Patents by Inventor Adam R. Renslo

Adam R. Renslo has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Modulators of the eIF2alpha pathway
    Patent number: 9708247
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Grant
    Filed: September 9, 2015
    Date of Patent: July 18, 2017
    Assignee: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • Compositions, Methods of Use, And Methods of Treatment
    Publication number: 20170088524
    Abstract: Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Application
    Filed: November 8, 2016
    Publication date: March 30, 2017
    Inventors: Yu Chen, Derek Nichols, Adam R. Renslo, Priyadarshini Jaishankar, Erica M. W. Lauterwasser
  • Compositions, methods of use, and methods of treatment
    Patent number: 9556131
    Abstract: Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Grant
    Filed: January 4, 2013
    Date of Patent: January 31, 2017
    Assignees: UNIVERSITY OF SOUTH FLORIDA, THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
    Inventors: Yu Chen, Derek Nichols, Adam R. Renslo, Priyadarshini Jaishankar, Erica M. W. Lauterwasser
  • CYCLIC PEROXIDES AS PRODRUGS FOR SELECTIVE DELIVERY OF AGENTS
    Publication number: 20160362439
    Abstract: Disclosed herein, inter alia, are prodrug compositions and methods of using the same for treatment and detection of disease. Specifically, disclosed herein is a compound of formula (I) having spiro-fused 1,2,4-trioxolane and piperidine rings, namely, 1,2,4-trioxa-8-azaspiro[4.5]decane. Also disclosed is a pharmaceutical composition containing the compound and a pharmaceutically acceptable carrier.
    Type: Application
    Filed: February 13, 2015
    Publication date: December 15, 2016
    Inventors: Adam R. RENSLO, Erica M.W. LAUTERWASSER, Shaun D. FONTAINE, Benjamin B. SPANGLER, James A. WELLS
  • MODULATORS OF THE EIF2ALPHA PATHWAY
    Publication number: 20160096800
    Abstract: Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2? phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
    Type: Application
    Filed: September 9, 2015
    Publication date: April 7, 2016
    Inventors: Peter Walter, Carmela Sidrauski, Diego Acosta Alvear, Michelle R. Arkin, Christopher G. Wilson, Kean Hooi Ang, Brian R. Hearn, Punitha Vedantham, Adam R. Renslo, Mervyn Maze, Susana Vacas
  • MODULATION OF K2P CHANNELS
    Publication number: 20160031814
    Abstract: Disclosed herein inter alia are compositions and methods useful in the treatment of diseases, for example pain, neurodegeneration, or mood disorders, and for modulating the activity of a K2P channel.
    Type: Application
    Filed: July 31, 2015
    Publication date: February 4, 2016
    Inventors: Daniel L. Minor, JR., Sviatoslav N. Bagriantsev, Adam R. Renslo
  • COMPOSITIONS, METHODS OF USE, AND METHODS OF TREATMENT
    Publication number: 20140378516
    Abstract: Embodiments of the present disclosure, in one aspect, relate to a beta-lactamase inhibitor, pharmaceutical compositions including a beta-lactamase inhibitor, methods of treatment of a condition (e.g., infection) or disease, methods of treatment using compositions or pharmaceutical compositions, and the like.
    Type: Application
    Filed: January 4, 2013
    Publication date: December 25, 2014
    Inventors: Yu Chen, Derek Nichols, Adam R. Renslo, Priyadarshini Jaishankar, Erica M.W. Lauterwasser
  • NOVEL ANTIPRION COMPOUNDS
    Publication number: 20140329863
    Abstract: Described herein are novel compositions and methods of treatment addressing diseases such as neurodegenerative diseases, including prion diseases and Alzheimer's disease.
    Type: Application
    Filed: February 26, 2014
    Publication date: November 6, 2014
    Applicant: The Regents of the University of California
    Inventors: Adam R. Renslo, Alejandra Gallardo-Godoy, Michael B. Silber, Stanley B. Prusiner, Kurt Giles, Zhe Li, R. Jeffrey Neitz
  • Activators of executioner procaspases 3, 6 and 7
    Patent number: 8642788
    Abstract: The present invention provides compounds as activators of procaspases 3, 6 and/or 7 and related derivatives, pharmaceutical compositions thereof, methods for their use, and methods for preparing these compounds. In one aspect, the compounds are useful for treating cancers and neoplastic diseases.
    Type: Grant
    Filed: January 9, 2009
    Date of Patent: February 4, 2014
    Assignee: The Regents of the University of California
    Inventors: Jim Wells, Adam R. Renslo, Dennis Wolan, Julie Zorn
  • Small-molecule inhibitors of the androgen receptor
    Patent number: 8580773
    Abstract: The present invention provides tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof. The present invention provides a method of using tetrahydropyrvinium (THP), derivatives thereof, benzoxazole compounds, and derivatives thereof.
    Type: Grant
    Filed: December 6, 2012
    Date of Patent: November 12, 2013
    Assignee: The Regents of the University of California
    Inventors: Marc I. Diamond, Jeremy O. Jones, Adam R. Renslo
  • ACTIVATORS OF EXECUTIONER PROCASPASES 3, 6 AND 7
    Publication number: 20110021522
    Abstract: The present invention provides compounds as activators of procaspases 3, 6 and/or 7 and related derivatives, pharmaceutical compositions thereof, methods for their use, and methods for preparing these compounds. In one aspect, the compounds are useful for treating cancers and neoplastic diseases.
    Type: Application
    Filed: January 9, 2009
    Publication date: January 27, 2011
    Applicant: The Regents of the University of California
    Inventors: Jim Wells, Adam R. Renslo, Dennis Wolan, Julie Zorn