Patents Examined by Thurman K. Page
  • Patent number: 7892574
    Abstract: Disclosed is a method of treating a non-topical infection selected from the group consisting of ear infections, skin and soft tissue infections, acne, infected wounds, bacteremia, in a useful warm blooded mammal who is in need of such treatment which comprises topical administration of a pharmaceutical formulation containing a transdermally effective amount of an Oxazolidinone.
    Type: Grant
    Filed: September 16, 2003
    Date of Patent: February 22, 2011
    Assignee: Pharmacia & Upjohn Company, LLC
    Inventors: Charles W. Ford, Jeffrey L. Watts
  • Patent number: 7429393
    Abstract: A process that enables the formation of a high damping, soft polymer gel includes reacting a maleimide copolymer with a maleated polyalkylene and an alkyl diamine under substantially dry conditions sufficient to form a polyalkylene-grafted maleimide copolymer product which then is dispersed with an extender sufficient to form the gel. The steps can be carried out sequentially in a high shear mixer without the need for intermediate steps of cooling and grinding the reaction product of one step before proceeding to the next.
    Type: Grant
    Filed: March 23, 2001
    Date of Patent: September 30, 2008
    Assignee: Bridgestone Corporation
    Inventors: Xiaorong Wang, Victor F. Foltz, Terrence E. Hogan, William M. Cole, Naruhiko Mashita, Yuichiro Wakana, Tadashi Utsunomiya
  • Patent number: 7375245
    Abstract: The present invention provides a compound of the following formula (I): wherein R1 is methyl or 4-aminobutyl, which may be acylated; X is phenyl or substituted phenyl; W is an esterified group removable by hydrogenolysis. Also disclosed is the preparation method and the application of formula (I) compound.
    Type: Grant
    Filed: July 7, 2004
    Date of Patent: May 20, 2008
    Assignee: Everlight USA, Inc.
    Inventors: Yu-Liang Liu, Rung-Tian Suen, Ying-Chi Chiu
  • Patent number: 7351702
    Abstract: This invention provides compounds of formula I: wherein Z is oxygen or sulfur; R1 is hydrogen, —CHN2, R, CH2OR, CH2SR, or —CH2Y; next to R3 represents a single or double bond; Y is an electronegative leaving group; R2 is CO2H, CH2CO2H, or esters, amides or isosteres thereof; R3 is a group capable of fitting into the S2 subsite of a caspase enzyme; R4 is a hydrogen or C1-6 alkyl or R3 and R4 taken together form a ring; Ring A and Ring B are each heterocyclic rings, and R and R5 are as described in the specification. The compounds are effective inhibitors of apoptosis and IL-1? secretion.
    Type: Grant
    Filed: May 23, 2002
    Date of Patent: April 1, 2008
    Assignee: Vertex Pharmaceuticals Incorporated
    Inventors: Michael Mortimore, Andrew Miller, John Studley, Jean-Damien Charrier
  • Patent number: 7300934
    Abstract: Compounds of the formula (I) wherein m, n, A, R1, R2, R3, R4, R5 and R6 are as described herein, together with methods for making the compounds and using the compounds for treatment of diseases or conditions mediated by Cathepsin K.
    Type: Grant
    Filed: June 1, 2004
    Date of Patent: November 27, 2007
    Assignee: Roche Palo Alto LLC
    Inventors: Tobias Gabriel, Nancy Elisabeth Krauss
  • Patent number: 7294736
    Abstract: A method is described for the preparation of polymorphic forms of water-soluble derivatives of probucol compounds having the following formula where R1, R2, R3, R4, R5, R6, Z and Z? are defined herein.
    Type: Grant
    Filed: April 9, 2004
    Date of Patent: November 13, 2007
    Assignee: Cambrex Charles City, Inc.
    Inventors: Paul Alan Jass, Jason Scott Douglas
  • Patent number: 7288679
    Abstract: A device comprises at least one organophosphonium transition metal dye or is provided with a filter, comprising at least one organophosphonium transition metal dye, wherein, in a particular embodiment said device is selected from the group consisting of a scanner, a digitizer, a display and a photographic device.
    Type: Grant
    Filed: August 6, 2004
    Date of Patent: October 30, 2007
    Assignee: AGFA-Gevaert
    Inventors: Luc Vanmaele, Paul Leblans, Luc Struye
  • Patent number: 7285596
    Abstract: Disclosed is an anionic diinitiator prepared using a diisopropenyl benzene compound and an organo lithium compound having primary polymerization sites. The anionic diinitiators are prepared by admixing a diisopropenyl benzene compound with diethyl ether, ethylene, an organo lithium compound, and a solvent under reaction conditions sufficient to prepare a diinitiator having primary lithium alkyl reactive sites. The diinitiators are particularly useful in preparing block copolymers.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: October 23, 2007
    Assignee: Kraton Polymers U.S. LLC
    Inventors: Carl L. Willis, Daniel E. Goodwin, Grant W. Haddix, Pierre N. Tutunjian, Joy P. Cocchiara, Harvey E. Atwood, Craig A. Stevens
  • Patent number: 7279550
    Abstract: Presented are compounds represented by the following general formulas (I) and (II), for inhibiting cysteine protease legumain for modulating associated disease states in subjects
    Type: Grant
    Filed: July 23, 2002
    Date of Patent: October 9, 2007
    Assignee: Probiodrug AG
    Inventors: André Niestroj, Ulrich Heiser, Bernd Gerhartz, Matthias Hoffmann, Hans-Ulrich Demuth
  • Patent number: 7271299
    Abstract: Optionally alkyl-substituted 1,4-butanediol is prepared from C4-dicarboxylic acids and/or of derivatives thereof by: a) a gas stream of the C4-dicarboxylic acid or the derivative thereof in a first reactor in the gas phase to obtain a product which contains mainly optionally alkyl-substituted ?-butyro-lactone; b) removing succinic anhydride from the product of step a); c) catalytically hydrogenating the product of step b) in a second reactor in the gas phase to obtain optionally alkyl-substituted 1,4-butanediol; d) removing the desired product from intermediates, by-products and any unconverted reactants; and e) optionally recycling unconverted intermediates into one or both hydrogenation stages. The catalysts employed in each of the hydrogenation stages comprise ?95% by weight of CuO, and ?5% by weight of an oxidic support, and the second reactor has a higher pressure than the first reactor.
    Type: Grant
    Filed: June 11, 2003
    Date of Patent: September 18, 2007
    Assignee: BASF Aktiengesellschaft
    Inventors: Michael Hesse, Stephan Schlitter, Holger Borchert, Markus Schubert, Markus Rösch, Nils Bottke, Rolf-Hartmuth Fischer, Alexander Weck, Gunther Windecker, Gunnar Heydrich
  • Patent number: 7270831
    Abstract: Sustained release oral solid dosage forms of opioid analgesics are provided as multiparticulate systems which are bioavailable and which provide effective blood levels of the opioid analgesic for at least about 24 hours. A unit dose of the opioid analgesic contains a plurality of substrates including the opioid analgesic in sustained release form. The substrates have a diameter from about 0.1 mm to about 3 mm.
    Type: Grant
    Filed: March 20, 2003
    Date of Patent: September 18, 2007
    Inventors: Benjamin Oshlack, Mark Chasin
  • Patent number: 7268253
    Abstract: The invention relates to a novel process for hydroxymethylating noncyclic ?,?-dialkylcarboxylic acid derivatives with formaldehyde using amide bases at temperatures of from ?40° C. up to the boiling point of the solvent or solvent mixture used.
    Type: Grant
    Filed: November 29, 2005
    Date of Patent: September 11, 2007
    Assignee: Consortium fuer Elektrochemische Industrie GmbH
    Inventors: Andreas Boehm, Hermann Petersen, Juergen Stohrer
  • Patent number: 7268249
    Abstract: A process for producing optically pure R-hydroxyphenoxypropanoic acid or a salt or ester thereof by reaction of hydroquinone or a salt thereof with an S-halopropanoic acid or a salt thereof in the presence of a mild reducing agent.
    Type: Grant
    Filed: August 16, 2004
    Date of Patent: September 11, 2007
    Assignee: Syngenta Limited
    Inventor: Ernest Stephen Cleugh
  • Patent number: 7268262
    Abstract: Describes a method for recovering trans-1,2-dichloroethene from a liquid feed composition comprising both the cis-and trans-isomers of 1,2-dichloroethene and contaminating amounts of other chlorinated hydrocarbons, e.g., lower alkyl chlorinated hydrocarbons, such as C1-C2 chlorinated hydrocarbons. In one of the described methods, the liquid feed composition is introduced into a first distillation column 10 wherein the stereoisomers and chlorinated hydrocarbons more volatile than the stereoisomers are removed as overhead 12 and charged to a second distillation column 20. In column 20, the stereoisomers are separated from the more volatile chlorinated hydrocarbons, and a bottoms fraction 24 comprising the stereoisomers is charged to a reactive distillation column 30 wherein the cis-isomer is isomerized to the trans-isomer in the liquid phase and in the presence of an organic free-radical initiator, e.g., an azonitrile initiator.
    Type: Grant
    Filed: April 29, 2004
    Date of Patent: September 11, 2007
    Assignee: PPG Industries Ohio, Inc.
    Inventors: Clark S. Graybill, Stephen R. Lester
  • Patent number: 7268260
    Abstract: This invention relates to 1,2-di(4-hydroxyaryl)tetrafluoroethanes of the general formula (I) wherein R are each, independently of one another, hydrogen, F, Cl, Br, I, CN, COOR2, C1-C4-alkyl, C1-C4-alkoxy, C1-C4-alkylthio, C1-C4-perfluoroalkyl, C1-C4-perfluoroalkoxy, C1-C4-perfluoroalkylthio, C1-C4-polyfluoroalkyl, C1-C4-polyfluoroalkoxy, or C1-C4-polyfluoroalkylthio, R2 is C1-C4-alkyl, and n is an integer from 0 to 4. This invention further relates to the preparation of such compounds as well as to precursors and intermediates that can be used in their preparation.
    Type: Grant
    Filed: August 3, 2006
    Date of Patent: September 11, 2007
    Assignee: LANXESS Deutschland GmbH
    Inventors: Albrecht Marhold, Käthe Baumann
  • Patent number: 7268124
    Abstract: The invention provides novel pyrophosphate synthase inhibitors of formula I as well as compositions comprising such inhibitors and methods for their use.
    Type: Grant
    Filed: August 25, 2005
    Date of Patent: September 11, 2007
    Assignee: University of Iowa Research Foundation
    Inventors: David F. Wiemer, Raymond J. Hohl
  • Patent number: 7265235
    Abstract: Silanes containing halogen which is bound to silicon are prepared using microwave energy. Silicon is reacted with mixtures of elements or compounds selected from the group consisting of halogen or halogen and organohalogen compounds or halogen and hydrogen or halogen and halogen hydrogen or organohalogen compounds or organohalogen compounds and hydrogen or organohalogen compounds and halogen hydrogen or halogen hydrogen or fluorosilanes and hydrogen, or fluorosilanes and halogen hydrogen or hydrogen containing chlorosilanes and hydrogen or hydrogen containing chlorosilanes and halogen hydrogen or organohalogensilanes and hydrogen or organohalogensilanes and halogen hydrogen or hydro-carbons and halogen hydro-carbons.
    Type: Grant
    Filed: April 15, 2003
    Date of Patent: September 4, 2007
    Assignee: Wacker Chemie AG
    Inventor: Norbert Auner
  • Patent number: 7265237
    Abstract: Certain chiral monophosphites and their monothio derivatives are suitable as ligands in the asymmetrical transition-metal-catalyzed hydrogenation, hydroborination and hydrocyanation of prochiral olefins, ketones and imines.
    Type: Grant
    Filed: June 5, 2001
    Date of Patent: September 4, 2007
    Assignee: Studiengesellschaft Kohle mbH
    Inventors: Manfred T. Reetz, Gerlinde Mehler, Andreas Meiswinkel
  • Patent number: 7265234
    Abstract: A silsesquioxane compound mixture having a high proportion of silsesquioxane compounds bearing bulky substituent groups on side chain and having a degree of condensation of substantially 100% is prepared by a first stage wherein a silane feed comprising a trifunctional silane bearing a bulky substituent group on side chain represented by formula (1): wherein Y is an aliphatic or aromatic organic group optionally having a functional group, X1, X2 and X3 are H, halogen, alkoxy or aryloxy is hydrolyzed in the presence of an acid or base catalyst, and a second stage wherein dehydrating condensation is carried out in the presence of a strong base catalyst while removing the water resulting from condensation out of the reaction system.
    Type: Grant
    Filed: March 31, 2006
    Date of Patent: September 4, 2007
    Assignee: Shin-Etsu Chemical Co., Ltd.
    Inventors: Yoshitaka Hamada, Mutsuo Nakashima
  • Patent number: 7261868
    Abstract: Fluorine compounds such as C2F6, CF4, CHF3, SF6 and NF3, are made to contact with a fluorine compound decomposition catalyst and a catalyst for the decomposition of at least one of CO, SO2F2 and N2O in the presence of water or in the presence of water and oxygen. The catalyst for the decomposition of at least one of CO, SO2F2 and N2O preferably contains at least one selected from Pd, Pt, Cu, Mn, Fe, Co, Rh, Ir and Au in the form of a metal or an oxide. According to the invention, the fluorine compound can be converted to HF, which can be absorbed by water or an alkaline aqueous solution. Furthermore, a substance such as CO, SO2F2 and N2O which is formed by decomposition of the fluorine compound can also be decomposed.
    Type: Grant
    Filed: November 15, 2004
    Date of Patent: August 28, 2007
    Assignee: Hitachi, Ltd.
    Inventors: Shuichi Kanno, Akio Honji, Hisao Yamashita, Shigeru Azuhata, Shin Tamata, Kazuyoshi Irie