Patents Examined by Tori Strong
  • Patent number: 10617662
    Abstract: Provided are a novel autophagy activation-inducing compound or salt thereof, and a use thereof, and particularly, a medicinal composition for treatment and prevention of neurodegenerative diseases, type II diabetes, or atopy or psoriasis dermatitis, a cosmetic composition for alleviation of aging or atopy or psoriasis dermatitis, and a food composition, including the compound capable of inducing autophagy activation or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: June 23, 2017
    Date of Patent: April 14, 2020
    Assignee: INCOSPHARM CORPORATION
    Inventors: Chaejin Lim, Heung Jae Kim, Hwa-Jee Chung, Juyeon Jung, Kayoung Shin, Beom Cheol Kim, Seok Jeong Yoon, Myung Ho Kor, Seon Deok Kwon, Keedon Park
  • Patent number: 10611775
    Abstract: Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the present application.
    Type: Grant
    Filed: July 2, 2019
    Date of Patent: April 7, 2020
    Assignee: Tianjin Hemay Pharmaceutical Co., Ltd.
    Inventors: Hesheng Zhang, Guanghuai Zeng, Yifei Gao
  • Patent number: 10610528
    Abstract: Oral film dosage forms that provide improved solubilization and stabilization of an active ingredient in particle form include at least one primary crystallization inhibitor in an amount that inhibits growth and/or agglomeration of the active ingredient, a polyoxyethylated fatty acid glycerides in an amount that further enhances inhibition of crystallization, growth and agglomeration of the particles of the pharmaceutically active ingredient; and at least one plasticizer present in an amount that is effective to increase flexibility and elasticity of the film dosage form.
    Type: Grant
    Filed: February 7, 2017
    Date of Patent: April 7, 2020
    Assignee: Intelgenx Corp.
    Inventors: Horst G. Zerbe, Nadine Paiement, Angela Angusti, Cormac Long, Rodolphe Obeid, Laetitia Rodes, Billal Tir
  • Patent number: 10568886
    Abstract: A method for regulating arterial vascular tone in a subject, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A and B are each individually selected from O or S; a is 1 to 4; and Ar is optionally substituted aryl or optionally substituted heteroaryl.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: February 25, 2020
    Assignee: University of Pittsburgh—Of the Commonwealth System of Higher Education
    Inventors: Adam C. Straub, Carlos J. Camacho, Mizanur Rahaman, Fabio Reinders
  • Patent number: 10561637
    Abstract: A method of treating a subject suffering from an angiogenesis-related disease, which is implemented by administering to the subject a pharmaceutical composition comprising a compound of formula I derived from Mitella formosana to inhibit the angiogenic function of endothelial progenitor cells.
    Type: Grant
    Filed: February 27, 2018
    Date of Patent: February 18, 2020
    Assignee: KAOHSIUNG MEDICAL UNIVERSITY
    Inventors: Hsun-Shuo Chang, Ih-Sheng Chen, Chien-Jou Peng, Shih-Wei Wang, Chih-Hsin Tang
  • Patent number: 10561708
    Abstract: Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more inhibitors of the JAK/STAT pathway which renders the cancer chemosensitive and/or radiosensitive.
    Type: Grant
    Filed: May 9, 2018
    Date of Patent: February 18, 2020
    Assignee: The University of Chicago
    Inventors: Nikolai Khodarev, Ravi Sood, Bernard Roizman, Ralph R. Weichselbaum
  • Patent number: 10555941
    Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
    Type: Grant
    Filed: March 14, 2016
    Date of Patent: February 11, 2020
    Assignee: Janssen Pharmaceutica NV
    Inventors: Kristi A. Leonard, Kent Barbay, James P. Edwards, Kevin D. Kreutter, David A. Kummer, Umar Maharoof, Rachel Nishimura, Maud Urbanski, Hariharan Venkatesan, Aihua Wang, Ronald L. Wolin, Craig R. Woods, Anne Fourie, Xiaohua Xue, Maxwell D. Cummings
  • Patent number: 10543184
    Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound aciclovir and a therapeutically-effective amount of the COX-2 inhibitor celecoxib. The invention is further related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of aciclovir and celecoxib.
    Type: Grant
    Filed: November 17, 2014
    Date of Patent: January 28, 2020
    Assignee: INNOVATIVE MED CONCEPTS, LLC
    Inventor: William L. Pridgen
  • Patent number: 10537643
    Abstract: The invention relates to chemoembolization compositions for anti-angiogenic agent delivery. The invention further relates to a method of preparing chemoembolization compositions and to the use of chemoembolization compositions in the method for treating solid tumour cancers.
    Type: Grant
    Filed: June 29, 2017
    Date of Patent: January 21, 2020
    Assignee: CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
    Inventors: Alban Denys, Pierre Bize, Olivier Jordan, Eric Doelker, Nathalie Boulens
  • Patent number: 10441557
    Abstract: Germicidal compositions and methods of using the same in the prevention and treatment of various hoof diseases are provided. The germicidal compositions generally comprise formic acid, at least one C2-C10 carboxylic acid, and one or more anionic surfactants, such as an ?-olefin sulfonate. The germicidal compositions may be applied topically to the hooves of an animal through various means including the use of footbaths.
    Type: Grant
    Filed: December 20, 2013
    Date of Patent: October 15, 2019
    Assignee: DeLaval Holding AB
    Inventors: Maria Buchalova, Alex Skender
  • Patent number: 10434079
    Abstract: Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.
    Type: Grant
    Filed: July 29, 2014
    Date of Patent: October 8, 2019
    Assignee: The Children's Hospital of Philadelphia
    Inventors: Harry Ischiropoulos, Paschalis-Thomas Doulias
  • Patent number: 10433551
    Abstract: Provided is a compound represented by formula (1): The compound represented by formula (1) has an excellent efficacy for controlling plant diseases, and is thus useful as an active ingredient for an agent for controlling plant diseases.
    Type: Grant
    Filed: August 24, 2017
    Date of Patent: October 8, 2019
    Assignee: SUMITOMO CHEMICAL COMPANY, LIMITED
    Inventor: Yuki Sato
  • Patent number: 10420755
    Abstract: The present invention relates to the use of the compound ciclopirox or a pharmaceutically acceptable salt or solvate thereof for the treatment and/or prevention of congenital erythropoietic porphyria (CEP).
    Type: Grant
    Filed: October 27, 2017
    Date of Patent: September 24, 2019
    Assignee: ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOCIENCIAS-CIC BIOGUNE
    Inventors: Oscar Millet Aguilar-Galindo, Arantza Sanz Parra, Ana Laín Torre, Pedro David Urquiza Ortiz, Juan Manuel Falcón Pérez
  • Patent number: 10413608
    Abstract: A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside, nucleotide, and/or analogs thereof; and exposing the administered compound to electromagnetic radiation.
    Type: Grant
    Filed: January 21, 2016
    Date of Patent: September 17, 2019
    Assignee: Case Western Reserve University
    Inventors: Carlos E. Crespo-Hernandez, Marvin Pollum
  • Patent number: 10407383
    Abstract: The present invention relates to cyclopent(adi)ene compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
    Type: Grant
    Filed: February 3, 2015
    Date of Patent: September 10, 2019
    Assignee: BASF SE
    Inventors: Pascal Bindschaedler, Wolfgang Von Deyn, Arun Narine, Karsten Koerber, Franz-Josef Braun
  • Patent number: 10385054
    Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
    Type: Grant
    Filed: June 26, 2014
    Date of Patent: August 20, 2019
    Assignee: Janssen Sciences Ireland Unlimited Company
    Inventors: David Craig McGowan, Serge Maria Aloysius Pieters, Stefaan Julien Last, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
  • Patent number: 10385062
    Abstract: Disclosed is a compound of formula (I), wherein R1, R2, R3, R4, R5, R6, R7 and R8 are as defined in the present application.
    Type: Grant
    Filed: March 24, 2017
    Date of Patent: August 20, 2019
    Assignees: Tianjin Hemay Bio-Tech Co., Ltd., Tianjin Michele Sci-Tech Development Co., Ltd.
    Inventors: Hesheng Zhang, Guanghuai Zeng, Yifei Gao
  • Patent number: 10342809
    Abstract: The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
    Type: Grant
    Filed: March 15, 2017
    Date of Patent: July 9, 2019
    Assignees: Washington University, Sage Therapeutics, Inc.
    Inventors: Douglas Covey, Albert Jean Robichaud
  • Patent number: 10336738
    Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
    Type: Grant
    Filed: June 3, 2015
    Date of Patent: July 2, 2019
    Assignee: CALCIMEDICA, INC.
    Inventors: Jeffrey P. Whitten, Yazhong Pei, Jianguo Cao, Zhijun Wang, Evan Rogers, Brian Dyck, Jonathan Grey
  • Patent number: 10315987
    Abstract: Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.
    Type: Grant
    Filed: December 9, 2011
    Date of Patent: June 11, 2019
    Assignee: Surmodics, Inc.
    Inventor: Aleksey V. Kurdyumov