Abstract: Devices and methods for positioning a portion of a sensor at a first predetermined location, displacing the portion of the sensor from the first predetermined location to a second predetermined location, and detecting one or signals associated with an analyte level of a patient at the second predetermined location are disclosed. Also provided are systems and kits for use in analyte monitoring.

Abstract: For measuring the concentration of a substance in body fluid, such as the glucose level in blood or tissue, a strip electrode (18) and a ring electrode (19) are arranged at the specimen. The ring electrode (19) is in direct electrical contact with the specimen while the strip electrode (18) is electrically insulated therefrom. The strip electrode (18) is arranged parallel to an arm or a leg for obtaining a large interaction length. The electrodes (18, 19) form a capacitor in a resonant circuit. A modulated voltage in the MHz range close to or at the resonance frequency is applied to the electrodes and the response of the body fluid is measured. This design allows a measurement of high accuracy.

Abstract: Disclosed herein are systems and methods for a continuous analyte sensor, such as a continuous glucose sensor. One such system utilizes first and second working electrodes to measure analyte or non-analyte related signal, both of which electrode include an interference domain.

Abstract: A system includes a port to receive brain activity data of a user, a processor to detect a beginning time of a user nap based upon the brain activity data, and a user interface to notify the user when a predetermined nap time has elapsed. A method of monitoring a user somnolence level receives brain activity data from a user, and determines a somnolence level from the brain activity data. If the somnolence level is sleep, the system determines if a nap has progressed to a waking point, and if the nap has progressed to a waking point, alerts the user.

Abstract: A system and method for the intra corporal, measuring of blood pressure includes a substantially rigid sensor structure and an antenna structure, which are separate components. The anchor structure is used to mount the within an appropriate location in the cardiovascular system, such as in the cardiac septum. The substantially rigid sensor structure includes at least one capacitive pressure sensor. Measured values are transmitted telemetrically from the sensor structure to an extra corporal monitoring device.

Abstract: Apparatus and methods for non-invasively determining cardiac output using partial re-breathing techniques are disclosed in which the apparatus is constructed with an instantaneously adjustable deadspace for accommodating differences in breathing capacities of various patients. The apparatus is constructed of inexpensive elements, including a single two-way valve which renders the apparatus very simple to use and inexpensive so that the unit may be readily disposable. The method of the invention provides a novel means of estimating cardiac output based on alveolar CO2 values rather than end-tidal CO2 values as previously practiced. A program for calculating cardiac output is also disclosed.

Abstract: The invention relates to a method and apparatus for detecting artifacts in a bioelectric signal, especially in a frontal EEG signal. In order to accomplish an uncomplicated mechanism for detecting artifacts in clinical applications, an impedance signal is measured through a first electrode set attached to the skin surface in a measurement area of a patient's body, the impedance signal being indicative of the impedance of the signal path formed between individual electrodes of the set. Simultaneously with the impedance measurement, a bioelectric signal is acquired through a second electrode set also attached to the skin surface of the measurement area, and the time periods are determined during which the impedance signal fulfills at least one predetermined criterion indicative of the presence of artifact in the bioelectric signal. In one embodiment, the first and second electrode sets are formed by a common set of two electrodes.

Abstract: A medical device system includes a brain monitoring element, cardiac monitoring element, therapy module and a processor. The processor is configured to activate the therapy module upon detection of a cardiac event in the cardiac signal. The processor is further configured to monitor the brain signal and communicate to the therapy module to change the cardiac triggered therapeutic output to the brain based upon the brain monitoring. A method of treating a person with a neurological disorder is also provided.

Abstract: A system and method for the intra corporal, telemetric measuring of blood pressure, particularly within the heart or a great vessel, includes a substantially rigid sensor chip mounted in a holder and an antenna. The holder is anchored within an appropriate location in the cardiovascular system, such as in the cardiac septum, via a catheter or other minimally-invasive procedure to position at least one capacitive pressure sensor on the chip in the blood flow to be sensed. Measured values are transmitted telemetrically from the chip to an extra corporal monitoring device.

Abstract: One method for diagnosing a cardiovascular-related condition in a breathing person comprises interfacing a valve system to the person's airway. The valve system is configured to decrease or prevent respiratory gas flow to the person's lungs during at least a portion of an inhalation event. The person is permitted to inhale and exhale through the valve system. During inhalation, the valve system functions to produce a vacuum within the thorax to increase blood flow back to the right heart of the person, thereby increasing blood circulation and blood pressure. Further, at least one physiological parameter is measured both prior to and while the person inhales and exhales through the valve system. The measured parameters are evaluated to confirm the initial diagnosis of a cardiovascular condition.

Abstract: An apnea classification system provides for apnea monitoring and differentiation based on several sleep apnea related parameters for diagnostic and therapeutic purposes. Monitoring of such sleep apnea related parameters allows the apnea classification system to differentiate among the different types of apnea. This information may then be used to determine the best method of therapy, or adjust current therapy parameters to more effectively treat a subject.

Abstract: In an embodiment, the present invention provides a device that identifies cardiovascular dysfunction of a subject. The claimed device comprises a controller, a transducer, and a processor. The controller initiates collection of a plurality of data related to a physiological condition. The transducer collects data over a plurality of cycles and transfers the data to the processor, which reduces the received data signal into an output using a novel formula. In an example the data correlate with data that are directly related to cardiovascular dysfunction but that are of limited use.

Abstract: A method of deriving a single integer figure of merit representative of vital signs of a mammalian, generally a human subject. A systolic blood pressure S, a diastolic pressure D, and a heart rate PR are used to calculate an Inferred Blood Flow (IBF) using the equation IBF=(S?D)* PR/C where C is a constant, typically 100. A procedure is provided for establishing a statistically valid baseline IBF number against which subsequent IBF readings may be compared to assess the wellness (physiological and emotional) of the subject relative to medical community limits and standards. A self-contained apparatus for making measurements, and computing and storing an IBF is also provided. A normalized single digit scale, the Millen Scale is provided and ideal for use with the present invention. A system for monitoring wellness and/or emotional state of being using the IBF parameter is also provided.

Abstract: Parametric characterization of nitric oxide (NO) gas exchange using a two-compartment model of the lungs is a non-invasive technique to characterize inflammatory lung diseases. The technique applies the two-compartment model to parametric characterization of NO gas exchange from a tidal breathing pattern. The model is used to estimate up to six flow-independent parameters, and to study alternate breathing patterns.

Abstract: In an apparatus for diagnosing a brain function of a subject 20 by giving a load to a functional site of a living organism of the subject 20, receiving reactions emitted from the living organism of the subject 20 as an electric signal 40, 50, 60 or 70 and analyzing the electric signal 40, 50, 60 or 70, the electric signals 40, 50, 60 and 70 are a voice signal 40, an nystagmus signal 50, a pulse wave signal 60 and a gravity center swinging signal 70. The apparatus selects at least two from among them, calculates chaos theoretical indexes such as Lyapunov exponents according to a chaos theoretical technique, detects changes in the chaos theoretical indexes with passage of time, and collectively evaluates and diagnoses the brain function.

Abstract: The present invention provides systems and methods for ambulatory, long term monitoring of a physiological signal from a patient. At least a portion of the systems of the present invention may be implanted within the patient in a minimally invasive manner. In preferred embodiments, brain activity signals are sampled from the patient and are transmitted to a handheld patient communication device for further processing.

Abstract: Embodiments of the present invention provide a new system and methods for monitoring blood glucose concentration. A user of a continuous glucose monitor may program upper and lower blood glucose notification thresholds to fluctuate over time in order to facilitate management of the short-term effects of food consumption, insulin delivery aberrations, physical activity, emotions, and unforeseen circumstances.

Abstract: This document discusses, among other things, a cardiac rhythm management device or other implantable medical device that uses thoracic impedance to determine how much fluid is present in the thorax, such as for detecting or predicting congestive heart failure, pulmonary edema, pleural effusion, hypotension, or the like. The thoracic fluid amount determined from the thoracic impedance is compensated for changes in blood resistivity, which may result from changes in hematocrit level or other factors. The blood-resistivity-compensated thoracic fluid amount can be stored in the device or transmitted to an external device for storage or display. The blood-resistivity-compensated thoracic fluid amount can also be used to adjust a cardiac pacing, cardiac resynchronization, or other cardiac rhythm management or other therapy to the patient. This document also discusses applications of the devices and methods for predicting or indicating anemia.

Abstract: A method for analyzing the mitochondrial function of a subject involves: conducting a first test wherein the average oxygen consumption of the subject during exercise is measured while the subject is breathing air having a first oxygen concentration, preferably room air having a concentration of 20-21% by weight; conducting a second test wherein the average oxygen consumption of the subject during exercise is measured while the subject is breathing air having a second oxygen concentration, preferably air having an oxygen concentration of 30-33% by weight; measuring first and second energy quotients obtained from the first and second tests, respectively; and then using the energy quotients to calculate the subject's Mitochondrial Factor. The Mitochondrial Factor is directly proportional to the subject's mitochondrial efficiency and function. If conducted periodically, the method can be used to determine whether the subject's mitochondrial efficiency is increasing or decreasing over time.

Abstract: A heat exchange fluid supply system for supplying a heat exchange fluid to an intravascular heat exchange catheter includes a disposable cassette having a bulkhead and an external heat exchanger, and which is configured to operate in combination with a reusable master control unit. The bulkhead includes a reservoir section and a pump section. The reservoir section is provided with a means to monitor the amount of heat exchange fluid that is in the system. The bulkhead provides the mechanism for priming the system with heat exchange fluid from an external source and for circulating fluid to the catheter in a closed circuit. The pump section is configured to allow for pumping of heat exchange fluid at a constant pressure.