Patents Examined by Yelena G. Gakh
  • Patent number: 10035147
    Abstract: An embodiment of the invention relates to a wafer comprising a plurality of biochips and interconnects on the wafer, the biochip comprising a biochip pad, a synthesis electrode and a gel comprising a probe, wherein a plurality of the biochip pads of the plurality of the biochips are interconnected by the interconnects to carry out a chemical reaction on a plurality of the synthesis electrodes.
    Type: Grant
    Filed: December 31, 2014
    Date of Patent: July 31, 2018
    Assignee: Intel Corporation
    Inventors: Valery M. Dubin, Nikolay Suetin
  • Patent number: 9977004
    Abstract: Systems and methods are provided for measuring the amount of cationic organic water treatment additives in water systems. Disclosed systems and methods monitor, analyze and control the amounts of cationic organic water treatment additive supplied to the water. Disclosed systems and methods may include various dyes and surfactants for facilitating the monitoring and control of the cationic organic water treatment additives.
    Type: Grant
    Filed: December 22, 2014
    Date of Patent: May 22, 2018
    Assignee: CHEMTREAT, INC.
    Inventors: John Richardson, Douglas McIlwaine, Benjamin Niemaseck
  • Patent number: 9964531
    Abstract: Disclosed herein are host or receptor compounds that bind targets of interest. In one embodiment the compounds bind ions, such as metal ions. A compound, or a protonate or salt thereof, having the formula of: Formula IIa wherein R6 is an aminoalkoxy, alkylamino, nitro or —NH2; n is 1 or 2; each R2 is independently selected from an optionally substituted alkyl, halogen, optionally substituted alkoxy, optionally substituted carboxyl, or amide; a is 0 to 4.
    Type: Grant
    Filed: January 21, 2014
    Date of Patent: May 8, 2018
    Assignee: University of Oregon
    Inventors: Michael M. Haley, Darren W. Johnson, Jeff Engle, Calden Carroll
  • Patent number: 9952228
    Abstract: A method for detecting adrenocorticotropic hormone comprising: bringing a liquid sample containing adrenocorticotropic hormone into contact with gelled casein to adsorb adrenocorticotropic hormone to the gelled casein; and detecting the adrenocorticotropic hormone adsorbed to the gelled casein is disclosed. An adsorbent of adrenocorticotropic hormone comprising gelled casein is also disclosed.
    Type: Grant
    Filed: January 11, 2013
    Date of Patent: April 24, 2018
    Assignee: Sysmex Corporation
    Inventor: Rena Tsuruoka
  • Patent number: 9952134
    Abstract: An analytical instrument for cellular analysis of cellular particles tagged with elemental tags, such as lanthanide-based elemental tags. The analytical instrument has a sample introduction system for generating a stream of particles from the sample. An inductively coupled plasma ionization system atomizes and ionizes particles in the stream as they are received. The instrument has an ion pretreatment system and a mass analyzer. The ion pretreatment system is adapted to transport ions generated by the ionization system to the mass analyzer. The ion pretreatment system can filter out low mass ions, such as using a high-pass mass filter or a bandpass mass filter, to allow the elemental tags to pass therethrough. The mass analyzer is adapted to measure the amount of at least one element in individual particles from the stream by performing mass analysis on the ions from the atomized particles.
    Type: Grant
    Filed: November 11, 2011
    Date of Patent: April 24, 2018
    Assignee: Fluidigm Corporation
    Inventors: Dmitry R. Bandura, Vladimir I. Baranov, Scott D. Tanner
  • Patent number: 9952157
    Abstract: Methods for reliable identification of low-contrast lesions within a tissue of a subject comprise delivering an excitation signal to the tissue, wherein the excitation signal is selected to stimulate tissue to produce autofluorescence and/or reflectance. The autofluorescence and/or reflectance is detected, and ratiometric images are produced based on the autofluorescence and/or reflectance images. An imaging system is provided which is configured to carry out such methods, irradiating tissue at a various possible excitation wavelengths, such as UV excitation wavelengths below 300 nm, to elicit fluorescence from specific native fluorophores.
    Type: Grant
    Filed: July 16, 2013
    Date of Patent: April 24, 2018
    Assignee: The Arizona Board of Regents on behalf of the University of Arizona
    Inventors: Urs Utzinger, Bhaskar Banerjee, Timothy E. Renkoski, Nathaniel S. Rial, Logan Graves
  • Patent number: 9945774
    Abstract: Disclosed is a multi-channel light measurement system adapted to illuminate and measure a test sample in a vessel. The multi-channel light measurement system has at least one photodetector per channel and a variable integrate and hold circuit coupled to each photodetector, the variable integrate and hold circuit allows adjustment of a sampling factor selected from a group of an integration time, a value of capacitance, an area of a discrete photodetector array, or any combination thereof. The system may readily equilibrate reference intensity output for multiple channels. Methods and apparatus are disclosed, as are other aspects.
    Type: Grant
    Filed: April 19, 2013
    Date of Patent: April 17, 2018
    Assignee: Siemens Healthcare Diagnostics Inc.
    Inventor: Frank Krufka
  • Patent number: 9947519
    Abstract: Based on the m/z of a precursor ion used in an MS2 analysis of a test sugar chain, a plurality of sugar-chain structure candidates are extracted from a sugar-chain database in which various sugar-chain structures are related to m/z (S2). Product ions that can be generated by cutting one sugar-chain bond are calculated for each sugar-chain structure candidate (S3). For each combination of two sugar-chain structure candidates, the product ions of one candidate are compared with those of the other to extract characteristic product ions for each sugar-chain structure candidate, and their m/z values are calculated (S4). Whether or not an MS2 spectrum of the test sugar chain has a peak located at m/z of any of the characteristic product ions is determined, and based on the determination result, the sugar-chain structure candidates are narrowed down (S5) and the obtained result is shown on a display unit (S6).
    Type: Grant
    Filed: January 29, 2014
    Date of Patent: April 17, 2018
    Inventor: Kentaro Morimoto
  • Patent number: 9945787
    Abstract: An optical device for determining the presence and/or concentration of analytes in a sample is presented. The optical device comprises a detector and a detection unit comprising optical path components. The detection unit has wavelength-dependent responsivity. The optical device further comprises a light source for emitting light of different respective usable wavelength ranges. The light is guidable through the optical path to the detector to generate baseline signals and response signals relative to the baseline signal indicative of the presence and/or concentration of analytes in the optical path. The intensity of the light reaching the detector is adjusted inverse to the wavelength-dependent responsivity with respect to at least two respective usable wavelength ranges so that a reduction of the ratio between the maximum baseline signal at one of the selected usable wavelength ranges and the minimum baseline signal at another of the selected usable wavelength ranges is obtained.
    Type: Grant
    Filed: January 9, 2013
    Date of Patent: April 17, 2018
    Assignee: Roche Diagnostics Operations, Inc.
    Inventors: Rik Harbers, Kurt Schildknecht
  • Patent number: 9927449
    Abstract: A liquid analysis system for a photometric determination of an analyte in a liquid sample includes an analyzer comprising a photometer, an RFID parameter reading device and an identifier reading device, and a cuvette package comprising an RFID parameter transponder and a plurality of test cuvettes of one batch. Each test cuvette comprises a reagent. Batch identification and batch-specific reagent data are stored in the RFID parameter transponder. Each test cuvette comprises a batch-specific identifier including a batch identification. The batch identification is configured to be read by the identifier reading device.
    Type: Grant
    Filed: October 1, 2009
    Date of Patent: March 27, 2018
    Assignee: HACH LANCE GMBH
    Inventors: Gabriel Rueeck, Helga Guthmann, Johannes Berssen, Michael Ziedrich, Carsten Schulz, Clemens Hanschke, Florens Engel, Dietmar Zangenberg, Markus Lenhard, Thomas Coeper
  • Patent number: 9920020
    Abstract: Squaraine dyes are used to detect the presence of protein in a test sample, which is a substance that may contain protein. A squarine dye is placed in water, and in some instances joined with an aggregation agent, to create an aqueous dye solution. That dye solution is joined with a test sample. When the dye solution is joined with the test sample and the resultant test solution is excited by the application of photons, a resulting fluorescence or absence thereof reveals if protein was present in the test sample.
    Type: Grant
    Filed: April 30, 2012
    Date of Patent: March 20, 2018
    Assignee: The University of Akron
    Inventors: Yi Pang, Yongqian Xu
  • Patent number: 9921167
    Abstract: An optical sensor for monitoring an environmental condition, the optical sensor comprising a perfluorosulfonate ionomer membrane comprising a solution, wherein the solution comprises a transition metal-free dye component, wherein exposure of the optical sensor to a specific environmental condition produces a color shift on the optical sensor.
    Type: Grant
    Filed: October 23, 2015
    Date of Patent: March 20, 2018
    Assignee: University of Cincinnati
    Inventors: Anastasios Angelopoulos, Subasri M Ayyadurai, Jonathan A. Bernstein, Daniel S. Kanter
  • Patent number: 9921233
    Abstract: The invention generally relates to mass spectral analysis. In certain embodiments, methods of the invention involve analyzing a lipid containing sample using a mass spectrometry technique, in which the technique utilizes a liquid phase that does not destroy native tissue morphology during analysis.
    Type: Grant
    Filed: October 12, 2015
    Date of Patent: March 20, 2018
    Assignee: Purdue Research Foundation
    Inventors: Robert Graham Cooks, Livia Schiavinato Eberlin, Christina Ramires Ferreira, Allison Lisa Dill, Demian R. Ifa
  • Patent number: 9897549
    Abstract: An analytical device, including: a processing system for treating a liquid sample and for supplying the treated liquid sample to a measuring cell, to the liquid sample; a measuring transducer for registering a measured value of the treated liquid sample variable; a control unit to control the processing system; and an evaluating unit for determining the measured variable based on the measured value registered by the measuring transducer. The analytical device includes at least one first supply container containing a first reagent component, at least one second supply container containing a second reagent component and a mixing apparatus, for mixing a predetermined amount of the first reagent component contained in the first supply container with a predetermined amount of the second reagent component to form a predetermined amount of the reagent.
    Type: Grant
    Filed: March 22, 2012
    Date of Patent: February 20, 2018
    Assignee: Endress+Hauser Conducta GmbH+Co. KG
    Inventors: Ulrich Kathe, Ralf Steuerwald, Thomas Schipolowski, Matthias Knopp, Tobias Zachmann, Thomas Baumgartner
  • Patent number: 9885725
    Abstract: The present invention provides a mass spectrometry method that can achieve analysis with high sensitivity using a matrix additive capable of improving ionization efficiency in mass spectrometry. A mass spectrometry method comprising the steps of: forming a mixed crystal for mass spectrometry on a target plate for mass spectrometry, the mixed crystal comprising a sample to be analyzed, a matrix, and a matrix additive selected from the group consisting of a 2,5-dihydroxybenzoate and a 3,5-dihydroxybenzoate that are represented by the following formula (I): where R represents an alkyl group having 4 to 14 carbon atoms; and irradiating the mixed crystal with laser to detect the sample to be analyzed.
    Type: Grant
    Filed: September 24, 2014
    Date of Patent: February 6, 2018
    Inventors: Yuko Fukuyama, Shunsuke Izumi
  • Patent number: 9878326
    Abstract: The direct integration of light and optical control into microfluidic systems presents a significant hurdle to the development of portable optical trapping-based devices. A simple, inexpensive fiber-based approach is provided that allows for easy implementation of diode-bars for optical particle separations within flowing microfluidic systems. Models have also been developed that demonstrate the advantages of manipulating particles within flow using linear geometries as opposed to individually focused point traps as traditionally employed in optical-trapping micromanipulation.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: January 30, 2018
    Assignee: Colorado School of Mines
    Inventors: Jeff Squier, David W. M. Marr, Robert Applegate, Tor Vestad
  • Patent number: 9880088
    Abstract: The disclosed subject matter relates to a force-clamp spectrometer that enables operation in constant force mode and allows for automated data acquisition and analysis, using feedback electronics and software. The disclosed subject matter also relates to methods of using the force-clamp spectrometer for the measurement of the dynamics of chemical reactions. The methods may include, but are not limited to, the measurement of the dynamics of substrate folding and unfolding, as well as bond cleavage and bond formation.
    Type: Grant
    Filed: January 14, 2013
    Date of Patent: January 30, 2018
    Assignee: The Trustees of Columbia University in the City of New York
    Inventors: Julio M. Fernandez, Raul Perez-Jimenez, Pallav Kosuri
  • Patent number: 9880092
    Abstract: A test kit is provided. The test kit includes a case including a top including a plurality of indicator pads and a crushing plate rotatable between a first position and a second position, the crushing plate including a plurality of crushing ribs. The case further includes a bottom hingedly coupled to the top, the bottom including a plurality of reagent ampoules storing reagents. When the case is closed with the crushing plate in the second position, the plurality of crushing ribs crush the the plurality of reagent ampoules. The test kit further includes a collector including a collector body, a plurality of swabs extending through the collector body, a removable cover covering a first side of the collector body, and a collector handle coupled to the collector body, wherein the collector is nestable within the case.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: January 30, 2018
    Assignee: Morphix Technologies, Inc.
    Inventors: Deborah Foy, Edward Locke, Julian Parker, Anthony Pomozzi, Matthew Rixon, III
  • Patent number: 9880079
    Abstract: The invention relates to a method in the preparation of samples for microscopic examination onto which a coverslip is applied. The method is notable for the fact that the coverslipping quality is checked automatically and at least partly optically. The invention further relates to an apparatus for carrying out the method, and to an apparatus for checking the coverslipping quality of samples onto which a coverslip is applied.
    Type: Grant
    Filed: February 19, 2013
    Date of Patent: January 30, 2018
    Assignee: Leica Biosystems Nussloch GmbH
    Inventors: Bernhard Neef, Christian Wilke, Karl-Heinrich Westerhoff
  • Patent number: 9862601
    Abstract: A system (100) is described for characterizing and/or manipulating molecules. The system may especially be suitable for biological molecules, although the invention is not limited thereto. The system (100) comprises a substrate (110) comprising a nanostructure (120) being suitable for translocation of molecules through the nanostructure (120). It furthermore comprises a means (210) for translocating molecules through the nanostructure (120) and a plasmonic force field generating means (130) adapted for influencing the translocation speed of the particle by applying a plasmonic force field at the nanostructure (120). A corresponding method also is described.
    Type: Grant
    Filed: December 24, 2010
    Date of Patent: January 9, 2018
    Assignees: IMEC, Katholieke Universiteit Leuven, KU LEUVEN R&D
    Inventors: Chang Chen, Pol Van Dorpe, Kai Cheng, Tim Stakenborg, Liesbet Lagae