Patents Examined by William H. Beisner
  • Patent number: 10834919
    Abstract: A cryopreservation instrument and method of using is provided. The instrument includes a substantially planar elongated member comprising a cryosafe material. The elongated member has a first end and a second end. The first end comprises a cap insert dimensioned and configured to be fit in the interior recess of a vial cap, the second end comprises a biological contact portion configured to accommodate biological material.
    Type: Grant
    Filed: September 2, 2015
    Date of Patent: November 17, 2020
    Assignee: Research Institute at Nationwide Children's Hospital
    Inventor: Kenneth John McLaughlin
  • Patent number: 10836991
    Abstract: The present disclosure is directed to systems and methods for sampling and/or controlling the productivity of a bioreactor. The system and methods can include a vessel capable of providing an environment suitable for containing whole broth that can produce the bioproduct, wherein the whole broth contains media and at least one undissolved species, an automated sampling system, a first analytical instrument, and a control system.
    Type: Grant
    Filed: August 30, 2019
    Date of Patent: November 17, 2020
    Assignee: Bend Research, Inc.
    Inventors: Roderick J. Ray, Adam S. Carroll, Brandon J. Downey, Lisa J. Graham
  • Patent number: 10821435
    Abstract: In a nucleic acid detection cassette, a predetermined syringe is crushed to supply a sample solution to an amplification unit via a channel and the amplification unit is heated from outside to amplify sample DNA in the sample solution. The sample solution containing an amplification product is supplied to a detection unit via the channel and a hybridization reaction occurs in the detection unit. Next, another syringe is crushed and an intercalating agent solution is supplied via another predetermined channel. Therefore, a nucleic acid detection cassette capable of automation from amplification of a sample to detection of an electrochemical reaction of the sample is provided.
    Type: Grant
    Filed: March 2, 2017
    Date of Patent: November 3, 2020
    Assignee: Canon Medical Systems Corporation
    Inventors: Jun Okada, Masayuki Yumoto, Kenichi Arame, Tetsuya Kuwabara, Hiroaki Kushima, Hirotaka Unno
  • Patent number: 10822633
    Abstract: A sampling device and a method for taking samples. The sampling device includes a cap having two ends and a collection sponge attached on one end, wherein a collection sponge diameter is greater than a collection sponge height. A lid is removably attached to a first end of the cap to cover the collection sponge; and a bowl is removably attached to a second and opposite end of the cap. The bowl can contain an enrichment broth.
    Type: Grant
    Filed: November 13, 2017
    Date of Patent: November 3, 2020
    Inventor: N. Robert Ward
  • Patent number: 10822289
    Abstract: The disclosure relates to a composting device including a housing defining an interior with an access opening providing access to the interior, a composter bin located within the interior and in communication with the access opening, and a funnel assembly integrated with the access opening.
    Type: Grant
    Filed: November 21, 2019
    Date of Patent: November 3, 2020
    Assignee: Whirlpool Corporation
    Inventors: Abhishek P. Buzruk, Christopher C. Wilcox, Michael S. Seeley
  • Patent number: 10814321
    Abstract: At least one exemplary embodiment of the invention is directed to a molecular diagnostic device that comprises a cartridge configured to eject samples comprising genomic material into a microfluidic chip that comprises an amplification area, a detection area, and a matrix analysis area.
    Type: Grant
    Filed: June 4, 2018
    Date of Patent: October 27, 2020
    Assignee: Canon U.S.A., Inc.
    Inventors: Hiroshi Inoue, Ivor T. Knight, Gregory A. Dale, Rita R. Colwell
  • Patent number: 10816542
    Abstract: A tear glucose measuring device includes a tear glucose test strip (101) and a reaction device, wherein the tear glucose test strip (101) is used for collecting tears which are then subjected to an elution reaction with a glucose assay reagent contained in the reaction device. With this device, a user can collect tears by himself by folding a leading portion (1014) of the tear glucose test strip (101) about a folding line (1021) and inserting the leading portion (1014) into the lower conjunctival sac inside the lower eyelid to allow the absorbance of tears therein. If tear glucose test strips (101) of the same lot are consistent in terms of thickness of a moisture-absorbent layer of the leading portion (1014), as long as a tear collection region (1020) of the leading portion (1014) has a fixed area, the leading portion (1014) can collect a quantitative amount of tears.
    Type: Grant
    Filed: January 13, 2016
    Date of Patent: October 27, 2020
    Inventor: Jianhui He
  • Patent number: 10808267
    Abstract: Provided is a novel production system that does not involve, or can minimize, the transport of liquid ammonia in the production of an organic compound or the production of a microorganism by microbial fermentation. A production system for an organic compound or a microorganism includes: an ammonia synthesis apparatus in which an ammonia-containing gas is synthesized by reaction of a source gas containing hydrogen and nitrogen in the presence of a supported ruthenium catalyst; and a culture apparatus that cultures a microorganism having organic compound productivity using ammonia originating from the ammonia-containing gas obtained by using the ammonia synthesis apparatus.
    Type: Grant
    Filed: August 11, 2017
    Date of Patent: October 20, 2020
    Assignees: Ajinomoto Co., Inc., Tokyo Institute of Technology
    Inventors: Mitsuhiro Kishino, Hiroyuki Kojima, Hideo Hosono, Michikazu Hara, Masaaki Kitano, Toshiharu Yokoyama, Toru Numaguchi, Munenobu Ito, Kazuteru Yamada, Hiromi Noguchi
  • Patent number: 10801004
    Abstract: The invention provides a device for growing cells—referred to as a cassette. The cell culturing device includes a housing that contains a lid having an optically clear window; a fluid distribution channel; a sample injection port fluidically connected to the fluid distribution channel; a base housing a porous media pad; and a media injection port fluidically connected to the media pad. The lid mates to the base to form a sterile seal; the fluid distribution channel is disposed over the media pad, which is viewable through the optical window; and sample fluid introduced into the fluid distribution channel is distributed evenly to the media pad, e.g., via a plurality of channels. The invention also provides kits that include cassettes of the invention and a tube set.
    Type: Grant
    Filed: August 28, 2017
    Date of Patent: October 13, 2020
    Assignee: Rapid Micro Biosystems, Inc.
    Inventors: Robert C. Aviles, Devin T. Michaud, Douglas J. Browne
  • Patent number: 10793816
    Abstract: A dual chamber bioreactor for producing complex, multilayer tissue, organs, organ parts, and skin replacements has been developed. The bioreactor is modular and incorporates a removable tissue culture cassette. By rotating the dual chamber bioreactor along the horizontal axis, different populations of cells with different growth requirements can be cultured on the different surfaces of the tissue culture cassette that are exposed to different media reservoirs. Culturing different populations of cells on different surfaces of the tissue culture cassette enables the production of multilayer tissue and organs. The tissue culture cassette can contain one or more discrete tissue culture sections.
    Type: Grant
    Filed: August 29, 2014
    Date of Patent: October 6, 2020
    Inventors: Paul M. Weinberger, Frederick A. Rueggeberg, Donald J. Mettenburg, Tanner Mobley
  • Patent number: 10793822
    Abstract: A means capable of simply and efficiently concentrating a cell suspension. A concentrator has a culture vessel having a first port and a second port, a server bag having a port, a case having a hollow fiber bundle in the internal space, a filtering device having an inlet port, a first outlet port, and a second outlet port, a collection vessel having a port, a liquid supply circuit connected to the first port, the inlet port, and the server bag's port so that flow passages are switchable, a liquid discharge circuit connected to the second port, the first outlet port, the second outlet port, and the collection vessel's port so that flow passages are switchable, a liquid supply mechanism having a switching mechanism, a supply pump, and a discharge pump, and a rotation mechanism rotating the filtering device.
    Type: Grant
    Filed: May 24, 2016
    Date of Patent: October 6, 2020
    Inventors: Norihisa Sasayama, Masakatsu Takeuchi, Atsushi Taguchi
  • Patent number: 10787636
    Abstract: The present invention relates to a non-powered constant-temperature cell transfer device, in which a first container, which accommodates living animal cells and a culture solution, is accommodated in a second container having a heat generating unit that emits heat generated by oxidation and reduction reactions of metal by introducing oxygen in the atmosphere in order to continuously provide an optimum culture temperature to a culture container even without being supplied with electric power, thereby maintaining activity and viability of the cells by maintaining a culture environment optimal for proliferation of the cells accommodated in the first container.
    Type: Grant
    Filed: September 15, 2017
    Date of Patent: September 29, 2020
    Inventor: Hyo Young Lee
  • Patent number: 10774296
    Abstract: Cell culture devices are described herein that have notched lids, notched lids with corresponding gripping pads included on their bases, or gripping tabs included on their bases to minimize or eliminate the need for a user to contact a lid when attempting to lift or move a lidded cell culture device. In addition, methods for using the cell culture devices are also described herein.
    Type: Grant
    Filed: March 31, 2017
    Date of Patent: September 15, 2020
    Assignee: Corning Incorporated
    Inventors: Thomas Landon Carter, Gregory Scott Jordan
  • Patent number: 10775400
    Abstract: The invention relates to a feeding system (10) having a feeding apparatus (30) for conveying laboratory vessels for samples, microorganisms, cell cultures or the like, and a carrier (12) having one or plural holders (16) for storing laboratory vessels, which feeding apparatus (30) has a loading area (36) and an unloading area (46) remote from the loading area (36) in which plural laboratory vessels can be stored in a vertically stacked configuration, with each receiving unit (34) being coupled to an endless conveyor unit (38) which transports the receiving unit (34) from the loading area (36) to the unloading area (46), and in which the carrier (12) can be used to introduce laboratory vessels into one or plural receiving units (34) in the loading area (36), for which purpose the carrier (12) is at least partially slid over the at least one receiving unit (34) which is to be loaded or unloaded, and for this purpose has projections (28, 32) and/or recesses that are associated with the carrier (12) and are provi
    Type: Grant
    Filed: February 24, 2017
    Date of Patent: September 15, 2020
    Inventor: Klaus-Guenter Eberle
  • Patent number: 10760042
    Abstract: The present invention is directed to a method and automated transfer means for transferring a container within an apparatus. The apparatus of the present invention may include a means for automated loading, a means for automated transfer and/or a means for automated unloading of a container (e.g., a specimen container). In one embodiment, the apparatus can be an automated detection apparatus for rapid non-invasive detection of a microbial agent in a test sample. The detection system also including a heated enclosure, a holding means or rack, and/or a detection unit for monitoring and/or interrogating the specimen container to detect whether the container is positive for the presence of a microbial agent. In other embodiment, the automated instrument may include one or more, bar code readers, scanners, cameras, and/or weighing stations to aid in scanning, reading, imaging and weighing of specimen containers within the system.
    Type: Grant
    Filed: September 1, 2015
    Date of Patent: September 1, 2020
    Assignee: bioMerieux, Inc.
    Inventors: James Clement Bishop, Mark Joseph Fanning, Lawrence E Guerra
  • Patent number: 10760040
    Abstract: A transfection device suitable for delivery of various macrostructures (e.g., mitochondria, bacteria, liposomes) is described and uses mechanical force to thereby induce active endocytosis in a target cell. Contemplated devices are able to achieve high throughput of transfected cells that remain viable and are capable of producing colonies.
    Type: Grant
    Filed: June 29, 2015
    Date of Patent: September 1, 2020
    Assignee: NANOCAV, LLC
    Inventor: Ting Wu
  • Patent number: 10745659
    Abstract: A culture container for activating lymphocytes includes immobilized anti-CD3 antibodies and an anti-CD3 antibody solution including anti-CD3 antibodies, wherein the culture container is formed in a bag-like shape and is formed of a soft-packaging material, the immobilized anti-CD3 antibodies are immobilized at a density of 10 to 300 ng/cm2 on one surface of opposing inner surfaces within the container, and the anti-CD3 antibody solution is enclosed in the container in an amount of 0.25 to 400 ng of the anti-CD3 antibodies in 0.1 to 800 ?l of the solution per 1 cm2 of a culture surface formed of the one surface.
    Type: Grant
    Filed: June 20, 2017
    Date of Patent: August 18, 2020
    Inventors: Takahiko Totani, Satoshi Tanaka
  • Patent number: 10738342
    Abstract: Several microfluidic chips are used to significantly accelerate the time to identify and quantify microbes in a biological sample and test them for antibiotic resistance, particularly for urinary tract infections. A first microfluidic chip uses antibody or similar probes to identify and quantify any microbes present. The same or a similar chip uses antibody or similar probes to identify microbes with DNA or RNA known to indicate antibiotic resistance. Another microfluidic chip tests for antibiotic susceptibility of any microbes by growing them in very small wells in the presence of antibiotics, reducing the time required for such testing by as much as 95%. Another microfluidic chip runs traditional urinalysis or similar tests.
    Type: Grant
    Filed: August 26, 2019
    Date of Patent: August 11, 2020
    Assignee: Urinary Technologies, Inc.
    Inventors: Michael D. Finch, Kee Onn Fong, Saurabh Kotian, Cyrus B. Munshi, Advitiya Mahajan, Beth A. Lindborg
  • Patent number: 10739364
    Abstract: Provided are a liquid surface inspection device, an automated analysis device, and a liquid surface inspection method with which instances of contamination can be minimized and the accuracy of the manner in which the surface conditions, such as bubbles or the like, of a liquid substance are detected can be enhanced. The device has: a light illumination unit for illuminating a container holding a liquid substance, as well as the surface of the liquid substance, with light; an image capture unit for acquiring a video image having at least color information and brightness information of light from the container and the liquid substance which are illuminated by the light illumination unit; and a detection unit for using the color information and brightness information in the video image captured by the image capture unit to detect the condition of the liquid surface.
    Type: Grant
    Filed: January 8, 2016
    Date of Patent: August 11, 2020
    Inventors: Yoshimichi Satou, Yoichiro Suzuki, Yuichi Abe
  • Patent number: 10738270
    Abstract: Microfluidic devices and methods for perfusing a cell with perfusion fluid are provided herein, wherein the gravitational forces acting on the cell to keep the cell at or near a retainer or a retaining position exceed the hydrodynamic forces acting on the cell to move it toward an outlet. Also provided, are methods for assaying cell products within the microfluidic device.
    Type: Grant
    Filed: March 13, 2020
    Date of Patent: August 11, 2020
    Assignee: The University of British Columbia
    Inventors: Carl L. G. Hansen, Veronique Lecault, James M. Piret, Anupam Singhal