Patents Examined by Rosalynd Williams
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Patent number: 5616563Abstract: A compound of the formula ##STR1## with R being hydrogen, alkyl, cycloalkyl or aryl, which may be substituted with halogen or alkyl, and R' and R.sup.a being hydroxyl, or --O-alkyl, pharmaceutically acceptable salts thereof; or mixtures thereof. An anti-neoplastic composition comprises the compound described above and a pharmaceutically acceptable carrier. In vitro and in vivo methods of preventing or inhibiting the growth and proliferation of neoplastic cells and/or tumors comprise contacting the cells with or administering to a subject an anti-growth and proliferation effective amount of the compound described above.Type: GrantFiled: June 24, 1994Date of Patent: April 1, 1997Assignee: University of Maryland Baltimore CampusInventors: Donald J. Creighton, Diana S. Hamilton
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Patent number: 5616812Abstract: A method of production of polyvinyl ether compound by which the polyvinyl ether compound having a desired degree of polymerization is produced reliably, safely and efficiently and a novel polyvinyl ether compound useful as lubricating oil for compression-type refrigerators, electric insulation oil and the like are disclosed. The method of production of the present invention is a method of producing a polyvinyl ether compound which comprises polymerizing a vinyl ether compound in the presence of a Lewis acid catalyst and a specific acetal or a method of producing a polyvinyl ether compound which comprises forming an acetal by reaction of a vinyl ether compound with a specific alcohol in the presence of a Lewis acid catalyst, then adding the vinyl ether compound to the acetal and polymerizing the vinyl ether compound. The polyvinyl ether compound of the present invention is homopolymer or a copolymer of an alkyl vinyl ether comprising the constituting unit expressed by the general formula: ##STR1## (R.sup.Type: GrantFiled: September 13, 1994Date of Patent: April 1, 1997Assignee: Idemitsu Kosan Co., Ltd.Inventors: Tatsuya Egawa, Yasuhiro Kawaguchi, Kenji Mogami, Nobuaki Shimizu
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Patent number: 5614501Abstract: Compositions containing hemicelluloses in combination with polyphenols, methods of preparing the compositions, and methods of treating humans or animals with the composition are provided. Also provided is a method for increasing growth rate, improving feed efficiency and decreasing scour after weaning in an animal by administering an effective amount of the composition to the animal. The hemicelluloses preferably are not consumed by human alimentary enzymes or harmful bacteria, such as putrefactive or pathogenic bacteria, in the gastrointestinal tract, and are consumed by beneficial bacteria, such as bifidobacteria, in the gastrointestinal tract. The polyphenols preferably decrease the amount of harmful bacteria in the gastrointestinal tract. The compositions can optionally contain a carrier or be used as a feed addition and are administered to humans or other animals in an amount sufficient to treat the gastrointestinal disorder.Type: GrantFiled: May 4, 1995Date of Patent: March 25, 1997Assignee: The University of MontanaInventor: Geoffrey N. Richards
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Patent number: 5612443Abstract: Low molecular weight polyaldehydes are prepared by converting the acetal groups of the low molecular weight polyacetal to aldehyde groups or by reacting an aldehyde-containing reagent (e.g., glyoxal) with a polyamide.Type: GrantFiled: June 2, 1995Date of Patent: March 18, 1997Assignee: National Starch and Chemical Investment Holding CorporationInventors: Gary T. Martino, Martin M. Tessler
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Patent number: 5608107Abstract: A process for preparing an alkoxyalkanoic acid by reacting the corresponding alkoxyalkanol with a resin-supported stable free radical nitroxide in the presence of a chlorine-containing oxidant and a solvent at a temperature in the range of from about 0.degree. C. to about 35.degree. C. and thereafter separating out the alkoxyalkanoic acid.Type: GrantFiled: May 31, 1995Date of Patent: March 4, 1997Assignee: Shell Oil CompanyInventors: Herbert E. Fried, David M. Singleton
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Patent number: 5607670Abstract: A composition of two compounds, (E,Z)-8,10-pentadecadien-1-ol acetate and (E)-9-pentadecen-1-ol acetate, is a highly effective attractant for the male cranberry fruitworm. The novel composition provides a sensitive tool for detection of this pest. By attracting male cranberry fruitworm moths to field traps, the composition provides a means for detecting, surveying, monitoring, and controlling the cranberry fruitworm. The attractant composition can also be used as a direct control tool by dispensing it throughout the host crop canopy, thereby preventing male cranberry fruitworms from locating and mating with the females.Type: GrantFiled: May 1, 1995Date of Patent: March 4, 1997Assignee: The United States of America as represented by the Secretary of AgricultureInventors: Leslie M. McDonough, Harry G. Davis, Constance L. Smithhisler
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Patent number: 5608106Abstract: A process for preparing an alkoxyalkanoic acid by reacting the corresponding alkoxyalkanol with a resin-supported stable free radical nitroxide in the presence of a NO.sub.x -generating compound and, optionally, an oxidant and/or a solvent at a temperature in the range of from about 0.degree. C. to about 100.degree. C. and thereafter separating out the alkoxyalkanoic acid.Type: GrantFiled: May 11, 1995Date of Patent: March 4, 1997Assignee: Shell Oil CompanyInventors: Herbert E. Fried, David M. Singleton, Raul A. Pabon, Jr.
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Patent number: 5606098Abstract: Amides and esters of perfluoropolyoxaalkylene-sulfo- or perfluoropolyoxaalkylene-carboxylic acids of the general following formula:R.sub.F R.sub.F.sup.I ZQ, whereR.sub.F =CF.sub.3 O--, C.sub.2 F.sub.5 O--, C.sub.3 F.sub.7 O--, C.sub.8 F.sub.17 O--,R.sub.F.sup.I= ##STR1## --(CF.sub.2 CF.sub.2 O--).sub.n CF.sub.2 --, --(CF.sub.2 CF.sub.2 CF.sub.2 O).sub.n CF.sub.2 CF.sub.2 --,where n=8-55;Z=--CO--, --SO.sub.2 --,Q=--N(C.sub.m H.sub.2m OH).sub.2, where m=2, 3, 4, 6, 8, 10--N[(C.sub.2 H.sub.4 O).sub.4 C.sub.3 H.sub.6 OH].sub.2,--NH--C.sub.2 H.sub.4 OR.sub..eta., where R.eta.=CH.sub.3 --, C.sub.2 H.sub.5 --, C.sub.3 H.sub.7 --,--NH(C.sub.2 H.sub.4 O).sub.5 H,--OC.sub.1 H.sub.21 N(C.sub.1 H.sub.21 OH).sub.2, where .eta.=1, 2, 4C.sub.k H.sub.2k+1 O--, where k=6, 8, 10.Type: GrantFiled: October 3, 1995Date of Patent: February 25, 1997Assignee: AO "Avtokoninvest"Inventors: Nikolai A. Ryabinin, Aleksandr N. Ryabinin
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Patent number: 5603916Abstract: This invention relates to methods of x-ray diagnostic imaging the blood pool, liver, spleen and/or lymph system of a mammal comprising administering a contrast effective amount of a contrast agent having the structure: ##STR1## wherein: n is 2;R.sup.1 is H or alkyl containing from 1 to 4 carbon atoms'R.sup.2 is H, alkyl containing from 1 to 4 carbon atoms, aryl or heteroaryl;and R.sup.3 is alkyl containing from 1 to 18 carbon atoms.This invention further relates to novel contrast agents having the above structure wherein R.sup.1 is H and R.sup.2 and R.sup.3 are CH.sub.3 to x-ray contrast compositions comprising such agents, and to method of x-ray diagnostic imaging utilizing such agents.Type: GrantFiled: May 22, 1995Date of Patent: February 18, 1997Assignee: Nano Systems L.L.C.Inventor: Baldev Singh
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Patent number: 5602280Abstract: Disclosed are a process for producing an unsaturated aldehyde and an unsaturated carboxylic acid which comprises subjecting propylene, isobutylene or tertiary butanol to gas phase catalytic oxidation with molecular oxygen in the presence of (i) a catalyst comprising composite oxide of the formula Mo.sub.a Bi.sub.b Fe.sub.c A.sub.d B.sub.e C.sub.f D.sub.g O.sub.x and (ii) a molybdenum oxide which in itself is substantially inert to the gas phase catalytic oxidation; a process for reusing the catalyst deteriorated due to the gas phase catalytic oxidation after mixing it with the molybdenum oxide; and a method of regenerating the deteriorated catalyst by mixing it with the molybdenum oxide.Type: GrantFiled: June 27, 1994Date of Patent: February 11, 1997Assignee: Sumitomo Chemical Company, LimitedInventors: Koichi Nagai, Yoshisaburou Nomura, Yoshihiko Nagaoka
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Patent number: 5599979Abstract: Formic acid is difficult to separate from acetic acid by conventional distillation or rectification because of the close proximity of their boiling points. Formic acid can be readily separated from acetic acid by using extractive distillation. Effective agents are propionic acid, butyric acid, valeric acid and 2-ethyl hexanoic acid.Type: GrantFiled: September 8, 1995Date of Patent: February 4, 1997Assignee: Lloyd BergInventor: Lloyd Berg
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Patent number: 5599977Abstract: Rapid temperature rises which characterize carbohydrate-nitric acid oxidation reactions used to form carbohydrate-derived acids may be moderated and temperature control readily maintained by blowing a gas such as air, oxygen, nitrogen or the like into the reaction mixture as needed to control the temperature of the reaction. The more moderate reaction conditions afford higher yield of the desired product with a concomitant reduction of byproducts which may be difficult to remove and usually are unwanted as well. Upon completion the oxidation mixture is made basic (e.g. with an alkali metal base hydroxide or carbonate, ammonia or an amine) to a pH at which the the carboxyl group or groups of the product carbohydrate-derived acid are entirely in the salt form. The aqueous solution is then passed through an ion retardation resin column to recover the carbohydrate-derived salt, using water as the eluent.Type: GrantFiled: June 2, 1995Date of Patent: February 4, 1997Inventors: Donald E. Kiely, Andy Carter, David P. Shrout
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Patent number: 5599976Abstract: A method is provided to improve the quality of recycle of certain residues by modifying the separation of alkanes and alkane-like materials and carbonyl-containing impurities from the recycle during the manufacture of acetic acid by the carbonylation of methanol. The improvement comprises partitioning the residues by the addition of water obtained from aqueous streams containing up to 50 wt. % acetic acid and which have been treated in a catalytic distillation unit to react the acetic acid with methanol to form recyclable methyl acetate and water and wherein the water is separated from the organics by distillation.Type: GrantFiled: April 7, 1995Date of Patent: February 4, 1997Assignee: Hoechst Celanese CorporationInventors: Mark O. Scates, Steven E. Parker, Jennifer B. Lacy, Russell K. Gibbs
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Patent number: 5597555Abstract: Fatty alkoxylate esters consisting of diesters of aliphatic or aromatic dicarboxylic acids, formed by reacting the acid with a stoichiometric excess of one or more polyalkoxylated fatty alcohols having fatty moieties containing from 14 to 22 carbon atoms. Non-aqueous compositions for topical application are also disclosed including one or more active ingredients, and an emollient agent of the fatty alkoxylate esters of the present invention.Type: GrantFiled: April 12, 1994Date of Patent: January 28, 1997Assignee: Croda, Inc.Inventors: Abel G. Pereira, Kevin F. Gallagher, Phillip G. Abend, John C. Carson, Jr.
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Patent number: 5597847Abstract: Object of this invention are nitric esters of derivatives of the 2-(2,6-di-halophenylamino)phenylacetic acid, having the following general formula: ##STR1## wherein: A and B are selected from among hydrogen and linear or branched, substituted or non substituted alkyl chains, X is a halogen selected from among chlorine and bromine, Y is selected from among oxygen, NH and NR.sub.1, wherein R.sub.1 is a linear or branched alkyl group, and n is comprised between 1 and 10 as well as their pharmaceutical utilization and process for their preparation.Type: GrantFiled: March 31, 1994Date of Patent: January 28, 1997Assignees: Corlay S.L., Metgrove Ltd.Inventors: Jose A. Matji, Antonio Alcaide
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Patent number: 5587509Abstract: A method of releasing a caged carboxylic acid in which a 2-alkoxy-5-nitro-phenyl photosensitive group blocks a carboxyl function and the compositions so produced are disclosed.Type: GrantFiled: March 8, 1995Date of Patent: December 24, 1996Assignee: Cornell Research Foundation, Inc.Inventors: George P. Hess, Barry K. Carpenter, Doraiswamy Ramesh, Raymond Wieboldt
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Patent number: 5583266Abstract: A two-step integrated process for the generation of diisopropyl ether from a crude by-product acetone stream which comprises:a) Hydrogenating said crude acetone over a supported, hydrogenation catalyst to give an isopropanol-rich effluent;b) passing said isopropanol-rich intermediate directly to a second reactor, andc) subject said IPA to dehydration conditions in the presence of hydrogen and a strong acid zeolite catalyst from the group consisting of .beta.-zeolite, optionally modified with one or more metals from Groups IB, VIB, VIIB and VIII of the Periodic Table, and a dealuminized Y-zeolite.Type: GrantFiled: May 2, 1994Date of Patent: December 10, 1996Assignee: Texaco Inc.Inventors: Robert J. Taylor, Jr., Pei-Shing E. Dai, John F. Knifton
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Patent number: 5583154Abstract: A composition for enhancing hair growth which comprises a compound represented by the following formula (I) as an active ingredient: ##STR1## wherein R.sup.1 represents an alkyl group having 1 to 8 carbon atoms, R.sup.2 represents an alkyl group having 1 to 10 carbon atoms, an alkenyl group having 2 to 6 carbon atoms or a cycloalkyl group having 3 to 8 carbon atoms and X represents --O-- or --NH-- and a carrier or diluent acceptable for topical composition.The composition for enhancing hair growth of the present invention has a hair growth enhancing activity and therefore is useful as a hair growth preparation.Type: GrantFiled: February 16, 1995Date of Patent: December 10, 1996Assignee: Nihon Nohyaku Co., Ltd.Inventors: Hiroyasu Koga, Kazuo Kanai, Masanori Yoshida
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Patent number: 5571845Abstract: The invention provides nitroaniline derivatives represented by general formula (I) where the nitro group is substituted at any one of the available benzene positions 2-6; where R and A separately represent the groups NO.sub.2, CN, COOR.sup.1, CONR.sup.1 R.sup.2, CSNR.sup.1 R.sup.2 or SO.sub.2 NR.sup.1 R.sup.2 and A is substituted at any one of the available benzene positions 2-6; where B represents N(CH.sub.2 CH.sub.2 halogen).sub.2 or N(CH.sub.2 CH.sub.2 OSO.sub.2 R.sup.3).sub.2 substituted at any one of the available benzene positions; and where R.sup.1, R.sup.2 and R.sup.3 separately represent H, or lower alkyl optionally substituted with hydroxyl, ether, carboxy or amino functions, including cyclic structures, or R.sup.1 and R.sup.2 together with the nitrogen form a heterocyclic structure, and pharmaceutical preparations containing them. These compounds have activity as hypoxia-selective cytotoxins, reductively-activated prodrugs for cytotoxins, hypoxic cell radiosensitisers, and anticancer agents.Type: GrantFiled: May 26, 1994Date of Patent: November 5, 1996Assignee: Cancer Research Campaign Technology LimitedInventors: William A. Denny, Brian D. Palmer, William R. Wilson
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Patent number: RE35458Abstract: This invention refers to a process to obtain new mixed copper aminoacidates complexes from phenanthrolines of an aromatic type to be used as anticancerigenic agents preferably with a therapeutic use for the treatment of liquid and solid cancerigenic tumors such as leukemia. The complexes obtained are of the [Cu (N-N) (N-O)].+-. NO.sub.3 type in which the N-N ligand corresponds to 4, 7-diphenyl-1, 10 phenanthroline and the N-O ligand preferably corresponds to one of the aminoacidates such as glycinate, alaninate, isoleucinate, leucinate, serinate and valinate. The process is characterized because it includes the following steps: making an aqueous solution based on an aliphatic alcohol and 4,7-diphenyl-1, 10 phehanthrolin react with a copper complex preferably Cu NO.sub.3 5H.sub.2 O at room temperature, and immediately after making the obtained product react in an aqueous aminoacidate solution adjusting a slightly alkaline pH.Type: GrantFiled: April 21, 1994Date of Patent: February 18, 1997Assignee: Universidad Nacional Autonoma De Mexica (UNAM)Inventor: Lena R. Azuara