Patents Examined by Srikanth Patury
  • Patent number: 10405961
    Abstract: Disclosed herein are medical products, including a surgical mesh, with a layer of dehydrated modified basement membrane preparation formed thereon. The basement membrane has been modified before dehydration of remove low molecular weight components. In some embodiments, the basement membrane is crosslinked. Methods of making and using the products also are disclosed.
    Type: Grant
    Filed: September 2, 2016
    Date of Patent: September 10, 2019
    Assignee: Cell and Molecular Tissue Engineering, LLC
    Inventors: Ulrike W. Klueh, Donald L. Kreutzer
  • Patent number: 10407709
    Abstract: A method of isolating cells includes providing a microfluidic device having at least one microfluidic channel coupled to an inlet and an outlet, the at least one microfluidic channel comprises at least one expansion region disposed along the length thereof. The at least one expansion region is an abrupt increase in a cross-sectional dimension of the at least one microfluidic channel configured to generate a vortex within the at least one expansion region in response to fluid flow. A solution containing a population of cells at least some of which have diameters ?10 ?m flows into the inlet. A portion of cells is trapped within vortex created within the at least one expansion region. The trapped cells may then released from the expansion region.
    Type: Grant
    Filed: August 5, 2015
    Date of Patent: September 10, 2019
    Inventors: Dino Di Carlo, Soojung C. Hur, Albert J. Mach
  • Patent number: 10391200
    Abstract: Cosmetic methods providing a significant improvement over existing hair transplantation methods by providing greater hair density per hair implant, which is achieved through the process of an enhanced hair multiplication in vivo (e.g. in the scalp of a subject). The cosmetic methods also provide improved aesthetic results, particularly, more realistic and natural looking results, relative to the results obtained by traditional methods. The cosmetic methods are particularly suitable for hair transplantation in recipient areas of a subject experiencing baldness or lack of hair, optionally due to Androgenic alopecia, burn injuries, cancer chemotherapy, or other genetic or environmental factors or scarring.
    Type: Grant
    Filed: December 12, 2013
    Date of Patent: August 27, 2019
    Inventor: Conradus Ghosal Gho
  • Patent number: 10335439
    Abstract: [Problem] To provide a method for producing human corneal epithelial sheet, wherein the human corneal epithelial-derived cells obtained by culturing human corneal epithelial cells are cultured on an amnion substrate. [Solution] A method for culturing human corneal epithelial cells using mesenchymal stem cells as the feeder cells; and a method for culturing human corneal epithelial cells using a medium containing a ROCK inhibitor, a phosphodiesterase inhibitor, a MAP kinase inhibitor and a TGF-? receptor inhibitor in various combinations.
    Type: Grant
    Filed: March 9, 2014
    Date of Patent: July 2, 2019
    Assignees: JCR Pharmaceuticals Co., Ltd., Kyoto Prefectural Public University Corporation
    Inventors: Kiwamu Imagawa, Kenichi Maeda, Yuki Hosoda, Shuichi Yokoyama, Naoki Okumura, Noriko Koizumi, Shigeru Kinoshita
  • Patent number: 10330685
    Abstract: Provided herein is technology relating to treatment of sepsis and particularly, but not exclusively, to methods for predicting a response of a sepsis patient to treatment with L-carnitine.
    Type: Grant
    Filed: April 28, 2015
    Date of Patent: June 25, 2019
    Inventors: Kathleen Stringer, Alan E. Jones, Mike Puskarich
  • Patent number: 10322080
    Abstract: A method for reducing hyaluronidase activity and promoting hyaluronic acid production in skin comprising topically applying to skin in need thereof a composition comprising an effective amount of Centella asiatica stem cells to reduce hyaluronidase activity in skin, an effective amount of tetradecyl aminobutyroylvalylamino butyric urea trifluoroacetate to promote hyaluronic acid production in skin, and an effective amount of tripeptide-1 to promote hyaluronic acid production in skin.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: June 18, 2019
    Assignee: Mary Kay Inc.
    Inventors: Tiffany Florence, Michelle Hines, David Gan
  • Patent number: 10272043
    Abstract: The present invention comprises methods and compositions for the reduction of oxalate in humans. For example, the invention provides methods and compositions for the delivery of one or more oxalate-reducing enzymes embedded in particle compositions. The compositions of the present invention are suitable in methods of treatment or prevention of oxalate-related conditions including, but not limited to, hyperoxaluria, absorptive hyperoxaluria, enteric hyperoxaluria, primary hyperoxaluria, idiopathic calcium oxalate kidney stone disease (urolithiasis), vulvodynia, oxalosis associated with end-stage renal disease, cardiac conductance disorders, inflammatory bowel disease, Crohn's disease, ulcerative colitis, and patients who have undergone gastrointestinal surgery and bariatric surgery (surgery for obesity), and/or who have undergone antibiotic treatment.
    Type: Grant
    Filed: October 27, 2014
    Date of Patent: April 30, 2019
    Inventors: Qingshan Li, Harmeet Sidhu
  • Patent number: 10274479
    Abstract: The present invention provides a microfluidic device and its use for cell motility classification. The microfluidic device comprises a fluid inlet, a sample inlet and a channel connecting the fluid inlet and the sample inlet, wherein the channel comprises at least two sections of different sizes, and the channel allows fluid flow from the fluid inlet to the sample inlet.
    Type: Grant
    Filed: June 1, 2012
    Date of Patent: April 30, 2019
    Assignee: CapitalBio Corporation
    Inventors: Tian Qiu, Rui Ma, Chao Han, Lan Xie, Jing Cheng
  • Patent number: 10267769
    Abstract: A method for fixing a biological sample includes delivering energy through a biological sample that has been removed from a subject, while fixing the biological sample. A change in speed of the energy traveling through the biological sample is evaluated to monitor the progress of the fixation. A system for performing the method can include a transmitter that outputs the energy and a receiver configured to detect the transmitted energy. A computing device can evaluate the speed of the energy based on signals from the receiver.
    Type: Grant
    Filed: March 4, 2011
    Date of Patent: April 23, 2019
    Assignee: Ventana Medical Systems, Inc.
    Inventors: Michael Otter, David Chafin, Abbey Pierson, Jefferson Curtis Taft
  • Patent number: 10258673
    Abstract: The invention relates a pharmaceutical composition containing botulinum toxin and a mucopolysaccharide uses thereof with increased pharmacological activity and long lasting botulinum toxin effect.
    Type: Grant
    Filed: May 14, 2014
    Date of Patent: April 16, 2019
    Assignee: Bosti Trading Ltd.
    Inventors: Evgeny Pokushalov, Vladislav Fomenko, Nariman Salakhudinov
  • Patent number: 10241119
    Abstract: Methods for measuring and analyzing parathyroid hormone-related peptide (PTHrP) using LC-MS/MS, including applications of the methods thereof, are disclosed and discussed. Such methods can include, along with the use of an isotope-labeled internal standard, purifying PTHrP from a biological sample, proteolytically digesting the PTHrP, and measuring specific digestion products using the using LC-MS/MS.
    Type: Grant
    Filed: May 9, 2016
    Date of Patent: March 26, 2019
    Assignee: University of Utah Research Foundation
    Inventors: Mark M. Kushnir, Alan L. Rockwood, A. Wayne Meikle
  • Patent number: 10213967
    Abstract: A fabricating device of a three-dimensional (3-D) scaffold comprises a bubble generator, a bubble mixing channel, a coagulating solution channel and a bubble collector. The bubble generator includes a gas channel and a gel solution channel crossing the gas channel. The bubble mixing channel is connected with a first outlet of the bubble generator. The coagulating solution channel is connected with the bubble mixing channel. The bubble collector is connected with a second outlet of the bubble mixing channel.
    Type: Grant
    Filed: June 11, 2014
    Date of Patent: February 26, 2019
    Assignee: Academia Sinica
    Inventors: Keng-Hui Lin, Yi-Hsuan Lee
  • Patent number: 10212941
    Abstract: The present invention provides methods for development of a virulent bacteriophage-based treatment for the control of plant diseases caused by Xylella fastidiosa. The invention further provides methods of isolating and propagating bacteriophage virulent to X. fastidiosa in a Xanthomonas bacterial host and for treating or reducing symptoms of X. fastidiosa infection in a plant. The invention further provides methods of isolating and propagating bacteriophage virulent to Xanthomonas axonopodis pv. citri and for treating or reducing symptoms of Xanthomonas axonopodis pv. citri infection in a plant.
    Type: Grant
    Filed: June 6, 2016
    Date of Patent: February 26, 2019
    Assignee: The Texas A&M University System
    Inventors: Carlos F. Gonzalez, Stephen J. Ahern, Mayukh Das, Ryland F. Young, III, Tushar Suvra Bhowmick
  • Patent number: 10189711
    Abstract: Methods and systems for removal and recovery of phosphorus from wastewater and producing inorganic phosphorus complexes including digestate recycle.
    Type: Grant
    Filed: August 30, 2011
    Date of Patent: January 29, 2019
    Assignee: Multiform Harvest Inc.
    Inventor: Keith E. Bowers
  • Patent number: 10190092
    Abstract: Methods and solutions for the preservation and procurement of placental stem cells. A method for collecting stem cells from a placenta includes draining cord blood from the placenta and collecting the drained cord blood in a first collection. The drained placenta is perfused with a first perfusion solution including a placental preservative base solution and a vasodilator. The placenta is perfused with a second perfusion solution including placental preservative base solution, a stem cell releasing agent, an antibiotic, and an anticoagulant, and a predetermined amount of time is allowed to elapse as the first and second perfusion solutions perfuse the placenta. The first and second perfusion solutions, which contain stem cells from the placenta, are then collected in a second collection.
    Type: Grant
    Filed: January 2, 2014
    Date of Patent: January 29, 2019
    Inventor: Robert A. Dracker
  • Patent number: 10174284
    Abstract: [Problem] To provide, in order to manufacture cells to transplant into patients with corneal endothelial failure, a medium used to culture corneal endothelial cells obtained from human corneal tissue and grow said cells while maintaining the morphology thereof as corneal endothelial cells. [Solution] A medium containing a conditioned medium from mesenchymal stem cells; and a method in which said medium is used to culture corneal endothelial cells.
    Type: Grant
    Filed: September 5, 2013
    Date of Patent: January 8, 2019
    Inventors: Michio Hagiya, Kiwamu Imagawa, Yuuki Hosoda, Noriko Koizumi, Naoki Okumura, Makiko Nakahara, Shigeru Kinoshita
  • Patent number: 10160953
    Abstract: The invention provides a nutrient medium composition and associated methods for lengthening the useful life of a culture of muscle cells. Disclosed is a method of culturing mammalian muscle cells, including preparing one or more carriers coated with a covalently bonded monolayer of trimethoxy-silylpropyl-diethylenetriamine (DETA); verifying DETA monolayer formation by one or more associated optical parameters; suspending isolated fetal rat skeletal muscle cells in serum-free medium according to medium composition 1; plating the suspended cells onto the prepared carriers at a predetermined density; leaving the carriers undisturbed for cells to adhere to the DETA monolayer; covering the carriers with a mixture of medium 1 and medium 2; and incubating.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: December 25, 2018
    Assignee: University of Central Florida Research Foundation, Inc.
    Inventors: James J. Hickman, Mainak Das, John W. Rumsey
  • Patent number: 10150947
    Abstract: In accordance with the purpose(s) of the present disclosure, as embodied and broadly described herein, embodiments of the present disclosure, in one aspect, relate to methods of making a structure including nanotubes, a structure including nanotubes, methods of delivering a fluid to a cell, methods of removing a fluid to a cell, methods of accessing intracellular space, and the like.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: December 11, 2018
    Assignee: The Board of Trustees of the Leland Stanford Junior University
    Inventors: Jules J. Vandersarl, Alexander M. Xu, Nicholas A. Melosh, Noureddine Tayebi
  • Patent number: 10144914
    Abstract: In the present specification and claims, three modified cell culture substrates are disclosed for protecting peptide mimetic surfaces used in cell culture technology. The methods are able to retain the functionality of the bioactive species conjugated to the surface. In particular, a vitronectin peptide fragment Ac-Lys-Gly-Gly-Pro-Gln-Val-Thr-Arg-Gly-Asp-Val-Phe-Thr-Met-Pro-NH2 was able to facilitate growth and proliferation of undifferentiated human embryonic stem cells after stabilization using 3 different modified cell culture substrates for of protection against gamma irradiation.
    Type: Grant
    Filed: February 22, 2011
    Date of Patent: December 4, 2018
    Assignee: Corning Incorporated
    Inventors: Dana Craig Bookbinder, Arthur Winston Martin, Santona Pal, Christopher Bankole Shogbon, Jennifer L. Weber, Yue Zhou
  • Patent number: 10126216
    Abstract: An aldehyde fixative solution at a first temperature is caused to contact a tissue sample for a first time period, additionally an aldehyde fixative solution is caused to contact the tissue sample at a second temperature higher than the first temperature for a second time period. The first time period typically ranges from about 15 minutes up to about 4 hours, and the first temperature typically is from greater than 0° C. to at least 15° C. The second temperature typically is from greater than about 22° C. to about 55° C., and the second time period ranges from about 1 hour to about 4 hours. Using this process, improved tissue morphology and IHC staining as well as superior preservation of post-translation modification signals have been accomplished in approximately 4 hours compared to 24 hours for room temperature protocols, and more even morphology and antigen preservation are observed.
    Type: Grant
    Filed: February 13, 2012
    Date of Patent: November 13, 2018
    Assignee: Ventana Medical Systems, Inc.
    Inventors: David Chafin, Abbey Pierson Theiss, Michael Otter, Esteban Roberts