Patents Examined by Robin Lyn Teskin
  • Patent number: 4540573
    Abstract: A mammalian blood protein-containing composition such as whole blood, plasma, serum, plasma concentrate, cryoprecipitate, cryosupernatant, plasma fractionation precipitate or plasma fractionation supernatant substantially free of hepatitis and other lipid coated viruses with the yield of protein activity to total protein being at least 80% is disclosed. The protein-containing composition is contacted with di- or trialkylphosphate, preferably a mixture of trialkylphosphate and detergent, usually followed by removal of the di- or trialkylphosphate.
    Type: Grant
    Filed: July 14, 1983
    Date of Patent: September 10, 1985
    Assignee: New York Blood Center, Inc.
    Inventors: Alexander R. Neurath, Bernard Horowitz
  • Patent number: 4539201
    Abstract: A medicament and method for inducing immunity in to infectious bovine keratoconjunctivitis in cattle. The medicament comprises the gram negative cocci Neisseria or Branhamella which are non-etiological agents of infectious Keratoconjunctivitis yet unexpectedly are found to afford an immunity to infectious bovine keratoconjunctivitis when administered to cattle.
    Type: Grant
    Filed: October 28, 1983
    Date of Patent: September 3, 1985
    Inventor: Robert M. Gwin
  • Patent number: 4535059
    Abstract: This invention provides an improved fermentation process for bioconversion of toluene to muconic acid.The process involves operating the bioconversion system under phosphate-limiting conditions so as to achieve an increase in specific muconic acid productivity with a stabilized population of microorganism such as an ATCC No. 31,916 type of Pseudomonas putida Biotype A mutant strain.
    Type: Grant
    Filed: January 13, 1983
    Date of Patent: August 13, 1985
    Assignee: Celanese Corporation
    Inventors: Jih-Han Hsieh, Sol J. Barer, Peter C. Maxwell
  • Patent number: 4534965
    Abstract: A method and composition is provided to control fungal infection of seeds and seedlings. Certain species of Streptomyces are grown on dried ground shrimp waste preferably suspended in a mineral salts medium. The supernate derived from the culture provides fungal infection control when used as a seed-coating or seed-soaking material. The residue, consisting of unused shrimp waste and a Streptomyces species, also provides protection against fungal infection of plants such as cotton seedlings. The residue is employed as a amendment to the soil in the immediate area of the newly planted seed.
    Type: Grant
    Filed: September 26, 1983
    Date of Patent: August 13, 1985
    Assignee: Chevron Research Company
    Inventors: Lewis R. Brown, Susan Brown-Skrobot
  • Patent number: 4534972
    Abstract: Compositions containing therapeutically or immunologically active proteins are rendered substantially free from infectious agents such as viable viruses and bacteria without substantial loss of therapeutic or immunologic activity by mixing the protein composition with a complex formed from source of transition metal ions, such as copper ions, and an angularly-fused, polynuclear heterocyclic arene having two nitrogen atoms in a "cis-ortho" relationship, such as phenanthroline, and a reducing agent such as a thiol in amounts and at a temperature and for a time sufficient to inactivate substantially all of the viruses and bacteria contained therein. Compositions containing therapeutically active proteins substantially free from viral and bacterial infectivity, which have heretofore been unattainable, can be prepared by the method of the invention.
    Type: Grant
    Filed: March 29, 1983
    Date of Patent: August 13, 1985
    Assignee: Miles Laboratories, Inc.
    Inventor: Kenneth J. Lembach
  • Patent number: 4533636
    Abstract: A culture medium and method for the isolation and culture of plant protoplasts is disclosed which includes in it a quantity of neutral mammalian blood serum. An addition of 1 to 25% serum to protoplast media results in a greater yield of viable protoplast cells, helps to protect the protoplasts in culture, and makes it possible to obtain and maintain corn protoplasts, a heretofore difficult task.
    Type: Grant
    Filed: August 25, 1983
    Date of Patent: August 6, 1985
    Assignee: Agracetus Madison Corporation
    Inventor: Ning-Sun Yang
  • Patent number: 4530834
    Abstract: Entomopathogenic fungi useful in the control of insects is prepared by culturing mycelia in a suitable medium, harvesting the growing mycelia, treating the mycelia with a protective agent, drying the treated mycelia and grinding and storing the dried product.
    Type: Grant
    Filed: September 17, 1982
    Date of Patent: July 23, 1985
    Assignee: The United States of America as represented by the Secretary of Agriculture
    Inventors: Dennis McCabe, Richard S. Soper
  • Patent number: 4521510
    Abstract: Monoclonal antibodies to theophylline having 5% or less cross-reactivity with caffeine and the continuous hybrid monoclonal cell lines for their production are provided. These antibodies are useful in a particle-enhanced turbidimetric inhibition immunoassay for theophylline.
    Type: Grant
    Filed: January 3, 1984
    Date of Patent: June 4, 1985
    Assignee: E. I. Du Pont de Nemours and Company
    Inventor: John E. Geltosky
  • Patent number: 4520016
    Abstract: A non-lysozyme highly active bacteriolytic protein which is heat stable and has a relatively low molecular weight. The protein may be produced by immunizing an insect against E. coli and recovering the protein from the insect. The protein is useful for extracting proteins from genetically engineered bacteria and as a pharmaceutical for inhibiting certain bacteria.
    Type: Grant
    Filed: August 2, 1982
    Date of Patent: May 28, 1985
    Assignee: KabiGen AB
    Inventors: Dan Hultmark, Hakan Steiner, Torgny Rasmuson, Hans G. Boman
  • Patent number: 4511558
    Abstract: A contraceptive agent is provided which comprises biologically-active alpha-lactalbumin. The agent can be administered to female mammals using a variety of pharmaceutically acceptable vehicles, provided the alpha-lactalbumin retains its biological activity in the presence of the vehicle.
    Type: Grant
    Filed: May 16, 1983
    Date of Patent: April 16, 1985
    Assignee: University Patents, Inc.
    Inventor: Barry D. Shur
  • Patent number: 4500451
    Abstract: Protein PP.sub.13 is isolated from human placental tissues using a variety of methods, e.g., immunoadsorption. The protein has utility in production of an antiserum which has diagnostic applications. The placental specific proteins (e.g., PP.sub.13) are frequently detected in increasing amounts in women as pregnancy advances, and in patients with tumors especially of the tryphoblastic and embryonal types.
    Type: Grant
    Filed: August 18, 1983
    Date of Patent: February 19, 1985
    Assignee: Behringwerke Aktiengesellschaft
    Inventors: Hans Bohn, Walter Kraus
  • Patent number: 4482483
    Abstract: An intravenous immune globulin preparation having at least 99% pure globulin protein and an anticomplement activity of less than 0.10 C'50 units/mg IgG prepared by: precipitating impurities from Cohn Fraction II in an aqueous-alcohol medium at defined temperature and pH, removing the precipitated impurities, stabilizing the diluted solution with albumin, concentrating the solution and removing the alcohol therefrom. Also prepared by this method, an intravenous, hyperimmune globulin preparation having increased antibody titers to sixteen serospecific strains of Pseudomonas aeruginosa.
    Type: Grant
    Filed: September 2, 1983
    Date of Patent: November 13, 1984
    Assignee: Armour Pharmceutical Company
    Inventors: Willie M. Curry, David L. Farb
  • Patent number: 4476109
    Abstract: A method of preparing gamma globulin suitable for intravenous administration comprising a first step of treating a supernatant liquid separated from human blood plasma with ethanol under conditions of a pH of 5.5 to 6.5, an ethanol concentration of 30 to 35%, and a protein concentration of 1 to 2% by weight.
    Type: Grant
    Filed: September 24, 1982
    Date of Patent: October 9, 1984
    Assignee: Fujirebio Kabushiki Kaisha
    Inventors: Tokusuke Kimura, Fumio Kurosu, Toshitsugu Inouchi, Masana Komatsu