Abstract: Embodiments herein relate to polymer coated prosthetic heart valves. In an embodiment, a method of manufacturing a heart valve is included, the method obtaining a frame, attaching a porous web to the frame, applying a coating over at least a portion of the porous web. In an embodiment a heart valve is included. The heart valve including a frame and a plurality of valve leaflets attached to the frame. Each valve leaflet can have a first polymer forming a porous support web and a second polymer forming a coating occluding pores in the porous support web. The valve leaflets can be attached to the frame with a connection structure that is at least partially covered by the coating. Other embodiments are also included herein.

Abstract: Devices, systems, and methods to improve both the reliability of soft tissue repair procedures and the speed at which the procedures are completed are provided. The devices and systems include one or more structured tissue augmentation constructs, which include constructs that are configured to increase a footprint across which suture applied force to tissue when the suture is tied down onto the tissue. The tissue augmentation constructs can be quickly and easily associated with the repair suture and can be useful in many different tissue repair procedures that are disclosed in the application. The present disclosure includes structured tissue augmentation blocks for tendon repair that have a flexible or semi-flexible skeleton integrated into the block. The skeleton can be bioabsorbable and can create both in-plane and out-of-plane curvature in the block.

Abstract: An implantable prosthetic device includes a coaption portion, paddles, and clasps. The paddles are moveable from a closed position to an open position. The clasps are also moveable from an open position to a closed position. The implantable prosthetic device can be used to repair a native valve, such as a native mitral valve. Other embodiments are also described.

Abstract: Embodiments comprise a breast prosthesis. The prosthesis includes a body and a set of straps. In some embodiments, the body is comprised of a cover, on which the straps are disposed, and internal components. The straps connect the body to the person's undergarment in such a way that doesn't need sewing to the undergarment itself. The straps also hold the prosthesis in place, such that it doesn't shift or move, or does so very minimally. A person can use their own bra or similar garment of their choosing, instead of having to purchase a special mastectomy bra.

Abstract: Disclosed herein are embodiments of a non-woven hybrid-scale fiber matrix sheet which can be used to improve wound healing. The non-woven hybrid-scale fiber matrix sheet may be both microporous, due to the hybrid-scale fiber matrix, as well as macroporous through the addition of cuts or perforations in the hybrid-scale fiber matrix sheet. The micro and macroporous sheet can improve biological healing at a wound site.

Abstract: A size adjustable cover used for soft tissue reinforcement which is adapted to envelop an implantable device, such as a breast implant, in a surgical application. The cover is formed using a circular two-dimensional implantable matrix material having an inner circle and a plurality of fringes which radiate circumferentially from the inner circle. The implantable device is positioned upon the inner circle, and the plurality of fringes are folded inwardly to form an overlapping implant pocket which envelops the implantable device. Each fringe further has a punched opening, allowing a loop of suture thread to link each fringe together. Certain fringes are excluded from the loop to create stabilization tabs which radiate from the inner circle and are attached to a site of host implantation to stabilize the cover and the implantable device within.

Abstract: A medical device may include an implantable device for treating a body tissue structure. The implantable device may include a plurality of bodies spaced from adjacent bodies and arranged so as to be configured to extend around an exterior surface of a body tissue structure. The bodies may be configured to apply a static force to the body tissue in a relaxed state and may adjust or move in response to a radially outward force above a threshold level that is acting on one or more of the bodies. The bodies may be pliable and/or made with a pliable material. The bodies may be interconnected via interconnecting regions. One or more of the bodies may be configured to articulate so as to conform to movement of a body tissue structure. A skeletal component may or may not extend through one or more of the plurality of bodies.

Abstract: A transcatheter device for treating the tricuspid valve regurgitation. The transcatheter device comprises a main shaft, a proximal portion, a distal tail, and a spacer body mounted on the main shaft and located between the proximal portion and the distal tail. This transcatheter device could be used for treating tricuspid valve regurgitation in a patient's heart. All or part of the transcatheter device is supported by the main shaft. The spacer body is mounted on the shaft, which travels through the spacer body. Also disclosed are a coaptation assembly that comprises the transcatheter device, and a method of treating tricuspid valve regurgitation using the transcatheter device.

Abstract: A fluid displacement and pressurizing device which includes a housing, a first piston in the housing, a plunger which extends from the housing and has a second piston thereon, and an actuator that works to selectively lock the piston to either the housing or the plunger depending on the position of the second piston in the housing. Effectively, the actuator includes a first locking mechanism that locks and unlocks the first piston relative to the housing and a second locking mechanism that locks and unlocks the plunger relative to the piston. As such, the first locking mechanism is not only a locking mechanism but is also an actuating mechanism with regard to actuating the second locking mechanism.

Abstract: Proposed is a biliary stent unit having a pulling string that is fixed to the skin of a human body to prevent a stent from separating from a diseased part of the biliary tract, and having a soft tube that reduces stimulus in the human body after a surgery because it has flexibility.

Abstract: Devices including a capsule having an interior and a clamp assembly including a plurality of clamps. Each clamp includes a first arm having a first free end and a second arm having a second free end. The device includes a clamp assembly including a compacted state in which the plurality of clamps are compressed within the capsule and a deployed state in which at least the free ends of the plurality of clamps are positioned outside of the interior of the capsule. The first free end is closer to the second free end in the compacted state as compared to the deployed state. The device can further include a push rod releasably secured to the clamp assembly and a delivery rod releasably secured to the capsule. Methods of using the devices are also disclosed.

Abstract: A fluid displacement and pressurizing device which includes a housing, a first piston in the housing, a plunger which extends from the housing and has a second piston thereon, and an actuator that works to selectively lock the piston to either the housing or the plunger depending on the position of the second piston in the housing. Effectively, the actuator includes a first locking mechanism that locks and unlocks the first piston relative to the housing and a second locking mechanism that locks and unlocks the plunger relative to the piston. As such, the first locking mechanism is not only a locking mechanism but is also an actuating mechanism with regard to actuating the second locking mechanism.

Abstract: A vascular prosthesis includes an outer crimped textile graft and an inner polymeric liner. The polymeric liner is secured to the valleys of the crimps of the textile graft while leaving the peaks of the textile graft free of the liner. The polymeric liner is impermeable to blood flow. The inner liner may include expanded polytetrafluoroethylene polymer, and the graft may include polyethylene terephthalate yarns.

Abstract: A clamping instrument (10), mainly comprising: a clamping base (20), a driving base (30), a clamping structure (40), which forms different clamping angles according to the distance between the clamping base (20) and the driving base (30); and a fine adjustment member (50), wherein the fine adjustment member (50) and the driving base (30) can be separated from each other or connected to each other, such that the driving base (30) can move rapidly or step by step relative to the clamping base (20), thereby achieving the aim of rapidly adjusting or finely adjusting the clamping angle of the clamping structure.

Abstract: Stents are disclosed herein. The stents described herein can comprise a hollow cylindrical body in which a middle region extends to a first end and also extends to an opposing second end. The first end and the second end can each comprise a plurality of flanges, within which the flanges can have either similar or different characteristics, particularly physical profiles.

Abstract: The present invention provides an anchor delivery device for repairing a heart valve, and relates to the technical field of medical instruments. The system comprises a bend adjustable tube assembly, an anchor delivery assembly, a suture locking mechanism, and a puncture assembly. The anchor delivery assembly is mounted in the bend adjustable tube assembly; the suture locking mechanism is connected to an anchor, and is provided with a guide portion located in the anchor; and the puncture assembly is mounted in an anchor delivery tube, and a puncture needle body of the puncture assembly penetrates the guide portion and is radially limited by the guide portion. According to the present invention, the puncture accuracy of the puncture needle body and the stability thereof after puncture can be ensured, and the accuracy and stability of the subsequent implantation of the anchor are improved.

Abstract: A fixing device for clamping a tissue comprises a support mechanism comprising a fixed connecting assembly and a drive assembly, and a clamp mechanism comprising closure members and capture portions, wherein each closure member comprises a closure connecting portion and a closure clamping portion in cooperation with one of the capture portions to clamp the tissue; wherein each closure connecting portion is provided with guide slots comprising a first slot portion and a second slot portion in communication therewith and has a relatively smaller radian, the fixed connecting assembly is provided with pins at least partially located in the guide slots, respectively, and the pins are slidable relative to the guide slots when the drive assembly moves relative to the fixed connecting assembly, so as to drive the closure clamping portions to move towards or away from each other. A system comprising the fixing device, and a method are provided.

Abstract: Embodiments of a Urological implant include an implant with an elongated body having a longitudinal axis. Optionally longitudinal ribs symmetrically oppose each other and are connected to elongated body. The longitudinal ribs are optionally elastically shiftable between a collapsed state and an expanded state relative to the spinal longitudinal axis, in order to retract or/and support periurethral tissue. Optionally the system includes an implant extraction handle. The extraction handle is optionally positioned proximally to the elongated body and connected to the longitudinal rib and subject to a pulling force to facilitate and/or force approximation of the longitudinal supports to the longitudinal axis. In some embodiments, an implant body includes longitudinally spaced arched members, interconnected via arch ends sequentially along a length of a first and second longitudinal rib.

Abstract: A ureteral stent is provided. The stent may include a first section having a first wall defining a first luminal section. The stent may further include a second section having a second wall defining a second luminal section. The second section can be enabled to substantially close at times external pressure is applied to the stent.

Abstract: A nasal tissue implant for reconstruction and tissue engineering of nasal tissue in a subject includes a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. The tissue scaffold component conforms to a portion of the subject's nasal region and defines at least a portion of the subject's nasal anatomy. A method of making an implantable nasal tissue implant for reconstructing a portion of a nasal anatomy of a human or other animal subject is also provided that includes laser sintering or three-dimensional (3D) printing a biocompatible polymeric material to form a tissue scaffold component comprising a biocompatible polymeric material having a plurality of open pores configured to support cell growth. Again, the tissue scaffold component substantially conforms to a nasal region specific to the human or other animal subject.