Patents Examined by Stephen Gucker
  • Patent number: 8128926
    Abstract: Endogenous Sp35 is a negative regulator for neuronal survival, axon regeneration, oligodendrocyte differentiation and myelination. Molecules that block endogenous Sp35 function, such anti-Sp35 antibodies can be used as therapeutics for the treatment of neuron and oligodendrocyte dysfunction. The present invention provides antibodies specific for Sp35, and methods of using such antibodies as antagonists of endogenous Sp35 function. The invention further provides specific hybridoma and phage library-derived monoclonal antibodies, nucleic acids encoding these antibodies, and vectors and host cells comprising these antibodies. The invention further provides methods of promoting oligodendrocyte survival and myelination in a vertebrate, comprising administering to a vertebrate in need of such treatment an effective amount of an anti-Sp35 antibody.
    Type: Grant
    Filed: March 24, 2009
    Date of Patent: March 6, 2012
    Assignee: Biogen Idec MA Inc.
    Inventors: Sha Mi, R. Blake Pepinsky, Zhaohui Shao, Ellen A. Garber, Steven D. Miklasz, Christilyn Graff
  • Patent number: 8124076
    Abstract: Anti-A?P scFvs and single domain antibodies were generated, and when these antibodies were displayed on filamentous phage or as soluble protein molecules, stabilized by the maltose binding protein, they could prevent the fibrilization of Abp 1-40 and disaggregate Abp 1-40 fibrils generated in vitro. The anti-A?p scFv antibodies also stained amyloid neuritic plaques on slices from transgenic mice. The anti-A?P scFv and single domain antibodies can be used for inhibiting or treating Alzheimer's disease.
    Type: Grant
    Filed: August 18, 2006
    Date of Patent: February 28, 2012
    Assignee: Ramot At Tel Aviv University Ltd.
    Inventors: Beka Solomon, Rachel Cohen-Kupiec
  • Patent number: 8071548
    Abstract: A method of inhibiting the binding between N-methyl-D-aspartate receptors and neuronal proteins in a neuron is disclosed. The method comprises administering to the neuron an effective inhibiting amount of a peptide replacement agent for the NMDA receptor or neuronal protein interaction domain that effect said inhibition of the NMDA receptor-neuronal protein interaction. The method is of value in reducing the damaging effect of injury to mammalian cells. Postsynaptic density-95 protein (PSD-95) couples neuronal N-methyl-D-aspartate receptors (NMDARs) to pathways mediating excitotoxicity, ischemic and traumatic brain damage. This coupling was disrupted by transducing neurons with peptides that bind to modular domains on either side of the PSD-95/NMDAR interaction complex.
    Type: Grant
    Filed: February 25, 2009
    Date of Patent: December 6, 2011
    Assignee: Nono, Inc.
    Inventor: Michael Tymianski
  • Patent number: 8048639
    Abstract: The invention relates to methods and reagents for diagnosing and assessing the prognosis of multiple sclerosis.
    Type: Grant
    Filed: February 11, 2010
    Date of Patent: November 1, 2011
    Assignee: Glycominds Ltd.
    Inventors: Nir Dotan, Avinoam Dukler, Jennifer Yarden
  • Patent number: 8038992
    Abstract: Methods are provided for decreasing demyelinating inflammatory disease in a subject by inhibiting the activity of chemokine-like receptor 1 (CMKLR1). Methods are also provided for screening for agents that find use in treating demyelinating inflammatory disease in a subject.
    Type: Grant
    Filed: May 11, 2009
    Date of Patent: October 18, 2011
    Assignees: The Board of Trustees of the Leland Stanford Junior University, Department of Veterans Affairs
    Inventors: Kareem Graham, Brian A. Zabel, Eugene C. Butcher
  • Patent number: 8007791
    Abstract: The invention concerns the prevention and treatment of complement-associated eye conditions, such as choroidal neovascularization (CNV) and age-related macular degeneration (AMD), by administration of Factor D antagonists.
    Type: Grant
    Filed: May 22, 2008
    Date of Patent: August 30, 2011
    Assignee: Genentech, Inc.
    Inventors: Philip Hass, Yin Jianping, Kenneth Katschke, Jr., Micah Steffek, Christian Wiesmann, Menno Van Lookeren Campagne
  • Patent number: 7998480
    Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
    Type: Grant
    Filed: August 11, 2008
    Date of Patent: August 16, 2011
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, Joan D. Tyner, Lowell J. Tyner, legal representative, Bailin X. Tu, Mary S. Pinkus, Jessie W. Shih, Bryan C. Tieman
  • Patent number: 7994302
    Abstract: The present invention is related to antibodies directed to IL-13 and uses of such antibodies. For example, in accordance with the present invention, there are provided human monoclonal antibodies directed to IL-13. Isolated polynucleotide sequences encoding, and amino acid sequences comprising, heavy and light chain immunoglobulin molecules, particularly sequences corresponding to contiguous heavy and light chain sequences spanning the framework regions (FR's) and/or complementarity determining regions (CDR's), are provided. Additionally, methods of using these antibodies to treat patients are also provided. Additionally, IL-13 dependent biomarkers and methods of their identification and use are also provided.
    Type: Grant
    Filed: August 4, 2009
    Date of Patent: August 9, 2011
    Assignee: Amgen Inc.
    Inventors: Ian Foltz, Raffaella Faggioni, Giorgio Senaldi, Kathy Manchulenko, Jaspal S. Kang, Palaniswami Rathanaswami, Kiran Ahluwalia, Orit Foord, Scott Klakamp
  • Patent number: 7994286
    Abstract: Novel anti-NRP1 antibodies and variants thereof having unique structural and functional characteristics are disclosed. Also provided are uses of the antibodies in research, diagnostic and therapeutic applications.
    Type: Grant
    Filed: April 22, 2008
    Date of Patent: August 9, 2011
    Assignee: Genentech, Inc.
    Inventors: Ryan J. Watts, Yan Wu
  • Patent number: 7985555
    Abstract: Methods to identify markers for brain damage using fresh brain tissue and methods and compositions for detecting these markers are disclosed.
    Type: Grant
    Filed: June 27, 2005
    Date of Patent: July 26, 2011
    Assignee: Washington University
    Inventors: Jack Ladenson, Yvonne Landt, Vijay Modur, Omar Laterza
  • Patent number: 7968678
    Abstract: Disclosed is the characterization and purification of DNA encoding a numerous polypeptides useful for the stimulation of glial cell (particularly, Schwann cell) mitogenesis and treating glial cell tumors. Also disclosed are DNA sequences encoding novel polypeptides which may have use in stimulating glial cell mitogenesis and treating glial cell tumors. Methods for the synthesis, purification and testing of both known and novel polypeptides for their use as both therapeutic and diagnostic aids in the treatment of diseases involving glial cells are also provided. Methods are also provided for the use of these polypeptides for the preparation of antibody probes useful for both diagnostic and therapeutic use in diseases involving glial cells.
    Type: Grant
    Filed: December 27, 2007
    Date of Patent: June 28, 2011
    Assignees: Acorda Therapeutics, Inc., Ludwig Institute for Cancer Research
    Inventors: Andrew David Goodearl, Paul Stroobant, Luisa Minghetti, Michael Waterfield, Mark Marchionni, Maio Su Chen, Ian Hiles
  • Patent number: 7943574
    Abstract: The invention provides cell-permeable peptides that selectively block the branch of the JNK signaling pathway controlled by the islet-brain (IB) proteins. The provided cell-permeable peptides block the binding of intermediate kinases in the c-Jun amino terminal kinase (JNK) signaling pathway, thereby decreasing the downstream effects of c-Jun amino terminal kinase (JNK).
    Type: Grant
    Filed: September 2, 2009
    Date of Patent: May 17, 2011
    Assignee: Xigen SA
    Inventor: Christophe Bonny
  • Patent number: 7939069
    Abstract: The present invention relates to antibodies that immunospecifically bind to human brain natriuretic peptide or a human brain natriuretic peptide fragment with a high binding affinity, methods for producing and selecting said antibodies, immunoassays for human brain natriuretic peptide or a human brain natriuretic peptide fragment that employ said antibodies and therapeutic compositions containing said antibodies.
    Type: Grant
    Filed: May 8, 2007
    Date of Patent: May 10, 2011
    Assignee: Abbott Laboratories
    Inventors: Susan E. Brophy, Joan D. Tyner, Bryan C. Tieman
  • Patent number: 7939078
    Abstract: Co-administration of an effective amount of autoantigen and UV light to mucosal associated lymphatic tissue (MALT) in a patient.
    Type: Grant
    Filed: July 7, 2005
    Date of Patent: May 10, 2011
    Assignee: Codman & Shurtleff
    Inventors: Thomas M. DiMauro, Mohamed Attawia, Sean Lilienfeld, Chantal Holy
  • Patent number: 7935339
    Abstract: The present invention relates to the use of inhibitors of the CD95 ligand/receptor system for the manufacture of a medicament for the treatment of neurological disorders or injuries in a mammal, particularly for the treatment of spinal cord injury, more particularly for the treatment of paraplegia.
    Type: Grant
    Filed: February 10, 2004
    Date of Patent: May 3, 2011
    Assignee: Deutsches Krebsforschungszentrum Stiftung des öffentlichen Rechts
    Inventors: Ana Martin-Villalba, Peter Krammer, Deana Demjen
  • Patent number: 7935671
    Abstract: Pantropic neurotrophic factors which have multiple neurotrophic specificities are provided. The pantropic neurotrophic factors of the present invention are useful in the treatment of neuronal disorders. Nucleic acids and expression vectors encoding the pantropic neurotrophins are also provided.
    Type: Grant
    Filed: March 10, 2009
    Date of Patent: May 3, 2011
    Assignee: Genentech, Inc.
    Inventors: Roman Urfer, Leonard G. Presta, John W. Winslow
  • Patent number: 7932352
    Abstract: The present invention provides a novel Semaphorin having neurite-outgrowth inhibition activity or proteins analogous thereto, peptide fragments of, or antibodies against, such proteins, genes encoding such proteins, expression vectors for said genes, transformed cells into which said expression vectors have been introduced, methods for producing a recombinant protein which employ said transformed cells, antisense nucleotides against the above genes, transgenic animals involving insertion or deletion of the above genes, and screening methods for antagonists of the above proteins, all of which are useful mainly in diagnoses, treatments, or studies relating to neurological diseases. The present invention further provides use of such proteins, peptides, antibodies, genes, or antisense nucleotides as pharmaceutical or diagnostic agents or laboratory reagents.
    Type: Grant
    Filed: November 28, 2008
    Date of Patent: April 26, 2011
    Assignee: Dainippon Sumitomo Pharma Co., Ltd.
    Inventors: Shinobu Inagaki, Tatsuo Furuyama
  • Patent number: 7927786
    Abstract: The invention provides parkin binding polypeptides and encoding nucleic acids. The invention also provides antibodies specific for the parkin binding polypeptides. The invention additionally provides methods of detecting a parkin binding polypeptide and detecting a nucleic acid encoding a parkin binding polypeptide. The invention further provides methods of using a parkin binding polypeptide. In one embodiment, the invention provides a method of identifying a candidate drug for treating Parkinson's disease by contacting a parkin binding polypeptide with one or more compounds and identifying a compound that alters the activity of the parkin binding polypeptide.
    Type: Grant
    Filed: February 18, 2004
    Date of Patent: April 19, 2011
    Assignee: Cedars-Sinai Medical Center
    Inventors: Stefan M. Pulst, Duong P. Huynh
  • Patent number: 7897575
    Abstract: The invention relates to compositions and methods for treating or preventing vascular dementia in a mammal comprising mucosal administration of an amount of E-selectin polypeptide sufficient to induce bystander immune tolerance in the mammal. Another aspect of the invention relates to compositions useful for treating or preventing vascular dementia.
    Type: Grant
    Filed: February 28, 2008
    Date of Patent: March 1, 2011
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: John M. Hallenbeck, Hideaki Wakita
  • Patent number: 7892845
    Abstract: The present invention relates to methods of diagnosing, monitoring, and assessing treatment effects for neurological and neurodegenerative diseases and disorders, such as Alzheimer's Disease, early in the course of clinical disease or prior to the onset of brain damage and clinical symptoms. Methods of measuring the in vivo metabolism of biomolecules produced in the CNS in a subject are provided.
    Type: Grant
    Filed: April 4, 2006
    Date of Patent: February 22, 2011
    Assignee: Washington University in St. Louis
    Inventors: Randall John Bateman, David Michael Holtzman