Abstract: A process for producing isomerized olefins, branched aldehydes, branched alcohols, branched surfactants and other branched derivatives through isomerization, hydroformylation, hydrogenation, surfactant forming reactions and other derivative forming reactions.
Abstract: Disclosed are a type of conjugated triene compounds (1), and a preparation and application thereof. In this method, a 2-(cyclohexenylidene)malonic acid derivative is sequentially subjected to isomerization, halogenation reaction in the presence of a halogenating agent and dehydrohalogenation to prepare the conjugated triene compounds (1). This disclosure further provides a method of preparing a 2-aryl malonic acid derivative from the conjugated triene compounds (1) through aromatization reaction.
Abstract: A method for preparing an aldehyde including forming a reaction product including an aldehyde by reacting an olefin-based compound with a synthetic gas in a hydroformylation reactor in the presence of a hydroformylation catalyst; introducing the reaction product including the aldehyde to a vaporizer; separating low-boiling point components of the reaction product from an upper part of a vaporizer catch pot included in the vaporizer; separating high-boiling point components of the reaction product from a lower part of the vaporizer catch pot; and recirculating at least a portion of the low-boiling point components separated from an upper part of the vaporizer catch pot back to the vaporizer.
Type:
Grant
Filed:
August 26, 2021
Date of Patent:
May 28, 2024
Assignee:
LG Chem, Ltd.
Inventors:
Jusang Yang, Sangjun Shin, Sungshik Eom, Tae Yun Kim, Dong Hyun Ko, Sungpil Yang
Abstract: A hydroformylation method including preparing an aldehyde by reacting a raw-C5 feed with a synthetic gas in the presence of a catalyst composition.
Abstract: A method of oxidizing ?9-tetrahydrocannabinol (?9-THC) in hemp oil to cannabinol (CBN) uses a heated spray system assisted with ultraviolet (UV) lights. The method includes heating the hemp oil to keep the hemp oil flowing freely in the heated spray system. ?9-THC to CBN is converted by forming droplets in the presence of oxygen and the UV lights.
Abstract: An object of the present invention is to provide a method for producing m-dialkylbenzaldehyde by using a reaction starting material containing 1,4-dialkylbenzene. The method for producing m-dialkylbenzaldehyde represented by formula (3), comprising a step of allowing carbon monoxide to react on a reaction starting material containing 1,4-dialkylbenzene represented by formula (1) in the presence of a Bronsted acid and a Lewis acid, wherein the reaction starting material is 1,4-dialkylbenzene represented by formula (1), or a mixture of 1,4-dialkylbenzene represented by formula (1) and 1,3-dialkylbenzene represented by formula (2), containing 10 mol % or more of the 1,4-dialkylbenzene represented by formula (1), wherein in formulae (1) to (3), R1 represents a methyl group or an ethyl group, and R2 represents a chain or cyclic alkyl group having 3 or more and 6 or less carbon atoms that has a tertiary carbon at the benzyl position.
Abstract: Embodiments relate to a continuous process for the production of hydroxyethylpiperazine that includes feeding neat piperazine, recycled piperazine, and ethylene oxide to a reactor to form crude hydroxyethylpiperazine, in which the reactor is a continuous stirred tank reactor or a plug flow reactor. The process further includes continuously feeding the crude hydroxyethylpiperazine from the reactor to a distillation system that includes at least one distillation column, the distillation system produces at least a recycled piperazine stream and a hydroxyethylpiperazine stream, the recycled piperazine stream includes the recycled piperazine that is fed to the reactor to form the crude hydroxyethylpiperazine, and the hydroxyethylpiperazine stream includes at least 60 wt % of hydroxyethylpiperazine based on a total weight of the hydroxyethylpiperazine stream.
Type:
Grant
Filed:
October 23, 2019
Date of Patent:
May 21, 2024
Assignee:
Dow Global Technologies LLC
Inventors:
Amanda M. Goodman, Jianping Zeng, Barry Archer, Christophe R. Laroche
Abstract: In a method for aromatizing an alicyclic region of a cannabinoid, especially in enantiopure, scalemic and/or racemic form, in particular for aromatizing the cyclohexene group in ?9-THC-C5, ?9-THCA-C5 A, ?9-THCV-C3, ?9-THCVA-C5 A, and/or scalemic or racemic mixtures of these substances, wherein an oxidizing agent is added to the cannabinoid, sulfur is used as the oxidizing agent.
Type:
Grant
Filed:
June 14, 2022
Date of Patent:
May 14, 2024
Assignees:
SWISS CANNAPHARMACEUTICAL SA, ETH ZURICH
Inventors:
Erick M. Carreira, Roman Sarott, Patrick Pfaff, Konrad Hurni, Remo Roth, Sarah Eichenberger, Jürg Stäubli
Abstract: The invention provides new heterocyclic compounds having the general formula (I) wherein B, C, L, X, Y, RL and R3 to R5 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.
Type:
Grant
Filed:
September 2, 2021
Date of Patent:
May 14, 2024
Assignee:
Hoffmann-La Roche Inc.
Inventors:
Joerg Benz, Uwe Grether, Benoit Hornsperger, Carsten Kroll, Bernd Kuhn, Rainer E. Martin, Fionn O'Hara, Bernd Puellmann, Hans Richter, Martin Ritter
Abstract: Provided are pamoate salts of ketamine having a stoichiometry of 2:1 of ketamine to pamoate, including R, S-ketamine pamoate, S-ketamine pamoate, or R-ketamine pamoate, and crystalline or amorphous forms of the pamoate salts, and having excellent safety and properties for pharmaceutical applications. Also provided are pharmaceutical compositions including the pamoate salts of ketamine and their uses in treating a CNS disease or serving as an anesthetic.
Abstract: Provided herein are processes for the separation of acetonitrile from low-purity feedstock streams. The provided processes are particularly useful for isolating acetonitrile at high purity from chemical manufacturing waste streams that include methanol, water, and allyl alcohol.
Abstract: Process for the production of a diacyl peroxide involving the reaction of an anhydride with hydrogen peroxide, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.
Type:
Grant
Filed:
June 11, 2020
Date of Patent:
May 7, 2024
Assignee:
NOURYON CHEMICALS INTERNATIONAL B.V.
Inventors:
Martinus Catharinus Tammer, Antonie Den Braber, Carolina Anna Maria Christina Dirix
Abstract: Disclosed are methods of treating seizures in a subject. The methods can include administering to the subject in need thereof an effective amount of uridine source and a ketogenic composition including a ketogenic compound.
Type:
Grant
Filed:
January 14, 2022
Date of Patent:
May 7, 2024
Assignees:
University of South Florida, Eötvös Loránd University
Inventors:
Zsolt Kovacs, Csilla Ari D'Agostino, Dominic D'Agostino
Abstract: Process for the production of a diacyl peroxide involving the reaction of an anhydride with an aldehyde and oxygen, removal of the formed carboxylic acid, production of an anhydride from said carboxylic acid, and recycling of the anhydride within the process.
Abstract: This disclosure relates to bivalent compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the bivalent compounds, and to methods of use the bivalent compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such bivalent compounds.
Abstract: There is provided herein a compound of formula (I), or a pharmaceutically acceptable salt thereof, wherein R1, R2, X1, X2, Y1 to Y4, Z1 to Z3 and n have meanings provided in the description.
Type:
Grant
Filed:
March 1, 2019
Date of Patent:
April 30, 2024
Assignee:
THOMAS HELLEDAYS STIFTELSE FÖR MEDICINSK FORSKNING
Inventors:
Armando Cázares-Körner, Thomas Helleday, Torkild Visnes, Olov Wallner, Tobias Koolmeister
Abstract: Use of a stereoselective transaminase in the asymmetric synthesis of a chiral amine. In particular, provided is use of a polypeptide in the production of a chiral amine or a downstream product using a chiral amine as a precursor. Further provided is a method for producing a chiral amine, comprising culturing a strain expressing the polypeptide so as to obtain a chiral amine. Further provided are novel prochiral compounds, a chiral amine production strain and a method for constructing the chiral amine production strain. The stereoselective transaminase has a broad substrate spectrum and thus has a broad application potential in the preparation of a chiral amine.
Type:
Grant
Filed:
May 5, 2022
Date of Patent:
April 23, 2024
Assignee:
ABIOCHEM BIOTECHNOLOGY CO., LTD
Inventors:
Zhanbing Cheng, Tao Zhang, Zhenhua Tian, Shaonan Ding
Abstract: The application relates to a process for the preparation of a compound of formula (II) by cyclisation of a polyene of formula (I), and to an intermediate of formula (III). The obtained compounds are useful intermediates in the preparation of specific isoprenoids, preferably in the production of vitamin A and derivatives of vitamin A.
Type:
Grant
Filed:
April 3, 2020
Date of Patent:
April 16, 2024
Assignee:
DSM IP ASSETS B.V.
Inventors:
Fabrice Aquino, Werner Bonrath, Marc-André Mueller, Bettina Wuestenberg
Abstract: The invention relates to methods of hydrodeoxygenation of oxygenated compounds into compounds with unsaturated carbon-carbon bonds, comprising the steps of: a) providing a reaction mixture comprising, an oxygenated compound containing one or more of a hydroxyl, keto or aldehyde group, an ionic liquid, a homogeneous metal catalyst, and carbon monoxide or a carbon monoxide releasing compound, b) reacting said reaction mixture under a H2 atmosphere at acidic conditions at a temperature between 180 and 250° C. and a pressure between 10 and 200 bar.