Patents by Inventor Adriana L. BOTES
Adriana L. BOTES has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 11268110Abstract: This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.Type: GrantFiled: October 18, 2019Date of Patent: March 8, 2022Assignee: INV Nylon Chemicals Americas, LLCInventors: Alex Van Eck Conradie, Adriana L. Botes, Alexander Brett Foster, Changlin Chen
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Publication number: 20200277634Abstract: This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.Type: ApplicationFiled: October 18, 2019Publication date: September 3, 2020Applicant: INVISTA North America S.á.r.l.Inventors: Alex Van Eck CONRADIE, Adriana L. BOTES, Alexander Brett FOSTER, Changlin CHEN
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Patent number: 10689673Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.Type: GrantFiled: December 21, 2012Date of Patent: June 23, 2020Assignee: INVISTA North America S.a.r.l.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
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Patent number: 10577634Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.Type: GrantFiled: March 20, 2017Date of Patent: March 3, 2020Assignee: INVISTA NORTH AMERICA S.A.R.L.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
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Patent number: 10519433Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.Type: GrantFiled: February 29, 2016Date of Patent: December 31, 2019Assignee: INVISTA NORTH AMERICA S.A.R.L.Inventors: Nadia Kadi, Adriana L. Botes, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Eric Althoff
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Publication number: 20190300871Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.Type: ApplicationFiled: January 2, 2019Publication date: October 3, 2019Applicant: INVISTA North America S.à.r.l.Inventors: Eric ALTHOFF, Nadia KADI, Mihai AZOITEI, Yih-En A. BAN, Daniela GRABS-RÖTHLISBERGER, Alexander PISARCHIK, Alexandre ZANGHELLINI, Adriana L. BOTES
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Patent number: 10214736Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.Type: GrantFiled: May 12, 2017Date of Patent: February 26, 2019Assignee: INVISTA North America S.à.r.l.Inventors: Eric Althoff, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Adriana L. Botes
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Publication number: 20180030431Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.Type: ApplicationFiled: May 12, 2017Publication date: February 1, 2018Applicant: INVISTA North America S.A.R.L.Inventors: Eric ALTHOFF, Nadia KADI, Mihai Luchian AZOITEI, Yih-En A. BAN, Daniela GRABS-RÖTHLISBERGER, Alexander PISARCHIK, Alexandre ZANGHELLINI, Adriana L. BOTES
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Publication number: 20170298396Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.Type: ApplicationFiled: March 20, 2017Publication date: October 19, 2017Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
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Publication number: 20170218406Abstract: This document describes biochemical pathways for producing pimeloyl-CoA using a polypeptide having the enzymatic activity of a hydroperoxide lyase to form non-3-enal and 9-oxononanoate from 9-hydroxyperoxyoctadec-10,12-dienoate. Non-3-enal and 9-oxononanoate can be enzymatically converted to pimeloyl-CoA or a salt thereof using one or more polypeptides having the activity of a dehydrogenase, a CoA ligase, an isomerase, a reductase, a thioesterase, a monooxygenase, a hydratase, and/or a thiolase. Pimeloyl-CoA can be enzymatically converted to pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, or 1,7-heptanediol, or corresponding salts thereof. This document also describes recombinant microorganisms producing pimeloyl-CoA, as well as pimelic acid, 7-aminoheptanoic acid, 7-hydroxyheptanoic acid, heptamethylenediamine, and 1,7-heptanediol, or corresponding salts thereof.Type: ApplicationFiled: January 31, 2017Publication date: August 3, 2017Applicant: INVISTA North America S.a.r.l.Inventors: Alexander Van Eck CONRADIE, Adriana L. BOTES, Alec FOSTER, Changlin CHEN
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Patent number: 9683227Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.Type: GrantFiled: August 24, 2015Date of Patent: June 20, 2017Assignee: INVISTA NORTH AMERICA S.A.R.L.Inventors: Eric Althoff, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Adriana L. Botes
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Patent number: 9663801Abstract: Disclosed are methods for producing butadiene from one or more of several diverse feedstocks including bioderived feedstocks, renewable feedstocks, petrochemical feedstocks and natural gas.Type: GrantFiled: June 15, 2012Date of Patent: May 30, 2017Assignee: INVISTA NORTH AMERICA S.A.R.L.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes
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Patent number: 9650653Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.Type: GrantFiled: June 29, 2012Date of Patent: May 16, 2017Assignee: INVISTA NORTH AMERICA S.A.R.L.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog
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Publication number: 20160304852Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.Type: ApplicationFiled: August 24, 2015Publication date: October 20, 2016Applicant: INVISTA S.a.r.l.Inventors: Adriana L. Botes, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Eric Althoff
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Publication number: 20160289656Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other ?,?-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.Type: ApplicationFiled: March 30, 2016Publication date: October 6, 2016Applicant: INVISTA North America S.a.r.l.Inventors: Paul S. PEARLMAN, Changlin CHEN, Adriana L. BOTES
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Publication number: 20160251644Abstract: The present disclosure provides novel polypeptides with improved 3-buten-2-ol dehydratase activity, polypeptides with improved linalool dehydratase activity, and polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene. Methods of making and using the polypeptides are also provided.Type: ApplicationFiled: February 26, 2016Publication date: September 1, 2016Applicant: INVISTA NORTH AMERICA S.A.R.L.Inventors: ADRIANA L. BOTES, Nadia Kadi
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Publication number: 20160251645Abstract: The present disclosure provides novel polypeptides with 3-buten-2-ol dehydratase activity, polypeptides with catalytic activity in the conversion of 3-methyl-3-buten-2-ol to isoprene, and crystal structure data for one of such polypeptides. Methods of making and using the polypeptides and their related crystal structure data are also provided.Type: ApplicationFiled: February 29, 2016Publication date: September 1, 2016Applicant: INVISTA North America S.a.r.l.Inventors: ADRIANA L. BOTES, Nadia Kadi, Mihai Luchian Azoitei, Yih-En A. Ban, Daniela Grabs-Röthlisberger, Alexander Pisarchik, Alexandre Zanghellini, Eric Althoff
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Patent number: 9422578Abstract: This document describes biochemical pathways for producing butadiene by forming two vinyl groups in a butadiene synthesis substrate. These pathways described herein rely on enzymes such as mevalonate diphosphate decarboxylase, isoprene synthase, and dehydratases for the final enzymatic step.Type: GrantFiled: November 30, 2012Date of Patent: August 23, 2016Assignee: INVISTA NORTH AMERICA S.A.R.L.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie
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Patent number: 9334508Abstract: The invention relates to methods for enriching monomer content in a cycloalkane oxidation process mixed organic waste stream. In particular, the methods involve combining a biocatalyst with a mixed organic waste stream from a cycloalkane oxidation process, and enzymatically converting dimeric and/or oligomeric components of said waste stream into monomeric components. The methods may enrich the content of diacids, adipic acid, and/or other ?,?-difunctional C6 alkanes in the mixed organic waste stream. Additionally, the treated mixed organic waste streams may have improved burning efficiency.Type: GrantFiled: June 15, 2012Date of Patent: May 10, 2016Assignee: INVISTA NORTH AMERICA S.A.R.L.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes
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Publication number: 20150337275Abstract: Embodiments of the present invention relate to methods for the biosynthesis of di- or trifunctional C7 alkanes in the presence of isolated enzymes or in the presence of a recombinant host cell expressing those enzymes. The di- or trifunctional C7 alkanes are useful as intermediates in the production of nylon-7, nylon-7,x, nylon-x,7, and polyesters.Type: ApplicationFiled: December 21, 2012Publication date: November 26, 2015Applicant: INVISTA TECHNOLOGIES S.a.r.l.Inventors: Paul S. Pearlman, Changlin Chen, Adriana L. Botes, Alex Van Eck Conradie, Benjamin D. Herzog