Patents Examined by Thomas J Visone
  • Patent number: 10533991
    Abstract: Various embodiments relate to p-phenylene ethynylene compounds as bioactive and detection agents. In various embodiments, the present invention provides a method of inducing germination of microbial spores including contacting the microbial spores with a p-phenylene ethynylene compound. In various embodiments, the present invention provides a method for detecting an enzyme, a method of protein analysis, or a method of detecting a chemical agent, including introducing a p-phenylene ethynylene compound to a composition including an enzyme substrate, and analyzing the fluorescence of the p-phenylene ethynylene compound. Various embodiments provide sensors that include a p-phenylene ethynylene compound and an enzyme substrate.
    Type: Grant
    Filed: March 13, 2015
    Date of Patent: January 14, 2020
    Assignee: STC.UNM
    Inventors: David G. Whitten, Harry Pappas, Eric H. Hill, Yue Zhang, Eva Yung Hua Chi, Arjun Thapa, Ying Wang, Patrick L. Donabedian, Kiran Bhaskar
  • Patent number: 10517996
    Abstract: The present invention relates to methods for recellurization of blood vessels. This method is particularly useful for producing an allogeneic vein, wherein a donor vein is decellularized and then recellularized using whole blood or bone marrow stem cells. The allogeneic veins produced by the methods disclosed herein are particularly advantageous for implantation or transplantation into patients with vascular diseases.
    Type: Grant
    Filed: April 7, 2017
    Date of Patent: December 31, 2019
    Assignee: Verigraft AB
    Inventors: Suchitra Sumitran-Holgersson, Michael Olausson
  • Patent number: 10519597
    Abstract: The present invention refers to a process for producing cellulose of market eucalyptus fibers having distinct features through the use of at least one enzymatic treatment with hydrolytic enzymes, such as for example, xylanases, cellulases or mixtures thereof, in association to at least one acidic treatment step. These treatments may be applied into different steps of the fibers process producing, wherein all of them happen before drying.
    Type: Grant
    Filed: October 16, 2009
    Date of Patent: December 31, 2019
    Assignee: Suzano S.A.
    Inventors: Braz Jose Demuner, Otavio Mambrim Filho
  • Patent number: 10513690
    Abstract: A biological composition has a mixture of mechanically selected allogeneic biologic material derived from bone marrow. The mixture has non-whole cellular components including vesicular components and active and inactive components of biological activity, cell fragments, cellular excretions, cellular derivatives, and extracellular components. The mixture is compatible with biologic function.
    Type: Grant
    Filed: May 10, 2017
    Date of Patent: December 24, 2019
    Assignee: Vivex Biologics Group, Inc.
    Inventors: Timothy Ganey, Wendy W. Weston, Miguel Quevedo, Stuart Oglesby, Gaetan Jean-Robert Delcroix, Paul C. Schiller, Gianluca D'Ippolito
  • Patent number: 10508293
    Abstract: Provided herein are methods of increasing the efficiency of biomass saccharification. In particular, the methods include ways of avoiding feedback inhibition of enzymatic reactions during the production of useful products. The methods also include saccharifying recalcitrance-reduced lignocellulosic biomass and adding an isomerization agent to the saccharified biomass. The saccharified biomass can be further converted into products by a microorganism.
    Type: Grant
    Filed: October 19, 2015
    Date of Patent: December 17, 2019
    Assignee: Xyleco, Inc.
    Inventors: Marshall Medoff, Thomas Craig Masterman, Michael W. Finn
  • Patent number: 10501724
    Abstract: The present invention provides a method for producing a retinal progenitor cell, including (1) a first step of subjecting pluripotent stem cells to floating culture in a serum-free medium to form an aggregate of pluripotent stem cells, and (2) a second step of subjecting the aggregate formed in step (1) to floating culture in a serum-free medium or serum-containing medium each being free of a substance acting on the Sonic hedgehog signal transduction pathway but containing a substance acting on the BMP signal transduction pathway, thereby obtaining an aggregate containing retinal progenitor cells.
    Type: Grant
    Filed: August 22, 2014
    Date of Patent: December 10, 2019
    Assignees: SUMITOMO CHEMICAL COMPANY, LIMITED, RIKEN
    Inventors: Tokushige Nakano, Yoshiki Sasai, Chikafumi Ozone
  • Patent number: 10494650
    Abstract: The invention relates to a process for production of biogas from a biodegradable substrate under anaerobic conditions, comprising the steps of introducing the substrate into a reaction space, the addition of a lime-based material having a particle diameter (d97) of less than 90 ?m and/or (d50) of less than 10 ?m to the substrate, and the biodegradation of the substrate to form biogas.
    Type: Grant
    Filed: September 21, 2012
    Date of Patent: December 3, 2019
    Assignee: Rheinkalk GmbH
    Inventors: Arnd Pickbrenner, Heiko Saure, Christopher Pust, Volker Spicker
  • Patent number: 10493111
    Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.
    Type: Grant
    Filed: June 22, 2017
    Date of Patent: December 3, 2019
    Assignee: REBIOTIX, INC.
    Inventors: Lee A. Jones, Courtney R. Jones, Edwin J. Hlavka, Ryan D. Gordon
  • Patent number: 10487312
    Abstract: Formulations and methods are disclosed for the harvesting and subsequent passaging of human pluripotent stem cells without the use of enzymes and/or scraping to dislodge cells from cell culture vessels. The formulations and methods permit the harvesting of cells as large clusters from the surface of various cell culture vessels including multilayer cell culture vessels. Further, the formulations and methods provide high yields of harvested cells for subsequent passaging and high post-harvest cell viability. Pluripotent stem cells passaged with the formulations according to the methods remain undifferentiated and express typical stem cell markers, while, at the same time, they retain the differentiation capability and are able to differentiate into the cells in all three germ layers and generate teratomas, even after numerous rounds of harvesting and passaging. These hPSCs also maintain normal karyotype after passaged with the formulations for extended period of time.
    Type: Grant
    Filed: December 15, 2017
    Date of Patent: November 26, 2019
    Assignee: LONZA WALKERSVILLE INC.
    Inventors: Ying Nie, Jonathan Allen Rowley, Thomas Fellner, Patrick Walsh
  • Patent number: 10479711
    Abstract: A composition remediation of soil and groundwater containing halogenated compounds. The remediation composition includes an elemental iron-based composition, which may include activated carbon capable of absorbing the halogenated compounds with numerous pores impregnated with elemental iron. The remediation composition further includes a first bioremediation material including a blend of one-to-many organisms capable of degrading the halogenated compounds. The remediation composition includes an organic compound or polymeric substance and a second bioremediation material including a blend of one-to-many organisms capable of degrading the organic compound or polymeric substance over time (e.g., 20 to 365 or more days to provide a time release substrate-creating material or platform) into smaller molecules or compounds used by the organisms in the first bioremediation material while degrading the halogenated compounds.
    Type: Grant
    Filed: May 5, 2016
    Date of Patent: November 19, 2019
    Assignee: REMEDIATION PRODUCTS, INC.
    Inventor: Scott Noland
  • Patent number: 10478525
    Abstract: A demineralized bone matrix is produced by a process in which a bone body is placed in a first processing solution comprising an acid to demineralize the bone body. The bone body is periodically removed from the first solution at specific time intervals to perform at least one test, such as a compression test, on a mechanical property of the bone body. When the test yields a desired result, the bone body is exposed to a second processing solution that is less acidic than the first, thus minimizing the exposure of the bone body to the harsh acidic conditions of the demineralization phase of the process.
    Type: Grant
    Filed: July 29, 2015
    Date of Patent: November 19, 2019
    Assignee: BACTERIN INTERNATIONAL, INC.
    Inventors: Nancy J. Shelby, Steven M. Scott, Benjamin P. Luchsinger, Gregory A. Juda, Kelly R. Kirker, Darrel L. Holmes, Jesus Hernandez
  • Patent number: 10472609
    Abstract: The invention relates to progenitor cells of mesodermal lineage and their use in therapy.
    Type: Grant
    Filed: July 6, 2012
    Date of Patent: November 12, 2019
    Assignee: Cell Therapy Limited
    Inventors: Thomas Averell Houze, Martin John Evans, Ajan Reginald, Ina Laura Pieper
  • Patent number: 10471107
    Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.
    Type: Grant
    Filed: June 16, 2017
    Date of Patent: November 12, 2019
    Assignee: REBIOTIX, INC.
    Inventors: Lee A. Jones, Courtney R. Jones, Edwin J. Hlavka, Ryan D. Gordon
  • Patent number: 10434126
    Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method may include a method of treating an infection. The method may comprise administering a microbiota restoration therapy composition to a patient with an infection. The microbiota restoration therapy composition may comprise a mixture of an effective amount of fecal microbiota and an effective amount of polyethylene glycol.
    Type: Grant
    Filed: June 30, 2017
    Date of Patent: October 8, 2019
    Assignee: REBIOTIX, INC.
    Inventors: Lee A. Jones, Courtney R. Jones, Edwin J. Hlavka, Ryan D. Gordon
  • Patent number: 10433556
    Abstract: The present invention relates to the treatment and/or prophylaxis of storage diseases of harvested material. This object is achieved by the use of the bacterium of Pseudomonas sp. Proradix (DSMZ 13134). This object is further achieved by a method comprising provision of harvested material, contacting said harvested material with a solution containing the bacterium of Pseudomonas sp. Proradix (DSMZ 13134), and storing the harvested material outside of the ground soil.
    Type: Grant
    Filed: May 2, 2014
    Date of Patent: October 8, 2019
    Assignee: SOURCON-PADENA GmbH & CO.KG.
    Inventor: Wolfgang Vogt
  • Patent number: 10434124
    Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method for manufacturing a microbiota restoration therapy composition may include collecting a human fecal sample and adding a diluent to the human fecal sample to form a diluted sample. The diluent may include a cryoprotectant. The method may also include mixing the diluted sample with a mixing apparatus and filtering the diluted sample. Filtering may form a filtrate. The method may also include transferring the filtrate to a sample bag and sealing the sample bag.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 8, 2019
    Assignee: REBIOTIX, INC.
    Inventors: Lee A. Jones, Courtney R. Jones, Edwin J. Hlavka, Ryan D. Gordon
  • Patent number: 10434125
    Abstract: Microbiota restoration therapy compositions and methods for manufacturing, processing, and/or delivering microbiota restoration therapy compositions are disclosed. An example method may include a method of treating an infection. The method may comprise administering a microbiota restoration therapy composition to a patient with an infection. The microbiota restoration therapy composition may comprise a mixture of an effective amount of fecal microbiota and an effective amount of polyethylene glycol.
    Type: Grant
    Filed: November 2, 2016
    Date of Patent: October 8, 2019
    Assignee: REBIOTIX, INC.
    Inventors: Lee A. Jones, Courtney R. Jones, Edwin J. Hlavka, Ryan D. Gordon
  • Patent number: 10429399
    Abstract: The present disclosure describes a method of processing a biological sample. The method includes contacting the sample with a pH indicator that changes color in response to changes in pH. The presence of a pH indicator such as cresol red provides the benefit of improved visualization of the sample, verification that the sample is properly frozen and thawed, and increased precision in pH adjustments during the assay, among other benefits.
    Type: Grant
    Filed: September 18, 2015
    Date of Patent: October 1, 2019
    Assignee: Good Start Genetics, Inc.
    Inventor: Eric D. Boyden
  • Patent number: 10426158
    Abstract: The invention concerns methods of treating stored blood and blood products maximizing shelf life and/or minimizing transfusion related complications such as nonĀ¬ hemolytic transfusion reactions such as fever, transfusion-related acute lung injury (TRALI), transfusion associated dyspnea (TAD), and allergic reactions by removing undesirable molecules in the blood and blood products milieu through use of a sorbent.
    Type: Grant
    Filed: August 10, 2012
    Date of Patent: October 1, 2019
    Assignee: CytoSorbents Corporation
    Inventors: Phillip P. Chan, Vincent J. Capponi, Thomas D. Golobish, Humayra Begum Ali
  • Patent number: 10420806
    Abstract: The present invention includes compositions and methods for eliminating or reducing microbial contamination in lymph nodes that enter the food supply from livestock comprising: identifying an animal in need of eliminating or reducing microbial contamination in non-gut associated lymph nodes that enter the food supply, and providing the animal with an effective amount of a lactic acid bacteria or probiotic bacterial sufficient to reduce or eliminate the microbial contamination in non-gut associated lymph nodes.
    Type: Grant
    Filed: December 30, 2014
    Date of Patent: September 24, 2019
    Assignee: Texas Tech University System
    Inventors: Mindy M. Brashears, Guy H. Loneragan, Kendra Nightingale, J. Chance Brooks