Patents Examined by Srikanth Patury
  • Patent number: 11506663
    Abstract: A method of screening/prognosis/diagnosis for colorectal cancer (CRC) wherein methionine aminopeptidase 2 (MetAP2) levels are detected in a non-tumor sample such as peripheral blood, peripheral blood mononuclear cells (PBMC) or lymphocytes. Based on the MetAP2 levels, the individual may be selected for further testing.
    Type: Grant
    Filed: May 13, 2015
    Date of Patent: November 22, 2022
    Assignee: Vastcon
    Inventors: Shailly Shrivastav, Anuraag Shrivastav
  • Patent number: 11492753
    Abstract: Lignocellulosic biomass can be fractionated for the purpose of increasing cellulose purity in the pulp, increasing native lignin content of the isolated lignin, and improving cellulose hydrolysis, by performing the steps of: (a) extracting the biomass with an extracting liquid comprising at least 20 wt % of a first organic solvent at a temperature below 100° C.; (b) treating the extracted biomass with a treatment liquid comprising a second organic solvent selected from lower alcohols, ethers and ketones, optionally water and optionally an acid, at a temperature between 120° C. and 280° C., and, optionally: (c) subjecting a cellulose-enriched product stream resulting from step (b) to enzymatic hydrolysis. The first and second organic solvent may be different or the same; in particular they comprise ethanol or acetone.
    Type: Grant
    Filed: February 17, 2014
    Date of Patent: November 8, 2022
    Inventors: Adrianus Theodorus Smit, Wouter Johannes Joseph Huijgen, Rudie Johan Hendrik Grisel
  • Patent number: 11491001
    Abstract: Disclosed herein are medical products, including an implantable device coated with a crosslinked extracellular matrix comprising at least one of Type IV collagen and laminin, wherein the crosslinked extracellular matrix contains no more than 0.024 mg/ml total concentration of glucose, amino acids and salts having a molecular weight of 2000 daltons or less. Corresponding systems and method also are disclosed.
    Type: Grant
    Filed: August 22, 2019
    Date of Patent: November 8, 2022
    Assignee: Cell and Molecular Tissue Engineering, LLC
    Inventors: Ulrike W. Klueh, Donald L. Kreutzer
  • Patent number: 11466260
    Abstract: The invention pertains to a PPA from a microorganism belonging to the family Halobacteriaceae (HPPA), for example, a PPA from Haloferax volcanii. The HPPA provided by the invention is soluble, thermostable and active at high concentrations of salt and/or organic solvent. An embodiment of the invention provides a method of increasing the rate of a reaction by adding an HPPA to the reaction mixture, wherein the reaction produces PPi, for example, an enzymatic reaction, and wherein the reaction is carried out at moderately high temperature and/or low water activity. Further embodiments of the invention provide an assay to detect the PPi released during a reaction which produces PPi by adding an HPPA to convert the PPi in to Pi and measuring the resultant Pi. The invention further pertains to an assay to monitor a reaction which produces PPi in the presence or the absence of an HPPA.
    Type: Grant
    Filed: October 19, 2016
    Date of Patent: October 11, 2022
    Inventors: Julie A. Maupin-Furlow, Nathaniel L. Hepowit, Lana McMillan
  • Patent number: 11427808
    Abstract: To provide a method for serum-free culture of human cartilage cells and a serum-free culture medium. A method for serum-free culture of cartilage cells, said method comprising: an enzymatic treatment step for treating a human cartilage cell-containing tissue with a protease; an inhibitor-treatment step for, after the enzymatic treatment step, treating the tissue with an inhibitor for the aforesaid protease; and a culture step for, after the inhibitor-treatment step, culturing the tissue in a serum-free culture medium that contains kartogenin and/or SAG, ITS, FGF2 and hydrocortisone. A serum-free culture medium for culturing cartilage cells, said serum-free culture medium containing kartogenin and/or SAG, ITS, FGF2 and hydrocortisone.
    Type: Grant
    Filed: October 26, 2015
    Date of Patent: August 30, 2022
    Assignee: Regenesis Science Co., Ltd.
    Inventors: Hiroko Yanaga, Katsu Yanaga
  • Patent number: 11408819
    Abstract: A detection of the Gram type of a bacterial strain includes: illumination, in the wavelength range 415 nm-440 nm, of at least one bacterium of said strain having a natural electromagnetic response in said range; acquisition, in the range 415 nm-440 nm, of a light intensity reflected by, or transmitted through, said illuminated bacterium; and determination of the Gram type of the bacterial strain as a function of the light intensity acquired in the range 415 nm-440 nm.
    Type: Grant
    Filed: June 13, 2017
    Date of Patent: August 9, 2022
    Assignee: BIOMÉRIEUX
    Inventors: Denis Leroux, Eric Laloum, Pierre Mahe, Rony Midahuen, Philippine Barlas
  • Patent number: 11389514
    Abstract: Compositions comprising a combination of myeloperoxidase and a peroxide-producing oxidase and methods of using the compositions to inactivate gram negative bacterial lipopolysaccharides and lipid A endotoxin are provided.
    Type: Grant
    Filed: April 13, 2017
    Date of Patent: July 19, 2022
    Assignee: EXOXEMIS, INC.
    Inventor: Robert C. Allen
  • Patent number: 11378578
    Abstract: Aspects of the invention include hematology analysis reagents, systems and methods that can be used to preserve blood cell morphology and integrity as well as provide sample integrity and optical clarity to facilitate optical analysis of blood samples. In some embodiments, the reagents include a non-phosphate organic buffer and a sphering surfactant. The pH and osmolality of the reagents may be adjusted to desired ranges. In addition, the reagents can be simply diluted with de-ionized water prior to use.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: July 5, 2022
    Assignee: Abbott Laboratories
    Inventors: Jiong Wu, Ji Lin
  • Patent number: 11364205
    Abstract: The present invention is directed to a pharmaceutical composition or dosage form having a stable, low (diluted) digestive enzyme content comprising at least one digestive enzyme and at least one carrier, or a dosage form thereof. The invention is also directed to a process of preparation of the composition or the dosage form. In addition the invention is directed to the treatment and prevention of disorders or conditions associated with a digestive enzyme deficiency in a patient in need thereof, comprising administering to said patient a pharmaceutically acceptable amount of the composition having a stable low digestive enzyme content or dosage form thereof.
    Type: Grant
    Filed: October 3, 2011
    Date of Patent: June 21, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Giovanni Ortenzi, Giuseppe De Franza, Danilo Clementi, Christian Stollberg, Luigi Boltri
  • Patent number: 11351201
    Abstract: The present invention describes a composition comprising a mixture of human foetal keratinocyte cells and human foetal fibroblast cells, the ratio between said keratinocyte and fibroblast cells ranging from 0.75 to 2.5, preferably being 1:1 or 7:3. This composition is advantageously included in a bandage, said bandage preferably being sterile and packaged in a container impermeable to microorganisms. The present invention finally concerns the use of this composition as a drug, in particular for treating a skin defect (wound, burn or ulcer).
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: June 7, 2022
    Assignees: Universite De Nantes, Chu Nantes
    Inventors: Brigitte Dreno, Thomas Zuliani, Soraya Saiagh
  • Patent number: 11352600
    Abstract: The invention pertains to a method for separating biomass from solid fermentation product wherein a slurry comprising biomass and solid fermentation product is provided to the top of a biomass separator unit and an aqueous medium is provided to the bottom of a biomass separator unit, while a product stream comprising solid fermentation product is withdrawn from the bottom of the biomass separator unit and a waste stream comprising biomass is withdrawn from the top of the biomass separator unit. It has been found that the method according to the invention makes it possible to provide a solid fermentation product which comprises very low amounts of remaining biomass, while product loss can be limited.
    Type: Grant
    Filed: May 29, 2017
    Date of Patent: June 7, 2022
    Inventors: Jeroen Bokhove, Andre Banier De Haan, Willem Jacob Groot
  • Patent number: 11339365
    Abstract: Described herein is a device and method for translocating a protein through a nanopore and monitoring electronic changes caused by different amino acids in the protein. The device comprises a nanopore in a membrane, an amplifier for providing a voltage between the cis side and trans side of the membrane, and an NTP driven unfoldase which processed the protein to be translocated. The exemplified unfoldase is the ClpX unfoldase from E. coli.
    Type: Grant
    Filed: February 15, 2013
    Date of Patent: May 24, 2022
    Inventors: Jeffrey Matthew Nivala, Douglas Benjamin Marks, Mark Albert Akeson
  • Patent number: 11248245
    Abstract: Processes for transesterifying wax esters. Implementations may include: providing a feedstock including wax esters, contacting the feedstock with a lipase, and catalytically transesterifying the wax esters in the feedstock with the lipase to form a transesterified product. An oxidative stability index (OSI) of the transesterified product may be greater than an OSI of the feedstock.
    Type: Grant
    Filed: December 19, 2014
    Date of Patent: February 15, 2022
    Assignee: International Flora Technologies, Ltd.
    Inventors: Jeff Addy, Clay Daly, James H. Brown
  • Patent number: 11214597
    Abstract: The present invention relates to embedding live or dead microorganisms and/or bioactive materials in a protective dry formulation matrix, wherein the formation includes the bioactive microorganism or material, a formulation stabilizer agent, and a protective agent. The formulation agent is prepared by dispersing all the solid components in a solution, with or without a vacuum, and cooling the solution to a temperature above its freezing temperature. The methods include a primary drying step of the formulation at a desired temperature and time period, and an accelerated secondary drying step under maximum vacuum and elevated temperature, to achieve a final desirable water activity of the dry material.
    Type: Grant
    Filed: December 20, 2018
    Date of Patent: January 4, 2022
    Assignee: Advanced BioNutrition Corp.
    Inventors: Mordechai Harel, Roger Drewes, Brian Carpenter, Elena Artimovich
  • Patent number: 11207449
    Abstract: This document provides methods and materials for treating a mammal (e.g., a human) having one or more stenotic blood vessels. For example, amnion coated balloons that can be used in balloon angioplasty are provided.
    Type: Grant
    Filed: November 7, 2019
    Date of Patent: December 28, 2021
    Inventor: Gary M. Petrucci
  • Patent number: 11191808
    Abstract: The present invention relates to a pharmaceutical composition for inhibiting rejection of transplanted cells including a high mobility group box 1 A domain (HMGB1A) as an active ingredient. The use of the pharmaceutical composition can minimize immunological rejection, which may occur upon cell transplantation, and increase the success rate of cell transplantation.
    Type: Grant
    Filed: May 18, 2015
    Date of Patent: December 7, 2021
    Inventors: Dong Yun Lee, Yong Hwa Hwang, Min Hyung Lee
  • Patent number: 11180760
    Abstract: Drug targets, pathways, kits and methods for treating conditions related to neurodegeneration or ocular disease, are disclosed.
    Type: Grant
    Filed: March 11, 2013
    Date of Patent: November 23, 2021
    Inventors: Donald J. Zack, Derek S. Welsbie
  • Patent number: 11142784
    Abstract: The invention relates to a mass spectrometric method to determine microbial resistances to antibiotics. The decrease or modification of specific nutrient components by microbes, and thus the metabolism of the microbes, is determined mass spectrometrically in culture media containing antibiotics. Hence it is not the microbes which are introduced into the mass spectrometric analysis, but the culture medium. The special nutrient components which are subject to the mass spectrometric observation are indicators for the metabolism exhibited by the microbes in the culture in the presence of antibiotics, and are thus indicators for their susceptibility or resistance.
    Type: Grant
    Filed: January 14, 2015
    Date of Patent: October 12, 2021
    Inventors: Markus Kostrzewa, Katrin Sparbier
  • Patent number: 11096971
    Abstract: The present disclosure relates to a mixture of bacteria belonging to at least six or seven different and specific bacterial species preferably for use in preventing or treating gastro-intestinal disorders. Preferably, the mixture of bacteria are grown together in a fermenter prior to administering the mixture to a subject in order to prevent or treat the disorder.
    Type: Grant
    Filed: February 3, 2017
    Date of Patent: August 24, 2021
    Inventors: Sam Possemiers, Massimo Marzorati, Tom Van De Wiele, Ilse Scheirlinck, Pieter Van Den Abeele, Selin Bolca, Davide Gottardi
  • Patent number: 11045525
    Abstract: The present disclosure provides, in one embodiment, a method of treating or preventing an ID2 protein-related disease in a patient at risk of developing or having such a disease by administering to the patient a composition in an amount and for a time sufficient to increase degradation of HIF? in a cell affected by the ID2 protein-related disease in the patent and/or to decrease half-life of HIF? in the cell affected by the ID2 protein-related disease in the patient, as compared to an untreated cell affected by the ID2 protein-related disease.
    Type: Grant
    Filed: July 2, 2018
    Date of Patent: June 29, 2021
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Antonio Iavarone, Anna Lasorella