Patents Examined by Robert V. Hines
  • Patent number: 4801750
    Abstract: Process for the production of 2-chloroacetoacetic acid amides. Diketene is converted at a temperature of +30.degree. to -40.degree. C. with the help of hydrogen chloride into acetoacetic acid chloride. Chlorine is introduced into the mixture at a temperature of +30.degree. to -40.degree. C., whereby 2-chloroacetoacetic acid chloride is formed. The latter is converted into the corresponding amide at a temperature of +50.degree. to -40.degree. C. by reaction with a N-compound having the formula: ##STR1## wherein (i) R=R'=H, or(ii) R=R'=alkyl, substituted alkyl, aryl, substituted aryl, alkyl aryl, substituted alkyl aryl, alkoxy aryl, substituted alkoxy aryl, alkoxy alkyl or substituted alkoxy alky, or(iii) R=H, and R'=alkyl, substituted alkyl, aryl, substituted aryl, alkyl aryl, substituted alkyl aryl, alkoxy aryl, substituted alkoxy aryl, alkoxy alkyl or substituted alkoxy alkyl.
    Type: Grant
    Filed: March 24, 1982
    Date of Patent: January 31, 1989
    Assignee: Lonza Ltd.
    Inventors: Leander Tenud, Raimund Miller, Barry Jackson
  • Patent number: 4801753
    Abstract: The present invention relates to novel biologically active tricyclic compounds, of the general formula I: ##STR1## and salts thereof, in which R.sub.1 represents hydrogen, alkyl of 1-6 carbon atoms, an optionally substituted aralkyl group or an acyl group,R.sub.2 represents hydrogen, alkyl (1-6 C), or an optionally substituted aralkyl group, orR.sub.1 +R.sub.2 together with the nitrogen atom represent a heterocyclic 5- or 6-membered ring, p1 X and Y each represent hydrogen, hydroxy, halogen, alkyl or alkoxy of 1-6 carbon atoms, nitro, CF.sub.3 or an acyloxy group, andthe dotted line signifies an optional extra bond.The compounds of the general formula I have valuable anti-depressant activity without a sustained influence on appetite.
    Type: Grant
    Filed: September 17, 1987
    Date of Patent: January 31, 1989
    Assignee: Akzona Incorporated
    Inventors: David S. Savage, Thomas Sleigh, John K. Clark
  • Patent number: 4798909
    Abstract: An arylamine such as aniline is condensed with formaldehyde in the presence of aqueous hydrochloric acid to form a mass containing the hydrogen chloride salt of a polyarylpolyamine. The mass is contacted with additional aniline thereby forming an organic phase and an aqueous phase, the 4,4'-polyarylpolyamine overwhelmingly being liberated from its salt form in the aqueous phase and being transferred to the organic phase. High recoveries of the 4,4'-diamino polycondensate are achieved.
    Type: Grant
    Filed: November 23, 1983
    Date of Patent: January 17, 1989
    Inventor: Efim Biller
  • Patent number: 4798618
    Abstract: Disclosed herein are novel chloroacetanilide derivatives which act as remarkably effective herbicides when sprayed in a paddy field, the chloroacetanilide derivatives being 2',6'-diethyl-N-[(cis-alkenyloxy)methyl]-2-chloroacetanilides [A] represented by the general formula ##STR1## wherein R is a cis-form alkenyl group having 4 or 5 carbon atoms. Also disclosed are herbicide compositions for use in a paddy field and containing at least one of said chloroacetanilide derivatives [A] and at least one pyrazole derivative [B] represented by the general formula ##STR2## wherein R is a hydrogen atom or methyl group and X is a 4-toluenesulfonyl group or benzoylmethyl group; or-.alpha.
    Type: Grant
    Filed: December 7, 1982
    Date of Patent: January 17, 1989
    Assignee: Agro-Kanesho Co., Ltd.
    Inventors: Shinzo Someya, Rokuro Akahira, Hiroshi Horino, Michihiro Ohnaka, Takashi Kiuchi
  • Patent number: 4795822
    Abstract: Nortriptyline functionalized compounds are provided for conjugation to antigenic compositions, particularly poly(amino acids), and enzymes. The antigenic conjugates are employed for the production of antibodies, which find use in immunoassays for the determination of nortriptyline in a sample, while the enzyme conjugates find use in an enzyme assay for the determination of nortriptyline in a sample.
    Type: Grant
    Filed: May 23, 1984
    Date of Patent: January 3, 1989
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Mae W. Hu, Prithipal Singh
  • Patent number: 4795854
    Abstract: A device for separating a high pressure polyphase mixture consisting of a gas charged with liquid particles, and particularly a mixture of ethylene and polyethylene, which comprises a cylindrical vertical enclosure into which extends an inlet means for supplying the mixture thereto and which is provided at its lower end with an outlet for discharging separated liquids; a vertical cyclone in communication with the enclosure for receiving separated gases therefrom and having an outlet at its upper end for discharging gases separated in the cyclone and a liquid outlet at its lower end for discharging separated liquids therefrom; and an ejector comprising a nozzle, through which the polyphase mixture is fed, a mixing zone connected to the liquid outlet of the cyclone and a diffuser section for reducing the speed of the resultant mixture and being connected to the inlet means for supplying the polyphase mixture to the enclosure.
    Type: Grant
    Filed: August 15, 1983
    Date of Patent: January 3, 1989
    Assignee: Societe Chimique des Charbonnages - CdF Chimie
    Inventor: Bernard Levresse
  • Patent number: 4792623
    Abstract: Novel meta phenylenediamines are provided having one or two particular benzyl radicals as substituents along with other optional substituents on the aromatic diamine ring and optionally substituents on the benzyl aromatic ring.The diamines are sterically hindered and thereby have lower amine reactivity as compared with the unsubstituted diamines.The diamines are useful as curing agents for epoxy resins and find particular utility as extenders in the formation of novel polyurethane-polyurea polymers.
    Type: Grant
    Filed: September 27, 1982
    Date of Patent: December 20, 1988
    Assignee: The Dow Chemical Company
    Inventor: Kwok K. Sun
  • Patent number: 4792570
    Abstract: Compounds useful for treating inflammation, swelling and associated pain, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: a is an integer of 0-3;b is an integer of 0-2;n is an integer of 3-12;each X and each Y are independently -halo, --R.sup.1, -alkoxy, or -phenyl; andB is selected from the group consisting of:--NR.sup.1 R.sup.2, --NR.sup.1 (CH.sub.2 CH.sub.2 OH), ##STR2## in which R.sup.1 and R.sup.2 are independently H, alkyl or cycloalkyl;R.sup.3 is H, alkyl or --CH.sub.2 CH.sub.2 OH; andm is an integer of 3-8.Novel compounds are those wherein n is at least 6 if both a and b are 0.
    Type: Grant
    Filed: April 6, 1984
    Date of Patent: December 20, 1988
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Peter H. Nelson, James P. Dunn, Stefan H. Unger, Thomas R. Thieme
  • Patent number: 4792551
    Abstract: Compounds useful for treating inflammation, pain and swelling, represented by the formula: ##STR1## and the pharmaceutically acceptable acid addition salts thereof, wherein: Y and Z are each independently halo, alkyl or alkoxy;l and m are each independently integers of 0-4;b is an integer of 2-12; andX is selected from the group consisting of:--NR.sup.1 R.sup.2, --NR.sup.1 (CH.sub.2 CH.sub.2 OH), ##STR2## in which R.sup.1 and R.sup.2 are independently H, alkyl or cycloalkyl;R.sup.3 is H, alkyl or CH.sub.2 CH.sub.2 OH; andn is an integer of 3-7.
    Type: Grant
    Filed: July 15, 1983
    Date of Patent: December 20, 1988
    Assignee: Syntex (U.S.A.) Inc.
    Inventors: Peter H. Nelson, Stefan H. Unger, Thomas R. Thieme
  • Patent number: 4792624
    Abstract: 'An improvement is described in the process of preparing polymethylene polyphenyl polyamines by condensing aniline and formaldehyde in the presence of an acid catalyst. The improvement entails adding a minor proportion of a polyamine mixture comprising di(aminophenyl)methanes and oligomeric polymethylene polyphenyl polyamines, collectively known as polymethylene polyphenyl polyamines or polymeric MDA, to an intermediate stage of the condensation reaction where the various intermediately formed aminobenzylamines are present. The process lends itself to either a batch or continuous method for preparing the polyamines.The improvement is actually observed in the polymethylene polyphenyl polyisocyanates derived from the polyamines which have substantially reduced color over those polyisocyanates prepared from polyamines prepared via a prior art method. Such color improvements invariably carry over to polyurethane products derived therefrom.
    Type: Grant
    Filed: February 26, 1987
    Date of Patent: December 20, 1988
    Assignee: The Dow Chemical Company
    Inventors: Richard Hatfield, Jr., Howard R. Steele, Nirad N. Shah
  • Patent number: 4788010
    Abstract: Hypotensive activity is exhibited by compounds having the formula ##STR1## and pharmaceutically acceptable salts thereof wherein R.sub.1 is hydrogen or alkyl;R.sub.2 and R.sub.3 are each independently phenyl, substituted phenyl, cycloalkyl, or R.sub.2 is hydrogen and R.sub.3 is heteroaryl;R.sub.4 and R.sub.5 are the same or different and each is hydrogen, hydroxy, alkoxy, alkanoyl or alkyl;R.sub.6 is hydrogen or alkyl; andn is 1, 2, 3 or 4; with the proviso that if R.sub.2 and R.sub.3 are each phenyl, at least one of R.sub.1, R.sub.4, R.sub.5 and R.sub.6 is other than hydrogen.
    Type: Grant
    Filed: April 24, 1985
    Date of Patent: November 29, 1988
    Assignee: E. R. Squibb & Sons, Inc.
    Inventors: David M. Floyd, Spencer D. Kimball, Steven Brandt
  • Patent number: 4786426
    Abstract: A borated oxazoline monoester, made by reacting a boron compound with the product of reaction between tris(hydroxymethyl)aminomethane and carboxylic acid is a new composition of matter. It is useful in a lubricating oil for reducing friction, and, therefore, fuel consumption in an internal combustion engine.
    Type: Grant
    Filed: January 7, 1980
    Date of Patent: November 22, 1988
    Assignee: Mobil Oil Corporation
    Inventors: Robert M. Gemmill, Jr., Andrew G. Horodysky
  • Patent number: 4777294
    Abstract: A compound of the formula: ##STR1## wherein A is a chain hydrocarbon group having 1 to 10 carbon atoms optionally substituted by hydroxyl, phenoxy, thienyl, furyl, pyridyl, cyclohexyl or an optionally substituted phenyl group, or a cyclic hydrocarbon group having 3 to 7 carbon atoms optionally substituted by hydroxyl, B is hydrogen or hydroxyl, and their production and use.These compounds exhibit excellent inhibitory activity against .alpha.-glucoside hydrolase, thus are useful for hyperglycemic symptoms and various disorders caused by hyperglycemia.
    Type: Grant
    Filed: April 17, 1987
    Date of Patent: October 11, 1988
    Assignee: Takeda Chemical Industries, Ltd.
    Inventors: Satoshi Horii, Yukihiko Kameda, Hiroshi Fukase
  • Patent number: 4777291
    Abstract: The present invention provides a process for the epimerization of (+)-N-methyl-3-(2-methylphenoxy)- 3-phenylpropylamine to its racemic form with an anion forming compound in a suitable solvent.
    Type: Grant
    Filed: February 27, 1985
    Date of Patent: October 11, 1988
    Assignee: Eli Lilly and Company
    Inventor: Jerry W. Misner
  • Patent number: 4777292
    Abstract: This invention relates, in one of its aspects, to a process for the preparation of ortho-methyl anilines from ortho-amino benzyl sulfoxides. An ortho-amino benzyl sulfoxide is converted to an ortho-amino benzyl halide by reaction with a nonoxidizing acid halide and is converted to a stable quaternary salt by reaction with a tertiary amine in the presence of an alcohol. The quaternary salt may be cleaved by hydrogenation to form ortho-methyl anilines. Other aspects of the invention relate to novel intermediate quaternary salts and to a process for forming those quartenary salts.
    Type: Grant
    Filed: February 13, 1985
    Date of Patent: October 11, 1988
    Assignee: Monsanto Company
    Inventors: Michael J. Miller, John P. Chupp
  • Patent number: 4772747
    Abstract: Disclosed is a process for the preparation of 2,4,6-trichlorophenylhydrazine by chlorinating the reaction product of phenylhydrazine and a dicarboxylic anhydride to obtain an N-(2,4,6-trichloroanilino)dicarboximide which is reacted with a base capable of liberating 2,4,6-trichlorophenylhydrazine therefrom.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: September 20, 1988
    Assignee: Eastman Kodak Company
    Inventors: Kevin J. Edgar, John A. Hyatt
  • Patent number: 4766242
    Abstract: Provided is a novel and effective process for the synthesis of aryl sulfides substituted with an alkanoylamino or (N-alkyl)alkanoylamino substituent. The process comprises reacting an appropriately substituted aromatic compound with a sulfur dihalide, preferably sulfur dichloride, in the presence of an alkali metal tetrafluoroborate catalyst and an ether comprising solvent.
    Type: Grant
    Filed: February 1, 1982
    Date of Patent: August 23, 1988
    Assignee: Hoechst Celanese Corporation
    Inventors: Harry T. Hanson, John B. Sapp, Jr.
  • Patent number: 4764533
    Abstract: Erythro-1,2,3-triphenyl-1-pentanones of Formula 1 ##STR1## wherein R.sup.1 may be a dimethylamino, diethylamino, piperidin-1-yl- or pyrrolidin-1-yl group and R.sup.2 represents a hydrogen atom, a methoxy or hydroxy group, and their pharmacologically acceptable salts, have a pronounced antiestrogenic effect and are suitable for the treatment of hormone-dependent tumors.They may be prepared by reacting 1,2-diphenyl-ethanone of Formula 2 ##STR2## wherein R.sup.1 is as set forth in Formula 1 and R.sup.2 represents a hydrogen atom or a methoxy group, with sodium hydride in anhydrous dimethyl-formamide, isolating after conversion with 1-chloro-1-phenylpropane, the erythro form from the reaction product and possibly releasing the hydroxy group from the methoxy group by selective cleavage with hydrobromic acid.
    Type: Grant
    Filed: July 2, 1984
    Date of Patent: August 16, 1988
    Assignee: Klinge Pharma GmbH
    Inventors: Helmut Schickaneder, Roland Loser
  • Patent number: 4764534
    Abstract: 4-Substituted-N-[2,4-dinitro-6-(trifluoromethyl)phenyl]-1-naphthalenamine derivatives, useful as anticoccidial agents both alone and in combination with polyether antibiotics.
    Type: Grant
    Filed: July 17, 1984
    Date of Patent: August 16, 1988
    Assignee: Eli Lilly and Company
    Inventors: Albert J. Clinton, deceased, George O. P. O'Doherty
  • Patent number: 4760181
    Abstract: This invention relates to polymers which contain amino-sulfide age-resistant groups, and their preparation by reaction of aminomercaptans.
    Type: Grant
    Filed: March 1, 1983
    Date of Patent: July 26, 1988
    Assignee: The Goodyear Tire & Rubber Company
    Inventor: Arthur H. Weinstein