Abstract: An intraocular lens for reducing aberrant optical effects includes an anterior surface, a posterior surface and a peripheral region/zone disposed about a central optical axis. The peripheral region/zone has an inflection region/transition area that is inclined with respect to the anterior surface at an angle between about 40 degrees and 120 degrees with respect to the optical axis.

Abstract: An improved self-centering phakic refractive lens is disclosed. The lens floats freely in the posterior chamber of the eye and corrects vision of the patient but also prevents buildup of intraocular pressure, cataract induction and iris pigment dispersion. The lens comprises an optical body, haptic members which extend outward from the optical body, and a small hole in the approximate center of the optical body for the purpose of allowing aqueous humor to flow through that hole. The lens is designed such that its posterior surface conforms to the shape of the anterior surface of the patient's natural crystalline lens.

Abstract: A device for prosthetic vision rehabilitation, which includes a scleral explant with a shape that is suitable for being in contact with at least one portion of the sclera of an eye, and at least one inducer arranged on the scleral explant.

Abstract: This apparatus treats the lens capsule so as to increase accommodation of the eye. The treatment of the lens capsule may comprise treating a portion of the lens capsule so as to stiffen the treated portion and improve accommodation of the eye. The intermediate portion of the lens capsule may be located between an optically used central portion of the lens capsule and a peripheral portion of the lens capsule connected to zonules of the eye. The stiffened intermediate portion of the lens capsule can improve coupling of the peripheral portion of the lens capsule to the central portion of the lens capsule, such that an amount of accommodation of the optically used central portion of the lens is increased. As the force of the lens capsule to a lens disposed within the lens capsule is increased, the lens may comprise the natural lens of the eye or an artificial lens such as an accommodative IOL.

Abstract: Stent-valves (e.g., single-stent-valves and double-stent-valves), associated methods and systems for their delivery via minimally-invasive surgery, and guide-wire compatible closure devices for sealing access orifices are provided.

Abstract: Stent-valves (e.g., single-stent-valves and double-stent-valves), associated methods and systems for their delivery via minimally-invasive surgery, and guide-wire compatible closure devices for sealing access orifices are provided.

Abstract: A stent-valve for transcatheter implantation to replace a cardiac valve, the stent valve being compressible to a compressed state for delivery, and expandable to an operative state for implantation, the stent-valve comprising a stent, a plurality of leaflets for defining a prosthetic valve, an inner skirt, an outer skirt, and a paravalve seal for sealing against surrounding tissue. In some embodiments, the paravalve seal comprises material that swells in response to contact with blood. In some embodiments, the seal comprises a flap or pocket that is distensible in response to backpressure and/or paravalve back-flow of blood.

Abstract: Embodiments disclosed herein are related to systems including at least one ophthalmic device (e.g., at least one intraocular lens or at least one contact lens) and methods of using the at least one ophthalmic device. The ophthalmic device includes a switchable lens that can selectively change a focal length thereof. The ophthalmic device also includes a plurality of sensors disposed therein or thereon that sense one or more characteristics. At least one of the plurality of sensors can sense one or more electromyography signals associated with a ciliary muscle of the eye. At least another of the plurality of sensors can sense one or more accelerations of the eye, one or more electromagnetic signals, one or more magnetic fields, one or more additional electromyography signals, or another suitable characteristic. The systems can also include at least one controller configured to direct changing the focal length of the switchable lens responsive to the characteristics sensed by the sensors.

Abstract: Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band has a first end, a first anchoring portion located proximate the first end, a second end, a second anchoring portion located proximate the second end, and a central portion. The central portion is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets. The band may be implanted via translumenal access or via thoracotomy.

Abstract: Mitral valve prolapse and mitral regurgitation can be treating by implanting in the mitral annulus a transvalvular intraannular band. The band is positioned so that it extends transversely across a coaptive edge formed by the closure of the mitral valve leaflets, to inhibit prolapse into the left atrium. At least one marginal chordae is severed, to permit leaflet closure against the band.

Abstract: An accommodating IOL comprises an optic adapted to focus light toward a retina of an eye, and a movement assembly coupled to the eye to provide effective accommodating movement, preferably axial movement, of the optic. At least a portion of the movement assembly is made from a material that is less stiff and/or more resilient than the material used to make the optic. Optionally, an outer ring or support portion made at least partially from either a relatively stiff material such as the material used in the optic or a relatively resilient material such as the material used in the movement assembly is also provided.

Abstract: The present disclosure is directed to a branched endoprosthesis comprising a graft component and at least one support component. In various embodiments, the branched endoprosthesis comprises a body portion and a plurality of leg portions, wherein the legs are in an aligned configuration for ease of cannulation. In various embodiments, at least one leg is in an open configuration for ease of cannulation. Cannulation methods are also taught.

Abstract: An accommodating intraocular lens (AIOL) for implantation within a capsular bag of a patient's eye comprises first and second components coupled together to define an inner fluid chamber and an outer fluid reservoir. The inner region of the AIOL provides optical power with one or more of the shaped fluid within the inner fluid chamber or the shape of the first or second components. The fluid reservoir comprises a bellows region with one or more folds of the bellows extending circumferentially around an optical axis of the eye. The bellows engages the lens capsule, and a compliant fold region between the inner and outer bellows portions allows the profile of the AIOL to deflect when the eye accommodates for near vision. Fluid transfers between the inner fluid chamber and the outer fluid reservoir to provide optical power changes when the eye accommodates.

Abstract: Disclosed herein are prosthetic devices and related methods for implantation at the native mitral valve of the heart by drawing an atrial portion and a ventricular portion toward each other from opposite sides of the native mitral valve, clamping the native mitral valve therebetween. One or more retention members passing through the mitral valve orifice or through a puncture in the native valve anatomy can couple the atrial and ventricular members together and keep them anchored onto the native mitral valve anatomy. The atrial portion can seat against the atrial side of the mitral annulus while the ventricular portion can include hooks and/or a sub-annular ring that engage and capture the native mitral valve apparatus to provide anchorage. The described technology can avoid the need to use sutures to anchor a prosthetic device at the mitral valve region.

Abstract: A prosthetic apparatus for implantation at a native valve complex includes a main body configured for placement within the native valve, at least one downstream arm and at least one upstream arm, each coupled to and disposed outside of the main body. The main body includes a compressed state for delivery and an expanded state. In the expanded state, a space exists between the downstream arm and an outer surface of the main body to receive an edge of a native valve leaflet. A portion of the downstream arm is configured to extend behind the received native leaflet and engage a downstream surface of the native valve complex while the edge of the received native leaflet is not engaged by the downstream arm. The upstream arm is configured to engage an upstream surface of the native valve complex at a location opposite the portion of the downstream arm.

Abstract: The present disclosure relates to an endoluminal prosthesis, such as a stent graft that includes one or more fenestrations to accommodate endovascular disease, such as an aneurysm in cases where one or more side branches is involved. In one aspect, the prosthesis includes fenestrations that are pivotable to accommodate the dynamic geometry of the aortic branches.

Abstract: Embodiments herein provide differential dilation stents for use in percutaneous interventions, such as transluminal bypass procedures. In some embodiments, the stents may be used in the process of creating an arteriovenous (AV) fistula during a percutaneous bypass procedure, and such stents may have two or more specialized regions that are configured to adopt a predetermined diameter, shape, and/or tensile strength upon insertion in order to suit the needs of the vessel or procedure. The disclosed stents may be used for creating and/or maintaining an arterial/venous fistula for bypass of an occlusion in a cardiac artery using a cardiac vein, or the femoral artery, for example using the tibial or popliteal vein.

Abstract: An accommodative hydraulic intraocular lens system (AHIOL) has a cylindrical actuator contained within which is a hydraulic lens assembly. The hydraulic lens assembly has a transparent elastically reconfigurable membrane coupled to a fixed focus lens by a bellows and a refractive hydraulic fluid contained in the space defined by the membrane, the bellows and the lens, and is maintained at the upper range of its diopter power by the elastic properties of the bellows, springs, or both.

Abstract: A method for treating a valve of a heart of a subject is provided. The method includes inserting a needle into the heart, and, using the needle, injecting a soft-tissue-filling material into an annulus of the valve. Other embodiments are also described.

Abstract: An illustrative stent may comprise an elongated tubular balloon having a first end and a second end and an intermediate region disposed therebetween. The elongated tubular balloon may have an inner wall and an outer wall, the inner wall and the outer wall connected at the first end and the second end to define an enclosed inflation chamber between the inner wall and the outer wall. The stent may further include an inflation valve.