Patents by Inventor Aiko Takayama
Aiko Takayama has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220120752Abstract: The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.Type: ApplicationFiled: December 28, 2021Publication date: April 21, 2022Applicants: Toray Industries, Inc., NATIONAL CANCER CENTERInventors: Mitsuaki Sanada, Michimoto Kobayashi, Aiko Takayama, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Patent number: 11266672Abstract: The present invention provides a novel pharmaceutical composition for treating and/or preventing cancer comprising, as an active ingredient, a polynucleotide derived from various miRNAs associated with cancer, a combination drug of the pharmaceutical composition and another antitumor agent, and a method for treating or preventing cancer in a subject having the cancer using the pharmaceutical composition or the combination drug. The present invention relates to a pharmaceutical composition for treating and/or preventing cancer comprising, as an active ingredient, a polynucleotide comprising the nucleotide sequence as set forth in SEQ ID NO: 1, or a nucleotide sequence comprising a substitution of one nucleotide in the nucleotide sequence as set forth in SEQ ID NO: 1 (wherein when at least a part of the polynucleotide is DNA, uracil in a region corresponding to the DNA in the nucleotide sequence is replaced with thymine).Type: GrantFiled: January 27, 2017Date of Patent: March 8, 2022Assignee: TORAY INDUSTRIES, INC.Inventors: Atsuko Miyano, Hiroko Sudo, Aiko Takayama, Taiga Arai
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Patent number: 11231423Abstract: The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.Type: GrantFiled: January 25, 2016Date of Patent: January 25, 2022Assignees: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Mitsuaki Sanada, Michimoto Kobayashi, Aiko Takayama, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Patent number: 10980826Abstract: The present application provides a pharmaceutical composition for treating and/or preventing a cancer comprising, as an active ingredient, a polynucleotide derived from miRNA associated with the cancer, a combination drug of the pharmaceutical composition and another antitumor agent, and a method for treating or preventing a cancer in a subject having the cancer using the pharmaceutical composition or the combination drug.Type: GrantFiled: November 2, 2016Date of Patent: April 20, 2021Assignee: TORAY INDUSTRIES, INC.Inventors: Atsuko Miyano, Hiroko Sudo, Aiko Takayama, Taiga Arai
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Patent number: 10907155Abstract: It is an object of the present invention to specify miRNA associated with the treatment and/or prevention of various cancer species, from among various miRNAs associated with cancer, and to provide a novel pharmaceutical composition for treating and/or preventing cancer which targets the specified miRNA. According to the present invention, provided are a pharmaceutical composition for treating and/or preventing cancer comprising, as an active ingredient, an antisense polynucleotide shown as hsa-miR4454, a combination drug comprising the aforementioned pharmaceutical composition and another antitumor agent, and a method for treating and/or preventing cancer, using the above-described pharmaceutical composition or combination drug.Type: GrantFiled: August 9, 2017Date of Patent: February 2, 2021Assignee: TORAY INDUSTRIES, INC.Inventors: Atsuko Miyano, Aiko Takayama, Hiroko Sudo, Taiga Arai
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Patent number: 10689649Abstract: The present invention provides a novel pharmaceutical composition for treating and/or preventing a cancer comprising, as an active ingredient, a polynucleotide derived from various miRNAs associated with cancer, a combination drug of the pharmaceutical composition and another antitumor agent, and a method for treating or preventing a cancer in a subject having the cancer using the pharmaceutical composition or the combination drug. The present invention relates to a pharmaceutical composition for treating and/or preventing a cancer comprising, as an active ingredient, a polynucleotide comprising the nucleotide sequence as set forth in SEQ ID NO: 1 or 2 (wherein when at least a part of the polynucleotide is DNA, uracil in a region corresponding to the DNA in the nucleotide sequence is replaced with thymine).Type: GrantFiled: December 9, 2016Date of Patent: June 23, 2020Assignee: TORAY INDUSTRIES, INC.Inventors: Atsuko Miyano, Hiroko Sudo, Aiko Takayama, Taiga Arai
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Publication number: 20190216839Abstract: The present application provides a pharmaceutical composition for treating and/or preventing a cancer comprising, as an active ingredient, a polynucleotide derived from miRNA associated with the cancer, a combination drug of the pharmaceutical composition and another antitumor agent, and a method for treating or preventing a cancer in a subject having the cancer using the pharmaceutical composition or the combination drug.Type: ApplicationFiled: November 2, 2016Publication date: July 18, 2019Applicant: TORAY INDUSTRIES, INC.Inventors: Atsuko MIYANO, Hiroko SUDO, Aiko TAKAYAMA, Taiga ARAI
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Publication number: 20190169617Abstract: It is an object of the present invention to specify miRNA associated with the treatment and/or prevention of various cancer species, from among various miRNAs associated with cancer, and to provide a novel pharmaceutical composition for treating and/or preventing cancer which targets the specified miRNA. According to the present invention, provided are a pharmaceutical composition for treating and/or preventing cancer comprising, as an active ingredient, an antisense polynucleotide shown as hsa-miR4454, a combination drug comprising the aforementioned pharmaceutical composition and another antitumor agent, and a method for treating and/or preventing cancer, using the above-described pharmaceutical composition or combination drug.Type: ApplicationFiled: August 9, 2017Publication date: June 6, 2019Applicant: TORAY INDUSTRIES, INC.Inventors: Atsuko MIYANO, Aiko TAKAYAMA, Hiroko SUDO, Taiga ARAI
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Publication number: 20190046551Abstract: The present invention provides a novel pharmaceutical composition for treating and/or preventing cancer comprising, as an active ingredient, a polynucleotide derived from various miRNAs associated with cancer, a combination drug of the pharmaceutical composition and another antitumor agent, and a method for treating or preventing cancer in a subject having the cancer using the pharmaceutical composition or the combination drug. The present invention relates to a pharmaceutical composition for treating and/or preventing cancer comprising, as an active ingredient, a polynucleotide comprising the nucleotide sequence as set forth in SEQ ID NO: 1, or a nucleotide sequence comprising a substitution of one nucleotide in the nucleotide sequence as set forth in SEQ ID NO: 1 (wherein when at least a part of the polynucleotide is DNA, uracil in a region corresponding to the DNA in the nucleotide sequence is replaced with thymine).Type: ApplicationFiled: January 27, 2017Publication date: February 14, 2019Applicant: TORAY INDUSTRIES, INC.Inventors: Atsuko MIYANO, Hiroko SUDO, Aiko TAKAYAMA, Taiga ARAI
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Publication number: 20180362981Abstract: The present invention provides a novel pharmaceutical composition for treating and/or preventing a cancer comprising, as an active ingredient, a polynucleotide derived from various miRNAs associated with cancer, a combination drug of the pharmaceutical composition and another antitumor agent, and a method for treating or preventing a cancer in a subject having the cancer using the pharmaceutical composition or the combination drug. The present invention relates to a pharmaceutical composition for treating and/or preventing a cancer comprising, as an active ingredient, a polynucleotide comprising the nucleotide sequence as set forth in SEQ ID NO: 1 or 2 (wherein when at least a part of the polynucleotide is DNA, uracil in a region corresponding to the DNA in the nucleotide sequence is replaced with thymine).Type: ApplicationFiled: December 9, 2016Publication date: December 20, 2018Applicant: TORAY INDUSTRIES, INC.Inventors: Atsuko MIYANO, Hiroko SUDO, Aiko TAKAYAMA, Taiga ARAI
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Publication number: 20180017564Abstract: The present invention provides a method for detecting biliary tract cancer by measuring the amounts of APOA2 protein variants in a test sample with anti-APOA2 antibodies, the anti-APOA2 antibodies for use in the above method and a detection kit for biliary tract cancer including the above antibodies.Type: ApplicationFiled: January 25, 2016Publication date: January 18, 2018Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Mitsuaki Sanada, Michimoto Kobayashi, Aiko Takayama, Yoshiyuki Sasajima, Giman Jung, Tesshi Yamada, Kazufumi Honda
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Publication number: 20160245815Abstract: It is intended to provide a method for detecting a pancreatic tumor (pancreatic cancer or benign pancreatic tumor) with low invasiveness to a test subject and with high detection sensitivity and accuracy. The present invention provides a method for detecting a pancreatic tumor by measuring the amounts of APOA2 protein variants in a sample of a test subject using anti-APOA2 antibodies, anti-APOA2 antibodies for use in the method, and a kit for the detection of a pancreatic tumor, comprising the antibodies.Type: ApplicationFiled: September 30, 2014Publication date: August 25, 2016Applicants: TORAY INDUSTRIES, INC., NATIONAL CANCER CENTERInventors: Mitsuaki SANADA, Michimoto KOBAYASHI, Aiko TAKAYAMA, Yoshiyuki SASAJIMA, Giman JUNG, Tesshi YAMADA, Kazufumi HONDA
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Patent number: 9309312Abstract: An object of the present invention is to detect a human CXCL1 protein with high sensitivity. An immunoassay method is provided for a human CXCL1 protein, by which human CXCL1 or a fragment thereof in a sample is measured using two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof, wherein: each of the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognizes any one of sequence regions of the amino acid sequences shown in SEQ ID NOS: 1-3, which are partial sequences of the amino acid sequence composing a human CXCL1 protein; and the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognize sequence regions that differ from each other. Monoclonal antibodies or fragments thereof are provided, each of which specifically recognizes any one sequence region of the amino acid sequences shown in SEQ ID NOS: 1-3 and has a new amino acid sequence.Type: GrantFiled: October 29, 2009Date of Patent: April 12, 2016Assignee: TORAY INDUSTRIES, INC.Inventors: Satoko Kanamori, Giman Jung, Yoshinori Tanaka, Aiko Takayama
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Patent number: 9127054Abstract: An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.Type: GrantFiled: December 5, 2011Date of Patent: September 8, 2015Assignees: TORAY INDUSTRIES, INC., KYOTO UNIVERSITYInventors: Michimoto Kobayashi, Yoshinori Tanaka, Aiko Takayama, Satoko Kanamori, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20140363825Abstract: This invention relates to a method for detecting or examining a cancer selected from colorectal cancer and esophageal cancer with high detection sensitivity and accuracy and with less invasiveness to a subject. Specifically, it relates to a method for examining a cancer comprising measuring in vitro a COTL1 protein in a body fluid sample from a subject and evaluating whether or not the subject suffers from the cancer based on the measured amount of the COTL1 protein. It further relates to a kit for diagnosis of a cancer selected from colorectal cancer and esophageal cancer comprising an antibody or a fragment thereof capable of specifically binding to the protein.Type: ApplicationFiled: August 28, 2012Publication date: December 11, 2014Applicants: KYOTO UNIVERSITY, TORAY INDUSTRIES, INC.Inventors: Michimoto Kobayashi, Yoshinori Tanaka, Aiko Takayama, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20130288277Abstract: An object of the present invention is to realize an antibody or a fragment thereof specifically recognizing a cofilin 1 protein, and a method for detecting and testing gastrointestinal cancer with high detection performance, which comprises performing immunoassay of the cofilin 1 protein using the antibody or a fragment thereof. An immunoassay of cofilin 1 protein is characterized by measuring cofilin 1 or a fragment thereof in a sample using 2 or more types of anti-cofilin 1 monoclonal antibody or fragments thereof specifically recognizing different peptide regions in the amino acid sequence constituting the cofilin 1 protein.Type: ApplicationFiled: December 5, 2011Publication date: October 31, 2013Applicants: KYOTO UNIVERSITY, TORAY INDUSTRIES, INC.Inventors: Michimoto Kobayashi, Yoshinori Tanaka, Aiko Takayama, Satoko Kanamori, Giman Jung, Yoshiharu Sakai, Hiroshi Okabe
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Publication number: 20110287444Abstract: An object of the present invention is to detect a human CXCL1 protein with high sensitivity. An immunoassay method is provided for a human CXCL1 protein, by which human CXCL1 or a fragment thereof in a sample is measured using two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof, wherein: each of the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognizes any one of sequence regions of the amino acid sequences shown in SEQ ID NOS: 1-3, which are partial sequences of the amino acid sequence composing a human CXCL1 protein; and the two or more types of anti-human CXCL1 monoclonal antibodies or fragments thereof specifically recognize sequence regions that differ from each other. Monoclonal antibodies or fragments thereof are provided, each of which specifically recognizes any one sequence region of the amino acid sequences shown in SEQ ID NOS: 1-3 and has a new amino acid sequence.Type: ApplicationFiled: October 29, 2009Publication date: November 24, 2011Applicant: TORAY INDUSTRIES, INC.Inventors: Satoko Kanamori, Giman Jung, Yoshinori Tanaka, Aiko Takayama