Patents by Inventor Agnel Sfeir

Agnel Sfeir has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for enhancing CRISPR activity by POLQ inhibition
    Patent number: 10760081
    Abstract: Provided are approaches to improving CRISPR-based DNA editing by performing the editing in cells in which pol ? (“POLQ”) enzyme and/or its function is reduced. Approaches are provided that are applicable to Cas9 nuclease and Cas9 nickase CRISPR editing. Also provided are kits that can contain a polynucleotide encoding a Cas9 and an agent for use in inhibiting POLQ, and/or or an expression vector configured for expressing a mutation template for use in CRISPR chromosome editing and an agent for use in inhibiting POLQ.
    Type: Grant
    Filed: October 7, 2016
    Date of Patent: September 1, 2020
    Assignee: New York University
    Inventors: Agnel Sfeir, Pedro Mateos-Gomez
  • COMPOSITIONS AND METHODS FOR ENHANCING CRISPR ACTIVITY BY POLQ INHIBITION
    Publication number: 20180305697
    Abstract: Provided are approaches to improving CRISPR-based DNA editing by performing the editing in cells in which pol ? (“POLQ”) enzyme and/or its function is reduced. Approaches are provided that are applicable to Cas9 nuclease and Cas9 nickase CRISPR editing. Also provided are kits that can contain a polynucleotide encoding a Cas9 and an agent for use in inhibiting POLQ, and/or or an expression vector configured for expressing a mutation template for use in CRISPR chromosome editing and an agent for use in inhibiting POLQ.
    Type: Application
    Filed: October 7, 2016
    Publication date: October 25, 2018
    Inventors: Agnel Sfeir, Pedro Mateos-Gomez