Patents Examined by Susan M. Hanley
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Patent number: 11612162Abstract: The present invention relates to methods of cryopreservation and compositions for use in such methods where the methods utilise non-Newtonian fluid properties of the cryopreservation medium to modulate the viscosity of that medium to deliver an improved cryopreservation process.Type: GrantFiled: October 25, 2016Date of Patent: March 28, 2023Assignee: ASYMPTOTE LTD.Inventors: Peter James Kilbride, George John Morris
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Patent number: 11608480Abstract: The present disclosure relates to a liquid surfactant composition containing a surfactant mixture, water and at least one amylase as defined herein. The present disclosure also relates to a method for cleaning textiles including providing a washing liquor by dosing a liquid surfactant composition, mixing this dosage into at least one solvent, and bring the resulting mixture into contact with the textiles.Type: GrantFiled: October 20, 2017Date of Patent: March 21, 2023Assignee: HENKEL AG & CO. KGAAInventors: Martina Seiler, Timothy O'Connell, Dieter Nickel
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Patent number: 11597694Abstract: Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 ?m and less than 1 ?m with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.Type: GrantFiled: May 14, 2020Date of Patent: March 7, 2023Assignee: Toray Industries, Inc.Inventors: Kenji Sawai, Hideki Sawai, Takashi Mimitsuka, Masateru Ito, Katsushige Yamada, Kenji Kawamura, Shin-ichi Minegishi, Izumi Nakagawa, Tatsuya Nagano
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Patent number: 11597845Abstract: A coating for conversion of formaldehyde to carbon dioxide includes an alcohol/aldehyde oxidase and a formate oxidase immobilized on a solid particulate support; and a latex binder.Type: GrantFiled: June 29, 2018Date of Patent: March 7, 2023Assignees: DOW GLOBAL TECHNOLOGIES LLC, ROHM AND HAAS COMPANY, GEORGIA TECH RESEARCH CORPORATION, GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.Inventors: John Anderson Roper, III, Sudhakar Balijepalli, Paul Doll, Andreas S. Bommarius, Christopher W. Jones, Christopher R. Murdock, John M. Robbins, Akihiro Nomura, Bettina R. Bommarius, Adam Holewinski, Giovanni Gadda
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Patent number: 11598792Abstract: A voltage indicator includes a polypeptide sequence comprising a voltage-sensitive opsin domain and a capture protein domain arranged and disposed to capture a fluorescent dye ligand. When the fluorescent dye ligand is captured and the voltage indicator is bound to a cell membrane, an increase in voltage across the cell membrane causes an increase in fluorescent emission.Type: GrantFiled: May 11, 2020Date of Patent: March 7, 2023Assignee: HOWARD HUGHES MEDICAL INSTITUTEInventors: Eric R. Schreiter, Ahmed Abdelfattah
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Patent number: 11591579Abstract: Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO-degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer.Type: GrantFiled: November 1, 2021Date of Patent: February 28, 2023Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventor: Everett Stone
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Patent number: 11589575Abstract: The present invention relates to a solution for the preservation of cells from placental blood, from bone marrow and from peripheral blood.Type: GrantFiled: September 9, 2016Date of Patent: February 28, 2023Assignees: ETABLISSEMENT FRANCAIS DU SANG, UNIVERSITÉ DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Zoran Ivanovic, Jean Chevaleyre, Laura Rodriguez, Esther Attebi
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Patent number: 11591359Abstract: It is an object of the present invention to provide a fluorescence imaging probe capable of selectively visualizing target cells such as cells expressing ?-galactosidase (lacZ expressing cells) at a single-cell level in a red fluorescence region, and of performing co-staining together with GFP.Type: GrantFiled: June 23, 2017Date of Patent: February 28, 2023Assignee: The University of TokyoInventors: Yasuteru Urano, Mako Kamiya, Hiroki Ito, Yu Kawamata
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Patent number: 11578353Abstract: The invention refers to a method and a device for the phenotypic detection of carbapenemases and carbapenemase producers by adding a substrate of general formula A-(L)-M1-(X)—Z, where M1 is a carbapenem backbone, A or Z is a quencher, the other one of the two, Z or A, is a fluorophore, L is an optional linker, X is an optional leaving group for linking Z to the carbapenem backbone, and Z is an optional leaving group, to a sample suspected of containing such carbapenemase producers and/or carbapenenmases. The invention further refers to a method for the phenotypic detection of resistant bacteria, in particular 3MRGN or 4MRGN, by releasing the enzymes of a bacterial culture into a lysate during lysis and then subjecting the lysate, as the sample to be analyzed, to an aforementioned method in order to phenotypically detect the presence of resistance-conferring carbapenemases.Type: GrantFiled: May 4, 2018Date of Patent: February 14, 2023Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.Inventors: Jennifer Schmidt, Sabine Trupp
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Patent number: 11566268Abstract: Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.Type: GrantFiled: March 14, 2014Date of Patent: January 31, 2023Assignees: GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OXFORD UNIVERSITY INNOVATION LIMITEDInventors: Kieran Clarke, Richard Lewis Veech, M. Todd King
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Patent number: 11549129Abstract: According to one broad aspect of this disclosure, a method is provided for producing polyhydroxyalkanoates (PHA) from organic waste. The method comprises homogenizing organic waste to obtain a feedstock that has 1:1 to 3:1 (w/w) water to organic waste ratio. The feedstock is inoculated with an inoculum of acidogenic fermentative bacteria in order to obtain an inoculated feedstock. The inoculated feedstock is incubated for 5 to 10 days, 3 to 10 days, optionally 7 days, optionally 3 days, to obtain a fermentation broth. The fermentation broth comprises volatile fatty acids (VFAs) and undigested organic waste. The fermentation broth is filtered with a filter with a pore size ranging from 0.2 ?m to 500,000 NMWC to remove the acidogenic fermentative bacteria and undigested organic waste, to obtain a clarified broth comprising concentrated VFAs. The clarified broth and high-PHA producing bacteria are incubated to produce intracellular PHA granules in the high-PHA producing bacteria.Type: GrantFiled: December 21, 2018Date of Patent: January 10, 2023Assignee: Genecis Bioindustries Inc.Inventors: Luna Yu, Hasitha de Alwis Weerasekera, Marcos Forattini Lemos Igreja, Vani Sankar, Michael James Williamson, Sudhanshu Sanjay Soman, Kaitlyn Chow
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Patent number: 11541102Abstract: The present disclosure provides methods for inducing cell cycle reentry of postmitotic cell. The present disclosure further provides cells and compositions for treating diseases, such as cardiovascular diseases, neural disorders, hearing loss, and diabetes.Type: GrantFiled: February 3, 2020Date of Patent: January 3, 2023Assignee: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David GladstoneInventors: Tamer M. A. Mohamed, Deepak Srivastava
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Patent number: 11535881Abstract: The present invention relates to an enzymatic electrode comprising a conductive surface and wherein a conjugate comprising at least one enzyme molecule is covalently bound to the conductive surface. The electrode is suitable for continuous analyte monitoring, particularly for continuous glucose monitoring (CGM) with glucose oxidase (GOD) as enzyme molecule. Further, the invention relates to an electrochemical sensor for measuring the concentration of an analyte, e.g. glucose under in vivo conditions comprising the enzymatic electrode.Type: GrantFiled: February 16, 2018Date of Patent: December 27, 2022Assignee: ROCHE DIABETES CARE, INC.Inventors: Reinhold Mischler, Angelika Fuerst, Daniel Kammerer
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Patent number: 11518990Abstract: Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.Type: GrantFiled: January 13, 2020Date of Patent: December 6, 2022Assignee: SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD.Inventors: Shidong Liu, Zhaoli Zhang, Xiaoming Ji
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Patent number: 11519017Abstract: Provided is a diagnostic kit for determining infection with Methicillin-Resistant Staphylococcus aureus (MRSA) in a specimen, and a method for determining the infection with MRSA using the diagnostic kit is performed by visually observing a color change after LAMP reaction, and the color change is caused by a change in a magnesium concentration and confirmed using a specific dye compound which sensitively reacts with magnesium ions. The amplification of the MRSA DNA is performed using the loop-mediated isothermal amplification (LAMP), so that the diagnostic kit has advantages of being conveniently used anytime and anywhere and quickly diagnosing.Type: GrantFiled: December 21, 2018Date of Patent: December 6, 2022Inventors: Jin Woo Park, Jae-Ho Choi, Bongkyu Lee, Hyoung Su Kim, Kiwon Kim, Jae-Sung Lee, Hyo Sung Jeon, Sora Yun
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Patent number: 11419885Abstract: A composition contains at least one fucosylated oligosaccharide, for use in preventing and/or treating a URT infection in an infant or young child fulfilling at least one of the following criteria: i) the infant or young child is born from a non-secretor mother and/or is fed with a mother's milk deficient in at least one fucosylated oligosaccharide, ii) the infant or young child has at least one sibling, and iii) the infant or young child was born by C-section.Type: GrantFiled: June 11, 2019Date of Patent: August 23, 2022Assignee: Societe des Produits Nestle S.A.Inventors: Norbert Sprenger, Clemens Kunz, Dominique Brassart
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Patent number: 11408891Abstract: The invention relates to platinum and rhenium complexes of formula (I) that may be used as imaging agents. In particular, the invention relates to imaging agents, for example imaging agents for use in the imaging of peroxisomes. Certain embodiments of the invention relate to compounds per se. Other embodiments relate to a process for the preparation of compounds and to the use of compounds as imaging agents.Type: GrantFiled: April 6, 2018Date of Patent: August 9, 2022Assignee: University of LancasterInventors: Michael Peter Coogan, Sarah Louise Allinson, Daria Maria Kania, Charlotte Meri Amber Farrow, Jane Harmer, Harriet Louise Steel
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Patent number: 11407725Abstract: High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. Herein, is presented AlDeSense, a turn-on green fluorescent probe for aldehyde dehydrogenase 1A1 (ALDH1A1) and Ctrl-AlDeSense, a matching non-responsive reagent. AlDeSense exhibits a 20-fold fluorescent enhancement when treated with ALDH1A1. Through the application of surface marker antibody staining, tumorsphere assays, and assessment of tumorigenicity, the disclosed results show that cells exhibiting high AlDeSense signal intensity have properties of cancer stem cells. Herein, is also reported the development of a red congener, red-AlDeSense. Importantly, red-AlDeSense represents one of only a few examples of a turn-on sensor in the red region using the d-PeT quenching mechanism.Type: GrantFiled: December 18, 2019Date of Patent: August 9, 2022Assignee: The Board of Trustees of the University of IllinoisInventors: Thomas Edward Bearrood, Chelsea Diane Anorma, Jefferson Chan
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Patent number: 11396647Abstract: Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO-degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer.Type: GrantFiled: January 6, 2021Date of Patent: July 26, 2022Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEMInventor: Everett Stone
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Patent number: 11389545Abstract: The present invention provides a composition of nanoparticles comprising a biological mimetic base component that forms the structure of the nanoparticle. By interacting with the functional groups of the base component, the half-life of a bioactive molecule is extended.Type: GrantFiled: January 9, 2019Date of Patent: July 19, 2022Inventor: Sean Matthew Anderson