Patents by Inventor Afsaneh Lavasanifar

Afsaneh Lavasanifar has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210085801
    Abstract: Micelle-forming amphiphilic block copolymers for use in targeting cardiac cells (e.g. fibrotic cells) of a subject suffering from heart failure, micelles containing the micelle-forming amphiphilic block copolymers together with a cardioactive agent, and related compositions and methods for treating or preventing heart failure, e.g. heart failure with preserved ejection fraction (HFpEF) also known as diastolic heart failure.
    Type: Application
    Filed: December 10, 2018
    Publication date: March 25, 2021
    Inventors: Afsaneh LAVASANIFAR, Anthony Ernest BOLTON
  • Publication number: 20200148675
    Abstract: There is described herein imidopiperidine compounds as inhibitors of human polynucleotide kinase phosphatase.
    Type: Application
    Filed: April 5, 2018
    Publication date: May 14, 2020
    Inventors: Dennis HALL, Michael WEINFELD, Sylvain BERNARD, Tristan VERDELET, Timothy MORGAN, Vikie LAMONTAGNE, Zahra SHIRE, Afsaneh LAVASANIFAR
  • Patent number: 9139553
    Abstract: The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer.
    Type: Grant
    Filed: September 26, 2012
    Date of Patent: September 22, 2015
    Assignee: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Afsaneh Lavasanifar, Abdullah Mahmud
  • Publication number: 20130116428
    Abstract: The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer.
    Type: Application
    Filed: September 26, 2012
    Publication date: May 9, 2013
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: AFSANEH LAVASANIFAR, ABDULLAH MAHMUD
  • Patent number: 8309515
    Abstract: The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer.
    Type: Grant
    Filed: March 21, 2007
    Date of Patent: November 13, 2012
    Assignee: The Governors of the University of Alberta
    Inventors: Afsaneh Lavasanifar, Abdullah Mahmud
  • Publication number: 20100137206
    Abstract: This application relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on both the poly(ethylene oxide) block and the poly(ester) block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agent, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer. A variety of targeting moieties can be coupled to the reactive group on the poly(ethylene oxide) block for targeting the bioactive agent to a particular tissue. The application also relates to a composition and method of use thereof for delivering bioactive agents.
    Type: Application
    Filed: December 17, 2007
    Publication date: June 3, 2010
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Afsaneh Lavasanifar, Xiao-Bing Xiong
  • Publication number: 20100069295
    Abstract: The present invention relates to micelle-forming poly(ethylene oxide)-block-poly(ester) block copolymers having reactive groups on the polyester block therein. The biodegradability of these copolymers and their biocompatibilities with a large number of bioactive agents make them suitable as carriers for various bioactive agents. The bioactive agents, such as DNA, RNA, oligonucleotide, protein, peptide, drug and the like, can be coupled to the reactive groups on the polyester block of the copolymer.
    Type: Application
    Filed: March 21, 2007
    Publication date: March 18, 2010
    Applicant: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA
    Inventors: Afsaneh Lavasanifar, Abdullah Mahmud
  • Publication number: 20080038353
    Abstract: The present invention is in the field of polymer-based nano-carriers for the solubilization and delivery of hydrophobic drugs, and relates to methods of making said carriers, and to pharmaceutical compositions comprising said carriers. Novel PEO-b-PCL micelles and micelles containing cyclosporine A or analogs thereof are provided as well as a novel method for making said micelles that reduces aggregation and enhances delivery, the toxicity profile and biodistribution of hydrophobic drugs.
    Type: Application
    Filed: June 2, 2005
    Publication date: February 14, 2008
    Applicants: THE GOVERNORS OF THE UNIVERSITY OF ALBERTA, WISCONSIN ALUMNI RESEARCH FOUNDATION
    Inventors: Afsaneh Lavasanifar, Glen Kwon
  • Patent number: 6939561
    Abstract: Provided are methods and compositions for reducing the toxicity of certain hydrophobic therapeutic agents, especially polyene antibiotics, in particular, Amphotericin B (AmB), and therapeutics such as paclitaxel, tamoxifen, an acylated prodrug or an acylated cis-platin, by incorporating these agents within micelles comprising an amphiphilic block-forming copolymer. Where the polyene is amphotericin B, desirably the spacer is an alkyl molecule of aabout 2 to about 8 carbon atoms, desirably 6 carbon atoms, and the core is an N-alkyl molecule of about 8 to about 28 carbon atoms, desirably 12 to 22 carbon atoms, advantageously, 12 to 18 carbon atoms, and as specifically embodied, 18 carbon atoms (stearate moiety). For the formulation of a larger polyene, the spacer and core are proportionately larger than those for amphotericin B. As specifically exemplified herein, the polymer backbone is a PEO of about 270 units with about 10-30 core-forming PLAA subunits, and advantageously about 14-24.
    Type: Grant
    Filed: June 28, 2002
    Date of Patent: September 6, 2005
    Assignee: Wisconsin Alumni Research Foundation
    Inventors: Glen S. Kwon, John Samuel, Afsaneh Lavasanifar
  • Publication number: 20030086964
    Abstract: Provided are methods and compositions for reducing the toxicity of certain hydrophobic therapeutic agents, especially polyene antibiotics, in particular, Amphotericin B (AmB), and therapeutics such as paclitaxel, tamoxifen, an acylated prodrug or an acylated cis-platin, by incorporating these agents within micelles comprising an amphiphilic block-forming copolymer. Where the polyene is amphotericin B, desirably the spacer is an alkyl molecule of aabout 2 to about 8 carbon atoms, desirably 6 carbon atoms, and the core is an N-alkyl molecule of about 8 to about 28 carbon atoms, desirably 12 to 22 carbon atoms, advantageously, 12 to 18 carbon atoms, and as specifically embodied, 18 carbon atoms (stearate moiety). For the formulation of a larger polyene, the spacer and core are proportionately larger than those for amphotericin B. As specifically exemplified herein, the polymer backbone is a PEO of about 270 units with about 10-30 core-forming PLAA subunits, and advantageously about 14-24.
    Type: Application
    Filed: June 28, 2002
    Publication date: May 8, 2003
    Inventors: Glen S. Kwon, John Samuel, Afsaneh Lavasanifar