Abstract: Provided herein are a locking mechanism including a male extension including a straight portion and a graduated step portion; and a female extension configured to receive the male extension, and including a pair of protruding tabs, which are spaced apart to allow the straight portion of the male extension to pass through a space between the protruding tabs, and which contact the graduated step portion if the male extension is inserted a first predetermined distance into the female extension.

Abstract: Methods and devices for ophthalmic tissue closure and fixation of ophthalmic prostheses are provided. In accordance with some embodiments, devices for both grasping and clipping a plurality of ocular tissue and ocular prostheses are provided. Various device embodiments are provided for both malleable clips and delivery of normally closed clips (i.e. shape memory). The device may accommodate a plurality of clips which include, but are not limited to: malleable metals, absorbable, shape memory, drug-eluting, and adhesive dispensing. The clips may be pigmented to match the colors of associated tissue (cornea, iris, conjunctiva, sclera, retina) to serve to camouflage fixation clips for healing duration or permanently. According to one aspect, shallow angle access to anatomy may be provided by specialized angulation of device shaft and closure jaws that are intended to access the eye through a small self-healing cornea incision and/or any ocular tissue.

Abstract: Provided herein are a locking mechanism including a male extension including a straight portion and a graduated step portion; and a female extension configured to receive the male extension, and including a pair of protruding tabs, which are spaced apart to allow the straight portion of the male extension to pass through a space between the protruding tabs, and which contact the graduated step portion if the male extension is inserted a first predetermined distance into the female extension.