Patents Examined by Shawn P. Foley
  • Patent number: 4770995
    Abstract: A process for predicting the sensitivity of cells, e.g., tumor cells, to the effects of tumor necrosis factor or lymphotoxin involving ascertaining the binding of the tumor necrosis factor or lymphotoxin to the cells, i.e., measuring the number of receptors on the cells.
    Type: Grant
    Filed: August 29, 1985
    Date of Patent: September 13, 1988
    Assignees: New York Blood Center, Inc, Sloan-Kettering Institute for Cancer Research
    Inventors: Berish Y. Rubin, Sylvia L. Anderson, Susan A. Sullivan, Lloyd J. Old, Barbara D. Williamson, Elizabeth C. Richards
  • Patent number: 4758508
    Abstract: Agent for the detection of esterolytic and/or proteolytic enzymes, containing (a) an amino acid ester or peptide ester of a phenol, as the chromogenic enzyme substrate, and (b) an alcohol as the substance which accelerates the enzymatic cleavage of the amino acid ester bond or peptide ester bond of component (a), characterized in that it contains a salt as the accelerating substance.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: July 19, 1988
    Assignee: Miles Inc.
    Inventors: Eugen Schnabel, James Travis, A. Christopher Skjold
  • Patent number: 4755462
    Abstract: Agent for the detection of esterolytic and/or proteolytic enzymes, containing (a) an amino acid ester or peptide ester of a phenol, as the chromogenic enzyme substrate, and (b) a substance which accelerates the enzymatic cleavage of the amino acid ester or peptide ester bond of component (a), characterized in that it contains a polyamino acid with a molecular weight of between 1,000 and 2,000,000 as the accelerating substance.
    Type: Grant
    Filed: March 11, 1985
    Date of Patent: July 5, 1988
    Assignee: Miles Inc.
    Inventor: Eugen Schnabel
  • Patent number: 4751079
    Abstract: The present invention concerns infectious bronchitis vaccines derived from infectious bronchitis viruses which spontaneously hemagglutinate chicken erythrocytes, and processes for the preparation thereof, novel infectious bronchitis virus strains which spontaneously hemagglutinate chicken erythrocytes, and a method for immunization of egg-laying birds against infectious bronchitis.
    Type: Grant
    Filed: January 31, 1983
    Date of Patent: June 14, 1988
    Assignee: AKZO N.V.
    Inventors: Alois G. Burger, Frans G. Davelaar, Heinrich D. Lutticken
  • Patent number: 4748111
    Abstract: A protein is covalently coupled to a 3'terminal end of a nucleic acid which carries several labels. In an assay the protein will specifically recognize some component of a test system; in an immunoassay the protein can be Protein A which will recognize the FC portion of IgG which is bound to an unknown antigen if present in the test sample.
    Type: Grant
    Filed: March 12, 1984
    Date of Patent: May 31, 1988
    Assignee: Molecular Diagnostics, Inc.
    Inventors: Nanibhushan Dattagupta, William J. Knowles, Vincent T. Marchesi, Donald M. Crothers
  • Patent number: 4748128
    Abstract: The amount of lipid bound sialic acid in a blood plasma or serum sample may be determined by a method which may be automated involving the following steps: diluting the sample with distilled water; mixing and then cooling the diluted sample; adding a mixture of a chlorinated lower alkyl hydrocarbon and a lower alkyl alcohol; mixing, diluting with water and then treating by mixing further and centrifuging to yield a substantially clear upper phase; recovering the upper phase and adding to it a mixture of a protein precipitating agent and adsorbing material, mixing the resulting admixture; recovering the resulting precipitate, suspending the precipitate in distilled water and determining the amount of lipid bound sialic acid present.
    Type: Grant
    Filed: March 18, 1985
    Date of Patent: May 31, 1988
    Assignee: Dianon Systems, Inc.
    Inventor: Nonda Katopodis
  • Patent number: 4735800
    Abstract: Methods and compositions are provided for the cloning and expression of Rift Valley Fever Virus genes in single cell host organisms. Also described are methods for culturing these novel single-cell organisms to produce Rift Valley Fever Virus gene gene products which may be formulated for use as products which may be formulated for use as immunogens in vaccines to protect against Rift Valley Fever Virus infections.
    Type: Grant
    Filed: August 23, 1984
    Date of Patent: April 5, 1988
    Assignee: Molecular Genetics, Inc.
    Inventors: Marc S. Collett, Anthony F. Purchio
  • Patent number: 4727021
    Abstract: Human monoclonal antibodies (HmAbs) capable of reacting with cytokeratin are disclosed. It has been found that HmAbs De8, M54, M307, Hull, C29, Hu22 and Pa24 may be used to detect these cytoskeletal proteins in various cells. By means of these HmAbs the embryological origin of cells may be determined. This information may be used to determine the possible tissue source of metastasized tumors and greatly affects the management of these cancers.
    Type: Grant
    Filed: June 1, 1984
    Date of Patent: February 23, 1988
    Assignee: Sloan-Kettering Institute for Cancer Research
    Inventors: Richard J. Cote, Timothy M. Thomson, Alan N. Houghton, Herbert F. Oettgen, Lloyd J. Old
  • Patent number: 4725547
    Abstract: Disclosed is a method for the purification of rabic virus, which comprises subjecting a solution containing the rabic virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified rabic virus which is useful for obtaining an effective vaccine against rabies.
    Type: Grant
    Filed: August 9, 1985
    Date of Patent: February 16, 1988
    Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Kuniaki Sakamoto, Kunio Ohkuma, Tetsuo Kawahara, Mitsuo Sakoh
  • Patent number: 4725546
    Abstract: Disclosed is a method for the purification of Japanese encephalitis virus, which comprises subjecting a solution containing the Japanese encephalitis virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified Japanese encephalitis virus, which is useful for obtaining an effective vaccine against Japanese encephalitis.
    Type: Grant
    Filed: August 9, 1985
    Date of Patent: February 16, 1988
    Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Kuniaki Sakamoto, Isao Gotoh, Tetsuo Kawahara, Mitsuo Sakoh
  • Patent number: 4724210
    Abstract: Disclosed is a method for the purification of an influenza virus, which comprises subjecting a solution containing the influenza virus to column chromatography using, as a gel for chromatography, a sulfuric acid ester of cellulose or a crosslinked polysaccharide. The method can provide highly purified influenza virus which is useful for obtaining an effective vaccine against influenza.
    Type: Grant
    Filed: August 9, 1985
    Date of Patent: February 9, 1988
    Assignee: Juridical Foundation the Chemo-Sero-Therapeutic Research Institute
    Inventors: Tetsuya Oka, Kunio Ohkuma, Tetsuo Kawahara, Mitsuo Sakoh
  • Patent number: 4724146
    Abstract: A method for the preparation of an herpes simplex virus subunit vaccine, which comprises subjecting a solution containing glycoproteins gA and gB to column chromatography using, as a gel for chromatography, sulfuric acid ester of cellulose or a crosslinked polysaccharide to adsorb the glycoproteins gA and gB onto the gel in the presence of an anionic surfactant or a nonanionic surfactant, eluting the adsorbed glycoproteins to obtain an eluate containing the glycoproteins, and subjecting the eluate to gel filtration to obtain a filtrate containing the glycoproteins.
    Type: Grant
    Filed: August 23, 1985
    Date of Patent: February 9, 1988
    Assignee: Juridical Foundation The Chemo-Sero-Therapeutic Research Institute
    Inventors: Youichiro Kino, Hiroshi Mizokami, Tetsuo Kawahara
  • Patent number: 4724138
    Abstract: Coherent powder compositions are formed by blending a powder phase containing at least 5 weight percent calcium sulfate hemihydrate with a liquid phase containing sufficient water to fully convert the hemihydrate to calcium sulfate dihydrate and drying the resultant blend. Uniformly pigmented products are formed by including a powdered pigment in the powder phase and 0.1 to 4.0 weight percent surfactant in the aqueous phase. Compositions suitable for use as cosmetic sticks are formed by employing at least 40 weight percent calcium sulfate hemihydrate. Preferably the products are formed by combining 40 to 60 parts by weight of aqueous phase with 50 parts by weight of powder phase. To improve pay-off characteristics the products are subjected to a temperature above 128.degree. C., the outer surface is abraded or up to 20 weight percent of the aqueous phase is glycerin or propylene glycol.
    Type: Grant
    Filed: November 20, 1986
    Date of Patent: February 9, 1988
    Assignee: Avon Products, Inc.
    Inventors: John A. Duffy, Richard D. Katstra
  • Patent number: 4720460
    Abstract: Described is a method to stabilize or preserve acid-producing bacteria in a buffered solution. A carrier may be added that is not a specific substrate for the bacteria in order to give texture, most preferably the carrier being polyethylene glycol or sodium alginate. Optionally, other ingredients such as anti-oxidants, mold inhibitors, and/or salts may be added. These compositions may be stored at temperatures above freezing for a time from a few days up to about 2 months or longer.
    Type: Grant
    Filed: April 4, 1985
    Date of Patent: January 19, 1988
    Assignee: Miles Laboratories, Inc.
    Inventors: Jeffrey T. Barach, Bassie J. Kamara
  • Patent number: 4714678
    Abstract: Disclosed is a temperature - sensitive (ts) mutant of bovine viral diarrhoea (BVD) virus which shows a considerably limited replication ability at the animal body temperature. The mutant is prepared by reacting wild-type BVD with a chemical mutagen such as nitrous acid. The mutant virous is advantageously used in vaccine compositions because it is capable of inducing immunity in bovines without causing serious side effects.
    Type: Grant
    Filed: July 31, 1986
    Date of Patent: December 22, 1987
    Assignee: SmithKline-RIT
    Inventors: Jean-Claude Delgoffe, Michele Lobmann, Nathan Zygraich
  • Patent number: 4714615
    Abstract: Method for retexturizing and smoothening the skin comprising topically applying to the skin a composition comprising from about 1.5 to about 2.5 parts by weight of a powdery, cosmetically acceptable inorganic material, such as calcium carbonate, and about 1 part by weight of nerve tissue such as the spinal cord.
    Type: Grant
    Filed: April 11, 1986
    Date of Patent: December 22, 1987
    Inventor: Rina Youssefyeh
  • Patent number: 4713118
    Abstract: A process for the modification, solubilization and/or hydrolysis of a glycosidically linked carbohydrate having reducing groups using a mixture comprising water, an inorganic acid and a halide of lithium, magnesium or calcium. The process is particularly useful for converting cellulose (derived for example from waste-paper, wood or sawdust) or starch to glucose. When cellulose is the starting material the preferred halide is a lithium halide. When starch is the starting material a magnesium halide is preferred.
    Type: Grant
    Filed: December 14, 1983
    Date of Patent: December 15, 1987
    Assignee: Imperial Chemical Industries PLC
    Inventors: Sidney A. Barker, Peter J. Somers
  • Patent number: 4710374
    Abstract: A composition suitable for treating the hair, nails and/or skin, which comprises, in an appropriate medium, at least one cationic polymer of the polyamine, polyamino polyamide or poly-(quaternary ammonium) type containing amine or ammonium groups in the polymer chain or joined thereto, and at least one anionic latex which is in the form of a colloidal suspension of particles of polymers containing anionic functional groups, in an aqueous or organic liquid phase.
    Type: Grant
    Filed: February 16, 1983
    Date of Patent: December 1, 1987
    Assignee: L'Oreal
    Inventors: Jean F. Grollier, Claude Dubief
  • Patent number: 4709011
    Abstract: Disclosed are immunologically active preparations of Herpes simplex virus envelope glycoproteins, gD-1 and gD-2. Preferably purified through use of a monoclonal anti-gD antibody immunodsorbent, gD-1 and gD-2 preparations are incorporated in vaccines useful in generating immunological responses protective against Herpes simplex virus disease states. Disclosed also is the preparation and use in vaccination procedures of synthetic polypeptides comprising amino acid squences which are: (1) substantially common to both gD-1 and gD-2; (2) cumulatively hydrophilic in nature; (3) specifically immunoreactive with a type common, monoclonal anti-gD antibody of Group VII classification. Vaccines incorporating the synthetic polypeptides give rise to protective immunological responses, e.g., they protect mice against Herpes simplex.
    Type: Grant
    Filed: May 15, 1985
    Date of Patent: November 24, 1987
    Assignee: University Patents, Inc.
    Inventors: Gary H. Cohen, Roselyn J. Eisenberg
  • Patent number: 4704354
    Abstract: A cytofluorograph is used to quantify poxvirus concentration. Virions producing a known cell bound antigen are added to a cell culture. The antigen is fluorescently labeled and the infected cells are counted cytofluorographically. Certain mutated virions do not produce the labeled antigen and are not counted. Alternately, the virion infected cell culture is stained with a phenanthridium dye. Only infected cells absorb the dye. Dead cells are counted with a cytofluorograph indicating virion concentration. The two tests combined discriminate between teratogens and carcinogens. Toxins which are teratogens reduce the number of infective virus, whereas carcinogens not only reduce the virus number, but increase the number of mutants.
    Type: Grant
    Filed: February 15, 1984
    Date of Patent: November 3, 1987
    Assignee: University of Cincinnati
    Inventor: Stephen J. Keller