process is carried out under pressure in the temperature range above 100.degree. C. and in an aqueous-organic medium. The process affords very pure 1-aminoanthraquinone, which is, inter alia, an important intermediate.Type: GrantFiled: October 19, 1987Date of Patent: September 13, 1988Assignee: Ciba-Geigy CorporationInventors: Eric Plattner, Gottfried Seifert, Tibor Somlo
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Patent number: 4749521Abstract: 1,4-Diaminoanthraquinone-2,3-disulfonic acid or salt thereof and 1,4-diaminoanthraquinone-2,3-dinitrile which are intermediate of anthraquinone dyes are economically prepared by allowing 1,4-diamino-2,3-dihalogenoanthraquinone to react with alkalimetal sulfite in aqueous solution in the presence of quaternary ammonium or phosphonium compound, while water is being removed, to obtain 1,4-diaminoanthraquinone-2,3-disulfonic acid or salt thereof and, if necessary, cyanogenating the reaction mixture above without removing the disulfonic acid or salt thereof produced above to obtain 1,4-diaminoanthraquinone-2,3-dinitrile. The quaternary ammonium or phosphonium compound is recovered from and re-used for the reactions above.Type: GrantFiled: January 6, 1987Date of Patent: June 7, 1988Assignee: Sumitomo Chemical Company, Ltd.Inventors: Makoto Hattori, Satoshi Kajitani
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Patent number: 4711743Abstract: A process for the production of anthraquinone-1-sulphonic acid by sulphonating anthraquinone with a sulphonating agent in the presence of palladium catalyst in a solvent, is characterized in that before sulphonation, the palladium is mixed with nitric acid or mineral acids containing nitric acid at room temperature and then the acid is removed from the treated palladium. Preferably, the sulphonating agent of 1-10% SO.sub.3 is first mixed with the nitric acid treated palladium as a solvent, and the same sulphonating agent of 50-65% SO.sub.3 is added for sulphonation at about 90-100 degs. C.Type: GrantFiled: January 21, 1987Date of Patent: December 8, 1987Assignee: 501 China Technical Consultants, Inc.Inventor: Feng-Feng Wey
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Patent number: 4678613Abstract: Triphenylmethane dyes are obtained in a purified or more concentrated condition which eliminates the excess aromatic amines and by-products obtained during the synthesis of the triphenylmethane dyes. These purified triphenylmethane dyes show special utility when used in combination with an electron acceptor (Lewis acid) to produce carbonless copy paper or when used as reactants in the manufacture of other dyes.Type: GrantFiled: December 23, 1982Date of Patent: July 7, 1987Assignee: PMC Specialties Group, Inc.Inventor: Robert J. Flores
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Patent number: 4543214Abstract: A process for the preparation of pure bromoanthraquinones by denitrobrominating corresponding nitroanthraquinones is described. The process comprises treating nitroanthraquinones of the formula I ##STR1## wherein X is hydroxy, mercapto, carboxy or halogen and m is 1, 2, 3 or 4 and n is 1 or 2, in the temperature range from 200.degree. to 350.degree. C.Bromoanthraquinones of more than 95% purity are valuable starting materials for dye synthesis and can be used directly without further purification.Type: GrantFiled: November 23, 1983Date of Patent: September 24, 1985Assignee: Ciba-Geigy AGInventors: Tibor Somlo, Johann Regli
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Patent number: 4532344Abstract: The present invention relates to compounds of formula (I) ##STR1## wherein Ar is a fluoranthene or substituted fluoranthene ring system; R.sup.1 is a C.sub.1-3 alkylene moiety; R.sup.2 is hydrogen or a C.sub.1-6 alkyl group; R.sup.3 is a hydroxy C.sub.1-6 alkyl group; R.sup.4 and R.sup.5 are the same or different and are hydrogen, C.sub.1-6 alkyl or hydroxy C.sub.1-6 alkyl, esters thereof derived from condensation of carboxylic acids and hydroxyl groups of R.sup.3, R.sup.4, and R.sup.5 ;Acid addition salts thereof, which have been found useful for the treatment of tumors in mammals.Type: GrantFiled: May 23, 1983Date of Patent: July 30, 1985Assignee: Burroughs Wellcome Co.Inventor: Kenneth W. Bair
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Patent number: 4507241Abstract: A method for the hydrocarbylation of naphthoquinones comprising cross-coupling addition of the hydrocarbyl moiety of selected organometallic reagents to leaving group-substituted naphthoquinones.Type: GrantFiled: March 7, 1983Date of Patent: March 26, 1985Assignee: E. I. Du Pont de Nemours and CompanyInventors: George W. Parshall, Wilson Tam
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Patent number: 4500458Abstract: An improved process for the preparation of .alpha.-6-deoxytetracyclines and more particularly to the stereo specific hydrogenation of the 6-methylene group of 6-deoxy-6-demethyl-6-methylene-5-hydroxytetracyline and of its 11a-halo-analog, is described in which the catalyst is the reaction product of a rhodium salt or a complex with a hydrazine or salt thereof.Type: GrantFiled: January 14, 1983Date of Patent: February 19, 1985Assignee: Plurichemie AnstaltInventors: Ivan Villax, Philip R. Page
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Patent number: 4497825Abstract: A method for the preparation of betaines is disclosed, the betaines having the general formulaR.sup.1 CONH(CH.sub.2).sub.x N.sup..sym. R.sup.2 R.sup.3 (CH.sub.2).sub.y COO.sup..crclbar.in whichR.sup.1 is the alkyl residue of a fatty acid with 6 to 18 carbon atoms,R.sup.2 and R.sup.3 are the same or different and represent alkyl residues with 1 to 4 carbon atoms,x=2 or 3, andy=1, 2 or 3.The betaines are prepared by quaternizing fatty acid amides having the formulaR.sup.1 CONH(CH.sub.2).sub.x NR.sup.2 R.sup.3with .omega.-halogenalkylcarboxylic acids having the formulaX(CH.sub.2).sub.y COOHwherein X is a halogen residue, and carrying out the quaternization at a pH of 7.5 to 10.5 measured at 98.degree. C. The reaction product obtained from the process is essentially free of unreacted amides and organically linked chlorine and thus avoids the skin irritations normally associated with compounds in which such betaines are used.Type: GrantFiled: November 16, 1982Date of Patent: February 5, 1985Assignee: Th. Goldschmidt AGInventor: Volkbert Bade
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Patent number: 4489096Abstract: New quinone compounds of the formula: ##STR1## wherein R is methyl or methoxy andY is formyl, carboxyl, an alkoxycarbonyl having 2 to 5 carbon atoms, carbamoyl, a mono- or di- alkylcarbamoyl whose alkyl moiety has 1 to 4 carbon atoms or carbamoyloxymethyl, ortheir hydroquinone-form compounds, or pharmaceutically acceptable salts thereof, have useful physiological activities such as antiasthmatic and antiallergic activities.Type: GrantFiled: July 5, 1983Date of Patent: December 18, 1984Assignee: Takeda Chemical Industries, Ltd.Inventors: Shinji Terao, Yoshitaka Maki
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Patent number: 4460795Abstract: Described are mono-oxomethyl substituted polyhydrodimethanonaphthalene derivatives having the generic structure: ##STR1## wherein the dashed line represents a carbon-carbon single bond or a carbon-carbon double bond; wherein R.sub.1, R.sub.1 ', R.sub.1 ", R.sub.1 "', R.sub.1 "", R.sub.3, R.sub.5, R.sub.5 ', R.sub.5 ", R.sub.5 "', R.sub.5 "" and R.sub.6 represent hydrogen or methyl with the provisos:(i) at least four of R.sub.1, R.sub.1 ', R.sub.1 ", R.sub.1 "' and R.sub.1 "" are hydrogen; and (ii) at least four of R.sub.5, R.sub.5 ', R.sub.5 ", R.sub.5 "' and R.sub.5 "" represent hydrogen;and wherein Z represents one of the moieties:(i) carboxaldehyde having the structure: ##STR2## (ii) alkylene dioxy or dialkoxy methyl having the structure: ##STR3## (iii) hydroxy methyl having the structure: ##STR4## (iv) acetoxymethyl having the structure: ##STR5## and wherein R.sub.7 and R.sub.8 taken separately represent C.sub.1 -C.sub.4 lower alkyl or R.sub.7 and R.sub.8 taken together represent C.sub.2 -C.sub.Type: GrantFiled: March 24, 1983Date of Patent: July 17, 1984Assignee: International Flavors & Fragrances Inc.Inventors: Mark A. Sprecker, Marie R. Hanna, Richard J. Tokarzewski, Robert P. Belko, Hugh Watkins, Manfred H. Vock
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Patent number: 4448724Abstract: A synthesis of 4-demethoxydaunomycinone and its derivatives from the known compound 9-acetyl-6,11-dihydroxy-7,8,9,10-tetrahydro-5,12-naphthacenedione. 4-Demet hoxydaunomycinone may be converted to 4-demethoxydaunorubicin which is an anthracycline derivative known to have antitumor activity.Type: GrantFiled: December 20, 1982Date of Patent: May 15, 1984Assignee: The Trustees of the University of PennsylvaniaInventors: Michael P. Cava, Domingo Dominguez
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Patent number: 4447364Abstract: Disclosed is a method for the preparation of a stable solution of aluminum citrate. The method involves combining a solution of aluminum chloride with a solution of citric acid while maintaining vigorous agitation. After formation of the aluminum citrate solution, sufficient alkali metal or ammonium hydroxide is added to increase the pH to a level of 5.5 to 7.5. During addition of the base, the agitation is continued and the temperature of the solution is maintained at a level of from 20.degree. C. to 90.degree. C.Type: GrantFiled: January 27, 1983Date of Patent: May 8, 1984Assignee: Miles Laboratories, Inc.Inventor: Philip W. Staal
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Patent number: 4438045Abstract: A new composition of matter is revealed.The composition of matter is the condensation product of succinic anhydride, 3-dimethylamino propylamine or 3-dimethyl aminoethanol and a specified glycidyl ether.The composition of matter is useful as an amphoteric surfactant.Type: GrantFiled: December 15, 1982Date of Patent: March 20, 1984Assignee: Texaco Inc.Inventors: Edward C. Y. Nieh, Carter G. Naylor
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Patent number: 4435296Abstract: A light colored, open gear lubricating grease is formed from:a lubricating base oila clay thickenera combination of a polymer, preferably atactic polypropylene, and a particulate mineral, preferably zinc oxide, as tactifier and filler, andand alkali metal borate as EP additive.The ratio of polymer to mineral, may be from 1.5:1 to 1:1.5. An aromatic disulphide, preferably dibenzyl disulphide, may also be present as an EP additive and, if so, the wt. ratio of borate to disulphide may be from 5:1 to 7:1.Type: GrantFiled: May 22, 1981Date of Patent: March 6, 1984Assignee: The British Petroleum Company LimitedInventors: Christopher P. Brooks, Stanley C. Dodson, Robert H. Newman
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Patent number: 4435324Abstract: Improved process for the preparation of 1-alkylaminoanthraquinones by aminolysis of 1-nitroanthraquinones with alkylamines at elevated temperature in water and organic water-immiscible solvents, in the presence of acid-binding agents, according to which process calcium hydroxide is used as the acid-binding agent.Type: GrantFiled: March 25, 1982Date of Patent: March 6, 1984Assignee: Bayer AktiengesellschaftInventor: Karl-Julius Reubke
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Patent number: 4432909Abstract: Herbicidally active thiolcarbamates are employed in combination with certain amine oxanilic acid salts having the formula ##STR1## in which R is selected from the group consisting of C.sub.1 -C.sub.6 alkyl, C.sub.2 -C.sub.6 alkenyl, phenyl and benzyl, and a and b are both integers from zero to four such that the sum of a and b is four. In a typical application, the amine oxanilic acid salts are included in sufficient quantity to lessen the rate of soil degradation of the thiolcarbamate. As a result, the herbicidal effectiveness of the thiolcarbamate is enhanced and prolonged, rendering a single application of the herbicide effective over a longer period of time.Type: GrantFiled: December 27, 1982Date of Patent: February 21, 1984Assignee: Stauffer Chemical CompanyInventor: Rayman Y. Wong
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Patent number: 4428882Abstract: This disclosure describes 1-(aminoalkylamino)-5,8-dihydroxy-4-substituted-anthraquinones useful as chelating agents and for inhibiting the growth of transplanted mouse tumors.Type: GrantFiled: February 24, 1982Date of Patent: January 31, 1984Assignee: American Cyanamid CompanyInventor: Keith C. Murdock
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Patent number: 4420412Abstract: A method of bleaching of certain triarylmethane dyes in aqueous systems with low concentration of hypochlorite ion, activated by the presence of bromide ion and ammonium ions. The method is particularly useful in providing a disappearing color signal in the automatic cleaning and sanitizing of toilet bowls with low concentrations of hypochlorite. Compositions and articles for implementing the practice of the method in the automatic cleaning and sanitizing of toilet bowls are also disclosed.Type: GrantFiled: December 23, 1981Date of Patent: December 13, 1983Assignee: The Procter & Gamble CompanyInventor: Louis F. Wong