Patents Examined by Vera C. Clarke
  • Patent number: 5350874
    Abstract: A continuous process for preparing a dialkylester of a naphthalenedicarboxylic acid comprising passing a liquid phase reaction mixture comprising a low molecular weight alcohol, a naphthalenedicarboxylic acid and a dialkylester of a naphthalenedicarboxylic acid at an elevated temperature through series arranged reaction zones while introducing a naphthalenedicarboxylic acid and a low molecular weight alcohol to an upstream reaction zone, agitating at least one reaction zone, and removing a liquid product mixture comprising the dialkylester of the naphthalenedicarboxylic acid produced by the reaction of the naphthalenedicarboxylic acid with the low molecular weight alcohol from a downstream reaction zone.
    Type: Grant
    Filed: November 24, 1992
    Date of Patent: September 27, 1994
    Assignee: Amoco Corporation
    Inventors: Paul K. Behrens, Juergen K. Holzhauer, Gregory P. Hussmann, David L. Sikkenga
  • Patent number: 5344969
    Abstract: A process for purifying a crude naphthalenedicarboxylic acid containing impurities and coloring substances obtained by the oxidation of a di-substituted naphthalene, dispense with the use of a large amount of alkali or acid, and producing a naphthalenedicarboxylic acid having a high purity and good color effectively and in a high recovery is disclosed, which comprises dissolving the crude naphthalenedicarboxylic acid in a mixed solvent comprising an amine compound and an alcohol and conducting crystallization.
    Type: Grant
    Filed: November 30, 1992
    Date of Patent: September 6, 1994
    Assignee: Mitsubishi Petrochemical Co., Ltd.
    Inventors: Hiroshi Iwane, Takahiro Sugawara, Miwa Shirasaki
  • Patent number: 5344939
    Abstract: The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the --CH.sub.2 F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH.sub.2 F is thus illustrated.
    Type: Grant
    Filed: March 11, 1993
    Date of Patent: September 6, 1994
    Assignee: Prototek, Inc.
    Inventor: James T. Palmer
  • Patent number: 5338882
    Abstract: The invention relates to a process for the production of a DMT intermediate product as well as its working up to fibregrade DMT and to medium pure and pure terephthalic acid.
    Type: Grant
    Filed: November 4, 1993
    Date of Patent: August 16, 1994
    Assignee: Huls Aktiengesellschaft
    Inventors: Hermann-Josef Korte, Anton Miletic, Hans U. Neutzler, Anton Schoengen, Johann H. Schroeder, Ralf Wirges
  • Patent number: 5336793
    Abstract: A method of preparing carboxylic acids or esters thereof by the oxidative cleavage of unsaturated fatty acids or esters thereof is carried out in a two-phase aqueous-organic system in which the organic phase contains the unsaturated fatty acid and/or the esters thereof and the aqueous phase contains hydrogen peroxide. The oxidative cleavage is carried out in the presence of a catalytic system including a catalyst belonging to the group constituted by tungstic and molybdic acids and alkaline salts thereof, and an onium salt which acts as a phase-transfer agent for the catalyst, and has the formula:(R.sub.2 R.sub.3 R.sub.4 R.sub.5 M).sup.+ Y.sup.-in which R.sub.2, R.sub.3, R.sub.4 and R.sub.5 represent hydrocarbon groups of which at least one must have more than 10 carbon atoms,M is N or P, andY.sup.- is an inorganic anion.
    Type: Grant
    Filed: December 10, 1992
    Date of Patent: August 9, 1994
    Assignee: Novamont S.p.A.
    Inventors: Andrea Gardano, Giampiero Sabarino, Marco Foa
  • Patent number: 5334754
    Abstract: Provided is a process for preparing 2,5-diphenylterephthalic acid, which is useful in preparing certain polyesters, especially liquid-crystalline polyesters. In this process, p-xylene is di-alkylated with cyclohexene to provide 2,5-dicyclo-hexyl-p-xylene, which is in turn dehydrogenated to provide 2,5-diphenylxylene. 2,5-Diphenylxylene is then oxidized to provide 2,5-diphenylterephthalic acid by utilization of a cobaltous/manganous/bromide oxidation system.
    Type: Grant
    Filed: August 14, 1992
    Date of Patent: August 2, 1994
    Assignee: Eastman Chemical Company
    Inventors: Charles E. Sumner, Jr., Bruce L. Gustafson, Ernest W. Arnold, III, Eric J. Fugate, Dewey W. Fuller, Jr.
  • Patent number: 5332858
    Abstract: The invention relates to a method for preparing an ester composition in which at least one activated phenolic ether group of a molecule is reacted with at least one haloformyl group of another molecule.
    Type: Grant
    Filed: July 17, 1992
    Date of Patent: July 26, 1994
    Assignee: Shell Oil Company
    Inventors: Feike De Jong, Jan H. H. Meurs
  • Patent number: 5332834
    Abstract: There is disclosed and claimed a process whereby S(+)-ibuprofen L-lysinate salt is produced by selective precipitation from a mixture containing enantiomers of ibuprofen and L-lysine. The quantity of L-lysine is not more than about a molar equivalent of the quantity of S(+)-ibuprofen in the ibuprofen enantiomeric mixture. The mother liquors after separating the above salt are enriched in R-ibuprofen which is racemized by a novel thermal racemization process and may then be recycled.
    Type: Grant
    Filed: December 2, 1992
    Date of Patent: July 26, 1994
    Assignee: Hoechst Celanese Corporation
    Inventors: Apurba Bhattacharya, John R. Fritch, Carl D. Murphy, Larry D. Zeagler, Carina Araullo-McAdams
  • Patent number: 5332859
    Abstract: Described is a batchwise process for producing tetrabromophthalic diester flame retardants having consistent product characteristics.
    Type: Grant
    Filed: November 3, 1992
    Date of Patent: July 26, 1994
    Assignee: Great Lakes Chemical Europe, Ltd.
    Inventor: Brian Tarbit
  • Patent number: 5328932
    Abstract: The present invention provides new thrombin inhibiting bisamidines derivatives, their pharmaceutically acceptable salts and hydrates, methods for their preparation, pharmaceutical composition, a process for their preparation, and use of the compounds in treatment of thrombosis, ischemia and stroke.
    Type: Grant
    Filed: June 17, 1993
    Date of Patent: July 12, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Neelakantan Balasubramanian, William Teh-Wei Han
  • Patent number: 5326903
    Abstract: A method for preparing isocyanates by the thermal decomposition of carbamates in the presence of a sintered oxide as catalyst under gaseous phase condition. The sintered oxide is composed of at least one element selected from the group consisting of boron, aluminum, silicon, tin, lead, antimony, zinc, yttrium, lanthanum, titanium, zirconium, niobium, tungsten, and iron. The sintered oxide may be composed of at least one element selected from the group consisting of phosphorus, alkali metal element, and alkaline earth metal element.
    Type: Grant
    Filed: December 28, 1992
    Date of Patent: July 5, 1994
    Assignee: Nippon Shokubai Co., Ltd.
    Inventors: Yuuji Shimasaki, Hideyuki Kanbe, Masako Hokazono
  • Patent number: 5324747
    Abstract: Compounds of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, R.sub.6, R.sub.7, R.sub.8, n, m, o, p and q are as hereinafter set forth, and, when R.sub.2 is hydrogen, pharmaceutically acceptable salts thereof with bases, are described. The compounds of formula 1 are potent inhibitors of phospholipases A.sub.2 (PLA.sub.2 's) and are therefore useful in the treatment of inflammatory diseases, such as psosiasis, inflammatory bowel disease, asthma, allergy, arthritis, dermatitis, gout, pulmonary disease, myocardial ischemia/reperfusion, and trauma induced inflammation, such as spinal cord injury.
    Type: Grant
    Filed: July 15, 1992
    Date of Patent: June 28, 1994
    Assignee: Hoffmann-La Roche Inc.
    Inventors: Mathew Carson, Ru-Jen L. Han, Ronald A. LeMahieu, Vincent S. Madison
  • Patent number: 5321046
    Abstract: Disclosed herein are novel unsymmetrical dithiol ketals which are useful in the treatment or prevention of hypercholesterolemia, hyperlipoproteinemia, and atherosclerosis.
    Type: Grant
    Filed: October 27, 1992
    Date of Patent: June 14, 1994
    Assignee: Bristol-Myers Squibb Company
    Inventors: Sing-Yuen Sit, John J. Wright, Jeff A. Field
  • Patent number: 5321154
    Abstract: (.+-.)-2-(4-Isobutylphenyl)-propionic acid can be resolved into optically active isomers easily and with high yields. The method is characterized by the use of the optically active amine of the following general formula (I) or (II) as a resolving agent.
    Type: Grant
    Filed: July 31, 1992
    Date of Patent: June 14, 1994
    Assignee: Nagase & Company, Ltd.
    Inventor: Hiroyuki Nohira
  • Patent number: 5319133
    Abstract: The present invention relates to a process for preparation of an isocyanate comprising (a) reacting an amide with an aqueous solution of hypochlorous acid in the presence of an water-immiscible organic solvent to produce an N-chloro amide; and (b) reacting said N-chloro amide with a base in the presence of a phase transfer catalyst and a water immiscible organic solvent to produce an isocyanate.
    Type: Grant
    Filed: December 28, 1992
    Date of Patent: June 7, 1994
    Assignee: Olin Corporation
    Inventors: Robert J. Raynor, Thomas A. Knowles
  • Patent number: 5319128
    Abstract: A process for the production of terephthalate diesters having the following formula (I). ##STR1## Substituents R and R' are the same or different and represent a straight chain, branched or cyclic aliphatic group, an aromatic group, an alkaryl group or an aralkyl group, each group having from 6 to 20 carbon atoms. The process involves reacting a terephthalate polyester with a high molecular weight alcohol or a mixture of high molecular weight alcohols each having from 6 to 20 carbon atoms, in the presence of a catalyst and recovering the desired compound according to formula (I). This process is particularly useful for recycling scrap terephthalate polyester products such as those produced from polyethylene terephthalate (PET), crystallized polyethylene terephthalate (CPET), glycol-modified polyethylene terephthalate copolyester (PETG), polybutylene terephthalate (PBT), polycyclohexanedimethylene terephthalate (PCT), as well as the acid- and glycol-modified copolyesters of PCT, respectively PCTA and PCTG.
    Type: Grant
    Filed: March 30, 1992
    Date of Patent: June 7, 1994
    Assignee: Synergistics Industries, Ltd.
    Inventors: Louis Dupont, Ved P. Gupta
  • Patent number: 5314916
    Abstract: Compounds having beta-2 adrenergic agonist activity and the use of these compounds in controlling intraocular pressure are disclosed. The compounds are believed to be useful in controlling intraocular pressure by increasing the outflow of aqueous humor. The compounds are considered to be less likely to cause cardiovascular side effects and various other side effects associated with stimulation of beta-1 receptors, relative to epinephrine.
    Type: Grant
    Filed: April 19, 1993
    Date of Patent: May 24, 1994
    Assignee: Alcon Laboratories, Inc.
    Inventors: Billie M. York, Evan P. Kyba
  • Patent number: 5314918
    Abstract: This invention relates to alkanoic acid compounds having phenyl and heteroarylthio substituents which are useful as leukotriene antagonists, processes for the preparation thereof, and pharmaceutical compositions containing such compounds.This invention also relates to methods of treating diseases in which leukotrienes are a factor by administration of an effective amount of the above compounds or compositions.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: May 24, 1994
    Assignee: SmithKline Beecham Corporation
    Inventors: James S. Frazee, John G. Gleason, Ralph F. Hall
  • Patent number: 5312969
    Abstract: Difunctional butenes are linearly dicarbonylated into 3-hexene-1,6-dioic acid or alkyl diesters thereof, well suited for the ultimate production of, e.g., adipic acid, by reacting such difunctional butene with carbon monoxide and, if appropriate, an alcohol, at an elevated temperature under superatmospheric pressure, in the presence of at least one source of hydrogen chloride and a catalytically effective amount of palladium, at least a portion of which palladium being in the zero oxidation state, as well as a quaternary onium chloride of nitrogen or phosphorus, the nitrogen or phosphorus atom being tetracoordinated to carbon atoms, with the proviso that the nitrogen atom may be coordinated to two pentavalent phosphorus atoms.
    Type: Grant
    Filed: May 18, 1992
    Date of Patent: May 17, 1994
    Assignee: Rhone-Poulenc Chimie
    Inventors: Marc Huser, Sylvain Mutez, Robert Perron
  • Patent number: RE34619
    Abstract: Diesters of the formula ##STR1## wherein R.sub.1 and R.sub.2 are hydrogen or alkyl of from 1 to about 20 carbon atoms, and X and Y are alkyl, alkenyl or .[.dienyl.]. .Iadd.alkadienyl .Iaddend.of from about 12 to about 18 carbon atoms, useful as low calorie synthetic oils suitable for consumption by mammals.
    Type: Grant
    Filed: November 8, 1990
    Date of Patent: May 24, 1994
    Assignee: Recot, Inc.
    Inventor: John Fulcher