Patents by Inventor Ae Nim Pae

Ae Nim Pae has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Bycyclic tetrahydrofuran derivatives and process for the preparation thereof
    Patent number: 7241906
    Abstract: The present invention relates to bicyclic tetrahydrofuran derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenol derivatives in the presence of alcohol compound, transitional metal catalyst and carbon monoxide: wherein n is 1 or 2; R is phenyl optionally substituted with C1-C6 alkyl, C1-C6 alkoxy, hydroxyl or C1-C6 hydroxyalkyl group; and R1 is C1-C6 alkyl group.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: July 10, 2007
    Assignee: Korea Institute of Science and Technology
    Inventors: Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Hun Yeong Koh, Chul Shin
  • Bicyclic tetrahydrofuran lactone derivatives and process for the preparation thereof
    Patent number: 7223874
    Abstract: The present invention relates to bicyclic tetrahydrofuran lactone derivatives of Formula (1) and a preparation method thereof, and particularly it relates to a process of preparing compounds of Formula (1) by performing an intramolecular cyclization of tetrahydrofuran-allenic acid derivatives in the presence of a phenyl halide, a palladium catalyst and a base: wherein n is 1 or 2, and R is phenyl optionally substituted with C1–C6 alkyl, C1–C6 alkoxy, hydroxyl or C1–C6 hydroxyalkyl group.
    Type: Grant
    Filed: December 15, 2005
    Date of Patent: May 29, 2007
    Assignee: Korea Institute of Science and Technology
    Inventors: Yong Seo Cho, Joo Hwan Cha, Ae Nim Pae, Hun Yeong Koh, Chul Shin
  • Reduction of carbonyl compounds using the carbonyl reductase of
    Patent number: 7094908
    Abstract: A compound represented by a general formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted ?-keto ester and can be used as an intermediate in preparing ?-lactam group antibiotics.
    Type: Grant
    Filed: December 23, 2002
    Date of Patent: August 22, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Hun Yeong Koh, Kyung Il Choi, Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Ye Sun Han, Jong Soo Lee, Hong Chul Yun
  • Synthesis of 7-membered carbocyclic compound having diexomethylene groups
    Patent number: 7094913
    Abstract: The present invention relates to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of a 7-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 7-membered carbocyclic compound is a useful intermediate for synthesis of other multicyclic compounds. In Chemical Formula 1, R1 is a C1 to C6 alkyl group, and R2 and R3 is respectively a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: August 22, 2006
    Assignee: Korea Institute of Science and Technology
    Inventors: Yong Seo Cho, Moon Ho Chang, Hun Yeong Koh, Ae Nim Pae, Hyun Jung Kang
  • Synthesis of 8-membered carbocyclic compound having diexomethylene groups
    Patent number: 6872840
    Abstract: The present invention relates to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, more particularly to a synthesis of an 8-membered carbocyclic compound having diexomethylene groups, a novel compound having the structure represented by the following Chemical Formula 1, from trimethylsilanylmethyl-allenol derivative by the intramolecular Prins cyclization using Lewis acid. The 8-membered carbocyclic compound is a useful intermediate for synthesis of other multicarbocyclic compounds. In Chemical Formula 1, R1 is a phenyl group, and R2 and R3 is a hydrogen atom, or R1, R2 and R3 may be connected with neighboring substituents to form a 5 to 10-membered aliphatic or aromatic ring.
    Type: Grant
    Filed: April 14, 2004
    Date of Patent: March 29, 2005
    Assignee: Korea Institute of Science And Technology
    Inventors: Yong Seo Cho, Moon Ho Chang, Hun Yeong Koh, Ae Nim Pae, Hyun Jung Kang
  • Methylidene oxazolidinone compound and preparation method thereof
    Publication number: 20040087633
    Abstract: A methylidene oxazolidinone compound represented by formula (1) or a pharmaceutically acceptable salt thereof, and a preparation method thereof, showing superior antimicrobial activities against gram-positive germs including resistant strains such as methicillic-resistant staphylococcus aureus and vancomycin-resistant enterococcus: 1
    Type: Application
    Filed: October 29, 2003
    Publication date: May 6, 2004
    Applicant: Korea Institute of Science and Technology
    Inventors: Hun Yeong Koh, Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Hye Yeon Kim, Jae Seok Lee, Hak Soo Kim, Sanghee Kim
  • Isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof
    Patent number: 6723724
    Abstract: The present invention relates to isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, wherein R1, R2, X and n are the same as defined in the specification.
    Type: Grant
    Filed: April 23, 2001
    Date of Patent: April 20, 2004
    Assignees: Korea Institute of Science and Technology, Korea Research Institute of Chemical Technology, Korea Advanced Institute of Science and Technology
    Inventors: Hun Yeong Koh, Kyung Il Choi, Yong Seo Cho, Ae Nim Pae, Kyung Ho Kang, Mi Young Cha, Jae Yang Kong, Dae Young Jeong, Hee-Yoon Lee
  • 4,5,-dihydroisoxazolylakylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof
    Patent number: 6673800
    Abstract: The present invention relates to 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors represented by the following Formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, wherein R1, R2, X and n are the same as defined in the specification.
    Type: Grant
    Filed: April 20, 2001
    Date of Patent: January 6, 2004
    Assignees: Korea Institute of Science and Technology, Korea Research Institute of Chemical Technology, Korea Advanced Institute of Science and Technology
    Inventors: Hun Yeong Koh, Kyung Il Choi, Yong Seo Cho, Ae Nim Pae, Jae Yang Kong, Dae Young Jeong, Sun Ho Jung, Ji Young Jung, Hee-Yoon Lee
  • Reduction of carbonyl compounds using the carbonyl reductase of kluyveromyces marxianus
    Publication number: 20030139464
    Abstract: A compound represented by a genera formula (Ia) or (Ib) and a stereo-selective preparation method thereof using a carbonyl reductase which is separated from Kluyveromyces marxianus. The compound can be prepared by reduction of substituted &bgr;-keto ester and can be used as an intermediate in preparing &bgr;-lactam group antibiotics.
    Type: Application
    Filed: December 23, 2002
    Publication date: July 24, 2003
    Applicant: Korea Institute of Science and Technology
    Inventors: Hun Yeong Koh, Kyuno Choi, Yong Seo Cho, Ae Nim Pae, Joo Hwan Cha, Ye Sun Han, Jong Soo Lee, Hong Chul Yun
  • Novel isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof
    Publication number: 20020119983
    Abstract: The present invention relates to a novel isoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptors represented by the following formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, 1
    Type: Application
    Filed: April 23, 2001
    Publication date: August 29, 2002
    Inventors: Hun Yeong Koh, Kyung II Choi, Yong Seo Cho, Ae Nim Pae, Kyung Ho Kang, Mi Young Cha, Jae Yang Kong, Dae Young Jeong, Hee-Yoon Lee
  • Novel 4,5,-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 or D4 receptor, and preparation thereof
    Publication number: 20020107253
    Abstract: The present invention relates to a novel 4,5-dihydroisoxazolylalkylpiperazine derivatives having selective biological activity at dopamine D3 and D4 receptors represented by the following Formula (1), and its preparation method through reductive amination reaction in the presence of reducing agent, 1
    Type: Application
    Filed: April 20, 2001
    Publication date: August 8, 2002
    Inventors: Hun Yeong Koh, Kyung IL Choi, Yong Seo Cho, Ae Nim Pae, Jae Yang Kong, Dae Young Jeong, Sun Ho Jung, Ji Young Jung, Hee-Yoon Lee