Patents by Inventor Ahmed F. Abdel-Magid

Ahmed F. Abdel-Magid has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • TOPICAL PHOSPHOINOSITIDE 3-KINASE INHIBITORS
    Publication number: 20230416269
    Abstract: The present invention provides compounds and topical formulations including the compounds for the treatment of vascular malformations, wherein the compounds are according to formula (I): wherein subscript m, L1, R1, and L1-R1 are as described herein.
    Type: Application
    Filed: April 10, 2023
    Publication date: December 28, 2023
    Inventors: Ahmed F. ABDEL-MAGID, Agis KYDONIEUS, Thomas ROSSI, Hock S. TAN
  • Topical phosphoinositide 3-kinase inhibitors
    Patent number: 11661429
    Abstract: The present invention provides compounds and topical formulations including the compounds for the treatment of vascular malformations, wherein the compounds are according to formula (I): wherein subscript m, L1, R1, and L1-R1 are as described herein.
    Type: Grant
    Filed: February 5, 2020
    Date of Patent: May 30, 2023
    Assignee: VENTHERA, INC.
    Inventors: Ahmed F. Abdel-Magid, Agis Kydonieus, Thomas Rossi, Hock S. Tan
  • TOPICAL PHOSPHOINOSITIDE 3-KINASE INHIBITORS
    Publication number: 20200247816
    Abstract: The present invention provides compounds and topical formulations including the compounds for the treatment of vascular malformations, wherein the compounds are according to formula (I): wherein subscript m, L1, R1, and L1-R1 are as described herein.
    Type: Application
    Filed: February 5, 2020
    Publication date: August 6, 2020
    Inventors: Ahmed F. ABDEL-MAGID, Agis KYDONIEUS, Thomas ROSSI, Hock S. Tan
  • Process for the preparation of compounds useful as inhibitors of SGLT
    Patent number: 9024009
    Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
    Type: Grant
    Filed: September 9, 2008
    Date of Patent: May 5, 2015
    Assignees: Janssen Pharmaceutica N.V., Mitsubishi Tanabe Pharma Corporation
    Inventors: Ahmed F. Abdel-Magid, Maureen Chislom, Steven Mehrman, Lorraine Scott, Kenneth M. Wells, Fan Zhang-Plasket, Sumihiro Nomura, Mitsuya Hongu, Yuichi Koga
  • Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives
    Patent number: 8669288
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Grant
    Filed: March 18, 2010
    Date of Patent: March 11, 2014
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman, Armin Roessler
  • Process for preparation of sulfamide derivatives
    Patent number: 8283478
    Abstract: The present invention is directed to novel process for the preparation of sulfonylimine and sulfamide derivatives.
    Type: Grant
    Filed: April 19, 2006
    Date of Patent: October 9, 2012
    Assignee: Janssen Pharmaceutica NV
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman
  • Liquid phase peptide synthesis of KL-4 pulmonary surfactant
    Patent number: 8217142
    Abstract: The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the ?-carbon.
    Type: Grant
    Filed: September 30, 2008
    Date of Patent: July 10, 2012
    Assignee: Ortho Pharmaceutical Corporation
    Inventors: Ahmed F. Abdel-Magid, Urs Eggmann, Cynthia Anne Maryanoff, Adrian Thaler, Frank J. Villani
  • NOVEL LYSINE SALTS OF 4-((PHENOXYALKYL)THIO)-PHENOXYACETIC ACID DERIVATIVES
    Publication number: 20110105616
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Application
    Filed: March 18, 2010
    Publication date: May 5, 2011
    Inventors: AHMED F. ABDEL-MAGID, STEVEN J. MEHRMAN, ARMIN ROESSLER
  • Lysine salts of 4-((phenoxyalkyl)thio)-phenoxyacetic acid derivatives
    Patent number: 7709682
    Abstract: The present invention is directed to a novel lysine salts, pharmaceutical compositions containing them and their use in the treatment of disorders and conditions modulated by PPAR delta. The present invention is further directed to a novel process for the preparation of said lysine salts.
    Type: Grant
    Filed: September 13, 2006
    Date of Patent: May 4, 2010
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman, Armin Roessier
  • Liquid Phase Peptide Synthesis of KL-4 Pulmonary Surfactant
    Publication number: 20090259021
    Abstract: The invention relates to improved liquid phase processes for the preparation of the 21 residue protein component, (Lys-Leu4)4-Lys, of the pulmonary surfactant KL-4. These process are amenable to large scale synthesis and one process employs a method of saponifying an ester which reduces the inherent racemization of the ?-carbon.
    Type: Application
    Filed: September 30, 2008
    Publication date: October 15, 2009
    Inventors: Ahmed F. Abdel-Magid, Urs Eggmann, Cynthia Anne Maryanoff, Adrian Thaler, Frank J. Villani
  • PROCESS FOR THE PREPARATION OF BENZO-FUSED HETEROARYL SULFAMATES
    Publication number: 20090247617
    Abstract: The present invention is directed to a process for the preparation of benzo-fused heteroaryl sulfamates, useful for the treatment of epilepsy and related disorders.
    Type: Application
    Filed: March 26, 2008
    Publication date: October 1, 2009
    Inventors: Ahmed F. Abdel-Magid, Steven J. Mehrman
  • PROCESS FOR THE PREPARATION OF COMPOUNDS USEFUL AS INHIBITORS OF SGLT
    Publication number: 20090233874
    Abstract: The present invention is directed to a novel process for the preparation of compounds having inhibitory activity against sodium-dependent glucose transporter (SGLT) being present in the intestine or kidney.
    Type: Application
    Filed: September 9, 2008
    Publication date: September 17, 2009
    Inventors: Ahmed F. Abdel-Magid, Maureen Chisholm, Steven Mehrman, Lorraine Scott, Kenneth M. Wells, Fan Zhang-Plasket, Sumihiro Nomura, Mitsuya Hongu, Yuichi Koga
  • Process for the preparation of benzotriazepine derivatives
    Patent number: 7582753
    Abstract: The present invention is directed to a novel process for the preparation of benzo[e][1,2,4]triazepin-2-one derivatives, useful in the preparation of gastrin and cholecystokinin receptor ligands.
    Type: Grant
    Filed: September 14, 2006
    Date of Patent: September 1, 2009
    Assignee: JanssenPharmaceutica, NV
    Inventors: Ahmed F. Abdel-Magid, Luigi Anzalone, Judith Cohen, Steven Mehrman, Frank Villani
  • Benzotriazapinone salts and methods for using same
    Patent number: 7524837
    Abstract: This invention relates to pharmaceutically acceptable salts of compounds of formula (I) Such salts are useful, for example, for the treatment of gastrin related disorders.
    Type: Grant
    Filed: April 27, 2004
    Date of Patent: April 28, 2009
    Assignee: Janssen Pharmaceutica N.V.
    Inventors: Ahmed F. Abdel-Magid, Judith H. Cohen
  • Process for preparing 1,5-diaryl-3-substituted pyrazoles
    Patent number: 7247745
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: August 30, 2005
    Date of Patent: July 24, 2007
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Process for preparing 1,5-diaryl-3-substituted pyrazoles
    Patent number: 6953860
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: June 12, 2003
    Date of Patent: October 11, 2005
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Process for preparing 1,5-diaryl-3-substituted pyrazoles
    Publication number: 20040230060
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III 1
    Type: Application
    Filed: June 12, 2003
    Publication date: November 18, 2004
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Process for preparing 1, 5-diaryl-3-substituted pyrazoles
    Patent number: 6613914
    Abstract: A process for making a compound of formula I wherein the substituents are as described in the specification comprising reacting a ketone of formula II with succinic anhydride and an alkoxide base to form a compound of formula III which is reacted with a compound of formula IV to form a compound of V and reacting with an alcohol to form the corresponding ester of formula VI and reacting the ester with N-methylhydroxylamine.
    Type: Grant
    Filed: March 1, 2002
    Date of Patent: September 2, 2003
    Assignee: Ortho-McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Bruce D. Harris, Cynthia A. Maryanoff
  • Synthesis of 3-amino-3-aryl propanoates
    Patent number: 6610855
    Abstract: A process for the synthesis of a compound of the formula wherein R1 is aryl, heteroaryl, substituted aryl or substituted heteroaryl and R2 is hydrogen, alkyl or aralkyl, or salt thereof.
    Type: Grant
    Filed: July 15, 2002
    Date of Patent: August 26, 2003
    Assignee: McNeil Pharmaceutical, Inc.
    Inventors: Ahmed F. Abdel-Magid, Judith H. Cohen, Cynthia A. Maryanoff, Frank John Villani, Jr., Hua M. Zhong
  • Process for preparing substituted cyclopentane derivatives and novel crystalline structures thereof
    Patent number: 6576786
    Abstract: The invention relates to a process for preparing substituted cyclopentane derivatives represented by the formula (I) wherein R1, R2, R3, R4, X and Y are as described in the specification, and pharmaceutically acceptable salts thereof. The invention further relates to a process for purifying the compound of formula (Ia) and novel crystalline forms of the compound of formula (Ia).
    Type: Grant
    Filed: November 26, 2001
    Date of Patent: June 10, 2003
    Assignee: Biocryst Pharmaceuticals Inc.
    Inventors: Ahmed F. Abdel-Magid, Hans-Ulrich Bichsel, Daniel J. Korey, Gunther G. Laufer, Erja A. Lehto, Sebastiano Mattei, Max Rey, Thomas W. Schultz, Cynthia Maryanoff