Abstract: Provided is a process for preparing Cinacalcet, (R)-?-methyl-N-[3-[3-(trifluoromethyl)phenyl]propyl]-1-naphthalenemethane amine and intermediates thereof.
Abstract: The invention provides a process for removing nitrocresols from wastewater of mononitrotoluene preparation, which comprises acidifying the alkaline wastewater of mononitrotoluene preparation with acids to a pH of at most 3 and treating the nitrocresols with an extractant. The invention further provides the preparation of dinitrotoluene by use of the nitrocresol-containing extracts as a feedstock.
Type:
Grant
Filed:
September 18, 2004
Date of Patent:
November 11, 2008
Assignee:
BASF SE
Inventors:
Johannes Buettner, Holger Allardt, Reinhard Tonder, Reiner Reetz, Michael Reichelt
Abstract: The invention relates to new compounds, namely capsaicin derivates, a new method for their production, and their use as micro-organism-repellent agents in paints and coatings, in particular for marine installations and ships, but also for land-based structures.
Abstract: Disclosed is a thiosphosphine compound of formula: wherein X represents with R1 being H or —CH3, R and R? represent, independently from each other, an alkyl radical, an alkoxy radical, an aryl radical or a phenyl radical which may be substituted with one or more alkyl and/or alkoxy groups, n is an integer from 0 to 4, n? is an integer from 0 to 5, x is an integer from 0 to 2, y is an integer from 1 to 5 with the proviso that y+n is an integer from 1 to 5. The compounds can be used to make optically transparent articles such as ophthalmic lenses.
Type:
Grant
Filed:
October 20, 2006
Date of Patent:
November 4, 2008
Assignee:
Essilor International Compagnie Generale d'Optique
Inventors:
Sirisoma Wanigatunga, Aref Jallouli, Martin Rickwood, Yassin Yusef Turshani
Abstract: The invention relates to ?-silanyl n-alkanal compounds, method for production and use thereof in the fuctionalization of solid supports, solid supports functionalized by the compounds and the use of solid supports thus functionalized for the immobilization and/or synthesis of biological molecules of interest.
Type:
Grant
Filed:
April 28, 2004
Date of Patent:
October 28, 2008
Assignees:
Commissariat a l'Energie Atomique, Centre National de la Recherche, Universite de Montpellier 2
Inventors:
Françoise Vinet, Gérard Lanneau, Michel Granier, Franck Martin
Abstract: The present invention relates to a sequence for the preparation of amino acids, for example alpha-amino acids, in particular methionine, by making use of an amidocarbonylation reaction in the presence of a cobalt carbonyl catalyst and separating the catalyst in the form of a Co(N-amino acid)2 compound.
Type:
Grant
Filed:
May 14, 2005
Date of Patent:
October 21, 2008
Assignee:
Degussa AG
Inventors:
Martin Hateley, Thomas Häussner, Christoph Weckbecker, Klaus Huthmacher, Dieter Buss
Abstract: A method for producing DME, which comprises separating a CO2 rich stream from a crude product stream containing DME and CO2 obtained by a DME synthesis from a feed syn gas; introducing the CO2 rich stream to a reverse water gas shift (RWGS) reactor wherein it is reacted with hydrogen in the presence of an oxide catalyst of either ZnO or NiO to provide a CO rich stream, and recycling the CO rich stream to the step of the methanol synthesis step.
Type:
Grant
Filed:
January 29, 2004
Date of Patent:
October 14, 2008
Assignee:
Korea Institute of Science and Technology
Abstract: A compound selected from those of formula (I): Medicinal products containing the same which are useful in the treatment of disorders of the melatoninergic system.
Type:
Grant
Filed:
June 29, 2007
Date of Patent:
October 14, 2008
Assignee:
Les Laboratoires Servier
Inventors:
Said Yous, Basile Peres, Ahmed Sabaouni, Pascal Berthelot, Michael Spedding, Philippe Delagrange, Daniel-Henri Caignard, Mark Millan
Abstract: The invention relates to novel sulfonylamino-acetic acid derivatives and their use as active ingredients in the preparation of pharmaceutical compositions. The invention also concerns related aspects including processes for the preparation of such compounds, pharmaceutical compositions containing one or more of those compounds and especially their use as orexin receptor antagonists.
Type:
Grant
Filed:
May 31, 2007
Date of Patent:
October 14, 2008
Assignee:
Actelion Pharmaceuticals Ltd.
Inventors:
Hamed Aissaoui, Martine Clozel, Walter Fischli, Ralf Koberstein, Thierry Sifferlen, Thomas Weller
Abstract: A method for synthesizing intermediates for use in the synthesis of carotenoid synthetic intermediates, carotenoid analogs, and/or carotenoid derivatives. The carotenoid analog, derivative, or intermediate may be administered to a subject for the inhibition and/or amelioration of any disease that involves production of reactive oxygen species, reactive nitrogen species, radicals and/or non-radicals. In some embodiments, the invention may include methods for synthesizing chemical compounds including an analog or derivative of a carotenoid. Carotenoid analogs or derivatives may include acyclic end groups. In some embodiments, a carotenoid analog or derivative may include at least one substituent. The substituent may enhance the solubility of the carotenoid analog or derivative such that the carotenoid analog or derivative at least partially dissolves in water.
Type:
Grant
Filed:
May 1, 2006
Date of Patent:
October 14, 2008
Assignee:
Cardax Pharmaceuticals, Inc.
Inventors:
Samuel F. Lockwood, Peng Cho Tang, Geoff Nadolski, Henry L. Jackson, Zhiqiang Fang, Yishu Du, Min Yang, William Geiss, Richard Williams, David Burdick
Abstract: The present invention relates to new crystalline molecular sieve SSZ-74 prepared using a hexamethylene-1,6-bis-(N-methyl N-pyrrolidinium) dication as a structure-directing agent, and processes employing SSZ-74 in a catalyst.
Abstract: In the production of carboxylic acid or carboxylic acid ester, a reaction product containing the carboxylic acid or carboxylic acid ester which has been produced by the reaction of an olefin, carbon monoxide, and water or an alcohol in the presence of HF is heat-treated in the presence of an acid catalyst and an acid adsorbent. By the heat treatment, the contamination of the carboxylic acid or carboxylic acid ester with HF and/or fluorine compounds such as acyl fluorides can be prevented, to enable the stable production of a high quality and high purity carboxylic acid or carboxylic acid ester without causing troubles such as corrosion of apparatus.
Abstract: The invention relates to cyclopalladated compounds containing bis-diphenyiphosphine-ferrocene ligands and their analogues which are active inhibitors of proteins and enzymes, for example, those of the serine peptidase, cysteine-protease, metalo-protease and endopeptidase families, involved in the development and metastases of malignant tumors, e.g. of the thyroid. An exemplary compound is shown in the figure. The compounds are able te modulate the immunological system due to their action on the enzymes and their interaction with DNA molecules.
Type:
Grant
Filed:
August 22, 2003
Date of Patent:
October 7, 2008
Assignee:
Fundação De Amparo À Pesquisa Do Estado de São Paulo
Inventors:
Antonio Carlos Fávero Caires, Claudia Bincoletto Trindade, Ivarne Luis dos Santos Tersariol
Abstract: The present invention provides a process for producing (Z)-1-phenyl-1-diethylaminocarbonyl-2-hydroxymethylcyclopropane, which comprises reacting 2-oxo-1-phenyl-3-oxabicyclo[3.1.0]hexane with diethylamine in the presence of alkali metal alkoxide.
Abstract: The present invention provides a methods and compounds for producing an enantiomerically enriched ?-(phenoxy)phenylacetic acid compound of the formula: from a mixture of its enantiomers, where R1 is alkyl or haloalkyl and X is halide.
Abstract: There are disclosed a catalyst and a process for production of acrylic acid using this catalyst, wherein, even under conditions where hot spots are formed, the catalyst is excellent in activity, selectivity, and catalyst life time and displays stable performances for a long time.
Abstract: Disclosed herein are compounds of the formula or salts or bioisosteres thereof. Therapeutic methods, medicaments, and compositions related thereto are also disclosed.
Abstract: Analogs of combretastatin have been discovered which demonstrate impressive cytotoxicity as well as a remarkable ability to inhibit tubulin polymerization. Such compounds are excellent clinical candidates for the treatment of cancer in humans. In addition, certain of these ligands, as pro-drugs, may well prove to be tumor selective vascular targeting chemotherapeutic agents or to have vascular targeting activity resulting in the selective prevention and/or destruction of nonmalignant proliferating vasculature.