Patents Examined by Vanessa L. Ford
  • Patent number: 10639367
    Abstract: The present invention provides methods and compositions for the stimulation of immune responses. In particular, the present invention provides compositions (e.g., vaccines) and methods of using the same for the induction of immune responses (e.g., innate and adaptive immune responses (e.g., for generation of host immunity against cancer (e.g., a tumor) or against any type of antigen (e.g. bacterial, viral, parasite-derived)). Compositions and methods of the present invention find use in, among other things, clinical (e.g. prophylactic, therapeutic and preventive medicine (e.g., vaccination)) and research applications. It particularly relates to the area of active specific immunotherapy of cancer (“cancer vaccines”), and provides procedures for the preparation of therapeutic vaccines that can eliminate cancer cells.
    Type: Grant
    Filed: November 1, 2013
    Date of Patent: May 5, 2020
    Assignee: CYTUVAX
    Inventor: Frank Walter Falkenberg
  • Patent number: 10626153
    Abstract: The present invention relates to HMGB1 variants that maintain HMGB1 wild type chemoattractant function while displaying abolished cytokine and/or chemokine stimulating properties. Such molecules are useful in therapy.
    Type: Grant
    Filed: July 26, 2013
    Date of Patent: April 21, 2020
    Assignee: OSPEDALE SAN RAFFAELE S.R.L.
    Inventors: Marco Emilio Bianchi, Maura Casalgrandi, Emilie Joelle Venereau, Silvia Brunelli
  • Patent number: 10611852
    Abstract: Provided are an insulin-lipid complex, a preparation method thereof, and a formulation thereof. The insulin-lipid complex is prepared by compounding insulin and a lipid material in an organic solvent system containing a low boiling point acid, and drying. The mass ratio of insulin to the lipid material is 1:3˜1:20. An oil solution of the insulin-lipid complex and vesicles containing insulin are further provided.
    Type: Grant
    Filed: February 13, 2018
    Date of Patent: April 7, 2020
    Assignee: INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES
    Inventors: Yuling Liu, Cuiping Zhou, Zhihui Song, Lin Li, Hongliang Wang, Xuejun Xia, Renyun Wang, Wujun Dong, Dujia Jin
  • Patent number: 10588941
    Abstract: The invention provides compositions and methods for targeting CCR10 and/or the CCR10/ligand axis to modulate the immune response in a subject.
    Type: Grant
    Filed: July 20, 2018
    Date of Patent: March 17, 2020
    Assignee: THE PENN STATE RESEARCH FOUNDATION
    Inventors: Na Xiong, Mingcan Xia
  • Patent number: 10576148
    Abstract: The present invention relates to inhibitors of VAP-1 and their use as medicaments in treating fibrotic conditions. Furthermore, the present invention relates to a method of diagnosing a fibrotic condition on the basis of elevated level of soluble VAP-1 or SSAO activity in a bodily fluid, and to a kit for use in said diagnostic method.
    Type: Grant
    Filed: September 21, 2017
    Date of Patent: March 3, 2020
    Assignees: BIOTIE THERAPIES CORP., THE UNIVERSITY OF BIRMINGHAM
    Inventors: Christopher Weston, Lee Charles Claridge, David Adams, David Smith, Nina Westerlund, Marjo Pihlavisto, Thua Österman
  • Patent number: 10570198
    Abstract: The invention provides antibodies that are modified to reduce aggregration propensity, and methods of producing such antibodies. The present invention also provides particularly stable and soluble scFv antibodies and Fab fragments specific for TNF, which comprise specific light chain and heavy chain sequences that are optimized for stability, solubility, in vitro and in vivo binding of TNF, and low immunogenicity. The nucleic acids, vectors and host cells for expression of the recombinant antibodies of the invention, methods for isolating them and the use of said antibodies in medicine are also disclosed.
    Type: Grant
    Filed: February 18, 2016
    Date of Patent: February 25, 2020
    Assignee: NOVARTIS AG
    Inventors: Leonardo Jose Borras, David Urech
  • Patent number: 10570211
    Abstract: Herein described are antibodies to epidermal growth factor receptor (EGFR) having an EGFR binding affinity that is sufficient to kill disease cells presenting EGFR at high density, but is insufficient for binding to normal cells. A therapeutic effect is thus achieved while avoiding adverse events that result from unintended binding to normal cells.
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: February 25, 2020
    Assignees: GILEAD SCIENCES, INC., NATIONAL RESEARCH COUNCIL OF CANADA
    Inventors: Ilia Alexandre Tikhomirov, Maria L. Jaramillo, Maureen D. O'Connor-McCourt, Traian Sulea, Renald Gilbert, Bruno Gaillet, Jason Baardsnes, Myriam Banville, Suzanne Grothe
  • Patent number: 10557856
    Abstract: This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of approximately fourteen Days measuring hyaluronic acid, death receptor 5, and/or transforming growth factor ?1 can be used to establish the risk of recovery versus non-recovery in patient's having suffered an acute kidney injury.
    Type: Grant
    Filed: September 16, 2011
    Date of Patent: February 11, 2020
    Assignee: University Of Pittsburgh-Of The Commonwealth System Of Higher Education
    Inventors: Kai Singbartl, John A. Kellum, Jr.
  • Patent number: 10550431
    Abstract: The technology described herein is directed to the diagnosis, prognosis, and treatment of infection, e.g. after burn injury.
    Type: Grant
    Filed: November 13, 2014
    Date of Patent: February 4, 2020
    Assignee: THE GENERAL HOSPITAL CORPORATION
    Inventors: Laurence Rahme, Shuangchun Yan, Yok-Ai Que, Amy Tsurumi
  • Patent number: 10537623
    Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a). Further, an in vitro method for preparing an antigen-presenting cell is provided. The method includes the step of contacting the antigen-presenting cell with the at least one polypeptide selected from: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 22, or 24; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).
    Type: Grant
    Filed: September 29, 2015
    Date of Patent: January 21, 2020
    Assignee: TORAY INDUSTRIES, INC.
    Inventors: Akira Kurihara, Fumiyoshi Okano
  • Patent number: 10513539
    Abstract: The present invention relates to hydrophobic modified peptides for the specific delivery of compounds to the liver, preferably to hepatocytes, in vitro as well as in vivo. The present invention relates to pharmaceutical compositions comprising said hydrophobic modified peptide(s) and the compound(s) to be specifically delivered to the liver. The present invention furthermore relates to the use of the inventive hydrophobic modified peptides as well as to a method for the prevention and/or treatment of liver diseases or disorders.
    Type: Grant
    Filed: February 10, 2012
    Date of Patent: December 24, 2019
    Assignee: Ruprecht-Karls-Universitat Heidelberg
    Inventors: Walter Mier, Stephan Urban, Stefan Mehrle, Uwe Haberkorn
  • Patent number: 10496949
    Abstract: A composition for treating cutaneous condition is provided and has 0.200 wt. % Aloe Barbadensis Leaf Juice, 10.000 wt. % Cyclopentasiloxane and Dimethicone Crosspolymer, 6.000 wt. % Dimethicone, 2.000 wt. % Ethoxydiglycol, 2.000 wt. % Glycerin, Water and Centella Asiatica Extract Mixture, 18.000 wt. % Glycerin, 3.000 wt. % Hydroxyethyl Acetate/Sodium Acryloyldimethy Taurate Copolymer, 1.100 wt. % Phenoxyyethanol and Ethylexylglycerin, 2.00 wt. % PPG-12 SMDI Copolymer, 0.004 wt. % GMP Grade Recombinant Human TGF-B3, 0.075 wt. % GMP Grade Recombinant Human IL10, 0.250 wt. % GMP Grade Recombinant Human bFGF, 0.500 wt. % Sodium Hyaluronate, 2.000 wt. % Tetrahexyldecyl Ascorbate, and water to make 100%.
    Type: Grant
    Filed: November 7, 2017
    Date of Patent: December 3, 2019
    Inventor: Christopher Zoumalan
  • Patent number: 10493151
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: December 3, 2019
    Assignee: Coherus BioSciences, Inc.
    Inventors: Mark Manning, Brian Murphy
  • Patent number: 10485858
    Abstract: Provided herein are cancer stem cell targeted cancer vaccines and methods for treating and vaccinating against cancer. Also contained herein are regimens by which cancer stem cell targeted cancer vaccines are administered, such regimens comprising peptides, compositions, immunomodulatory agents, and emulsifiers. Also provided are the patient populations to which the regimens are to be administered, and the dosages, schedules, route of administration for the regimens.
    Type: Grant
    Filed: May 15, 2013
    Date of Patent: November 26, 2019
    Assignee: Stemline Therapeutics, Inc.
    Inventors: Ivan Bergstein, Christopher Brooks, Thomas P. Cirrito
  • Patent number: 10485869
    Abstract: The invention provides stabilized aqueous pharmaceutical etanercept compositions suitable for long-term storage of etanercept, methods of manufacture of these compositions, methods of administration, and kits containing same.
    Type: Grant
    Filed: October 18, 2012
    Date of Patent: November 26, 2019
    Assignee: Coherus BioSciences, Inc.
    Inventors: Mark Manning, Brian Murphy
  • Patent number: 10487145
    Abstract: Embodiments of the invention provide swallowable devices, preparations and methods for delivering drugs and other therapeutic agents within the GI tract. Many embodiments provide a swallowable device for delivering the agents. Particular embodiments provide a swallowable device such as a capsule for delivering drugs into the intestinal wall or other GI lumen. Embodiments also provide various drug preparations that are configured to be contained within the capsule, advanced from the capsule into the intestinal wall and degrade to release the drug into the bloodstream to produce a therapeutic effect. The preparation can be operably coupled to delivery means having a first configuration where the preparation is contained in the capsule and a second configuration where the preparation is advanced out of the capsule into the intestinal wall. Embodiments of the invention are particularly useful for the delivery of drugs which are poorly absorbed, tolerated and/or degraded within the GI tract.
    Type: Grant
    Filed: June 24, 2016
    Date of Patent: November 26, 2019
    Assignee: Rani Therapeutics, LLC
    Inventor: Mir Imran
  • Patent number: 10478394
    Abstract: The present disclosure describes compositions and methods to promote wound healing. The compositions and methods include an interleukin-1 beta (IL-1B) receptor antagonist (IL-1Ra), such as anakinra.
    Type: Grant
    Filed: March 10, 2016
    Date of Patent: November 19, 2019
    Assignee: Wayne State University
    Inventor: Fu-Shin X. Yu
  • Patent number: 10472425
    Abstract: The present invention provides pharmaceutical formulations comprising a human antibody that specifically binds to human proprotein convertase subtilisin/kexin type 9 (PCSK9). The formulations may contain, in addition to an anti-PCSK9 antibody, at least one amino acid, at least one sugar, or at least one non-ionic surfactant. The pharmaceutical formulations of the present invention exhibit a substantial degree of antibody stability after storage for several months.
    Type: Grant
    Filed: May 24, 2017
    Date of Patent: November 12, 2019
    Assignee: Regeneron Pharmaceuticals, Inc.
    Inventors: Scott M. Walsh, Daniel B. Dix
  • Patent number: 10463725
    Abstract: Provided is a method for inducing immunity for therapy of a cancer(s). The method includes the step of administering to an individual with cancer at least one polypeptide selected from the polypeptides (a) or (b) below, and/or a recombinant vector(s) that comprise(s) a polynucleotide(s) encoding the at least one polypeptide, the recombinant vector(s) being capable of expressing the polypeptide(s) in vivo: (a) a polypeptide in any one of the amino acid sequences of SEQ ID NOs: 2, 4, 8, 10 and 12; and (b) a polypeptide having a sequence identity of not less than 95% to the polypeptide (a).
    Type: Grant
    Filed: October 13, 2015
    Date of Patent: November 5, 2019
    Assignee: TORAY INDUSTRIES, INC.
    Inventors: Akira Kurihara, Fumiyoshi Okano
  • Patent number: 10463724
    Abstract: Compositions and methods for immunization against human breast cancer are disclosed. A breast cancer vaccine comprises an immunogenic polypeptide comprising human ?-lactalbumin.
    Type: Grant
    Filed: September 11, 2015
    Date of Patent: November 5, 2019
    Assignee: The Cleveland Clinic Foundation
    Inventors: Vincent K. Tuohy, Justin M. Johnson, Ritika Jaini