Patents by Inventor Aaron Leigh Downey

Aaron Leigh Downey has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20220220146
    Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
    Type: Application
    Filed: August 4, 2021
    Publication date: July 14, 2022
    Inventors: Roy W. WARE, Venkat LAKSHMANAN, Aaron Leigh DOWNEY
  • Publication number: 20220144782
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Application
    Filed: June 16, 2021
    Publication date: May 12, 2022
    Inventors: Roy Wendell WARE, Aaron Leigh DOWNEY
  • Publication number: 20220002335
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: January 27, 2021
    Publication date: January 6, 2022
    Inventors: John Henry BOUGHER, III, Ramamurty V S CHANGALVALA, Aaron Leigh DOWNEY, John C. DRACH, Ernest Randall LANIER, JR., Andrew Louis MCIVER, Bradley David ROBERTSON, Dean Wallace SELLESETH, Phiroze Behram SETHNA, Leroy TOWNSEND, Roy W. WARE
  • Patent number: 11111264
    Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
    Type: Grant
    Filed: September 21, 2018
    Date of Patent: September 7, 2021
    Assignee: Chimerix, Inc.
    Inventors: Roy W. Ware, Venkat Lakshmanan, Aaron Leigh Downey
  • Patent number: 11066373
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: October 11, 2019
    Date of Patent: July 20, 2021
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Aaron Leigh Downey
  • Patent number: 10941175
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: August 6, 2019
    Date of Patent: March 9, 2021
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Publication number: 20200277323
    Abstract: The present disclosure relates to crystalline morphic forms of 4-amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl) tetrahydrofuran-2-yl)-2-methyl-7H-pyrrolo[2,3-d]pyrimidine-5-carboxamide. The morphic form can be a stable hemihydrate crystalline form.
    Type: Application
    Filed: September 21, 2018
    Publication date: September 3, 2020
    Inventors: Roy W. WARE, Venkat LAKSHMANAN, Aaron Leigh DOWNEY
  • Publication number: 20200199167
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: August 6, 2019
    Publication date: June 25, 2020
    Inventors: John Henry BOUGHER, III, Ramamurty V S CHANGALVALA, Aaron Leigh DOWNEY, John C. DRACH, Ernest Randall LANIER, Jr., Andrew Louis MCIVER, Bradley David ROBERTSON, Dean Wallace SELLESETH, Phiroze Behram SETHNA, Leroy TOWNSEND, Roy W. WARE
  • Publication number: 20200095208
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Application
    Filed: October 11, 2019
    Publication date: March 26, 2020
    Inventors: Roy Wendell WARE, Aaron Leigh DOWNEY
  • Patent number: 10487061
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: September 19, 2018
    Date of Patent: November 26, 2019
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Aaron Leigh Downey
  • Publication number: 20190016687
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Application
    Filed: September 19, 2018
    Publication date: January 17, 2019
    Inventors: Roy Wendell WARE, Aaron Leigh DOWNEY
  • Patent number: 10112909
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: December 1, 2017
    Date of Patent: October 30, 2018
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Aaron Leigh Downey
  • Publication number: 20180086721
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Application
    Filed: December 1, 2017
    Publication date: March 29, 2018
    Inventors: Roy Wendell Ware, Aaron Leigh Downey
  • Patent number: 9862687
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: May 20, 2016
    Date of Patent: January 9, 2018
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
  • Publication number: 20170253628
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Application
    Filed: May 18, 2017
    Publication date: September 7, 2017
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, JR., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Patent number: 9708359
    Abstract: The present disclosure provides pyrrolopyrimidine nucleoside analogs of the Formula I, Formula IA, Formula IB, or Formula II and phospholipid conjugates and pharmaceutical compositions thereof wherein Rc and A are defined herein. Also presented are methods of treating and/or preventing viral infection and/or viral infection-associated disease or disorder with one or more compounds of Formula I, Formula IA, Formula IB, or Formula II.
    Type: Grant
    Filed: August 8, 2016
    Date of Patent: July 18, 2017
    Assignees: Chimerix, Inc., The Regents of the University of Michigan
    Inventors: John Henry Bougher, III, Ramamurty V S Changalvala, Aaron Leigh Downey, John C. Drach, Ernest Randall Lanier, Jr., Andrew Louis McIver, Bradley David Robertson, Dean Wallace Selleseth, Phiroze Behram Sethna, Leroy Townsend, Roy W. Ware
  • Publication number: 20160264531
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Application
    Filed: May 20, 2016
    Publication date: September 15, 2016
    Inventors: Roy Wendell Ware, JR., Aaron Leigh Downey
  • Patent number: 9371344
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: January 23, 2015
    Date of Patent: June 21, 2016
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey
  • Publication number: 20150210724
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Application
    Filed: January 23, 2015
    Publication date: July 30, 2015
    Inventors: Roy Wendell Ware, JR., Aaron Leigh Downey
  • Patent number: 8962829
    Abstract: The disclosure describes methods of synthesis of phosphonate ester compounds. The methods according to the disclosure allow for large-scale preparation of phosphonate ester compounds having high purity and stability. Also disclosed are morphic forms of phosphonate ester compounds.
    Type: Grant
    Filed: October 10, 2014
    Date of Patent: February 24, 2015
    Assignee: Chimerix, Inc.
    Inventors: Roy Wendell Ware, Jr., Aaron Leigh Downey