Patents Examined by Vanessa L. Ford
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Patent number: 11963996Abstract: Knee pain caused by osteoarthritis is relieved by modifying the shape change of bone(s) underlying articular cartilage, by a method comprising evaluating the bone shape of the patient's joint, injecting the patient with a peptide of SEQ ID No. 1 or applying other therapeutic interventions that can reduce the shape change of the bone(s) underlying articular cartilage, and thereafter evaluating the bone shape of the patient's joint.Type: GrantFiled: September 27, 2019Date of Patent: April 23, 2024Assignee: ORTHOTROPHIX, Inc.Inventors: Yoshinari Kumagai, Dawn McGuire, Meghan Miller, David Rosen
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Patent number: 11965032Abstract: Provided herein are populations of anti-CD20 antibody proteins with specified ranges of post-translational modifications. Also provided are methods of using and methods of making such populations of anti-CD20 antibody proteins.Type: GrantFiled: February 10, 2023Date of Patent: April 23, 2024Assignees: TG Therapeutics, Inc., Laboratoire Francais du Fractionnement et des BiotechnologiesInventors: George Costas Avgerinos, Patrick Michael Hossler, Jill A. Myers, Yune Z. Kunes
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Patent number: 11965010Abstract: Disclosed are a method for preparing a porcine-derived interferon-delta 5 (pIFN-?5) and an application of the pIFN-?5, where the method for preparing pIFN-?5 includes the following steps: step S1, obtaining a DNA fragment containing pIFN-?5 gene through reverse transcription-polymerase chain reaction (RT-PCR) amplification by using the total RNA of pretreated porcine small intestinal epithelial cells IPEC-J2; step S2, inserting the DNA fragment containing pIFN-?5 gene into an exogenous expression vector to construct a recombinant expression vector for expressing the pIFN-?5 gene; and step S3, introducing the recombinant expression vector into a suitable host cell, and driving the host cell to express the pIFN-?5 gene to obtain the pIFN-?5. The recombinant pIFN-?5 protein is used to prepare drugs or preparations for inhibiting infection of porcine epidemic diarrhea virus (PEDV), porcine transmissible gastroenteritis virus (TGEV), porcine delta coronavirus (PDCoV) and porcine rotavirus (PRoV).Type: GrantFiled: April 27, 2023Date of Patent: April 23, 2024Assignee: JIANGSU ACADEMY OF AGRICULTURAL SCIENCESInventors: Baochao Fan, Bin Li, Shiying Song, Xuehan Zhang, Xuejiao Zhu, Jinzhu Zhou, Yongxiang Zhao, Jizong Li, Rongli Guo, Weilu Guo, Xue Zhang
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Patent number: 11957715Abstract: The present invention discloses an in-vitro method for transferring biological material into activated NK cells with a pseudotyped retroviral vector particle or a virus-like particle thereof, comprising the steps a) activation of NK cells, and b) addition of said pseudotyped retroviral vector particle or virus-like particle thereof to said activated NK cells, wherein said pseudotyped retroviral vector particle or virus-like particle thereof comprises a modified baboon endogenous retrovirus (BaEV) envelope glycoprotein that is able of binding to and fusing with a hematopoietic cell membrane, thereby transferring biological material into said activated NK cells. Preferentially, the activating of NK cells is performed by the addition of a IL-1 family cytokine to the NK cells.Type: GrantFiled: December 19, 2018Date of Patent: April 16, 2024Assignee: MILTENYI BIOTEC B.V. & CO. KGInventors: Rafijul Bari, Markus Granzin, Wing Leung, Nina Moker, Volker Huppert
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Patent number: 11951128Abstract: The present disclosure relates to particular subsets of CD4+ and CD8+ T-cells, methods of isolating and generating these cells, compositions comprising these cells, and methods of treatment of a tumor or cancer by administering these cells alone or in combination with each other and/or additional therapies.Type: GrantFiled: August 2, 2018Date of Patent: April 9, 2024Assignee: LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGYInventors: Hilde Cheroutre, Nicolas Thiault, Alexandre Larange, Hitoshi Iwaya
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Patent number: 11931421Abstract: Aspects of the disclosure relate to complexes and other aspects relate to formulations (e.g., aqueous, lyophilized forms) comprising such complexes comprising an oligonucleotide (e.g., useful for targeting DMPK) covalently linked to an antibody (e.g., anti-TfR1 antibody).Type: GrantFiled: April 19, 2023Date of Patent: March 19, 2024Assignee: Dyne Therapeutics, Inc.Inventors: Scott Hilderbrand, Timothy Weeden, John Najim, Stefano Zanotti, Romesh R. Subramanian, Mohammed T. Qatanani, Cody A. Desjardins, Kim Tang, Brendan Quinn
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Patent number: 11884712Abstract: Provided herein are multi-chain chimeric polypeptides that include: (a) a first chimeric polypeptide including a first target-binding domain, a soluble tissue factor domain, and a first domain of a pair of affinity domains; and (b) a second chimeric polypeptide including a second domain of a pair of affinity domains and a second target-binding domain, where the first chimeric polypeptide and the second chimeric polypeptide associate through the binding of the first domain and the second domain of the pair of affinity domains. Also provided here are methods of using these multi-chain chimeric polypeptides and nucleic acids encoding these multi-chain chimeric polypeptides.Type: GrantFiled: November 19, 2020Date of Patent: January 30, 2024Assignee: HCW Biologics, Inc.Inventor: Hing Wong
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Patent number: 11883398Abstract: The success of anti-tumor immune responses requires effector T cells to infiltrate solid tumors, a process guided by chemokines. Herein, we demonstrate that in vivo post-translational processing of chemokines by dipeptidylpeptidase 4 (DPP4, also known as CD26) limits lymphocyte migration to sites of inflammation and tumors. Inhibition of DPP4 enzymatic activity enhanced tumor rejection by preserving biologically active CXCL10, and increasing trafficking into the tumor by lymphocytes expressing the counter-receptor CXCR3. Furthermore, DPP4 inhibition improved adjuvant-based immunotherapy, adoptive T cell transfer and checkpoint blockade. These findings provide the first direct in vivo evidence for controlling lymphocyte trafficking through CXCL10 cleavage and support the use of DPP4 inhibitors for stabilizing the biologically active form of chemokines as a strategy to enhance tumor immunotherapy.Type: GrantFiled: December 15, 2021Date of Patent: January 30, 2024Assignees: INSTITUT PASTEUR, INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)Inventors: Rosa Barreira Da Silva, Matthew Albert
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Patent number: 11873326Abstract: The present invention relates to a transgenic CHO cell line in which the BMP receptor gene BMPRIA or BMPRII is knocked out. The BMP type I receptor BMPRIA or BMP type II receptor BMPRII gene which plays an important role in intracellular signal transduction in CHO cells is knocked out to prevent the activation of self concentration control pathway and the signal transduction mediated by BMP in CHO cells, so that the productivity of a target protein to be produced can be improved.Type: GrantFiled: August 30, 2019Date of Patent: January 16, 2024Inventors: Gyun-Min Lee, Che Lin Kim
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Patent number: 11872269Abstract: A method of treating sarcopenia comprises immunizing a subject in need thereof against AGE-modified proteins or peptides of a cell. Immunizing a subject includes administering a vaccine that comprises an AGE antigen. Vaccines against AGE-modified proteins or peptides contain an AGE antigen, an adjuvant, optional preservatives and optional excipients.Type: GrantFiled: May 11, 2018Date of Patent: January 16, 2024Assignee: Siwa CorporationInventor: Lewis S. Gruber
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Patent number: 11865159Abstract: This disclosure relates to the field of therapeutic RNAs for treatment of solid tumor cancers.Type: GrantFiled: April 30, 2021Date of Patent: January 9, 2024Assignee: SanofiInventors: Friederike Gieseke, Ugur Sahin, Timothy R. Wagenaar, Dmitri G. Wiederschain, Christian Hotz
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Patent number: 11840702Abstract: An adenovirus comprising a sequence of formula (I) 5?ITR-B1-BA-B2-BX-BB-BY-B3-3?ITR wherein BY comprises a transgene cassette containing four transgenes, said genes encoding a FAP-Bispecific T cell activator, CXL10, CXL9, and IFN. The disclosure also extends to a pharmaceutical composition comprising the virus, and use of the virus or formulation in treatment.Type: GrantFiled: August 28, 2018Date of Patent: December 12, 2023Assignee: AKAMIS BIO LIMITEDInventors: Brian Champion, Alice Claire Noel Bromley
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Patent number: 11835530Abstract: The present disclosure relates to biomarkers of preterm birth, biomarkers of term birth, and methods of use thereof. In particular, the present disclosure provides methods of determining whether a pregnant woman is at an increased risk for premature delivery. The present disclosure further provides methods for decreasing a pregnant woman's risk for premature delivery.Type: GrantFiled: January 20, 2021Date of Patent: December 5, 2023Assignee: NX Prenatal Inc.Inventors: Alan M. Ezrin, Brian D. Brohman
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Patent number: 11833213Abstract: Compositions and methods for the treatment of viral infections include conjugates containing inhibitors of viral neuraminidase (e.g., zanamivir, peramivir, or analogs thereof) linked to an Fc monomer, an Fc domain, and Fc-binding peptide, an albumin protein, or albumin-binding peptide. In particular, conjugates can be used in the treatment of viral infections (e.g., influenza viral infections).Type: GrantFiled: April 21, 2021Date of Patent: December 5, 2023Assignee: Cidara Therapeutics, Inc.Inventors: James M. Balkovec, Daniel C. Bensen, Allen Borchardt, Thomas P. Brady, Zhi-Yong Chen, Jason Cole, Quyen-Quyen Thuy Do, Simon Doehrmann, Wanlong Jiang, Thanh Lam, Alain Noncovich, Leslie W. Tari
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Patent number: 11827701Abstract: The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6). In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments are particularly useful for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).Type: GrantFiled: August 10, 2021Date of Patent: November 28, 2023Assignee: ARGENX BVInventors: Christophe Blanchetot, Johannes Joseph Wilhelmus De Haard, Torsten Dreier, Natalie De Jonge, Sebastian Paul Van Der Woning, Nicolas Ongenae
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Patent number: 11823773Abstract: A patient having cancer can be treated using coordinated treatment regimens based on at least two omics data sets obtained from a solid tumor and a liquid biopsy that may indicates a plurality of tumor status in the patient's body. The treatment regimens can use various compounds and compositions that drive a tumor from the escape phase of cancer immunoediting to the elimination and equilibrium phase of cancer immunoediting.Type: GrantFiled: April 11, 2019Date of Patent: November 21, 2023Assignee: Nant Holdings IP, LLCInventor: Patrick Soon-Shiong
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Patent number: 11814427Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.Type: GrantFiled: March 24, 2020Date of Patent: November 14, 2023Assignee: RANI THERAPEUTICS, LLCInventor: Mir Imran
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Patent number: 11815514Abstract: Provided are methods, kits and compositions related to toxicity associated with administration of cell therapy for the treatment of diseases or conditions, e.g., cancer, including methods for use in predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a parameter of a biomarker or individually a parameter of each biomarker in a panel of biomarkers, such as a concentration, amount or activity, and comparing the detected parameter to a reference value for the parameter to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS.Type: GrantFiled: December 2, 2016Date of Patent: November 14, 2023Assignees: Juno Therapeutics, Inc., Fred Hutchinson Cancer Research CenterInventors: He Li, Mark J. Gilbert, David Maloney, Stanley R. Riddell, Cameron J. Turtle
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Patent number: 11801300Abstract: The disclosure is directed to pharmaceutical products and stable liquid compositions of IL-17 antibodies and antigen-binding fragments thereof, e.g., AIN457 (secukinumab), and processes of making these pharmaceutical products and compositions. The disclosure is also directed to the use of these pharmaceutical products and liquid compositions (e.g., as part of a kit having instructions for use) for the treatment of various IL-17-mediated disorders (e.g., autoimmune disorders, such as psoriasis, ankylosing spondylitis, psoriatic arthritis, and rheumatoid arthritis).Type: GrantFiled: December 21, 2015Date of Patent: October 31, 2023Assignee: NOVARTIS AGInventors: Susanne Joerg, Kathrin Serno-Schersch
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Patent number: 11793860Abstract: The invention relates to compositions of vault complexes containing recombinant cytokine fusion proteins that include a cytokine and a vault targeting domain, and methods of using the vault complexes to deliver the cytokines to a cell or subject, and methods for using the compositions to treat cancer, such as lung cancer.Type: GrantFiled: August 12, 2020Date of Patent: October 24, 2023Assignees: The Regents of the University of California, The United States Government as Represented by the Department of Veterans AffairsInventors: Leonard H. Rome, Valerie Ann Kickhoefer, Steven M. Dubinett, Sherven Sharma, Upendra K. Kar