Patents Examined by Vasu S. Jagannathan
  • Patent number: 5702919
    Abstract: Canine granulocyte macrophage colony stimulating factor (caGM-CSF) corresponding to that found in canine serum and/or tissues, structural variants thereof, genes that encode these materials, related expression vectors and cells, recombinant methods for making caGM-CSF, and veterinary treatments therewith.
    Type: Grant
    Filed: June 14, 1994
    Date of Patent: December 30, 1997
    Assignee: Fred Hutchinson Cancer Research Center
    Inventors: Richard A. Nash, Rainer Storb
  • Patent number: 5703145
    Abstract: There is disclosed a hot melt type ink for an ink jet which has a small rate of a volume change accompanied with a phase change from a melt status to a solid matter and does not cause an offset and which provides a clear color image on an OHP sheet. The above ink composition has a volume change rate falling in a range of less than 10%, preferably 8 to 4% and a phase change temperature range of 60.degree. C. to the jetting temperature.
    Type: Grant
    Filed: October 31, 1995
    Date of Patent: December 30, 1997
    Assignee: Hitachi Koki Co., Ltd.
    Inventors: Akemi Sagawa, Masahiko Sakai, Michio Ebata, Ren Itoh
  • Patent number: 5703153
    Abstract: An adhesive composition is comprised of a mixture of an EVA copolymer and two tackifying resins, a high temperature tackifying resin and a low temperature tackifying resin. The viscosity of the adhesive composition is between 2,000 cps to 80,000 cps over a temperature range of 250.degree. F. to 380.degree. F. The composition comprises 60% by weight of the copolymer, 15% by weight of the low temperature tackifying resin and 25% by weight of the high temperature tackifying resin.
    Type: Grant
    Filed: November 7, 1994
    Date of Patent: December 30, 1997
    Assignee: Uniplast, Inc.
    Inventor: Elias Shukri Maayeh
  • Patent number: 5698639
    Abstract: The invention provides ethylene-propylene-diene rubbers capable of imparting excellent heat resistance, weather resistance and dynamic fatigue resistance to vulcanized rubbers made therefrom. The ethylene-propylene-diene rubbers have sulfur uniformly dispersed therein by mixing a solution of the sulfur with a solution of the ethylene-propylene-diene rubber prior to the addition of vulcanization accelerators or other rubber additives to the rubbers. The vulcanized rubbers are particularly suitable for use as automobile components which require dynamic fatigue resistance such as muffler hangers, belts, rubber vibration insulators, engine mounts, tire treads for pneumatic tires, sidewalls for pneumatic tires and white sidewalls.
    Type: Grant
    Filed: August 21, 1996
    Date of Patent: December 16, 1997
    Assignee: Mitsui Petrochemical Industries, Ltd.
    Inventors: Hidenari Nakahama, Takashi Mishima
  • Patent number: 5698623
    Abstract: Addition of a polyurethane or polyurea polymer to each part of a particulate filled precursor of a two-part resin stabilizes the filler against settling from suspension, and provides thixotropic response when the precursors are expressed from a container.
    Type: Grant
    Filed: June 12, 1996
    Date of Patent: December 16, 1997
    Inventor: Richard L. Jacobs
  • Patent number: 5695950
    Abstract: A method of identifying compounds or molecules which alter (enhance or inhibit) stimulation of kinase activity of pre-MPF and, thus, alter (enhance or inhibit) activation of MPF and entry into mitosis. The present method thus makes it possible to identify compounds or molecules which can be administered to regulate the cell cycle; such compounds are also the subject of this invention.
    Type: Grant
    Filed: January 31, 1994
    Date of Patent: December 9, 1997
    Assignee: Cold Spring Harbor Laboratory
    Inventors: David H. Beach, Konstantin Galaktionov
  • Patent number: 5695964
    Abstract: This invention relates to novel vectors and host cells containing nucleic acids coding for a polypeptide having thrombin binding ability, anticoagulant activity and thrombolytic activity. The polypeptide can be efficiently produced in large quantities by means of genetic recombination techniques using the vectors and host cells of the present invention. Since the polypeptide exhibits anticoagulant activity and thrombolytic activity without generating side effects such as bleeding tendencies, it can be applied effectively to the prevention and treatment of hypercoagulability-related diseases.
    Type: Grant
    Filed: January 17, 1996
    Date of Patent: December 9, 1997
    Assignee: Mochida Pharmaceutical Co., Ltd.
    Inventors: Atsushi Nii, Hideaki Morishita, Akio Uemura, Ei Mochida
  • Patent number: 5695968
    Abstract: The present invention is directed to a gene which is related to a D-N-carbamoyl-.alpha.-amino acid amidohydrolase which is an enzyme capable of converting D-N-carbamoyl-.alpha.-amino acids into D-.alpha.-amino acids; a recombinant plasmid in which a DNA fragment containing the gene is incorporated into a vector; a microorganism belonging to the genus Escherichia, Pseudomonas, Flavobacterium, Bacillus, Serratia, Corynebacterium, or Brevibacterium, which is transformed by incorporating the recombinant plasmid thereinto; a process for the production of D-N-carbamoyl-.alpha.-amino acid amidohydrolases, comprising the steps of cultivating the transformed microorganism and collecting the desired product therefrom; a D-N-carbamoyl-.alpha.-amino acid amidohydrolase obtained by the method; and a process for the production of D-.alpha.-amino acids with the aid of an action of the enzyme.The D-N-carbamoyl-.alpha.-amino acid amidohydrolase can be fixed on a support for immobilization and used as an immobilized enzyme.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: December 9, 1997
    Assignee: Kanegafuchi Kagaku Kogyo Kabushiki Kaisha
    Inventors: Hirokazu Nanba, Yukio Yamada, Masayuki Takano, Yasuhiro Ikenaka, Satomi Takahashi, Kazuyoshi Yajima
  • Patent number: 5695958
    Abstract: A method is described for isolating an exogenous polypeptide in a non-native conformation from cells, such as an aqueous fermentation broth, in which it is prepared comprising contacting the polypeptide with a chaotropic agent and preferably a reducing agent and with phase-forming species to form multiple aqueous phases, with one of the phases being enriched in the polypeptide and depleted in the biomass solids and nucleic acids originating from the cells. Preferably, the method results in two aqueous phases, with the upper phase being enriched in the polypeptide.
    Type: Grant
    Filed: May 17, 1995
    Date of Patent: December 9, 1997
    Assignee: Genentech, Inc.
    Inventors: Stuart Builder, Roger Hart, Philip Lester, John Ogez, David Reifsnyder
  • Patent number: 5695754
    Abstract: A method for producing the derivatives of the invention by preparing a DNA fragment comprising at least the part of the coding sequence of staphylokinase that provides for its biological activity; performing in vitro site-directed mutagenesis on the DNA fragment to replace one or more codons for wild-type amino acids by a codon for another amino acid; cloning the mutated DNA fragment in a suitable vector; transforming or transfecting a suitable host cell with the vector; and culturing the host cell under conditions suitable for expressing the DNA fragment. Preferably the DNA fragment is a 466 bp EcoRI-HINDIII fragment of the plasmid pMEX602SAK, the in vitro site-directed mutagenesis is performed by an oligonucleotide-directed mutagenesis system using the plasmid pMa/c and the repair deficient E. coli strain WK6MutS, and the mutated DNA fragment is cloned in E. coli strain-WK6.
    Type: Grant
    Filed: January 11, 1995
    Date of Patent: December 9, 1997
    Assignees: Leuven Research & Development VZW, Desire Collen
    Inventor: Desire Collen
  • Patent number: 5693697
    Abstract: The present invention provides flame-resistant polycarbonate moulding compositions with a concentration of alkali metal or alkaline earth metal salts and of silicon compounds and their preparation.
    Type: Grant
    Filed: November 3, 1995
    Date of Patent: December 2, 1997
    Assignee: Bayer Aktiengesellschaft
    Inventors: Richard Weider, Klaus Horn, Klaus Berg
  • Patent number: 5693779
    Abstract: An isolated polynucleotide of anti-dorsalizing morphogenetic protein (ADMP-1) is obtained from Xenopus. The protein is most closely related to human BMP-3. ADMP-1 functions as a modulator for dorsalizing influences, and prevents syndromes involving inappropriate proliferation of tissues.
    Type: Grant
    Filed: November 8, 1994
    Date of Patent: December 2, 1997
    Assignee: The United States of America as represented by the Department of Health and Human Services
    Inventors: Malcolm Moos, Jr., Marie Krinks, Shouwen Wang
  • Patent number: 5691168
    Abstract: This invention is directed to isolated DNA sequences encoding AlaGlu-IGF-1, as well as vectors and microorganisms comprising such sequences.
    Type: Grant
    Filed: May 18, 1995
    Date of Patent: November 25, 1997
    Assignee: Novo Nordisk A/S
    Inventors: Lars Skriver, Kim Ry Hejn.ae butted.s, Henrik Dalb.o slashed.ge
  • Patent number: 5691415
    Abstract: A reinforced elastic body is disclosed, which comprises a chlorosulfonated polyolefin reinforced with polyester fibers having an adhesive containing an isocyanate compound and/or an epoxy compound and an adhesive composed of a mixture of a resorcin-formaldehyde resin and a 2,3-dichlorobutadiene-containing polymer. Also, a production process of the reinforced elastic body is disclosed, which comprises vulcanizing-adhering polyester fibers treated with an adhesive containing an isocyanate compound and/or an epoxy compound and then treated with an adhesive composed of a mixture of a resorcin-formaldehyde resin and a 2,3-dichlorobutadiene-containing polymer to a chlorosulfonated olefin compounded material.
    Type: Grant
    Filed: June 1, 1995
    Date of Patent: November 25, 1997
    Assignee: Tosoh Corporation
    Inventors: Yasumichi Miyagawa, Kenji Kuwata
  • Patent number: 5691391
    Abstract: A variable pitch fan for a helicopter equipped with a NOTAR.RTM. mechanical antitorque directional control system comprises a plurality of blade assemblies. Each blade assembly includes a blade portion, which is molded from a blended material which includes fiber reinforced polypropylene. A key to the invention is the use of long fibers, having a length of at least approximately one-half inch, for reinforcement, the long fibers providing for about twice the pull-out strength of short or chopped fibers. Another key aspect of the invention is the use of a blowing agent in the blended material, which serves to reduce weight and warpage by creating a foamed structure having a variable density, the structure retaining considerable strength because of the fiber reinforcement. The blade portion is molded about a spar which has holes therethrough, the holes providing a mechanical interlock between the blade and the spar.
    Type: Grant
    Filed: December 5, 1994
    Date of Patent: November 25, 1997
    Assignee: McDonnell Douglas Helicopter
    Inventors: Steve P. Chen, John E. Schibler, Ramesh J. Patel
  • Patent number: 5688662
    Abstract: A novel taste cell specific guanine nucleotide binding protein, gustducin, is disclosed as well as polynucleotide sequences encoding the .alpha. subunit of gustducin. Also disclosed are methods of modifying taste involving agents that inhibit or activate the gustducin .alpha. subunit, methods for identifying such taste modifying agents and various taste modifying agents.
    Type: Grant
    Filed: April 9, 1992
    Date of Patent: November 18, 1997
    Assignee: Linguagen Corporation
    Inventor: Robert F. Margolskee
  • Patent number: 5688851
    Abstract: An improved gel coat for integral molded products having increased hardness consists of a synthetic resin mixed with tabular alumina and a surface treating agent such as gamma-Methacryloxypropyltrimethoxysilane. The gel coat may be applied as a first layer over a mold, pattern, part, or other surface with a filler reinforced resin layer applied to the first layer or with an intermediate layer of resin filled with calcium silicate applied between the gel coat and the reinforced layer. The gel coat may also be used as a surface coating for steel, composite, and concrete structures.
    Type: Grant
    Filed: September 18, 1995
    Date of Patent: November 18, 1997
    Assignee: Ceramal Research & Development Corporation
    Inventor: Russell L. Kress
  • Patent number: 5688760
    Abstract: Polypeptides comprising an N-terminal amino acid sequence corresponding to amino acids 107-111 of parathyroid hormone related protein (PTHrP) having bone resorption inhibitory activity are provided. The polypeptides are provided in pharmaceutical compositions for the treatment of diseases and disorders where inhibition of bone resorption is indicated.
    Type: Grant
    Filed: August 12, 1993
    Date of Patent: November 18, 1997
    Assignees: Genentech, Inc., The University of Melbourne
    Inventors: Bruce E. Kemp, Geoffrey C. Nicholson, Thomas J. Martin, Anna J. Fenton, R. Glenn Hammonds
  • Patent number: 5686268
    Abstract: This invention relates to composite somatotropin peptides and fusion protein thereof useful in the potentiating of growth hormone activity. Also disclosed are vector and host cells useful in the recombinant production of such molecules. Vaccines containing composite somatotropin and fusion proteins thereof and methods of using same as disclosed.
    Type: Grant
    Filed: January 27, 1995
    Date of Patent: November 11, 1997
    Assignee: Pfizer Inc.
    Inventors: Hector Wasunna Alila, Michael Thomas Clark, Elaine Verne Jones, Timothy Joe Miller, Shawn Patrick O'Brien, Ganesh Madhusudan Sathe
  • Patent number: 5686265
    Abstract: This invention concerns the cloning of the alpha-subunit of the p150,95 leukocyte adhesion receptor molecule. The invention also concerns the alpha-subunit of p150,95, as well as fragments of this receptor molecule. The invention further pertains to the diagnostic and therapeutic uses for such molecules.
    Type: Grant
    Filed: December 30, 1994
    Date of Patent: November 11, 1997
    Assignee: Dana Farber Cancer Institute
    Inventors: Angel A. Corbi, Timothy A. Springer