Patents Examined by Taylor V. Oh
  • Patent number: 10919871
    Abstract: A method of treatment of an aqueous effluent stream obtained during production of furfural is disclosed. The aqueous effluent stream containing organic solvents, furfural, and water is subjected to azeotropic distillation to obtain a distillate stream and a treated effluent stream having lower BOD and COD values which can be further reduced by biomethanation.
    Type: Grant
    Filed: June 1, 2017
    Date of Patent: February 16, 2021
    Assignee: BASF SE
    Inventors: Sunil Sadashiv Divekar, Pramod Shankar Kumbhar, Rahul Vasantrao Bagal, ShreekantUttam Satav
  • Patent number: 10919872
    Abstract: Provided is a method for producing a 2-alkylcarbonylnaphtho[2,3-b]furan-4,9-dione-related substance, which is suitable for the production on an industrial scale. The present invention provides: a method for producing an intermediate for the production of a 2-alkylcarbonyl[2,3-b]furan-4,9-dione, which comprises reacting a 1-butyne derivative in which a ketone or an alcohol is protected with a 2-hydroxy-1,4-naphthoquinone derivative having a leaving group at position-3 in a solvent in the presence of a metal or a metal compound and a base; and a substance relating to the intermediate.
    Type: Grant
    Filed: April 17, 2020
    Date of Patent: February 16, 2021
    Inventors: Kazuhiko Takahashi, Shoji Watanabe, Katsuya Uchiyama, Kento Senami
  • Patent number: 10906882
    Abstract: A group of polyfunctional oxetane-based compounds having a structure as represented by general formula (I) or a product obtained by a reaction between a compound of general formula (I) and epichlorohydrin, an ester compound, or an isocyanate compound. When these polyfunctional oxetane-based compounds are used as cation polymerizable monomers in combination with an epoxy compound, the curing speed is high, and the cured product has highly excellent hardness, flexibility, adherence, and heat resistance.
    Type: Grant
    Filed: January 11, 2019
    Date of Patent: February 2, 2021
    Inventor: Xiaochun Qian
  • Patent number: 10907181
    Abstract: This disclosure describes biosynthesized compounds including anhydromevalonolactone and ?-methyl-?-valerolactone. This disclosure further describes biosynthetic methods for making these compounds. In some embodiments, the biosynthetic methods can include a combination of biosynthesis and chemical steps to produce ?-methyl-?-valerolactone. Finally, this disclosure described recombinant cells useful for the biosynthesis of these compounds.
    Type: Grant
    Filed: December 20, 2019
    Date of Patent: February 2, 2021
    Inventors: Kechun Zhang, Mingyong Xiong
  • Patent number: 10906864
    Abstract: Nitroalkene non-steroidal anti-inflammatory compounds, pharmaceutical compositions thereof, and methods of treating inflammation related conditions.
    Type: Grant
    Filed: August 7, 2019
    Date of Patent: February 2, 2021
    Inventors: Carlos Batthyány, Gloria Virginia López, Carlos Escande, Jorge Rodriguez Duarte, Williams Arturo Porcal Quinta, Rosina Dapueto Capuccio, Germán Adrian Galliussi López, María Pia Garat Nuñez, Paulina Invernizzi, Mariana Ingold, Lucia Colella
  • Patent number: 10899773
    Abstract: In one aspect, the present invention provides novel derivatives of trioxacarin analogs of the formula (I) wherein the variables are as defined herein. The application also provides compositions, methods of treatment, and methods of synthesis thereof.
    Type: Grant
    Filed: December 18, 2015
    Date of Patent: January 26, 2021
    Assignee: William Marsh Rice University
    Inventors: Kyriacos C Nicolaou, Quan Cai
  • Patent number: 10899729
    Abstract: A method for producing a compound, such as 2-propanyl 4-{(3S,5aR,6R,7R,8aS)-6-[(1E,3R)-4-(2,5-difluorophenoxy)-3-hydroxy-1-buten-1-yl]-7-hydroxyoctahydro-2H-cyclopenta[b]oxepin-3-yl}butanoate, and a novel intermediate suitable for the method, whereby the compound can be stably supplied with a high total reaction yield, by changing the starting material and improving the metathesis reaction, asymmetric reduction reaction and the like.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 26, 2021
    Inventors: Hideki Moriguchi, Yusuke Tanaka, Tatsunori Ino, Tohru Kambe, Taihei Nishiyama, Shinichiro Tsujiyama, Yohei Ueda
  • Patent number: 10898887
    Abstract: In one example, a method for converting a first compound into a second compound is provided. The method includes providing the first compound in an entrance of a flow through reactor, wherein the entrance comprises a first catalyst and an oxidant, converting the first compound and the oxidant into the second compound as the first compound and the oxidant contact the first catalyst in the entrance of the flow through reactor while moving towards a tail end of the flow through reactor, and converting the first compound and the oxidant into the second compound via a solid catalyst comprising a white crystalline solid with a titanium content of about 0.5 to about 1.5 weight percent (wt %) in the tail end of the flow through reactor.
    Type: Grant
    Filed: August 22, 2017
    Date of Patent: January 26, 2021
    Inventors: Alexander Okrut, Alexander Katz
  • Patent number: 10889559
    Abstract: Process for the preparation of a compound with at least one monothiocarbonate group by reacting:—a compound with at least one mercaptoalcohol group and—a dialkylcarbonate, in the presence of a catalyst wherein the catalyst is a salt of a metal selected from group IIIb or IVb of the periodic system.
    Type: Grant
    Filed: August 7, 2018
    Date of Patent: January 12, 2021
    Assignee: BASF SE
    Inventors: Peter Rudolf, Jan-Dirk Arndt, Nicole Holub, Verena Mormul, Indre Thiel
  • Patent number: 10874676
    Abstract: Provided are immediate or prolonged administration of certain potassium ATP (KATP) channel openers, optionally in combination with growth hormone, to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of KATP channel openers that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are methods of co-administering KATP channel openers with other drugs (e.g., in combination with growth hormone) to treat diseases of humans and animals (e.g., Prader-Willi Syndrome (PWS), Smith-Magenis syndrome (SMS), and the like.
    Type: Grant
    Filed: September 17, 2019
    Date of Patent: December 29, 2020
    Assignee: ESSENTIALS, INC.
    Inventor: Neil M. Cowen
  • Patent number: 10875835
    Abstract: The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
    Type: Grant
    Filed: February 24, 2020
    Date of Patent: December 29, 2020
    Inventors: Toshikazu Yagi, Satoshi Suzuki, Hiroto Tatamidani, Kazuki Hashimoto
  • Patent number: 10875873
    Abstract: This invention relates to a process for preparing (±)-2-exo-(2-Methylbenzyloxy)-1-methyl-4-iso-propyl-7-oxabicyclo[2.2.1]heptane of the formula (I), (I) any one of its individual enantiomers or any non-racemic mixture thereof comprising the steps of (a) deprotonating (±)-2-exo-hydroxy-1-methyl-4-isopropyl-7-oxabicyclo[2.2.
    Type: Grant
    Filed: February 5, 2018
    Date of Patent: December 29, 2020
    Assignee: BASF AGRO B.V.
    Inventors: Stefan Benson, Michael Rack, Roland Goetz, Bernd Wolf, Joachim Gebhardt, Helmut Kraus
  • Patent number: 10870631
    Abstract: In a process for the epoxidation of propene, comprising continuously reacting a propene feed with hydrogen peroxide in the presence of an epoxidation catalyst in a reaction step, using propene in excess to hydrogen peroxide, to provide a liquid reaction mixture comprising non-reacted propene, extra safety measures caused by the presence of oxygen during work-up of the liquid reaction mixture of the epoxidation reaction can be avoided by stripping liquid reaction mixture from step a) with an inert gas to provide an oxygen depleted stripped liquid reaction mixture and a strip gas stream, selecting the amount of inert gas to provide an oxygen concentration in the strip gas stream in the range of from 0.1 to 10% by weight, separating non-reacted propene from the strip gas stream and recycling it to the reaction step, and separating propene oxide from the stripped liquid reaction mixture.
    Type: Grant
    Filed: May 16, 2018
    Date of Patent: December 22, 2020
    Inventors: Willi Hofen, Thomas Haas, Wolfgang Wöll, Jürgen Schemel, Hans-Christian Dietz, Marc Brendel
  • Patent number: 10865190
    Abstract: A process for producing furan dicarboxylic acid or an ester thereof from a feedstock comprising hydroxymethyl furfural (HMF) and humins is disclosed. Humins are a byproduct from reactions forming HMF from sugars and are typically removed from the HMF prior to any further processing. A humins-containing HMF feedstock is utilized to produce furan dicarboxylic acids and ester substantially free from humins.
    Type: Grant
    Filed: June 20, 2019
    Date of Patent: December 15, 2020
    Inventors: Pranit S Metkar, Ronnie Ozer, Bhuma Rajagopalan
  • Patent number: 10858330
    Abstract: In a method and an apparatus furfural is separated from a material stream (3) which is formed in a treatment of a pretreated wood based material (1). The material stream (3) which comprises at least furfural is introduced to a separation column (5). A top vapor condensate (6) is introduced from a top end of the separation column (5) to a decanter (10) in which two liquid phases (9,11) are separated from each other. An organic phase (9) which comprises at least furfural is recovered, and an aqueous phase (11) is supplied as a reflux to the separation column (5). Further, the invention relates to a furfural based product and chemical product and a use of the organic phase.
    Type: Grant
    Filed: December 22, 2017
    Date of Patent: December 8, 2020
    Inventors: Juha Tamper, Hans Hasse, Nadia Galeotti, Fabian Jirasek, Jakob Burger
  • Patent number: 10858611
    Abstract: The present invention relates to a process for preparing two mixtures of epoxidized fatty acid esters, comprising in the order given a transesterification of an epoxidized vegetable oil, followed by a reduction of the volatile saturated non-epoxidized fraction by short path distillation of the transesterified epoxidized vegetable oil, followed by a selection on the one hand of the non-vaporized fraction (residue) of the previous process step as the first mixture of epoxidized fatty acid esters and a selection on the other hand of the vaporized fraction (distillate) as the second mixture of epoxidized fatty acid esters. The first mixture is in particular suitable as plasticizer in halogenated polymers, the second mixture being particularly suitable as plasticizer in non-halogenated polymers.
    Type: Grant
    Filed: September 26, 2018
    Date of Patent: December 8, 2020
    Assignee: Proviron Holding N.V.
    Inventors: Arnaud Verraes, Jelle Cornelus
  • Patent number: 10851074
    Abstract: The present disclosure provides processes for the production of 2-5-furandicarboxylic acid (FDCA) and intermediates thereof by the chemocatalytic conversion of a furanic oxidation substrate. The present disclosure further provides processes for preparing derivatives of FDCA and FDCA-based polymers. In addition, the present disclosure provides crystalline preparations of FDCA, as well as processes for making the same.
    Type: Grant
    Filed: April 6, 2020
    Date of Patent: December 1, 2020
    Assignee: Stora Enso Oyj
    Inventors: Valery Sokolovskii, Vincent J. Murphy, Thomas R. Boussie, Gary M. Diamond, Eric L. Dias, Guang Zhu, James M. Longmire, Stanley Herrmann, Staffan Torssell, Mayya Lavrenko
  • Patent number: 10849901
    Abstract: Disclosed herein are compounds and methods for inhibiting Arf6. Pharmaceutical compositions and methods for treating a subject with an inhibitor of Arf6 are also disclosed herein.
    Type: Grant
    Filed: May 27, 2015
    Date of Patent: December 1, 2020
    Assignees: Navigen, Inc., The University of Utah Research Foundation
    Inventors: Kirill Ostanin, Mark Shenderovich, Ashok Bajji, Christopher L. Cioffi, Neil Moss, Hariprasad Vankayalapati, Dean Li
  • Patent number: 10844048
    Abstract: The present invention generally relates to crystalline forms of Lumacaftor, processes for its preparation and pharmaceutical compositions thereof. The present invention also relates to an improved process for preparation of Lumacaftor.
    Type: Grant
    Filed: January 6, 2018
    Date of Patent: November 24, 2020
    Assignee: Laurus Labs Limited
    Inventors: Ravindra Babu Bollu, Prasanta Kumar Dalasingh, Sushmita Dwarampudi, Chandrahasa Reddy Annem, Uma Maheswer Rao Vasireddi
  • Patent number: 10844412
    Abstract: A solid form of (?)-Ambrox formed by a bioconversion process.
    Type: Grant
    Filed: April 20, 2017
    Date of Patent: November 24, 2020
    Assignee: Givaudan S. A.
    Inventors: Ghislain Sanhaji, Alix Rousseaux, Sandrine Noel, Eric Eichhorn