Patents Examined by Susan M. Hanley
  • Patent number: 11612162
    Abstract: The present invention relates to methods of cryopreservation and compositions for use in such methods where the methods utilise non-Newtonian fluid properties of the cryopreservation medium to modulate the viscosity of that medium to deliver an improved cryopreservation process.
    Type: Grant
    Filed: October 25, 2016
    Date of Patent: March 28, 2023
    Assignee: ASYMPTOTE LTD.
    Inventors: Peter James Kilbride, George John Morris
  • Patent number: 11608480
    Abstract: The present disclosure relates to a liquid surfactant composition containing a surfactant mixture, water and at least one amylase as defined herein. The present disclosure also relates to a method for cleaning textiles including providing a washing liquor by dosing a liquid surfactant composition, mixing this dosage into at least one solvent, and bring the resulting mixture into contact with the textiles.
    Type: Grant
    Filed: October 20, 2017
    Date of Patent: March 21, 2023
    Assignee: HENKEL AG & CO. KGAA
    Inventors: Martina Seiler, Timothy O'Connell, Dieter Nickel
  • Patent number: 11597694
    Abstract: Lactic acid is obtained by a method including (A) a step of continuous fermentation wherein a fermentation culture medium of a microorganism having an ability of lactic acid fermentation is filtered through a porous membrane having an average pore size of not less than 0.01 ?m and less than 1 ?m with a transmembrane pressure difference within the range of 0.1 to 20 kPa, and the permeate is collected, while retaining the non-permeated liquid in or returning the non-permeated liquid to the culture, and adding a fermentation feedstock to the culture; (B) a step of filtering the permeate obtained in Step (A) through a nanofiltration membrane; and (C) a step of distilling the permeate obtained in Step (B) under a pressure of not less than 1 Pa and not more than atmospheric pressure, at 25° C. to 200° C. to recover lactic acid.
    Type: Grant
    Filed: May 14, 2020
    Date of Patent: March 7, 2023
    Assignee: Toray Industries, Inc.
    Inventors: Kenji Sawai, Hideki Sawai, Takashi Mimitsuka, Masateru Ito, Katsushige Yamada, Kenji Kawamura, Shin-ichi Minegishi, Izumi Nakagawa, Tatsuya Nagano
  • Patent number: 11597845
    Abstract: A coating for conversion of formaldehyde to carbon dioxide includes an alcohol/aldehyde oxidase and a formate oxidase immobilized on a solid particulate support; and a latex binder.
    Type: Grant
    Filed: June 29, 2018
    Date of Patent: March 7, 2023
    Assignees: DOW GLOBAL TECHNOLOGIES LLC, ROHM AND HAAS COMPANY, GEORGIA TECH RESEARCH CORPORATION, GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC.
    Inventors: John Anderson Roper, III, Sudhakar Balijepalli, Paul Doll, Andreas S. Bommarius, Christopher W. Jones, Christopher R. Murdock, John M. Robbins, Akihiro Nomura, Bettina R. Bommarius, Adam Holewinski, Giovanni Gadda
  • Patent number: 11598792
    Abstract: A voltage indicator includes a polypeptide sequence comprising a voltage-sensitive opsin domain and a capture protein domain arranged and disposed to capture a fluorescent dye ligand. When the fluorescent dye ligand is captured and the voltage indicator is bound to a cell membrane, an increase in voltage across the cell membrane causes an increase in fluorescent emission.
    Type: Grant
    Filed: May 11, 2020
    Date of Patent: March 7, 2023
    Assignee: HOWARD HUGHES MEDICAL INSTITUTE
    Inventors: Eric R. Schreiter, Ahmed Abdelfattah
  • Patent number: 11591579
    Abstract: Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO-degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer.
    Type: Grant
    Filed: November 1, 2021
    Date of Patent: February 28, 2023
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Everett Stone
  • Patent number: 11589575
    Abstract: The present invention relates to a solution for the preservation of cells from placental blood, from bone marrow and from peripheral blood.
    Type: Grant
    Filed: September 9, 2016
    Date of Patent: February 28, 2023
    Assignees: ETABLISSEMENT FRANCAIS DU SANG, UNIVERSITÉ DE BORDEAUX, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Zoran Ivanovic, Jean Chevaleyre, Laura Rodriguez, Esther Attebi
  • Patent number: 11591359
    Abstract: It is an object of the present invention to provide a fluorescence imaging probe capable of selectively visualizing target cells such as cells expressing ?-galactosidase (lacZ expressing cells) at a single-cell level in a red fluorescence region, and of performing co-staining together with GFP.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: February 28, 2023
    Assignee: The University of Tokyo
    Inventors: Yasuteru Urano, Mako Kamiya, Hiroki Ito, Yu Kawamata
  • Patent number: 11578353
    Abstract: The invention refers to a method and a device for the phenotypic detection of carbapenemases and carbapenemase producers by adding a substrate of general formula A-(L)-M1-(X)—Z, where M1 is a carbapenem backbone, A or Z is a quencher, the other one of the two, Z or A, is a fluorophore, L is an optional linker, X is an optional leaving group for linking Z to the carbapenem backbone, and Z is an optional leaving group, to a sample suspected of containing such carbapenemase producers and/or carbapenenmases. The invention further refers to a method for the phenotypic detection of resistant bacteria, in particular 3MRGN or 4MRGN, by releasing the enzymes of a bacterial culture into a lysate during lysis and then subjecting the lysate, as the sample to be analyzed, to an aforementioned method in order to phenotypically detect the presence of resistance-conferring carbapenemases.
    Type: Grant
    Filed: May 4, 2018
    Date of Patent: February 14, 2023
    Assignee: Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V.
    Inventors: Jennifer Schmidt, Sabine Trupp
  • Patent number: 11566268
    Abstract: Embodiments of the present invention are directed to processes for the production of (R)-3-hydroxybutyl (R)-3-hydroxybyrate. Poly (R)-3-hydroxybyrate is transesterified with an alcohol, to form a first ester portion and a second ester portion. The first ester portion is reduced to the diol to form a diol portion and the diol portion is reacted with the second ester portion to produce (R)-3-hydroxybutyl (R)-3-hydroxybyrate.
    Type: Grant
    Filed: March 14, 2014
    Date of Patent: January 31, 2023
    Assignees: GOVERNMENT OF THE USA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES, OXFORD UNIVERSITY INNOVATION LIMITED
    Inventors: Kieran Clarke, Richard Lewis Veech, M. Todd King
  • Patent number: 11549129
    Abstract: According to one broad aspect of this disclosure, a method is provided for producing polyhydroxyalkanoates (PHA) from organic waste. The method comprises homogenizing organic waste to obtain a feedstock that has 1:1 to 3:1 (w/w) water to organic waste ratio. The feedstock is inoculated with an inoculum of acidogenic fermentative bacteria in order to obtain an inoculated feedstock. The inoculated feedstock is incubated for 5 to 10 days, 3 to 10 days, optionally 7 days, optionally 3 days, to obtain a fermentation broth. The fermentation broth comprises volatile fatty acids (VFAs) and undigested organic waste. The fermentation broth is filtered with a filter with a pore size ranging from 0.2 ?m to 500,000 NMWC to remove the acidogenic fermentative bacteria and undigested organic waste, to obtain a clarified broth comprising concentrated VFAs. The clarified broth and high-PHA producing bacteria are incubated to produce intracellular PHA granules in the high-PHA producing bacteria.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: January 10, 2023
    Assignee: Genecis Bioindustries Inc.
    Inventors: Luna Yu, Hasitha de Alwis Weerasekera, Marcos Forattini Lemos Igreja, Vani Sankar, Michael James Williamson, Sudhanshu Sanjay Soman, Kaitlyn Chow
  • Patent number: 11541102
    Abstract: The present disclosure provides methods for inducing cell cycle reentry of postmitotic cell. The present disclosure further provides cells and compositions for treating diseases, such as cardiovascular diseases, neural disorders, hearing loss, and diabetes.
    Type: Grant
    Filed: February 3, 2020
    Date of Patent: January 3, 2023
    Assignee: The J. David Gladstone Institutes, a testamentary trust established under the Will of J. David Gladstone
    Inventors: Tamer M. A. Mohamed, Deepak Srivastava
  • Patent number: 11535881
    Abstract: The present invention relates to an enzymatic electrode comprising a conductive surface and wherein a conjugate comprising at least one enzyme molecule is covalently bound to the conductive surface. The electrode is suitable for continuous analyte monitoring, particularly for continuous glucose monitoring (CGM) with glucose oxidase (GOD) as enzyme molecule. Further, the invention relates to an electrochemical sensor for measuring the concentration of an analyte, e.g. glucose under in vivo conditions comprising the enzymatic electrode.
    Type: Grant
    Filed: February 16, 2018
    Date of Patent: December 27, 2022
    Assignee: ROCHE DIABETES CARE, INC.
    Inventors: Reinhold Mischler, Angelika Fuerst, Daniel Kammerer
  • Patent number: 11518990
    Abstract: Disclosed in the present invention are an immobilized cycloaliphatic peptide acyltransferase and a preparation method and use thereof. The cycloaliphatic peptide acyltransferase is immobilized on a carrier; the cycloaliphatic peptide acyltransferase is derived from natural or artificial mutants or variants thereof, or can be obtained by introducing a foreign cyclic acyltransferase gene and transforming thereafter; the material of the carrier is selected from an inorganic carrier or a polypropylene resin carrier. Also disclosed in the present invention are the preparation method for the immobilized cycloaliphatic peptide acyltransferase and uses thereof.
    Type: Grant
    Filed: January 13, 2020
    Date of Patent: December 6, 2022
    Assignee: SHANGHAI TECHWELL BIOPHARMACEUTICAL CO., LTD.
    Inventors: Shidong Liu, Zhaoli Zhang, Xiaoming Ji
  • Patent number: 11519017
    Abstract: Provided is a diagnostic kit for determining infection with Methicillin-Resistant Staphylococcus aureus (MRSA) in a specimen, and a method for determining the infection with MRSA using the diagnostic kit is performed by visually observing a color change after LAMP reaction, and the color change is caused by a change in a magnesium concentration and confirmed using a specific dye compound which sensitively reacts with magnesium ions. The amplification of the MRSA DNA is performed using the loop-mediated isothermal amplification (LAMP), so that the diagnostic kit has advantages of being conveniently used anytime and anywhere and quickly diagnosing.
    Type: Grant
    Filed: December 21, 2018
    Date of Patent: December 6, 2022
    Inventors: Jin Woo Park, Jae-Ho Choi, Bongkyu Lee, Hyoung Su Kim, Kiwon Kim, Jae-Sung Lee, Hyo Sung Jeon, Sora Yun
  • Patent number: 11419885
    Abstract: A composition contains at least one fucosylated oligosaccharide, for use in preventing and/or treating a URT infection in an infant or young child fulfilling at least one of the following criteria: i) the infant or young child is born from a non-secretor mother and/or is fed with a mother's milk deficient in at least one fucosylated oligosaccharide, ii) the infant or young child has at least one sibling, and iii) the infant or young child was born by C-section.
    Type: Grant
    Filed: June 11, 2019
    Date of Patent: August 23, 2022
    Assignee: Societe des Produits Nestle S.A.
    Inventors: Norbert Sprenger, Clemens Kunz, Dominique Brassart
  • Patent number: 11408891
    Abstract: The invention relates to platinum and rhenium complexes of formula (I) that may be used as imaging agents. In particular, the invention relates to imaging agents, for example imaging agents for use in the imaging of peroxisomes. Certain embodiments of the invention relate to compounds per se. Other embodiments relate to a process for the preparation of compounds and to the use of compounds as imaging agents.
    Type: Grant
    Filed: April 6, 2018
    Date of Patent: August 9, 2022
    Assignee: University of Lancaster
    Inventors: Michael Peter Coogan, Sarah Louise Allinson, Daria Maria Kania, Charlotte Meri Amber Farrow, Jane Harmer, Harriet Louise Steel
  • Patent number: 11407725
    Abstract: High aldehyde dehydrogenase 1A1 (ALDH1A1) activity has emerged as a reliable marker for the identification of both normal and cancer stem cells. Herein, is presented AlDeSense, a turn-on green fluorescent probe for aldehyde dehydrogenase 1A1 (ALDH1A1) and Ctrl-AlDeSense, a matching non-responsive reagent. AlDeSense exhibits a 20-fold fluorescent enhancement when treated with ALDH1A1. Through the application of surface marker antibody staining, tumorsphere assays, and assessment of tumorigenicity, the disclosed results show that cells exhibiting high AlDeSense signal intensity have properties of cancer stem cells. Herein, is also reported the development of a red congener, red-AlDeSense. Importantly, red-AlDeSense represents one of only a few examples of a turn-on sensor in the red region using the d-PeT quenching mechanism.
    Type: Grant
    Filed: December 18, 2019
    Date of Patent: August 9, 2022
    Assignee: The Board of Trustees of the University of Illinois
    Inventors: Thomas Edward Bearrood, Chelsea Diane Anorma, Jefferson Chan
  • Patent number: 11396647
    Abstract: Disclosed herein are compositions related to conjugated polypeptides with MTA/ADO-degrading enzyme activity. The conjugated polypeptides are engineered to allow for maximal conjugation while maintaining catalytic activities. Also disclosed are nucleic acids, expression vectors, and host cells related to the conjugated polypeptides. Further disclosed are methods of using the pharmaceutical formulations comprising above to treat cancer.
    Type: Grant
    Filed: January 6, 2021
    Date of Patent: July 26, 2022
    Assignee: BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
    Inventor: Everett Stone
  • Patent number: 11389545
    Abstract: The present invention provides a composition of nanoparticles comprising a biological mimetic base component that forms the structure of the nanoparticle. By interacting with the functional groups of the base component, the half-life of a bioactive molecule is extended.
    Type: Grant
    Filed: January 9, 2019
    Date of Patent: July 19, 2022
    Inventor: Sean Matthew Anderson