Abstract: An applied make-up of long durability and/or a transfer-free make-up composition is removed from the skin by applying to the skin a composition consisting of an aqueous phase and an oily phase, which are distinct, to remove the make-up or transfer-free make-up.

Abstract: Lipcolor comprising a salt or hydroxide of di-or trivalent metal, a water-soluble alginate, a red or orange lake color having a COONa or COOK group, and an oil coponent having appearance of liquid at 20° C. The lipcolor less yields a dry feeling or an uneasy feeling with the passage of time, and its color comes off less in friction with foods and drinks.

Abstract: The foregoing invention relates to a new microbubble preparation and thrombolytic therapy which relies on microbubbles and ultrasound for its lytic activity. The pharmaceutical composition of the invention comprises a liquid solution of microbubbles with an internal atmosphere enhanced with the perfluorocarbon gas which cavitate in the presence of an ultrasound field following intravenous injection or infusion of said composition into said host. For thrombolysis the area of a thrombus is exposed to an ultrasound field in the presence of the microbubbles and significant lysis is experienced. The method and pharmaceutical composition of the invention exhibit thrombolytic properties similar to those of other thrombolytic agents such as urokinase and are less toxic and are clot specific in that they do not introduce a systemic lytic state to a said animal.

Abstract: The present invention provides a pressure sensitive skin adhesive comprising: (a) a copolymer of one or more alkyl(meth)acrylates containing 4 to 12 carbon atoms in the alkyl group and one or more hydrophilic monomers; (b) a mixture of penetration enhancers comprising: (i) an alkyl ester of an aliphatic monocarboxylic acid containing 1 to 5 carbon atoms in the alkyl group (ii) an alkyl pyrrolidone and (iii) an alkane polyol (c) a therapeutically effective amount of diclofenac or a pharmaceutically acceptable salt thereof. Further provided is a transdermal drug delivery device containing the pressure sensitive skin adhesive.

Abstract: This invention relates to locally administrable, biodegradable and sustained-release pharmaceutical composition for periodontitis and process for preparation thereof, which can show continuous drug effect for a long time by controlling the release time and by making the drug remain in the periodontal pocket for a prolonged time. The composition is prepared by i) making a microsphere containing the physiologically active substance, ii) making the mixture of the microspheres and water-soluble polymer such as polysaccharides iii) making the mixture into the form of film or strip or/and iv) coating the film or strip with a cation aqueous solution such as calcium and barium. The present pharmaceutical composition can be easily administered using forceps, has minimized side effects and maximizes the effect by releasing the active substance at the minimum dose, and make the patients feel comfortable.

Abstract: The invention concerns a solid pharmaceutical composition comprising less than 7% by weight of an oil or oily substance, a low dosage active ingredient, and a water insoluble non-cross-linked polymeric excipient capable of binding water and having a mean particle size greater than 150 &mgr;m. The composition can be obtained by a simple procedure comprising mixing the water insoluble non-cross-linked polymeric excipient capable of binding water and the active ingredient, which is dissolved or dispersed in an oil or an oily substance, in an aqueous dispersion thereof, or in water.

Abstract: Disclosed are anhydrous antiperspirant cream compositions that have improved wash-off performance and good antiperspirant efficacy, which compositions have a penetration force value of from about 75 gram·force to about 500 gram·force, a delta stress value of from about 300 dyne/cm2 to about 8,000 dyne/cm2 as measured after extrusion of the composition through a shear force delivery means, and a static yield stress value of at least about 1,000 dyne/cm2 as measured after extrusion of the composition through a shear force delivery means. These compositions comprise from about 0.1% to about 20% by weight of a crystalline gellant, from about 10% to about 80% by weight of an anhydrous liquid carrier for the crystalline gellant wherein the anhydrous liquid carrier has a solubility parameter of from about 3 to about 13, from about 5% to about 35% by weight of a particulate antiperspirant active, and from about 0.

Abstract: The present invention relates to orally administered suspensions of pharmaceutical active substances of the NSAID type, particularly the antirheumatic agent Meloxicam, which are stabilized by the addition of small amounts of highly dispersed silicon dioxide using high shear forces and adding small amounts of hydrophilic polymers to form a three-dimensional siloid structure, and a process for the preparation thereof.

Abstract: The invention relates to insecticidal silicone elastomers, processes for their preparation and their use for controlling or repelling insects, in particular in interiors, characterized in that they comprise at least one type of a pyrethroid insecticide which is incorporated in a suitable silicone elastomer.

Abstract: Substantially non-antigenic polymers containing pI and/or pH optimum modulating moieties are disclosed. The polymers are useful as intermediates for synthesis of amine-based polymers and in the formation of activated polymers for conjugation with nucleophiles. Conjugates and methods of preparation and treatment with the conjugates are also disclosed.

Abstract: A cosmetic or dermatological composition for treating keratinous material, particularly hair, including a cosmetically or dermatologically acceptable medium containing at least one silicone-grafted polymer with a polysiloxane backbone grafted by non-silicone organic monomers and at least one silicone selected from silicones which comprise at least one optionally quaternary amine function, silicone resins, and silicone gums, is disclosed. Such compositions are particularly suitable for use as rinsable or non-rinsable products for washing and conditioning hair, hair setting, or hair styling.

Abstract: Sterile pharmaceutical compositions parenteral administration containing propofol in an oil-in-water emulsion additionally containing an amount of the preservative tromethamine sufficient to prevent signficant growth of microorganisms for at least 24 hours after extrinsic contamination.

Abstract: A solid preparation characteristically containing for a binder methyl cellulose whose MeO content is 27.5-31.5 wt % and whose 2 wt % aqueous solution has a viscosity of 2-12 cP at 20° C. The present invention can provide a solid preparation which has an adequate hardness and at the same time disintegrates quickly for easy absorption.

Abstract: The present invention relates to novel liquid formulations for the controlled and sustained release of insecticidally active compounds by means of a heat source and the water-based pre-solutions required for preparing these formulations.

Abstract: The invention provides methods and compositions which are mild and nonirritating for reducing and eliminating skin disorders, particularly blemishes and redness associated with acne. The hydroalcoholic compositions of the invention contain a keratolytic compound, preferably a &bgr;-hydroxy carboxylic acid, more preferably salicylic acid or pharmaceutically acceptable salt thereof; and a glycerophosphate ester or salt, formulated with pharmaceutically acceptable carriers. Preferred glycerophosphate salts for use in the methods and compositions of the invention are sodium glycerophosphate and calcium glycerophosphate. Additional anti-irritancy agents are not required in the compositions of the present invention, as the glycerophosphate salt component uniquely endows the compositions with nonirritant properties. Other components which may be formulated into the compositions of the invention include fragrances, colorants, emollients, humectants and antimicrobial agents.

Abstract: There is provided novel pharmaceutical compositions containing tyloxapol as the active ingredient. These formulations comprise tyloxapol at concentrations above 0.125%, preferably from about 0.25% to about 5.0%. In addition, the invention encompasses pharmaceutical compositions having reduced hypertonicity which compositions comprise tyloxapol in pharmaceutically acceptable solutions without significant concentrations of hypertonic agents or other active ingredients NaHCO.sub.3, or active phospholipids, such as DPPC. The less hypertonic formulations allow one to derive all the benefits of the active ingredient tyloxapol, such as its reduced toxicity and enhanced half-life, while avoiding or reducing side effects, such as bronchospasms, associated with the various hypertonic agents or other active ingredient agents.

Abstract: The invention relates to combinations of atovaquone and proguanil, their use in the treatment and prophylaxis of parasitic infections such as protozoal parasitic infections, e.g., malaria and toxoplasmosis, and infections caused by P. carinii and their use in the manufacture of medicaments for the treatment and/or prophylaxis of such infections. The combinations can conveniently be administered in a single pharmaceutical formulation. Preferably, atovaquone and proguanil are administered in a potentiating ratio so that they act in synergy.

Abstract: Disclosed is a cosmetic soap-gelled solid stick composition, which maintains its shape and aesthetic properties even when stored at high temperatures for long periods of time. The composition includes at least one alcohol (monohydric and/or polyhydric), water, and a soap gelling agent, the alcohol being a solvent for the soap gelling agent, the soap gelling agent being alkali metal (e.g., sodium) salts of fatty acids having C.sub.12 -C.sub.22 carbon chain length. At least 65% by weight, of the total weight of the soap gelling agent, are alkali metal salts of fatty acids having C.sub.20 -C.sub.22 carbon chain length.

Abstract: Disclosed is a poultice capable of rapidly curing an affected part of a patient's body and of enhancing a curative value by increasing an infiltration efficiency of medicine into a hypodermic tissue of the affected part with the aid of a low-frequency electro therapy. Both surfaces of compress sheets of the poultice are coated with predetermined skin-adhesive medicines adapted to cure an affected part of a patient's body. A thin film is attached to lower surfaces of the compress sheets. The thin film can be detached from the lower surfaces of the compress sheets during use of the poultice. An attaching sheet for attaching the poultice to the affected part of the patient's body is located on upper surfaces of the compress sheets. A pair of conductive layers are coated on a lower surface of the attaching sheet, which is opposite to the upper surfaces of the compress sheets. A low-frequency oscillator for applying a low-frequency energy into the compress sheets is installed between the conductive layers.

Abstract: A process for the manufacture of particles comprises mechanically working a mixture of a drug and a hydrophobic and/or hydrophilic fusible carrier in a high speed mixture so as to form agglomerates, breaking the agglomerates to give controlled release particles and optionally continuing the mechanical working with the optional addition of a low percentage of the carrier or diluent.