Patents Examined by Xiaoyan Zou
-
Patent number: 11691144Abstract: There is provided an assembly, useable to screen sample fluids for predefined molecules, the comprising, a needle unit comprising n hollow needles, wherein n is greater than one; a flow cell unit comprising m flow cells, wherein m is greater than one, each flow cell having an input and an output, and a test surface on which ligands can be provided; a first selector valve unit which is fluidly connected between the needle unit and flow cell unit, which is operable to selectively fluidly connect any one of the n hollow needles with the m flow cells in the flow cell unit; a pumping means which is selectively operable to provide negative pressure; a second selector valve unit which is fluidly connected between the pumping means and the output of each flow cell. There are further provided methods of screening sample fluids for predefined molecule.Type: GrantFiled: December 13, 2018Date of Patent: July 4, 2023Assignee: Creoptix AGInventor: Kaspar Cottier
-
Patent number: 11693002Abstract: A method for image analysis of medical test results, comprising receiving information from a mobile device application regarding a test performed using a testing device, wherein the testing device includes a plurality of immunoassay test strips and at least one test function indicator on a surface thereof, wherein the mobile device application is configured to recognize the at least one test function indicator to trigger performance of one or more of the plurality of medical test functions, receiving at the server an image of the testing device from the mobile device application, determining by the server RGB values for a plurality of pixels of the image, normalizing by the server the RGB values into a single value, comparing the single value to a control value, and providing by the server a risk indicator, wherein the risk indicator indicates a likelihood of a presence of a medical condition.Type: GrantFiled: November 6, 2017Date of Patent: July 4, 2023Assignee: RELIANT IMMUNE DIAGNOSTICS, INC.Inventors: Jovan Hutton Pulitzer, Henry Joseph Legere, III
-
Patent number: 11684919Abstract: Methods for screening a plurality of sample fluids for molecules which can bind to predefined ligands, comprising, selecting one of a plurality of flow cell groups by fluidly connecting the selected flow cell group to a sample delivery unit; injecting a sample fluid to be screened from the sample delivery unit into the flow cells in the selected flow cell group; for each flow cell in the selected flow cell group, recording a signal using a sensor which represents the binding and/or the dissociation of molecules of the sample fluid to/from ligands on the test surface of that flow cell; carrying out a damage assessment step using said recorded signals; if it is determined that the test surface of a flow cell in the selected flow cell group is damaged, then fluidly connecting the other flow cell group to the sample delivery unit. There is further provided assemblies which can be used to implement the afore-mentioned methods.Type: GrantFiled: December 13, 2018Date of Patent: June 27, 2023Assignee: Creoptix AGInventor: Kaspar Cottier
-
Patent number: 11655458Abstract: Embodiments of the present disclosure provide a target capturing apparatus and a manufacturing method thereof, and a target detecting method. The target capturing apparatus includes a cavity structure, the cavity structure includes: an inlet portion, an outlet portion and a capture region positioned between the inlet portion and the outlet portion, and the capture region includes a capture component, and a combination specifically combined with a to-be-captured target is included in the capture component so as to capture the target in a sample entering the cavity structure.Type: GrantFiled: October 17, 2018Date of Patent: May 23, 2023Assignee: BOE TECHNOLOGY GROUP CO., LTD.Inventor: Defeng Mao
-
Patent number: 11635430Abstract: An expanded polytetrafluoroethylene substrate comprising a microporous microstructure, an interlayer over at least a portion of the microstructure, the interlayer containing a reactive functionality, and a functional layer attached to the interlayer, the interlayer comprising a sol-gel or a polyvinylalcohol. The functional layer of the substrate having functional sites with a density of at least 50 nanomoles/cm2.Type: GrantFiled: January 31, 2019Date of Patent: April 25, 2023Assignee: W. L. Gore & Associates, Inc.Inventors: Anit Dutta, Heidi Flannery, William P. Mortimer, Jr.
-
Patent number: 11614446Abstract: To provide an immunochromatographic test device capable of accurate diagnosis even when an excess sample is introduced. Provided is the immunochromatographic test device consisting: a test strip; a lower housing including a plurality of support bases that support the test strip; and an upper housing including a dropping hole for dropping a sample into the test strip and a detection window in a direction in which the sample introduced from the dropping hole develops on the test strip, wherein a width of the support base that supports portion of the test strip exposed from the detection window is smaller than a width of the test strip, or wherein among the plurality of support bases, the width of the support base arranged on the lower housing between a position corresponding to the detection window and a position corresponding to the dropping hole is larger than the width of the test strip.Type: GrantFiled: December 14, 2018Date of Patent: March 28, 2023Assignee: SEKISUI MEDICAL CO., LTD.Inventors: Kanako Azuma, Shinya Okuyama, Kazunori Saito, Keigo Kohno, Motoki Morita
-
Patent number: 11585882Abstract: Superparamagnetic nanoparticle-based analytical method comprising providing a sample having analytes in a sample matrix, providing a point of care chip having analytical regions, each of which is a stationary phase having at least one or more sections, labeling each of the analytes with a superparamagnetic nanoparticle and immobilizing the labeled analytes in the stationary phase, providing an analytical device having a means for exciting the superparamagnetic nanoparticles in vitro and a means for sensing, receiving, and transmitting response of the excited superparamagnetic nanoparticles, placing the chip in the analytical device and exciting the superparamagnetic nanoparticles in vitro, sensing, receiving, and transmitting the response of the superparamagnetic nanoparticles, and analyzing the response and determining characteristic of the analytes, wherein the response of the superparamagnetic nanoparticles comprises harmonics.Type: GrantFiled: April 9, 2019Date of Patent: February 21, 2023Assignee: Mars Sciences LimitedInventors: Ronald T. Laborde, Yu Ge, Kevin N. Walda
-
Patent number: 11585733Abstract: Contamination detection systems, kits, and techniques are described for testing surfaces for the presence of hazardous contaminants, while minimizing user exposure to these contaminants. Even trace amounts of contaminants can be detected. A collection kit provides a swab that is simple to use, easy to hold and grip, allows the user to swab large areas of a surface, and keeps the user's hands away from the surface being tested. The kit also provides open and closed fluid transfer mechanism to transfer the collected fluid to a detection device while minimizing user exposure to hazardous contaminants in the collected fluid. Contamination detection kits can rapidly collect and detect hazardous drugs, including trace amounts of antineoplastic agents, in healthcare settings at the site of contamination.Type: GrantFiled: September 18, 2018Date of Patent: February 21, 2023Assignee: Becton, Dickinson and CompanyInventors: Weston F. Harding, Erik K. Witt, Austin Jason McKinnon, Ray Isaacson, Bart Peterson, Marcel Arantes Souza, Matthew Oshinski
-
Patent number: 11531028Abstract: An antibody specifically reactive with an epitope of collagen type X alpha 1 comprised in the NC1 domain C-terminal amino acid sequence SFSGFLVAPM-COOH (SEQ ID NO: 1), and a method of immunoassay for detecting in a biological sample an epitope in the NC1 domain C-terminal amino acid sequence SFSGFLVAPM-COOH (SEQ ID NO: 1) of collagen type X alpha 1, by contacting the biological sample with the antibody, and determining the amount of binding of the antibody.Type: GrantFiled: February 1, 2020Date of Patent: December 20, 2022Assignee: Nordic Bioscience A/SInventors: Anne Christine Bay-Jensen, Yi He, Morten Karsdal
-
Patent number: 11513115Abstract: The present application discloses methods and apparatus for detecting a complex including an analyte that include contacting a sample in a solution with a population of functionalized beads of a first type, which are magnetic functionalized beads and are functionalized to include a first moiety that associates with an analyte under suitable conditions, contacting the sample solution with a population of functionalized beads of a second type, which are functionalized to include a second moiety that associates with the analyte under suitable conditions, contact resulting in formation of a complex including one of the first type of functionalized bead, the analyte, and one of the second type of functionalized bead, and detecting the complex including the analyte by detecting magnetic fields produced by the magnetic functionalized bead and by detecting the functionalized bead of the second type associated with the analyte in the complex.Type: GrantFiled: December 22, 2017Date of Patent: November 29, 2022Assignee: Quantum Diamond Technologies Inc.Inventors: Colin B. Connolly, Jeffrey D. Randall, John C. Pena
-
Patent number: 11504714Abstract: A system and method for isolating and analyzing single cells, wherein the system includes: an array of wells defined at a substrate, each well including an open surface and a well cavity configured to capture cells in one of a single-cell format and single-cluster format, and a fluid delivery module including a fluid reservoir superior to the array of wells through which fluid flow is controlled along a fluid path in a direction parallel to the broad face of the substrate; and wherein the method includes: capturing a population of non-cell particles into the array of wells in single-particle format; releasing, from the non-cell particles, a set of probes into the array of wells; capturing a population of cells into the array of wells in single-cell format; releasing biomolecules from each captured cell into the array of wells; and generating a set of genetic complexes comprising the biomolecules associated with a single captured cell and a subset of probes within individual wells of the array of wells.Type: GrantFiled: February 13, 2020Date of Patent: November 22, 2022Assignee: Bio-Rad Laboratories, Inc.Inventors: Kalyan Handique, Vishal Sharma, Priyadarshini Gogoi, William Chow, Austin Payne, Kyle Gleason, Brian Boniface, John Connolly, Sam Tuck
-
Patent number: 11493507Abstract: An immunoassay for the detection of an analyte in a sample includes a plurality of moieties capable of binding to the analyte. Capture moieties, which are not specific for the same epitope, are bound to a solid substrate, and at least one epitope-specific detection moiety is bound to a detectable marker. The detectable marker is a large particle marker having a particle size of ?50 nm and ?5000 nm.Type: GrantFiled: September 7, 2010Date of Patent: November 8, 2022Assignee: Siemens Healthineers Nederland B.V.Inventors: Wendy Uyen Dittmer, Toon Hendrik Evers, Marco Hendrikus Hefti, David Walterus Cornelis Dekkers, Michael Franciscus Wilhelmus Cornelis Martens
-
Patent number: 11467163Abstract: The present invention describes methods of determining the glycosylation signature and determining the level of a protein in a sample obtained from a patient. The present invention also describes use of a patient protein glycosylation profile to identify the presence or absence of a disease in subjects.Type: GrantFiled: December 23, 2016Date of Patent: October 11, 2022Assignees: Randox Laboratories Ltd.Inventors: Ivan McConnell, Peter Fitzgerald, John Lamont, Ciaran Richardson
-
Patent number: 11391748Abstract: Aspects of the disclosure relate to lateral flow assays having a number of different detection zones tuned to extend the dynamic range of the assay in indicating concentration of a hazardous contaminant in a test sample. Some aspects relate to assay reader devices configured with instructions to generate a result representing the concentration of the hazardous contaminant in the test sample based on some or all of the detection zones.Type: GrantFiled: September 18, 2018Date of Patent: July 19, 2022Assignee: Becton, Dickinson and CompanyInventors: Ray Isaacson, Brian Patrick Dwyer, Austin Jason Mckinnon
-
Patent number: 11353453Abstract: Provided are: a coloring cellulose microparticle enabling false positive to be significantly reduced while maintaining a high detection sensitivity; and an immunochromatographic diagnostic kit using the same.Type: GrantFiled: March 28, 2018Date of Patent: June 7, 2022Assignee: Asahi Kasei Kabushiki KaishaInventors: Yoshiyuki Shiomi, Atsushi Horii, Takeshi Matsuse, Ken Muraoka
-
Patent number: 11353451Abstract: The present invention relates to a test system or an assay system (detection system) and test method preferably for use in the Point-of-Care (PoC) field.Type: GrantFiled: December 27, 2018Date of Patent: June 7, 2022Assignee: DTS DIAGNOSTISCHE SYSTEME & TECHNOLOGIEN GMBHInventors: Marc Dangers, René Rübenhagen
-
Patent number: 11346839Abstract: The disclosure concerns a method for determining the interaction between a test compound and a receptor. The receptor may be immobilized. The disclosure also concerns a sample holder assembly including a functionalized test well wall, which may be used in combination with a Total Internal Reflection Fluorescence source.Type: GrantFiled: August 2, 2019Date of Patent: May 31, 2022Assignee: INSINGULO ABInventors: Tim Kaminski, Fredrik Höök
-
Patent number: 11325984Abstract: The present invention relates to methods for separating target cells from non-target cells using immunorosettes and magnetic particles. The method involves contacting a sample containing target cells and secondary targets such as erythrocytes with an antibody composition which allows immunorosettes of the target cells and the secondary targets to form. The sample is subsequently contacted with a second antibody composition which allows the binding of magnetic particles to the formed immunorosettes and free secondary targets. The immunorosettes and secondary targets labeled with magnetic particles are separated from non-target cells using a magnetic field. The antibody composition optionally contains bifunctional antibodies or tetrameric antibody complexes.Type: GrantFiled: August 22, 2018Date of Patent: May 10, 2022Assignee: StemCell Technologies Inc.Inventor: Andy Isamu Kokaji
-
Patent number: 11293923Abstract: The invention includes a bioelectronic interface comprising a self-assembling unit, wherein the self-assembling unit comprises a variant GPCR fusion protein bound to an S-layer fusion protein. The invention also encompasses a biosensor or device comprising the bioelectronic interface and methods of screening for a ligand of a GPCR.Type: GrantFiled: August 31, 2018Date of Patent: April 5, 2022Assignee: Massachusetts Institute of TechnologyInventors: Shuguang Zhang, Rui Qing, Andreas Breitwieser, Uwe Sleytr
-
Patent number: 11280782Abstract: Disclosed is a sensor chip for detecting a target molecule in a sample. The sensor chip includes a substrate having a surface and a layer of hydrogel particles immobilized on the substrate surface at two or more locations on the surface, wherein the hydrogel particles at a first location comprise a plurality of first probe molecules bound to the particles and the hydrogel particles at a second location comprise a plurality of second probe molecules bound to the particles. Systems that include the sensor chip, as well as methods of preparing and using the sensor chip, are also disclosed.Type: GrantFiled: February 8, 2016Date of Patent: March 22, 2022Assignee: UNIVERSITY OF ROCHESTERInventors: Benjamin L. Miller, Mark A. Lifson, Jared A. Carter