Patents Examined by Zachary C. Tucker
  • Quinoxaline derivatives, and light emitting element using thereof
    Patent number: 7245073
    Abstract: It is an object to provide an organic compound that has a bipolar property and also a light emitting property, and further has heat resistance. A quinoxaline derivative represented by a general formula (1) is provided. In the formula, A represents any one of an alkylene chain, silicon (Si), oxygen (O), nitrogen (N), and sulfur (S). R1 to R8, which may be identical or different, individually represent any one of a lower alkyl group, an aryl group, and a heterocyclic group.
    Type: Grant
    Filed: July 28, 2004
    Date of Patent: July 17, 2007
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Satoko Shitagaki, Hiroko Abe, Satoshi Seo
  • Hexa- and octahydro-pyrido[1,2-a]pyrazine derivatives with NKantagonistic activity
    Patent number: 7244734
    Abstract: The invention relates to hexahydro-pyrido[1,2-a]pyrazine derivatives having interesting neurokinin-NK1 receptor antagonistic activity. The invention also relates to methods for the preparation of these compounds, to pharmaceutical compositions containing a pharmacologically active amount of at least one of these compounds as an active ingredient, as well as to the use of these compositions for the treatment of disorders in which neurokinin receptors are involved. The invention relates to compounds represented by the general formula (1) wherein the symbols have the meanings as given in the description.
    Type: Grant
    Filed: September 22, 2004
    Date of Patent: July 17, 2007
    Assignee: Solvay Pharmaceuticals B.V.
    Inventors: Wouter I. Iwema Bakker, Gustaaf J. M. Van Scharrenburg, Adrianus Van Den Hoogenband, Andrew C. McCreary
  • Amino-substituted 1H-pyrazin-2-ones and 1H-quinoxalin-2-ones
    Patent number: 7244722
    Abstract: Compounds of the general formula (I): wherein m, n, R1, R2, R3 and R4 are as described in the specification. Further included are pharmaceutical compositions comprising the compounds, processes for their preparation, as well as the use of the compounds for the preparation of a medicament for the treatment of 5-HT2A receptor-related disorders or medical conditions.
    Type: Grant
    Filed: July 17, 2003
    Date of Patent: July 17, 2007
    Assignee: Biovitrum AB
    Inventors: Magnus Cernerud, Helena Lundström, Björn M Nilsson, Markus Thor
  • Process for preparing cyclic N-substituted alpha-imino carboxylic acids
    Patent number: 7244845
    Abstract: The present invention relates to the novel methods of making matrix metalloproteinase inhibitors of Formula (I):
    Type: Grant
    Filed: November 4, 2004
    Date of Patent: July 17, 2007
    Assignee: Sanofi-Aventis Deutschland GmbH
    Inventor: Gerrit Schubert
  • Process for the preparation of azoxystrobin and analogues thereof
    Patent number: 7244737
    Abstract: The present invention relates to a compound of the general formula: wherein R1 is a 4-pyrimidinyl ring substituted at the 6-position by halo, hydroxy, 2-cyanophenoxy, 2,6-difluorophenoxy, 2-nitrophenoxy or 2-thiocarboxamidophenoxy and wherein R2 is any group which can be transesterified to form a methyl ester. The present invention is also directed to a process of preparing said compound.
    Type: Grant
    Filed: June 20, 2006
    Date of Patent: July 17, 2007
    Assignee: Syngenta Limited
    Inventors: David Anthony Jackson, James Peter Muxworthy, Mark Robert Sykes
  • Methods of using phenolic guanidine sodium channel blockers
    Patent number: 7241766
    Abstract: The present invention relates to compounds represented by formula (I): in which at least one of R3 and R4 is a group represented by formula (A): where the structural variables are defined herein. The compounds are useful for blocking sodium channels.
    Type: Grant
    Filed: April 21, 2004
    Date of Patent: July 10, 2007
    Assignee: Parion Sciences, Inc.
    Inventor: Michael R. Johnson
  • Organometal complex and light-emitting element using the same
    Patent number: 7238806
    Abstract: An organometallic complex according to the present invention comprises a structure represented by the following general formula (1). In the formula, R1 to R5 are any one selected from the group consisting of hydrogen, a halogen element, an acyl group, an alkyl group, an alkoxyl group, an aryl group, a cyano group, and a heterocyclic group, Ar is an aryl group having an electron-withdrawing group or a heterocyclic group having electron-drawing group, and M is an element of Group 9 or an element of Group 10.
    Type: Grant
    Filed: December 28, 2004
    Date of Patent: July 3, 2007
    Assignee: Semiconductor Energy Laboratory Co., Ltd.
    Inventors: Hideko Inoue, Satoshi Seo, Satoko Shitagaki, Hiroko Abe
  • Imidazolyl derivatives
    Patent number: 7238695
    Abstract: The present invention is directed to imidazolyl derivatives or pharmaceutically acceptable salts thereof which are useful as agonists or antagonists of somatostatin receptors, having the following formula (I), wherein the substituents are defined in the specification.
    Type: Grant
    Filed: February 4, 2004
    Date of Patent: July 3, 2007
    Assignee: Societe de Conseils de Recherches et d'Applications Scientifiques, SAS
    Inventors: Christophe Alain Thurieau, Lydie Francine Poitout, Marie-Odile Galcera, Christophe Philippe Moinet, Thomas D. Gordon, Barry A. Morgan
  • Substituted tetrahydrobenzothienopyrimidinamine compounds useful for treating hyper-proliferative disorders
    Patent number: 7238701
    Abstract: The present invention relates to a compound of Formula (I) and its use in treating lung and breast cancer.
    Type: Grant
    Filed: July 23, 2004
    Date of Patent: July 3, 2007
    Assignee: Bayer Pharmaceuticals Corporation
    Inventors: Chengzhi Zhang, Gaetan H. Ladouceur, Catherine Brennan, Brent Chandler, Julie A. Dixon, Karl Miranda, Dongping Fan, Qingming Zhu, Sharad Verma, Jacques Dumas
  • Modulators of the glucocorticoid receptor and method
    Patent number: 7235662
    Abstract: Novel non-steroidal compounds are provided which are glucocorticoid receptor modulators which are useful in treating diseases requiring glucocorticoid receptor agonist or antagonist therapy such as obesity, diabetes, inflammatory and immune disorders, and have the structure where R1–R9, X, Y and Z are defined herein.
    Type: Grant
    Filed: June 10, 2004
    Date of Patent: June 26, 2007
    Assignee: Bristol-Myers Squibb Company
    Inventors: Sara Sabine Hadida-Ruah, Xiaohui He, Johnny Yasuo Nagasawa
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo[1,5-c]pyrimidines
    Patent number: 7235659
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed.
    Type: Grant
    Filed: November 29, 2004
    Date of Patent: June 26, 2007
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, Loc Thanh Tran, Pengyi Zhang
  • Substituted 3,4-dihydropyrido[1,2-a]pyrimidines
    Patent number: 7230103
    Abstract: Substituted 3,4-dihydropyrido[1,2-a]pyrimidines of formula I and processes for the production thereof Also disclosed are substance libraries and pharmaceutical compositions containing the compound, and methods of treatment for pain, urinary incontinence, pruritus, tinnitus and/or diarrhoea using the pharmaceutical composition.
    Type: Grant
    Filed: April 11, 2003
    Date of Patent: June 12, 2007
    Assignee: Gruenenthal GmbH
    Inventors: Matthias Gerlach, Corinna Maul, Utz-Peter Jagusch
  • Aminoheteroaryl compounds as protein kinase inhibitors
    Patent number: 7230098
    Abstract: Aminopyridine and aminopyrazine compounds of formula (1), compositions including these compounds, and methods of their use are provided.
    Type: Grant
    Filed: February 26, 2004
    Date of Patent: June 12, 2007
    Assignee: Sugen, Inc.
    Inventors: Jingrong Jean Cui, Dilip Bhumralkar, Iriny Botrous, Ji Yu Chu, Lee A. Funk, Cathleen Elizabeth Hanau, G. Davis Harris, Lei Jia, Joanne Johnson, Stephen A. Kolodziej, Pei-Pei Kung, Xiaoyuan (Sharon) Li, Jason (Qishen) Lin, Jerry Jialun Meng, Mitchell David Nambu, Christopher G. Nelson, Mason Alan Pairish, Hong Shen, Michelle Tran-Dube, Allison Walter, Fang-Jie Zhang, Jennifer Zhang
  • Derivatives of 3,3-diphenylpropylamines
    Patent number: 7230030
    Abstract: The invention concerns novel derivatives of 3,3-diphenylpropylamines, methods for their preparation, pharmaceutical compositions containing the novel compounds, and the use of the compounds for preparing drugs. More particularly, the invention relates to novel prodrugs of antimuscarinic agents with superior pharmacokinetic properties compared to existing drugs such as oxybutynin and tolterodine, methods for their preparation, pharmaceutical compositions containing them, a method of using said compounds and compositions for the treatment of urinary incontinence, gastrointestinal hyperactivity (irritable bowel syndrome) and other smooth muscle contractile conditions.
    Type: Grant
    Filed: January 27, 2004
    Date of Patent: June 12, 2007
    Assignee: Schwarz Pharma AG
    Inventors: Claus Meese, Bengt Sparf
  • Compounds, their use and preparation
    Patent number: 7226925
    Abstract: The invention relates to compounds of the general Formula (I): The compounds may be prepared by per se conventional methods and can be used for treating a human or animal subject suffering from a serotonin-related disorder. The invention also relates to such use as well as to pharmaceutical compositions comprising a compound of Formula (I).
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: June 5, 2007
    Assignee: Biovitrum AB
    Inventors: Björn M. Nilsson, Erik Ringberg, Birger Sjöberg, Mattias Jönsson
  • Process for preparing substituted 5-amino-pyrazolo-[4,3-e]-1,2,4-triazolo-[1,5-c]-pyrimidines
    Patent number: 7223861
    Abstract: A process for preparing substituted 5-amino-pyrazolo[4,3-e]-1,2,4-triazolo-[1,5-c]pyrimidine compounds having an aminoalkyl substituent at the 7-position is disclosed, wherein the pyrimidine ring is cyclized using a cyanating agent.
    Type: Grant
    Filed: October 26, 2004
    Date of Patent: May 29, 2007
    Assignee: Schering Corporation
    Inventors: Shen-Chun Kuo, David Jieh-Shyh Tsai, Loc Thanh Tran, Pengyi Zhang, Andrew D. Jones
  • Bi-cyclic pyrimidine inhibitors of TGF?
    Patent number: 7223766
    Abstract: Compounds in which a pyrimidine nucleus is bridged at the 5 and 6 position and are further substituted at positions 2 and 4 with substituents comprising aromatic moieties are useful in treating subjects with rheumatoid arthritis ameliorated by inhibition of TGF? activity.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: May 29, 2007
    Assignee: Scios, Inc.
    Inventors: Sundeep Dugar, Sarvajit Chakravarty, Aurelia Conte, Jonathan Axon, Glenn McEnroe, Alison Murphy
  • Inhibitors of Akt activity
    Patent number: 7223738
    Abstract: The present invention is directed to compounds comprising a 2,3-diphenylquinoxaline moiety which inhibit the activity of Akt, a serine/threonine protein kinase. The invention is further directed to chemotherapeutic compositions containing the compounds of this invention and methods for treating cancer comprising administration of the compounds of the invention.
    Type: Grant
    Filed: April 4, 2003
    Date of Patent: May 29, 2007
    Assignee: Merck & Co., Inc.
    Inventors: Mark T. Bilodeau, Mark E. Duggan, John C. Hartnett, Craig W. Lindsley, Peter J. Manley, Zhicai Wu, Zhijian Zhao
  • Synthesis of hydrazine and chlorinated derivatives of bicyclic pyridazines
    Patent number: 7220858
    Abstract: The present invention relates to both a novel method of preparing hydralazine hydrochloride and to a novel method of preparing hydrazine derivatives of compounds containing a pyridazine ring, including, for example, pyridazines, phthalazines and other compounds containing the pyridazine ring.
    Type: Grant
    Filed: December 23, 2003
    Date of Patent: May 22, 2007
    Assignee: Barbeau Pharma, Inc.
    Inventor: Deanna J. Nelson
  • Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
    Patent number: 7211572
    Abstract: The present invention relates to a nitrogen-containing fused ring compound represented by the following formula [I] wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof, and an anti-HIV agent containing such compound. The compound of the present invention has an HIV integrase inhibitory activity, and is useful as an agent for the prophylaxis or treatment of AIDS, or as an anti-HIV agent. In addition, by the combined use with other anti-HIV agents such as a protease inhibitor, a reverse transcriptase inhibitor and the like, it can be a more effective anti-HIV agent. Because it shows integrase-specific high inhibitory activity, the compound can be a pharmaceutical agent safe on human body, which causes only a fewer side effects.
    Type: Grant
    Filed: October 13, 2005
    Date of Patent: May 1, 2007
    Assignee: Japan Tobacco Inc.
    Inventors: Susumu Miyazaki, Susumu Katoh, Kaoru Adachi, Hirotaka Isoshima, Satoru Kobayashi, Yuji Matsuzaki, Wataru Watanabe, Kazunobu Yamataka, Shinichi Kiyonari, Shuichi Wamaki