Abstract: Provided are a novel autophagy activation-inducing compound or salt thereof, and a use thereof, and particularly, a medicinal composition for treatment and prevention of neurodegenerative diseases, type II diabetes, or atopy or psoriasis dermatitis, a cosmetic composition for alleviation of aging or atopy or psoriasis dermatitis, and a food composition, including the compound capable of inducing autophagy activation or a pharmaceutically acceptable salt thereof.
Type:
Grant
Filed:
June 23, 2017
Date of Patent:
April 14, 2020
Assignee:
INCOSPHARM CORPORATION
Inventors:
Chaejin Lim, Heung Jae Kim, Hwa-Jee Chung, Juyeon Jung, Kayoung Shin, Beom Cheol Kim, Seok Jeong Yoon, Myung Ho Kor, Seon Deok Kwon, Keedon Park
Abstract: Oral film dosage forms that provide improved solubilization and stabilization of an active ingredient in particle form include at least one primary crystallization inhibitor in an amount that inhibits growth and/or agglomeration of the active ingredient, a polyoxyethylated fatty acid glycerides in an amount that further enhances inhibition of crystallization, growth and agglomeration of the particles of the pharmaceutically active ingredient; and at least one plasticizer present in an amount that is effective to increase flexibility and elasticity of the film dosage form.
Type:
Grant
Filed:
February 7, 2017
Date of Patent:
April 7, 2020
Assignee:
Intelgenx Corp.
Inventors:
Horst G. Zerbe, Nadine Paiement, Angela Angusti, Cormac Long, Rodolphe Obeid, Laetitia Rodes, Billal Tir
Abstract: A method for regulating arterial vascular tone in a subject, comprising administering to a subject in need thereof, a therapeutically effective amount of a compound, or a pharmaceutically acceptable salt thereof, having a structure of: wherein A and B are each individually selected from O or S; a is 1 to 4; and Ar is optionally substituted aryl or optionally substituted heteroaryl.
Type:
Grant
Filed:
September 11, 2015
Date of Patent:
February 25, 2020
Assignee:
University of Pittsburgh—Of the Commonwealth System of Higher Education
Inventors:
Adam C. Straub, Carlos J. Camacho, Mizanur Rahaman, Fabio Reinders
Abstract: A method of treating a subject suffering from an angiogenesis-related disease, which is implemented by administering to the subject a pharmaceutical composition comprising a compound of formula I derived from Mitella formosana to inhibit the angiogenic function of endothelial progenitor cells.
Abstract: Compositions, kits and methods for treating cancer in a subject in need thereof are disclosed involving one or more inhibitors of the JAK/STAT pathway which renders the cancer chemosensitive and/or radiosensitive.
Type:
Grant
Filed:
May 9, 2018
Date of Patent:
February 18, 2020
Assignee:
The University of Chicago
Inventors:
Nikolai Khodarev, Ravi Sood, Bernard Roizman, Ralph R. Weichselbaum
Abstract: The present invention comprises compounds of Formula I. wherein: R1, R2, R3, R4, R5, R6, R7, R8, and R9 are defined in the specification. The invention also comprises a method of treating or ameliorating a syndrome, disorder or disease, wherein said syndrome, disorder or disease is rheumatoid arthritis or psoriasis. The invention also comprises a method of modulating ROR?t activity in a mammal by administration of a therapeutically effective amount of at least one compound of claim 1.
Type:
Grant
Filed:
March 14, 2016
Date of Patent:
February 11, 2020
Assignee:
Janssen Pharmaceutica NV
Inventors:
Kristi A. Leonard, Kent Barbay, James P. Edwards, Kevin D. Kreutter, David A. Kummer, Umar Maharoof, Rachel Nishimura, Maud Urbanski, Hariharan Venkatesan, Aihua Wang, Ronald L. Wolin, Craig R. Woods, Anne Fourie, Xiaohua Xue, Maxwell D. Cummings
Abstract: The present invention relates to pharmaceutical compositions comprising a combination of a therapeutically-effective amount of the antiviral compound aciclovir and a therapeutically-effective amount of the COX-2 inhibitor celecoxib. The invention is further related to methods of treating functional somatic syndromes by administering a therapeutically-effective combination of aciclovir and celecoxib.
Abstract: The invention relates to chemoembolization compositions for anti-angiogenic agent delivery. The invention further relates to a method of preparing chemoembolization compositions and to the use of chemoembolization compositions in the method for treating solid tumour cancers.
Type:
Grant
Filed:
June 29, 2017
Date of Patent:
January 21, 2020
Assignee:
CENTRE HOSPITALIER UNIVERSITAIRE VAUDOIS
Inventors:
Alban Denys, Pierre Bize, Olivier Jordan, Eric Doelker, Nathalie Boulens
Abstract: Germicidal compositions and methods of using the same in the prevention and treatment of various hoof diseases are provided. The germicidal compositions generally comprise formic acid, at least one C2-C10 carboxylic acid, and one or more anionic surfactants, such as an ?-olefin sulfonate. The germicidal compositions may be applied topically to the hooves of an animal through various means including the use of footbaths.
Abstract: Compositions and methods for inhibiting, treating, and/or preventing fatty acid metabolism disorders, particularly fatty acid oxidation disorders, in a subject are provided.
Type:
Grant
Filed:
July 29, 2014
Date of Patent:
October 8, 2019
Assignee:
The Children's Hospital of Philadelphia
Inventors:
Harry Ischiropoulos, Paschalis-Thomas Doulias
Abstract: Provided is a compound represented by formula (1): The compound represented by formula (1) has an excellent efficacy for controlling plant diseases, and is thus useful as an active ingredient for an agent for controlling plant diseases.
Abstract: The present invention relates to the use of the compound ciclopirox or a pharmaceutically acceptable salt or solvate thereof for the treatment and/or prevention of congenital erythropoietic porphyria (CEP).
Type:
Grant
Filed:
October 27, 2017
Date of Patent:
September 24, 2019
Assignee:
ASOCIACIÓN CENTRO DE INVESTIGACIÓN COOPERATIVA EN BIOCIENCIAS-CIC BIOGUNE
Inventors:
Oscar Millet Aguilar-Galindo, Arantza Sanz Parra, Ana Laín Torre, Pedro David Urquiza Ortiz, Juan Manuel Falcón Pérez
Abstract: A method of using a compound in a phototherapy procedure includes administering to a subject in need of treatment a therapeutically effective amount of a thio-substituted nucleobase, nucleoside, nucleotide, and/or analogs thereof; and exposing the administered compound to electromagnetic radiation.
Type:
Grant
Filed:
January 21, 2016
Date of Patent:
September 17, 2019
Assignee:
Case Western Reserve University
Inventors:
Carlos E. Crespo-Hernandez, Marvin Pollum
Abstract: The present invention relates to cyclopent(adi)ene compounds of formula I wherein the variables are as defined in the claims and description. The compounds are useful for combating or controlling invertebrate pests, in particular arthropod pests and nematodes. The invention also relates to a method for controlling invertebrate pests by using these compounds and to plant propagation material and to an agricultural and a veterinary composition comprising said compounds.
Type:
Grant
Filed:
February 3, 2015
Date of Patent:
September 10, 2019
Assignee:
BASF SE
Inventors:
Pascal Bindschaedler, Wolfgang Von Deyn, Arun Narine, Karsten Koerber, Franz-Josef Braun
Abstract: This invention concerns pyrrolo[3,2-d]pyrimidine derivatives, processes for their preparation, pharmaceutical compositions, and their use in treatment and/or therapy of diseases.
Type:
Grant
Filed:
June 26, 2014
Date of Patent:
August 20, 2019
Assignee:
Janssen Sciences Ireland Unlimited Company
Inventors:
David Craig McGowan, Serge Maria Aloysius Pieters, Stefaan Julien Last, Werner Embrechts, Tim Hugo Maria Jonckers, Pierre Jean-Marie Bernard Raboisson
Abstract: The present disclosure is generally directed to neuroactive 19-alkoxy-17-substituted steroids as referenced herein, and pharmaceutically acceptable salts thereof, for use as, for example, an anesthetic, and/or in the treatment of disorders relating to GABA function and activity. The present disclosure is further directed to pharmaceutical compositions comprising such compounds.
Type:
Grant
Filed:
March 15, 2017
Date of Patent:
July 9, 2019
Assignees:
Washington University, Sage Therapeutics, Inc.
Abstract: Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
Type:
Grant
Filed:
June 3, 2015
Date of Patent:
July 2, 2019
Assignee:
CALCIMEDICA, INC.
Inventors:
Jeffrey P. Whitten, Yazhong Pei, Jianguo Cao, Zhijun Wang, Evan Rogers, Brian Dyck, Jonathan Grey
Abstract: Described herein is a linking agent that includes a polymeric or non-polymeric core molecule and one or more photoreactive groups covalently attached to the core molecule by one or more linking elements that include a urea linkage, a carbamate linkage, or a combination thereof.