Patents Examined by Vera C. Clarke
  • Patent number: 5214194
    Abstract: A process for the preparation of 5-substituted 2-aminophenols via nitrones, comprises two reactions. First, a nitrone is reacted with a trihaloacetyl halide to regiospecifically convert the nitrone to a 5-substituted-2-aminophenol derivative (I). Subsequently, the derivative is hydrolyzed to form the 5-substituted-2-aminophenol. The product is useful as a chemical intermediate, e.g. for the preparation of couplers used in photographic chemistry.
    Type: Grant
    Filed: September 24, 1991
    Date of Patent: May 25, 1993
    Assignee: Eastman Kodak Company
    Inventors: Ping-Wah Tang, Jeffrey R. Neff, Frank T. Melia, Donald J. Schuster
  • Patent number: 5214192
    Abstract: Diacetoxyatene compounds are obtained by reacting a perborate such as sodium perborate monohydrate or tetrahydrate and acetic acid with an iodoarene compound under mild conditions, such as 40 to 50.degree. C. The iodoarene can be further substituted by a wide range of substituents, such as halo, nitro, alkyl, alkoxy or carbosylic acid, in any position around the nucleus, except that electron withdrawing substituents occupy meta positions only. The invention process thus enables a wide range of substituted diacetoxyarene compounds to be produced using widely available and easily handled materials under mild operating conditions.
    Type: Grant
    Filed: October 2, 1991
    Date of Patent: May 25, 1993
    Assignee: Interox Chemicals Limited
    Inventors: Alexander McKillop, Duncan Kemp
  • Patent number: 5214201
    Abstract: This invention relates to certain salts of leukotriene antagonists and the use of a particular amine to form these salts as a means for selectively crystallizing optical isomers of the leukotriene antagonists disclosed herein.
    Type: Grant
    Filed: December 12, 1991
    Date of Patent: May 25, 1993
    Assignee: SmithKline Beecham Corporation
    Inventor: Robert J. Mills
  • Patent number: 5210278
    Abstract: A process for preparing a substituted styrene by reacting a bisarylalkyl ether in the presence of an acid catalyst is disclosed. The process is preferably used for the preparation of 4-acetoxystyrene from 4,4'-(oxydiethylidene)bisphenol diacetate and 4-methoxystyrene from 4,4'-(oxydiethylidene)bisphenol dimethyl ether. A process for preparing a bisarylalkyl ether by reacting a corresponding arylalkanol in the presence of an acid catalyst is also disclosed.
    Type: Grant
    Filed: August 25, 1992
    Date of Patent: May 11, 1993
    Assignee: Hoechst Celanese Corporation
    Inventors: Mohammad Aslam, Brad L. Smith, George Kvakovszky
  • Patent number: 5210292
    Abstract: A process for purifying a crude terephthalic acid obtained by neutralization of the disodium terephthalate from alkali waste water from a polyester fabric-treatment process, into polymer grade terephthalic acid. The crude terephthalic acid is crushed, and fed to the kiln at 150.degree.-300.degree. C. for thermal treatment in an aqueous solution. The ammoniated, and the impurities in the solution are removed by adsorption followed by deammoniation, which may be accomplished by heating or by treatment with sulfuric acid.
    Type: Grant
    Filed: October 12, 1990
    Date of Patent: May 11, 1993
    Assignee: Korea Research Institute of Chemical Technology
    Inventors: Sang F. Park, Tae S. Chang, Young K. Lee, Kyu W. Choi
  • Patent number: 5210291
    Abstract: The present invention is directed to a method for producing dichlorophenylthioglycolic acid which comprises reacting monobromodichlorobenzene or trichlorobenzene with a thioglycolate in a ratio of 0.5 to 2.5 mols of the latter to 1 mol of the former in a polar solvent, and to a method for producing dichlorophenylthioglycolic acid comprising further reacting the reaction mixture obtained as above with a monohalogenoacetate.The method of the present invention is very useful industrially, advantageously producing dichlorophenylthioglycolic acid in high yield.
    Type: Grant
    Filed: November 20, 1991
    Date of Patent: May 11, 1993
    Assignee: Sumitomo Seika Chemicals Co., Ltd.
    Inventors: Michio Suzuki, Hiroyuki Hata, Masato Yoshikawa, Toshiyuki Ohe, Hirokazu Kagano, Hiroshi Goda, Masahito Nakano, Masaki Teramoto
  • Patent number: 5210285
    Abstract: The invention relates to a new process for the preparation of known .beta.-halogeno-tert.-alkyl isocyanates of the formula ##STR1## in which X represents chlorine,Y represents hydrogen or chlorine,R.sup.1 represents in each case straight-chain or branched alkyl or halogeno alkyl andR.sup.2 represents in each case straight-chain or branched alkyl or halogeno alkyl or optionally halogen-and/or trifluoromethyl-substituted phenyl,where tert.-alkyl isocyanates of the formula (II) ##STR2## are reacted with chlorine, optionally under irradiation or in the presence of catalysts, in a suitable apparatus.
    Type: Grant
    Filed: April 2, 1992
    Date of Patent: May 11, 1993
    Assignee: Bayer Aktiengesellschaft
    Inventor: Rudiger Schubart
  • Patent number: 5210284
    Abstract: Organic mono- or di-isocyanates are prepared by the decomposition of the corresponding urethanes, by means of a continuous process in which:(a) an urethane flow is continuously fed to a decomposition reactor containing a liquid mixture, composed of a high boiling inert organic solvent, of an unaltered urethane and isocyanate, kept at the boiling conditions of the solvent, at a temperature suitable to decompose the urethane and evaporate the alcohol which is the co-product of the reaction;(b) the liquid mixture is continuously withdrawn from the reactor in (a) and is fed to a flash equipment, at an operating temperature lower than the decomposition temperature of the urethane, where the isocyanate is partially evaporated and the residuous liquid mixture is recycled to the reactor in (a); and(c) the steam flow generated in (b) is distilled to separate the isocyanate in pure or substantially pure form.
    Type: Grant
    Filed: December 19, 1991
    Date of Patent: May 11, 1993
    Assignee: Enichem Synthesis S.p.A.
    Inventors: Franco Mizia, Carlo Calderoni
  • Patent number: 5210280
    Abstract: A process for the preparation of alkanedioic acid derivatives comprising reacting an alkenoic acid derivative with carbon monoxide and a nucleophilic compound having a mobile hydrogen atom in the presence of a catalyst system comprising a source of a Group VIII metal, a source of a bidentate diphosphine liquid, a source of an anion and a source of a quinone promoter.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: May 11, 1993
    Assignee: Shell Oil Company
    Inventor: Eit Drent
  • Patent number: 5210272
    Abstract: The preparation of magnesium benzyl fluoromalonate and other equivalent materials, the synthetic equivalents of the --CH.sub.2 F moiety, is described. Reaction between these reagents and the in situ-formed imidazolides of various carboxylic acids gives beta-keto-alpha-fluoroesters, which upon hydrogenation and spontaneous decarboxylation yields fluoromethyl ketones in excellent yields. The overall transformation from RCOOH to RCOCH.sub.2 F is thus illustrated.
    Type: Grant
    Filed: August 14, 1991
    Date of Patent: May 11, 1993
    Assignee: Prototek, Inc.
    Inventor: James T. Palmer
  • Patent number: 5208368
    Abstract: Mixtures of diphenylmethane diisocyanates and polyphenylpolymethylene polyisocyanates (crude MDI) of reduced iodine color number are prepared by reacting the corresponding mixtures of diphenylmethanediamines and polyphenylpolymethylenepolyamines with phosgene in the presence of at least one inert organic solvent at elevated temperature, at least one monohydric or polyhydric polyoxyalkylene alcohol, preferably having a functionality of from 2 to 3, and advantageously having a hydroxyl number of from 20 to 1800, or mixtures thereof in an effective amount, expediently in an amount of from 0.1 to 10% by weight, based on the weight of the crude MDI, being introduced into the reaction mixture when the phosgenation is complete, the phosgene and the inert organic solvent then being removed, up to 5% by weight, based on the weight of crude MDI, of at least one phenol-based antioxidant and/or aryl phosphite being added, if desired to the reaction product, and the reaction mixture being heated.
    Type: Grant
    Filed: June 28, 1991
    Date of Patent: May 4, 1993
    Assignee: BASF Aktiengesellschaft
    Inventors: Dietrich Scherzer, Roland Minges, Bernd Bruchmann, Wolfgang Heider, Willy van Pee, Peter Keller
  • Patent number: 5208366
    Abstract: An improved process is provided for the preparation of esters of polyhalophthalic acids, polyhalobenzoic acids, and polyhalophthalic anhydride useful as flame retardants for thermoplastic and thermosetting resins, which comprises the reaction of the above acids or anhydride with alcohols in the presence of certain metal and metallorganic compounds as catalysts. Also provided are certain esters per se.
    Type: Grant
    Filed: August 19, 1991
    Date of Patent: May 4, 1993
    Assignee: Elf Atochem North America, Inc.
    Inventors: Joseph M. Bohen, Anthony J. Mancuso
  • Patent number: 5206417
    Abstract: The ethylenically unsaturated organic compounds are of the general formula ##STR1## where R is alkyl, aryl or a radical R.sup.1, and R.sup.1 is a radical ##STR2## where R.sup.2 to R.sup.6 are each H, alkyl, OH, Oalkyl, SH, Salkyl, halogen, N(alkyl).sub.2 or N(alkyl)(aryl), and not less than one but not more than three of the radicals R.sup.2 to R.sup.6 are each a radical ##STR3## where X is alkylene or oxaalkylene, each of 2 to 10 carbon atoms, and Y is H or CH.sub.3. These compounds have particularly high photochemical reactivity in the medium-wavelength to relatively long-wavelength UV range.
    Type: Grant
    Filed: December 18, 1991
    Date of Patent: April 27, 1993
    Inventors: Andreas Boettcher, Gerd Rehmer
  • Patent number: 5206418
    Abstract: The invention relates to aminotetrahydronaphthalene derivatives which are intermediates for the preparation of sulfonylaminotetrahydronaphthalenes.
    Type: Grant
    Filed: March 13, 1992
    Date of Patent: April 27, 1993
    Assignee: Tanabe Seiyaku Co., Ltd.
    Inventors: Hideo Nakai, Toyoharu Yamashita, Harumichi Kohno, Yasuhiko Sasaki, Akio Odawara
  • Patent number: 5202469
    Abstract: Partially fluorinated dicarboxylic acid and the acid chloride thereof, a process for its preparation and its use.The compound of the formula (I) ##STR1## and the acid chloride thereof are prepared by air oxidation in the presence of a catalyst mixture composed of the ions of cobalt, manganese and bromine in an acid organic medium. The compounds can be used for the preparation of linear polycarboxamides and polycarboxylic acid esters.
    Type: Grant
    Filed: June 20, 1991
    Date of Patent: April 13, 1993
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Freimund Rohrscheid, Wolfgang Appel, Gunter Siegemund
  • Patent number: 5202470
    Abstract: The invention provides a compound of the formula[NH.sub.2 NH.sub.2 ].sub.a [C.sub.6 H.sub.3 (COOH) (SO.sub.3 H) (OH)].sub.bwhereina is 1 andb is from 1 to 2.The compound is useful for stabilizing tin (II) compounds against oxidation, in particular in the electrolytic coloring of aluminium or aluminium alloys.
    Type: Grant
    Filed: November 19, 1990
    Date of Patent: April 13, 1993
    Inventor: Erich Ruf
  • Patent number: 5200555
    Abstract: The invention relates to a process for the preparation of S(+)-6-methoxy-.alpha.-methyl-2-naphthalene-acetic acid by resolution of R,S-6-methoxy-.alpha.-methyl-2-naphthalene-acetic acid. According to the invention R,S-6-methoxy-.alpha.-methyl-2-naphthalene-acetic acid and R(-)-2-amino-1-butanol are dissolved in water at 40.degree.-60.degree. C. Then the solution thus obtained is cooled to 25.degree.-35.degree. C. Subsequently the obtained solution is grafted with a salt of S(+)-6-methoxy-.alpha.-methyl-2-naphthalene-acetic acid and R(-)-2-amino-1-butanol, further it is cooled to 5.degree.-15.degree. C. The thereby formed crystals are separated from the solution and washed with water and subsequently hydrolyzed by adding a strong acid, whereby S(+)-6-methoxy-.alpha.-methyl-2-naphthalene-acetic acid crystallizes and the obtained crystals are separated from the mother liquor and the R(-)-6-methoxy-.alpha.
    Type: Grant
    Filed: July 23, 1991
    Date of Patent: April 6, 1993
    Assignee: Westpur Investment Limited
    Inventor: Gerard Kessels
  • Patent number: 5200551
    Abstract: The present invention relates to an improved method for the preparation of an intermediate for bambuterol, i.e. for the preparation of 2'-bromo-3,5-di[N,N-dimethylcarbamoyloxy]acetophenone (1), by reacting 3,5-dihydroxyacetophenone with N,N-dimethylcarbamoylchloride in ethyl acetate, isopropylacetate, butylacetate, ethylmethylketone or isobutylmethylketone as a solvent with small amount of pyridine as a catalyst and using crystallized potassium carbonate as a base, quenching with water, removing the solvent and dissolving of the resulting 3,5-di[N,N-dimethylcarbamoyloxy]acetophenone in ethyl acetate, to which dissolved hydrogen bromide is added and then bromine, whereupon the resulting intermediate (1) is collected in the form of crystals.
    Type: Grant
    Filed: July 31, 1991
    Date of Patent: April 6, 1993
    Assignee: Aktiebolaget Astra
    Inventor: Peter Jaksch
  • Patent number: 5200557
    Abstract: A process is disclosed for counter-current positive displacement of an aliphatic carboxylic acid of 1 to 5 carbon atoms from a filter cake of an aromatic polycarboxylic acid containing the aliphatic carboxylic acid wherein mother liquor retained by the aromatic polycarboxylic acid has a concentration of the aliphatic carboxylic acid of 5000 ppmw, or less, based upon weight of the aromatic polycarboxylic acid present. This method is useful for the manufacture of crude terephthalic acid which is used after purification for the preparation of polyesters used for the manufacture of fabrics, fibers and plastic bottles.
    Type: Grant
    Filed: January 15, 1992
    Date of Patent: April 6, 1993
    Assignee: Amoco Corporation
    Inventors: John C. Gee, Jeffrey I. Rosenfeld, Thomas M. Bartos
  • Patent number: 5198548
    Abstract: A process for the preparation of D(-) and L(+)-3,3-diphenylalanine and D(-) and L(+)-substituted 3,3-diphenylalanines is described where N-protected DL-3,3-diphenylalanine or N-protected-DL-substituted 3,3-diphenylalanine are treated with (-)cinchonidine and the resulting salt resolved into the desired enantiomers, as well as derivatives thereof and valuable intermediates used in the process.
    Type: Grant
    Filed: January 30, 1992
    Date of Patent: March 30, 1993
    Assignee: Warner-Lambert Company
    Inventors: Vladimir Beylin, Huai G. Chen, Om P. Goel, John G. Topliss