Patents by Inventor Abulkalam M. Shamsuddin

Abulkalam M. Shamsuddin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 7989435
    Abstract: The present invention provides a chemical compound or a salt thereof having the chemical formula of: wherein said R is H or citrate and wherein at least one R is citrate. The salt of the chemical compound is the Na+, K+, Mg2+, or Ca2+ salt of said chemical compound. The chemical compound is a chelator which chelates sodium, potassium or lithium, magnesium, calcium, copper, iron, lead, zinc, aluminum, mercury, cadmium, or chromium. It is also be used as an artery plaque dissolver and/or to treat age-related degenerative disorders, such as Alzheimer's disease. The present invention also provides a method for producing the phytic citrate compound and/or its salt.
    Type: Grant
    Filed: February 27, 2009
    Date of Patent: August 2, 2011
    Assignee: IP-6 Research, Inc.
    Inventors: Carl A. Coppolino, Abulkalam M. Shamsuddin
  • Publication number: 20090221531
    Abstract: The present invention provides a chemical compound or a salt thereof having the chemical formula of: wherein said R is H or citrate and wherein at least one R is citrate. The salt of the chemical compound is the Na+, K+, Mg2+, or Ca2+ salt of said chemical compound. The chemical compound is a chelator which chelates sodium, potassium or lithium, magnesium, calcium, copper, iron, lead, zinc, aluminum, mercury, cadmium, or chromium. It is also be used as an artery plaque dissolver and/or to treat age-related degenerative disorders, such as Alzheimer's disease. The present invention also provides a method for producing the phytic citrate compound and/or its salt.
    Type: Application
    Filed: February 27, 2009
    Publication date: September 3, 2009
    Applicant: IP-6 Research, Inc.
    Inventors: Carl A. Coppolino, Abulkalam M. Shamsuddin
  • Patent number: 7517868
    Abstract: The present invention provides a chemical compound or a salt thereof having the chemical formula of: wherein said R is H or citrate and wherein at least one R is citrate. The salt of the chemical compound is the Na+, K+, Mg2+, or Ca2+ salt of said chemical compound. The chemical compound is a chelator which chelates sodium, potassium or lithium, magnesium, calcium, copper, iron, lead, zinc, aluminum, mercury, cadmium, or chromium. It is also be used as an artery plaque dissolver and/or to treat age-related degenerative disorders, such as Alzheimer's disease. The present invention also provides a method for producing the phytic citrate compound and/or its salt.
    Type: Grant
    Filed: December 30, 2005
    Date of Patent: April 14, 2009
    Assignee: IP-6 Research Inc
    Inventors: Carl A. Coppolino, AbulKalam M. Shamsuddin
  • Publication number: 20070293458
    Abstract: Inositol hexaphosphate (IP-6) is a polyphosphorylated carbohydrate with potent antioxidant activity to prevent active oxygen species-mediated mutagenesis, cell injury and carcinogenesis. IP-6 also activates DNA repair mechanisms. Sublethal radiation causes DNA damage through the formation of free radicals, reactive oxygen species, and pyrimidine crosslinks leading to cellular proliferation, cell cycle arrest and apoptosis. In the skin it results in the induction of skin cancer, premature skin aging, immuno-suppression, inflammation, and cell death. Likewise sublethal exposure to ionizing radiation as in nuclear blasts (war-time, accidental, terrorist-induced etc), cosmic radiation, etc. also causes the same spectrum of damage to the cells and the organisms with acute symptoms and eventual high risk of many cancers.
    Type: Application
    Filed: June 16, 2006
    Publication date: December 20, 2007
    Inventors: AbulKalam M. Shamsuddin, Ivana Vucenik
  • Patent number: 5348860
    Abstract: An improved screening test method and kit for cancerous and precancerous conditions which is rapid, employs reagents which can be provided in kit form and which does not give false negatives due to sampling error, immobilizes a sample of a proteinaceous body fluid in a membrane filter, tests for marker carbohydrates therein which have vicinal galactose moieties and which are enzymatically oxidized with galactose oxidase to vicinal aldehydic moieties which then visualizes any thus-produced vicinal aldehydic moieties with Schiff's Reagent, then further oxidizes those samples which test negative for the marker carbohydrates with periodic acid, thereby rendering the sample visualizable with Schiff's Reagent if the sample contains glycoprotein, which applies the galactose oxidase directly to the membrane filter, thereby speeding up color developed, and employs Schiff's Reagent which was refrigerated after preparation until its color faded to a straw shade before being treated with activated charcoal, which treatme
    Type: Grant
    Filed: October 15, 1991
    Date of Patent: September 20, 1994
    Inventor: Abulkalam M. Shamsuddin
  • Patent number: 5162202
    Abstract: An improved rectal mucus screening test method and kit for cancerous and precancerous conditions which is rapid, employs reagents which can be provided in kit form and which does not give false negatives due to sampling error, immobilizes the mucus sample in a membrane filter, tests for marker carbohydrates which have vicinal galactose moieties and which are oxidized with galactose oxidase to vicinal aldehydic moieties which are visualized with Schiff's reagent and oxidizes those samples which test negative for the marker carbohydrates with periodic acid, renders the sample visualizable with Schiff's reagent, applies the galactose oxidase directly to the membrane filter, thereby speeding up color developed and employs the Schiff's Reagent which was refrigerated after preparation until the color faded to a straw shade before being treated with activated charcoal, which renders the solution storage stable ability for many months and enhances its color development ability.
    Type: Grant
    Filed: December 12, 1989
    Date of Patent: November 10, 1992
    Inventor: Abulkalam M. Shamsuddin
  • Patent number: 5082833
    Abstract: A method for moderating the rate of cellular mitosis in a living mammalian tissue having a pathologically elevated rate of cellular mitosis sensitive to treatment with a solution below which comprises perfusing said tissue under mitotic growth conditions with a safe and effective amount and concentration of a composition consisting essentially of a) inositol hexaphosphate or a physiologically acceptable salt thereof; and b) a source of inositol or a physiologically acceptable salt thereof, for a period of time sufficient to moderate the elevated rate of cellular mitosis to a normal, non-pathological rate for said tissue. The method is useful in human and mammalian diseases wherein NK cell activity is altered in the laboratory, e.g. tumors, other cancers including leukemia, immunosuppressed individuals (AIDS and transplant recipients), and in viral, fungal or protozoal infections.
    Type: Grant
    Filed: June 30, 1988
    Date of Patent: January 21, 1992
    Inventor: Abulkalam M. Shamsuddin
  • Patent number: 4857457
    Abstract: The disaccharide .beta.-D-Gal (1->>3)-D-GalNAc, which specifically binds with peanut agglutinin (PNA) or oxidized by galactose oxidase, has been discovered in the colorectal mucus of patients with cancer or precancer. Because of the presence of .beta.-D-Gal-(1>>3)-D-GalNAc also on neuraminidase treated erythrocytes of the ABO type, their competitive binding with PNA has been exploited to develop a hemagglutination inhibition assay. Additional methods of simple detection of this disaccharide include a latex agglutination test, enzyme-avidin-biotinylated PNA, and a galactose oxidase strip test. This rapid, simple and inexpensive assay is designed to test the presence of .beta.-D-Gal-(1>>3)-D-GalNAc in large intestine mucus obtained by routine digital-rectal examination and has the potential for screening populations for large intestinal carcinomas.
    Type: Grant
    Filed: July 24, 1986
    Date of Patent: August 15, 1989
    Inventors: Abulkalam M. Shamsuddin, Alaaeldeen M. Elsayed, Glenn A. Jockle