Patents by Inventor A Reum Han

A Reum Han has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10000534
    Abstract: A peptide comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows proliferation and differentiation promotion of osteoblast and proliferation and activation promotion of periodontal ligament fibroblast. A peptide, according to the present invention, increases BMP signaling such as SMAD1/5/8 phosphorylation and increases the growth of osteoblast and the expression of a differentiation marker such as COL1A1, BSP and ALP, thereby ultimately showing osteoblast activation. A peptide, according to the present invention, promotes the growth of periodontal ligament fibroblast by means of PI3K and Akt phosphorylation and increases the expression of an activation marker such as COL1A1 and DSPP, thereby ultimately showing periodontal tissue regeneration activation. Provided are a composition for preventing or treating bone diseases and a composition for preventing or treating periodontal diseases, the compositions comprising the aforementioned peptide.
    Type: Grant
    Filed: August 5, 2014
    Date of Patent: June 19, 2018
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim, Eung Ji Lee, A Reum Han, Hyun A Jung
  • Patent number: 9908916
    Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (CON), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).
    Type: Grant
    Filed: October 25, 2013
    Date of Patent: March 6, 2018
    Assignee: CAREGEN CO., LTD.
    Inventors: Yong Ji Chung, Eun Mi Kim, Eung-Ji Lee, Tae-Hoon Lee, A Reum Han
  • Publication number: 20170260233
    Abstract: A peptide which is formed from an amino acid sequence selected from the group comprising amino acid sequences of SEQ ID NO: 1 to SEQ ID NO: 3, according to the present invention, has osteoclast differentiation and activation inhibition and is highly effective for preventing or treating bone diseases related to the destruction of the bone. A peptide, according to the present invention, reduces expression of cathepsin K and TRAP related to osteoclast differentiation, inhibits nuclear translocation of NF-kB, and ultimately inhibits osteoclast differentiation. Provided is a composition, for preventing or treating bone diseases, comprising the peptide.
    Type: Application
    Filed: August 5, 2014
    Publication date: September 14, 2017
    Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung Ji LEE, A Reum HAN, Hyun Jung KWON
  • Publication number: 20170247411
    Abstract: A peptide comprising an amino acid sequence of SEQ ID NO: 1 or SEQ ID NO: 2, according to the present invention, shows proliferation and differentiation promotion of osteoblast and proliferation and activation promotion of periodontal ligament fibroblast. A peptide, according to the present invention, increases BMP signaling such as SMAD1/5/8 phosphorylation and increases the growth of osteoblast and the expression of a differentiation marker such as COL1A1, BSP and ALP, thereby ultimately showing osteoblast activation. A peptide, according to the present invention, promotes the growth of periodontal ligament fibroblast by means of PI3K and Akt phosphorylation and increases the expression of an activation marker such as COL1A1 and DSPP, thereby ultimately showing periodontal tissue regeneration activation. Provided are a composition for preventing or treating bone diseases and a composition for preventing or treating periodontal diseases, the compositions comprising the aforementioned peptide.
    Type: Application
    Filed: August 5, 2014
    Publication date: August 31, 2017
    Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung Ji LEE, A Reum HAN, Hyun A JUNG
  • Publication number: 20170049847
    Abstract: Provided is a peptide, which has an anti-inflammatory activity and an activity for promoting osteogenic differentiation, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1, SEQ ID NO: 2, and SEQ ID NO: 3. And provided is a peptide, which has a hair growth promoting activity, formed from the amino acid sequence selected from the group comprising the amino acid sequences of SEQ ID NO: 1 and SEQ ID NO: 2. A peptide formed from the amino acid sequence of SEQ ID NO: 1, SEQ ID NO: 2, or SEQ ID NO: 3, according to the present invention, consequently shows an anti-inflammatory activity by inhibiting an inflammatory cytokine expression and proliferation of inflammatory cells, and consequently promotes osteogenic differentiation by increasing phosphorylation of PI3K, Smad1, Smad5 and Smad8, which contribute to osteogenesis, and by increasing ALP, OPG and BSP expressions.
    Type: Application
    Filed: November 21, 2014
    Publication date: February 23, 2017
    Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung Ji LEE, Kyoung Mi CHO, A Reum HAN
  • Publication number: 20160176927
    Abstract: The peptide of the present invention performs a function, which is the same as or similar to that of natural interleukin (IL)-3, and has superior skin permeability due to the small size thereof. In addition, the peptide of the present invention suppresses the activation of NF-?B and nuclear transition by inhibiting the receptor activator of nuclear factor kappa-B ligand (RANKL)-RANK signaling pathway, and suppresses the expression of a RANKL or an inflammatory cytokine-induced tartrate-resistant acid phosphatase (TRAP), cathepsin K, or TNF receptor type 1 or type 2, thereby inhibiting osteoclast differentiation depending on the treatment concentration. Moreover, the peptide of the present invention can contribute to osteoblast differentiation by promoting the expression of osteoblast differentiation markers such as osteocalcin (OCN), osteoprotegerin (OPG), bone sialoprotein (BSP), or osteopontin (OPN).
    Type: Application
    Filed: October 25, 2013
    Publication date: June 23, 2016
    Inventors: Yong Ji CHUNG, Eun Mi KIM, Eung-Ji LEE, Tae-Hoon LEE, A Reum HAN
  • Patent number: 9352303
    Abstract: The present invention relates to a mixed metal oxide catalyst in which a hydrotalcite precursor containing an alkali metal is impregnated or intercalated with a nonprecious metal, a method of manufacturing the same, and a method of decomposing nitrogen oxide using the mixed metal oxide catalyst. The mixed metal oxide catalyst has excellent catalytic activity because it can decompose NOx, N2O or a mixture thereof even at low temperature, and is economical because it does not use a precious metal.
    Type: Grant
    Filed: September 30, 2010
    Date of Patent: May 31, 2016
    Assignee: Sangmyung University, Council for Industry Academic Cooperation
    Inventors: Kil Sang Chang, Xiaoshan Peng, Seo Young Park, Ki Seon Yang, A Reum Han
  • Patent number: 9213129
    Abstract: Disclosed is a brightness enhancing film, including a multilayered thin film wherein a plurality of first thin film layers which are optically anisotropic and a plurality of second thin film layers which are optically isotropic are alternately stacked, the multilayered thin film including a first wavelength reflection region which reflects a wavelength of 160˜451 nm, a second wavelength reflection region which reflects a wavelength of 451˜836 nm, and a third wavelength reflection region which reflects a wavelength of 836˜1040 nm, and a thickness of each of the first and second thin film layers in the first and second wavelength reflection regions is linearly increased from the short wavelength reflection side toward the long wavelength reflection side, and a thickness of each of the first and second thin film layers in the third wavelength reflection region is nonlinearly increased from the short wavelength reflection side toward the long wavelength reflection side.
    Type: Grant
    Filed: June 27, 2013
    Date of Patent: December 15, 2015
    Assignee: KOLON INDUSTRIES, INC.
    Inventors: A Reum Han, Jeong Yeol Moon
  • Publication number: 20150323717
    Abstract: Disclosed is a brightness enhancing film, including a multilayered thin film wherein a plurality of first thin film layers which are optically anisotropic and a plurality of second thin film layers which are optically isotropic are alternately stacked, the multilayered thin film including a first wavelength reflection region which reflects a wavelength of 160˜451 nm, a second wavelength reflection region which reflects a wavelength of 451˜836 nm, and a third wavelength reflection region which reflects a wavelength of 836˜1040 nm, and a thickness of each of the first and second thin film layers in the first and second wavelength reflection regions is linearly increased from the short wavelength reflection side toward the long wavelength reflection side, and a thickness of each of the first and second thin film layers in the third wavelength reflection region is nonlinearly increased from the short wavelength reflection side toward the long wavelength reflection side.
    Type: Application
    Filed: June 27, 2013
    Publication date: November 12, 2015
    Applicant: KOLON INDUSTRIES, INC
    Inventors: A REUM HAN, Jeong Yeol MOON
  • Patent number: 8899770
    Abstract: Disclosed is a luminance enhancement film which is suitable for use in a display and includes a multilayered thin film and a uniaxially drawn film formed on one surface of the multilayered thin film.
    Type: Grant
    Filed: December 29, 2011
    Date of Patent: December 2, 2014
    Assignee: Kolon Industries, Inc.
    Inventors: A Reum Han, Dae Shik Kim, Deug Soo Ryu, Jeong Yeol Moon
  • Publication number: 20120314287
    Abstract: The present invention relates to a luminance-enhanced film used for displays. The present invention provides a luminance enhancement film including a multilayer thin film, which can ensure the reliability to external environmental changes, such as temperature change and the like, and a backlight unit including the luminance enhancement film.
    Type: Application
    Filed: December 29, 2011
    Publication date: December 13, 2012
    Applicant: KOLON INDUSTRIES, INC.
    Inventors: Jeong Yeol Moon, A Reum Han, Kyung Nam Kim, Deug Soo Ryu, Dae Shik Kim
  • Publication number: 20120314401
    Abstract: Disclosed is a luminance enhancement film which is suitable for use in a display and includes a multilayered thin film and a uniaxially drawn film formed on one surface of the multilayered thin film.
    Type: Application
    Filed: December 29, 2011
    Publication date: December 13, 2012
    Applicant: KOLON INDUSTRIES, INC.
    Inventors: A Reum Han, Dae Shik Kim, Deug Soo Ryu, Jeong Yeol Moon
  • Publication number: 20120230899
    Abstract: The present invention relates to a mixed metal oxide catalyst in which a hydrotalcite precursor containing an alkali metal is impregnated or intercalated with a nonprecious metal, a method of manufacturing the same, and a method of decomposing nitrogen oxide using the mixed metal oxide catalyst. The mixed metal oxide catalyst has excellent catalytic activity because it can decompose NOx, N2O or a mixture thereof even at low temperature, and is economical because it does not use a precious metal.
    Type: Application
    Filed: September 30, 2010
    Publication date: September 13, 2012
    Inventors: Kil Sang Chang, Xiaoshan Peng, Seo Young Park, Ki Seon Yang, A Reum Han
  • Patent number: D745542
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 15, 2015
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Sung-Han Kim, Eun-Young Kim, Yoo-Ra Oh, Jin-Hui Sun, Ah-Reum Han, Hyun-Jung Kwon, Bo-Yeon Kim, Ji-Won Yoo, Eun-Sun Chae, Yong-Man Park, Ji-Hyun Moon, Hee-Kyoung Choi
  • Patent number: D757764
    Type: Grant
    Filed: September 3, 2013
    Date of Patent: May 31, 2016
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Ah-Reum Han, Eun-Young Kim, Yoo-Ra Oh, Hye-Rim Kwak, Hyun-Jung Kwon, Bo-Yeon Kim, Ji-Won Ryu, Jin-Hui Sun
  • Patent number: D759683
    Type: Grant
    Filed: March 12, 2013
    Date of Patent: June 21, 2016
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Sunghan Kim, Eun Young Kim, Yoora Oh, Jinhui Sun, Ah Reum Han, Hyun Jung Kwon, Boyeon Kim, Jiwon Yoo, Eun Sun Chae
  • Patent number: D764511
    Type: Grant
    Filed: December 18, 2014
    Date of Patent: August 23, 2016
    Assignee: SAMSUNG ELECTRONICS CO., LTD.
    Inventors: Ah-Reum Han, Joo-Eun Kwak, Hye-Rim Kwak, Yoon-Jung Choi, Ja-Kyoung Lee
  • Patent number: D768710
    Type: Grant
    Filed: February 19, 2014
    Date of Patent: October 11, 2016
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Min-Sun Kim, Eun-Young Kim, Yoo-Ra Oh, Ah-Reum Han
  • Patent number: D773489
    Type: Grant
    Filed: March 13, 2013
    Date of Patent: December 6, 2016
    Assignee: Samsung Electronics Co., Ltd.
    Inventors: Sunghan Kim, Eun Young Kim, Yoora Oh, Jinhui Sun, Ah Reum Han, Hyun Jung Kwon, Boyeon Kim, Jiwon Yoo, Eun Sun Chae