Patents Examined by Renee Danega
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Patent number: 8764676Abstract: The invention relates to systems and methods for estimating a response of at least a part of a physiological system to a first deterministic stimulus signal. The methods include separating a measured first signal into a plurality of segments, each segment representing a response of the physiological system to a corresponding portion of the first stimulus signal and generating a template signal representing the plurality of segments. The methods further include calculating a measure of similarity of each segment in the plurality of segments to the template signal to provide a set of scalar quantities, and determining a metric representing a characteristic of the response of at least a part of the physiological system to the first stimulus signal.Type: GrantFiled: May 7, 2010Date of Patent: July 1, 2014Assignee: Massachusetts Eye & Ear InfirmaryInventors: Srinivasamurthy Ravi Prakash, John J. Guinan, Jr., Barbara Herrmann, Steven D. Rauch
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Patent number: 8758268Abstract: A shaped guidewire for use in medical applications is disclosed. The guidewire is shaped so as to prevent inadvertent advancement of the guidewire into the corpus of a patient during use. In one embodiment, the guidewire includes an elongate body that defines proximal and distal ends. The guidewire body further defines a shaped portion that is positioned intermediate the proximal and distal ends. The shaped portion of the guidewire is at least partially composed of a shape memory material, such as nitinol, and is deflected from a longitudinal axis defined by an undeflected portion of the guidewire body. The shaped portion is disposed in one embodiment at the proximal end of the guidewire. In another embodiment, a proximal portion of the nitinol guidewire can be treated to impart malleability and enable deflection by a clinician. Methods for forming the shaped or malleable guidewire to include a deflected portion are disclosed.Type: GrantFiled: February 8, 2008Date of Patent: June 24, 2014Assignee: C. R. Bard, Inc.Inventors: Matthew W. Bown, David M. Butts
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Patent number: 8758271Abstract: A device for measuring a mechanical property of a tissue includes a probe configured to perturb the tissue with movement relative to a surface of the tissue, an actuator coupled to the probe to move the probe, a detector configured to measure a response of the tissue to the perturbation, and a controller coupled to the actuator and the detector. The controller drives the actuator using a stochastic sequence and determines the mechanical property of the tissue using the measured response received from the detector. The probe can be coupled to the tissue surface. The device can include a reference surface configured to contact the tissue surface. The probe may include a set of interchangeable heads, the set including a head for lateral movement of the probe and a head for perpendicular movement of the probe. The perturbation can include extension of the tissue with the probe or sliding the probe across the tissue surface and may also include indentation of the tissue with the probe.Type: GrantFiled: August 31, 2010Date of Patent: June 24, 2014Assignee: Massachusetts Institute of TechnologyInventors: Ian W. Hunter, Yi Chen
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Patent number: 8755535Abstract: According to certain described aspects, multiple acoustic sensing elements are employed in a variety of beneficial ways to provide improved physiological monitoring, among other advantages. In various embodiments, sensing elements can be advantageously employed in a single sensor package, in multiple sensor packages, and at a variety of other strategic locations in the monitoring environment. According to other aspects, to compensate for skin elasticity and attachment variability, an acoustic sensor support is provided that includes one or more pressure equalization pathways. The pathways can provide an air-flow channel from the cavity defined by the sensing elements and frame to the ambient air pressure.Type: GrantFiled: October 14, 2010Date of Patent: June 17, 2014Assignee: Masimo CorporationInventors: Valery G. Telfort, Massi Joe E. Kiani
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Patent number: 8740783Abstract: Systems and methods for performing neurophysiologic assessments of neural tissue including nerve pathology monitoring which may or may not be augmented by adding the ability to assess or monitor the pressure being exerted upon a nerve or nerve root before, during and/or after retraction.Type: GrantFiled: July 20, 2006Date of Patent: June 3, 2014Assignee: NuVasive, Inc.Inventors: James Gharib, Allen Farquhar, Scot Martinelli, David Ivanko, Benjamin VerHage
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Patent number: 8740813Abstract: A sample of a body fluid such as blood or interstitial fluid is obtained from a body by lancing a portion of a user's skin, preferably in an area other than a finger tip, to form an incision. After the needle has been removed from the incision, a force is applied to depress the skin in a manner forming a ring of depressed body tissue in surrounding relationship to the incision, causing the incision to bulge and the sides of the incision to open, whereby body fluid is forced out through the opening of the incision. A stimulator member is mounted to an end of a lancet-carrying housing for applying the force. The stimulator member can be movable relative to the housing, and can be either heated or vibrated to promote movement of the body fluid.Type: GrantFiled: July 30, 2012Date of Patent: June 3, 2014Assignee: Roche Diagnostics Operations, Inc.Inventors: Joel S. Douglas, Jeffrey N. Roe, Henry M. Grage
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Patent number: 8734345Abstract: A real time tissue sampling and analysis system includes a catheter including an elongated body defining at least one internal lumen, a sampling device positionable within the at least one internal lumen of the catheter for collecting a tissue sample, and a biochip disposed within the at least one internal lumen. The biochip includes a substrate for receiving the tissue sample, a marker for interacting with the tissue sample, and a sensor for identifying a characteristic of the tissue sample and transmitting data about the tissue sample to a processing unit for analysis.Type: GrantFiled: August 1, 2011Date of Patent: May 27, 2014Assignee: Covidien LPInventors: Manish Deshpande, Terri A. Kapur
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Patent number: 8738124Abstract: Methods and systems are provided for the noninvasive measurement of the subepithelial impedance of the breast and for assessing the risk that a substantially asymptomatic female patient will develop or be at substantially increased risk of developing proliferative or pre-cancerous changes in the breast, or may be at subsequent risk for the development of pre-cancerous or cancerous changes. A plurality of electrodes are used to measure subepithelial impedance of parenchymal breast tissue of a patient at one or more locations and at least one frequency, particularly moderately high frequencies. The risk of developing breast cancer is assessed according to measured and expected or estimated values of subepithelial impedance for the patient and according to one or more experienced-based algorithms. Devices for practicing the disclosed methods are also provided.Type: GrantFiled: December 8, 2008Date of Patent: May 27, 2014Assignee: Epi-Sci, LLCInventor: Richard J. Davies
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Patent number: 8728007Abstract: The present invention relates to a method and apparatus for managing patient data. In one aspect, the invention relates to a system for managing patient data having many instruments. The instruments have a sampling member for sampling a body fluid from a patient and are in direct communication with at least one other instrument.Type: GrantFiled: May 16, 2011Date of Patent: May 20, 2014Assignee: Instrumentation Laboratory CompanyInventors: Anwar A Azer, Ramon E Benet
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Patent number: 8715207Abstract: A device for measuring an internal dimension of a native cardiac valve annulus includes an elongated support member having a proximal portion and a distal portion. A measuring portion is coupled to the distal portion, and an indicator is coupled to the proximal portion of the support member. The measuring portion is biased towards a deployed configuration such that when deployed it applies an outwardly directed radial force to the native valve annulus.Type: GrantFiled: March 18, 2010Date of Patent: May 6, 2014Assignee: Sorin Group Italia S.r.l.Inventors: Giovanni Righini, Felice G. Carlino, Giovanni Rolando
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Patent number: 8715206Abstract: According to certain described aspects, multiple acoustic sensing elements are employed in a variety of beneficial ways to provide improved physiological monitoring, among other advantages. In various embodiments, sensing elements can be advantageously employed in a single sensor package, in multiple sensor packages, and at a variety of other strategic locations in the monitoring environment. According to other aspects, to compensate for skin elasticity and attachment variability, an acoustic sensor support is provided that includes one or more pressure equalization pathways. The pathways can provide an air-flow channel from the cavity defined by the sensing elements and frame to the ambient air pressure.Type: GrantFiled: October 14, 2010Date of Patent: May 6, 2014Assignee: Masimo CorporationInventors: Valery G. Telfort, Anand Sampath
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Patent number: 8702629Abstract: The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a treatment delivery system for treating a subject in response to changes in the severity of a subject's symptoms. The present invention further provides for a system and method, which can accurately quantify symptoms of movement disorders, utilizing continuously obtained kinetic information to be analyzed, accurately distinguishing between symptoms of movement disorders and activities of daily living, relating quantified symptoms to a standard clinical rating scale, and correlating a subject's symptoms with certain physiological and environmental factors. The present invention still further provides for home monitoring of symptoms in subjects with these movement disorders in order to capture the complex fluctuation patterns of the disease over the course of days, weeks, months, or years.Type: GrantFiled: July 18, 2011Date of Patent: April 22, 2014Assignee: Great Lakes Neuro Technologies Inc.Inventors: Joseph P. Giuffrida, Dustin A. Heldman, Thomas O. Mera
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Patent number: 8702738Abstract: A tissue cutting device that is especially suited for neurosurgical applications is disclosed and described. The device includes a handpiece and an outer cannula in which a reciprocating inner cannula is disposed. The inner cannula includes a hinge between a body section and a cutting section that allows the cutting section to pivot when the inner cannula reciprocates within the outer cannula. A tissue collector is also provided and is in fluid communication with the lumen of the inner cannula. The handpiece includes a proximal section that is angled with respect to a distal section.Type: GrantFiled: February 24, 2009Date of Patent: April 22, 2014Assignee: Nico CorporationInventor: Joseph L. Mark
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Patent number: 8702627Abstract: According to certain described aspects, multiple acoustic sensing elements are employed in a variety of beneficial ways to provide improved physiological monitoring, among other advantages. In various embodiments, sensing elements can be advantageously employed in a single sensor package, in multiple sensor packages, and at a variety of other strategic locations in the monitoring environment. According to other aspects, to compensate for skin elasticity and attachment variability, an acoustic sensor support is provided that includes one or more pressure equalization pathways. The pathways can provide an air-flow channel from the cavity defined by the sensing elements and frame to the ambient air pressure.Type: GrantFiled: October 14, 2010Date of Patent: April 22, 2014Assignee: Masimo CorporationInventors: Valery G. Telfort, Dimitar Dimitrov, Phi Trang
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Patent number: 8690799Abstract: According to certain described aspects, multiple acoustic sensing elements are employed in a variety of beneficial ways to provide improved physiological monitoring, among other advantages. In various embodiments, sensing elements can be advantageously employed in a single sensor package, in multiple sensor packages, and at a variety of other strategic locations in the monitoring environment. According to other aspects, to compensate for skin elasticity and attachment variability, an acoustic sensor support is provided that includes one or more pressure equalization pathways. The pathways can provide an air-flow channel from the cavity defined by the sensing elements and frame to the ambient air pressure.Type: GrantFiled: October 14, 2010Date of Patent: April 8, 2014Assignee: Masimo CorporationInventors: Valery G. Telfort, Dimitar Dimitrov, Phi Trang, Massi Joe E. Kiani, Anand Sampath
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Patent number: 8690791Abstract: An apparatus and method for harvesting bone and bone marrow are provided. The apparatus may include a driver operable to be releasably engaged with an intraosseous device. The intraosseous device may include a cannula having a first end operable to penetrate bone and bone marrow and to allow retrieval of portions of bone and/or bone marrow. The cannula may have a second end operable to be releasably engaged with bone marrow sampling equipment. The apparatus may include a removable trocar. The removable trocar may have an inner channel operable to convey portions of bone and/or bone marrow. The removable trocar may have an inner channel and a side port communicating with the inner channel. The removable trocar may have a first end operable to penetrate bone and bone marrow.Type: GrantFiled: April 21, 2009Date of Patent: April 8, 2014Assignee: Vidacare CorporationInventor: Larry J. Miller
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Patent number: 8684946Abstract: The present disclosure describes a psychophysical test to assess the cone photoreceptor pathway by determining the sensitivity of the cone photoreceptors. The test may be used to determine of a subject is suffering from, or is likely to suffer from, a disease state involving the fovea, parafovea, macula, neurological pathways used by these area to communicate with the visual processing centers in the brain and cone photoreceptors and/or ganglion cells. The present disclosure also describes an apparatus for such testing purposes. Using the novel cone photoreceptor sensitivity test and apparatus, the present disclosure shows that cone photoreceptor sensitivity in subjects with primary open angle glaucoma was decreased as compared to a control group (p=0.04). This cone photoreceptor sensitivity test is shown to have excellent repeatability, can be administered in a short time, does not require extensive subject instruction and meets other limitations required for application in a clinical setting.Type: GrantFiled: December 19, 2006Date of Patent: April 1, 2014Assignee: The UAB Research FoundationInventors: Janene Sims, Robert N. Kleinstein
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Patent number: 8682608Abstract: A behavior recognition apparatus includes a hand movement observation unit which outputs hand movement data indicating a hand movement made by a user; a velocity variation detection unit which detects a time at which the hand movement matches a predetermined movement pattern; and a feature selection unit which selects the hand movement data outputted at the time detected by the velocity variation detection unit. A standard behavior pattern storage unit stores a movement pattern data sequence represented by a hand movement data sequence, in association with a user behavior; and a behavior recognition unit calculates a degree of similarity between the movement pattern data sequence stored in the standard behavior pattern storage unit and the hand movement data selected by the feature selection unit, and recognizes, as the user behavior, a behavior represented by the movement pattern data sequence when the degree of similarity is the highest.Type: GrantFiled: May 27, 2010Date of Patent: March 25, 2014Assignee: Panasonic CorporationInventors: Takashi Tsuzuki, Mototaka Yoshioka, Kazutoyo Takata
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Patent number: 8679407Abstract: This invention is in the field of medical devices. Specifically, the present invention provides portable medical devices that allow real-time detection of analytes from a biological fluid. The methods and devices are particularly useful for providing point-of-care testing for a variety of medical applications.Type: GrantFiled: March 24, 2006Date of Patent: March 25, 2014Assignee: Theranos, Inc.Inventors: Elizabeth A. Holmes, Ian Gibbons, John Howard, Shaunak Roy, Chengwang Wang, Timothy M. Kemp
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Patent number: 8679038Abstract: The present invention relates to a movement disorder monitor, and a method of measuring the severity of a subject's movement disorder. The present invention additionally relates to a drug delivery system for dosing a subject in response to the increased severity of a subject's symptoms. The present invention provides for a system and method, which can accurately quantify symptoms of movements disorders, accurately quantifies symptoms utilizing both kinetic information and electromyography (EMG) data, that can be worn continuously to provide continuous information to be analyzed as needed by the clinician, that can provide analysis in real-time, that allows for home monitoring of symptoms in subject's with these movement disorders to capture the complex fluctuation patterns of the disease over the course of days, weeks or months, that maximizes subject safety, and that provides remote access to the clinician or physician.Type: GrantFiled: April 25, 2012Date of Patent: March 25, 2014Assignee: Great Lakes NeuroTechnologies Inc.Inventor: Joseph Giuffrida