Abstract: Disclosed are pharmaceutical formulations and methods using Verteporfin Ribavirin and/or Gemcitabine for use in the treatment of diseases by various routes of administration including inhalation, intratumoral, topical and/or systemic injection administration. This invention relates more specifically to the use of Verteporfin, Ribavirin, Gemcitabine, and/or combinations thereof as an inhaled dry powder treatment for COVID-19 and/or other lung infections, cancer and other non-cancer applications, which may be followed by other treatment regimens including radiation therapy, photodynamic therapy, and/or sonodynamic therapy. These pharmaceutical compositions containing one or more of Verteporfin, Ribavirin, and Gemcitabine may be included in pharmaceutical kits containing the compositions, and to methods for the treatment of cancer and non-cancer diseases with the active agents of the pharmaceutical compositions.
Abstract: Suspensions of metronidazole or baclofen and/or salts or ester derivative thereof, such as metronidazole benzoate, are disclosed. The suspension my include metronidazole or baclofen, and/or a salt or ester derivative thereof a hydrocolloid stabilizer, simethicone emulsion, a buffer, such as sodium citrate, (dihydrate), a preservative, a thickening agent, a sweetener, and water.
Type:
Grant
Filed:
April 21, 2022
Date of Patent:
September 20, 2022
Assignee:
Azurity Pharmaceuticals, Inc.
Inventors:
Ken Fallin, Zeus Pendon, Priya Capila, Neal Muni
Abstract: The topical cosmetic compositions and methods of the subject invention can be used to treat and/or prevent a variety of skin conditions, including, for example, age spots, acne, scars, body odor, aging-related conditions (e.g., wrinkles, looseness and dryness), and scalp issues (e.g., dandruff, seborrheic dermatitis and hair loss). In preferred embodiments, the compositions according to the subject invention comprise biological amphiphilic molecules produced by microorganisms.
Type:
Grant
Filed:
April 30, 2018
Date of Patent:
September 20, 2022
Assignee:
LOCUS IP COMPANY, LLC
Inventors:
Sean Farmer, Ken Alibek, Sharmistha Mazumder
Abstract: A liquid oral pharmaceutical dosage form, comprising pharmacologically effective amounts of at least one histamine H2-receptor antagonist in a hydrophobic/lipophilic liquid substantially free from water comprising at least one viscosity enhancing agent, and pharmacologically effective amounts of one or more antacid(s) in a liquid comprising at least one viscosity enhancing agent and at least one flavor, wherein the two liquids are physically separated from each other and wherein the two liquids have matching rheological profiles and a package comprising multiple liquid oral dosage forms as well as a method of treating a gastric disease or disorder by use of the liquid oral pharmaceutical dosage form.
Type:
Grant
Filed:
April 24, 2019
Date of Patent:
September 6, 2022
Assignee:
Johnson & Johnson Consumer Inc.
Inventors:
Salih Muhsin Muhammed, Katarina Lindell, Jill Nilgard, Sofi Nöjd
Abstract: The present invention provides a solution and related composition of matter and methods which synergistically improves a fungicide's effectiveness in resisting undesired fungal growth. The invention also provides wood and wood products which have been treated with the solution, method or compound.
Type:
Grant
Filed:
October 4, 2018
Date of Patent:
September 6, 2022
Assignee:
KOP-COAT, INC.
Inventors:
Ronald W. Clawson, Jr., Kenneth A. Cutler, Justin J. Bohn
Abstract: A method for treatment of irritation or damage to corneal or conjunctival epithelial cells, particularly for irritation or damage to corneal or conjunctival epithelial cells due to severe Sjögren's syndrome, comprising applying topically to an affected eye an aqueous solution of glycerol characterized by a glycerol concentration of >1% (w/v), most preferably 2.5% (w/v). The method is effective even in the case of very low tear formation, and its effectiveness cannot be explained by the known humectant effect of glycerol.
Type:
Grant
Filed:
March 3, 2021
Date of Patent:
August 30, 2022
Assignee:
Resdevco Research and Development Co. Ltd.
Abstract: Provided is a method for removing keratotic plugs capable of sufficiently exhibiting an excellent keratotic plug-removing effect without a burden, such as pain and of irritation, on the skin. The present invention relates to a method for removing keratotic plugs comprising using a composition comprising (X) one or more selected from the group consisting of (X1) 2-amino-2-hydroxymethyl-1,3-propanediol (X2), 2-amino-2-methyl-1-propanol, and (X3) 2-amino-2-methyl-1,3-propanediol.
Abstract: A cosmetic including at least one cyclic silicone represented by formula (1), and having a boiling point of 205 to 255° C. and a viscosity of less than 5 mm2/s (25° C.). This cosmetic has a light touch, a good spread, and excellent water repellency, forms a uniform cosmetic film, can achieve a feeling of use without a strong oily feeling, and has stability over time and cosmetic persistence when a variety of oil such as a silicone, hydrocarbon oil, and ester, an organic ultraviolet absorber, or an oily component being solid at 25° C. is mixed. (Wherein R1 is a monovalent hydrocarbon group having 2 or 3 carbon atoms, R2, R3, R4, R5, and R6 are each independently a monovalent hydrocarbon group having 1 to 3 carbon atoms, “a” is a positive number satisfying 0<a<4, and “b” and “c” are each independently a number of 0 to 3, provided that (a+b+c)?4.
Abstract: The invention is directed to a stable, high polyol containing wash composition. More particularly, the invention is directed to a wash composition comprising polyol, surfactant and a gelling agent whereby the wash composition is air pocket free, has excellent moisturizing capabilities, a viscosity of 40,000 cps or less, and a slope from ?0.5 to 0.0. The isotropic composition has an oil-like appearance.
Abstract: The present invention provides microparticles comprising a sulphur-containing compound, such as cysteamine, or a pharmaceutically acceptable salt, hydrate or ester thereof. Also provided is a composition comprising the microparticles and a stabilizing agent.
Abstract: A colon-targeted composition of a biological active component is disclosed, as well as formulations and preparation methods thereof. The colon-targeted composition of a biological active component includes in weight percentage: 10-99% hydroxypropyl methylcellulose, 1-60% biological active component and 0-80% auxiliary material, wherein the viscosity of hydroxypropyl methylcellulose is greater than 1,000 mPa·s. The colon-targeted composition of a biological active component has an improved colon-targeted effect and improves the bioavailability and in vivo activity of the biological active component.
Type:
Grant
Filed:
November 9, 2017
Date of Patent:
May 24, 2022
Assignee:
NANJING HEALSOUL LIFE SCIENCE AND TECHNOLOGY CO., LTD.
Abstract: Personal care topical compositions at skin-tolerant pH with cystine which is solubilized or has small crystal size below 20 microns. A process of making the composition is also described.
Type:
Grant
Filed:
December 18, 2017
Date of Patent:
May 24, 2022
Assignee:
Conopco, Inc.
Inventors:
Maria Buchalova, Teanoosh Moaddel, Qiang Qiu
Abstract: A method of lyophilizing exosomes using a cryoprotectant comprising methionine, mannitol and trehalose is disclosed. The lyophilized exosome product shows a good appearance which maintains a porous sponge shape without forming ice crystals. In addition, the lyophilized exosome product can be applied to a pharmaceutical composition, a skin external preparation and a cosmetic composition. For example, the lyophilized exosome product can be used as a solution obtained by simply mixing it with a diluent.
Type:
Grant
Filed:
June 26, 2020
Date of Patent:
May 24, 2022
Assignee:
ExoCoBio Inc.
Inventors:
Kwang Il Kim, Byong Seung Cho, Yong Weon Yi
Abstract: The present disclosure concerns a deodorant emulsion for an aerosol spray comprising triethyl citrate, ethylhexyl palmitate and polydimethylsiloxane, as well as a deodorant aerosol spray product comprising a pressure or pump spray container with a spray head containing the deodorant emulsion, and optionally a propellant and/or further solvent, and a method for deodorizing human skin.
Type:
Grant
Filed:
September 24, 2020
Date of Patent:
May 10, 2022
Assignee:
HENKEL AG & CO. KGAA
Inventors:
Inga Kerstin Vockenroth, Daniel Solich, Iris Marina Stadler
Abstract: Suspensions of metronidazole or baclofen and/or salts or ester derivative thereof, such as metronidazole benzoate, are disclosed. The suspension my include metronidazole or baclofen, and/or a salt or ester derivative thereof a hydrocolloid stabilizer, simethicone emulsion, a buffer, such as sodium citrate, (dihydrate), a preservative, a thickening agent, a sweetener, and water.
Type:
Grant
Filed:
December 23, 2020
Date of Patent:
May 10, 2022
Assignee:
AZURITY PHARMACEUTICALS, INC.
Inventors:
Ken Fallin, Zeus Pendon, Priya Capila, Neal Muni
Abstract: Disclosed are a biosealant system and method for treatment of a pulmonary air leak comprising applying the biosealant system to the locus of the air leak.
Type:
Grant
Filed:
April 1, 2019
Date of Patent:
April 5, 2022
Assignee:
The Trustees of Columbia University in The City of New York
Inventors:
Matthew Bacchetta, Brandon Guenthart, Jinho Kim, John O'Neill, Gordana Vunjak-Novakovic
Abstract: The present disclosure provides a silicone-free hair oil including one or more polyamides, one or more esters, one or more natural oils, one or more fatty alcohols, or a mixture thereof, and one or more hydrocarbons. The present disclosure also provides a method of using the silicone-free hair oil for the care of keratin fibres.
Abstract: The present invention relates to compositions comprising molecular iodine and a vehicle comprising a semifluorinated alkane. The compositions of the invention may be used to treat or prevent diseases or conditions caused by, or associated with microorganisms.