Abstract: The method includes: sending, by a first base station, a first message to a second base station, where the first message is used to request to add a data radio bearer DRB; receiving, by the first base station, a second message sent by the second base station, where the second message is used to indicate an identifier of at least one DRB; and sending, by the first base station, first information to user equipment, where the first information includes DRB configuration information, and the DRB configuration information includes the identifier of the at least one DRB. In the embodiments of this application, the first base station can add the DRB based on a radio resource management policy and a network condition of the first base station, to reconfigure a mapping relationship between a QoS flow and the DRB, so that setting of the DRB is more flexible and effective.

Abstract: A method and a base station for obtaining a data radio bearer identifier are disclosed. The method includes: the first base station sends a first message to a second base station; receives a second message sent by the second base station; and sends first information to user equipment, where the first message is used to request to add a data radio bearer (DRB), the second message is used to indicate an identifier of at least one DRB, and the first information comprises DRB configuration information including the identifier of the at least one DRB. In this way, the first base station can add the DRB based on a radio resource management policy and a network condition, to reconfigure a mapping relationship between a QoS flow and the DRB, so that setting of the DRB is more flexible and effective.

Abstract: Disclosed is a switch protection circuit and a power converter, configured to set upper and lower limit-value current signals which can be adjusted along with an input voltage, so that instantaneous power of a main power switch can be prevented from being too high, and the main power switch can always be operated within a safe operating range, thereby solving the problem that the power converter is easy to be damaged in applications under a high-current circumstance.

Abstract: Disclosed are biomarkers and methods for accurate non-invasive diagnosis or prognosis of liver fibrosis in subjects with non-alcoholic fatty liver disease (NAFLD). The biomarkers include circulating levels of thrombospondin 2 (TSP2) and can be measured at any time during the course of the disease. The methods include any one of non-invasive evaluation of circulating levels of TSP2 alone, or together with other molecular biomarkers, physiologic or radiographic biomarkers. The methods are highly sensitive and detect advanced liver fibrosis with a sensitivity of about or greater than 80%. The methods may use the circulating levels of TSP2 alone, or together with other molecular biomarkers, physiologic or radiographic biomarkers to accurately predict the risk of developing advanced liver fibrosis in a subject.

Abstract: Disclosed is a power conversion circuit for quick response and a switching power supply, wherein an error compensation signal is obtained according to a sampled signal representing an output feedback signal or an average current through the inductor. A PWM control signal is generated according to the error compensation signal, a ramp signal, and a proportional signal, and is used to control switching operations of a main power switch transistor, the proportional signal is proportional to an input voltage or/and an output voltage, thus the system can quickly respond to transient change of the input voltage or the output signal and provide stable output. Output voltage information or/and input voltage information can be fed back to a control loop, thus the system can quickly obtain a switching duty cycle which allows the system to operate in a state close to steady, and dynamic response speed of the system is fast.

Abstract: An improved method for the chemical synthesis of glycosylated peptides has been developed. The method uses stereoselective glycan synthesis and chemical peptide ligation to produce glycopeptides at lower-cost and with higher efficiency/yield compared to conventional methods. In particular, a method for the large-scale, chemical synthesis of hydroxylated amino acid building blocks and glycosylated amino acids suitable for solid phase peptide synthesis (SPPS) are disclosed. SPPS-based methods using the glycosylated amino acids to chemically synthesize adiponectin-like peptides are also described. In vivo studies show that the adiponectin mimicking glycopeptides exhibit significant anticancer, anti-obesity and insulin sensitizing effects. Pharmaceutical compositions of the synthetic glycopeptides and methods of use thereof in treating diseases associated with deficient adiponectin are also described.

Abstract: The present invention provides an A-FABP neutralizing monoclonal antibody or antigen-binding fragment thereof and a preparation method and use thereof, which comprises: complementarity determining regions 1 to 3 of a heavy chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:1-3, respectively, and/or complementarity determining regions 1-3 of the light chain variable region, the amino acid sequences of which are set forth in SEQ ID NOs:4-6. This monoclonal antibody is highly specific for A-FABP and has no cross-reactivity with human and mouse epidermal FABP and heart FABP; it has a good binding affinity for human A-FABP and mouse A-FABP; and its treatment alleviates MCAO-induced ischemic stroke injury in mice, which is associated with alleviated BBB disruption and reduced activation of pro-inflammatory JNK signaling; treatment of healthy mice for 21 days does not change physiological parameters, indicating its safety.

Abstract: A control method of a switching circuit, a control circuit of the switching circuit and the switching circuit are provided. The control circuit includes a slope buffer and a first operational amplifier. The slope buffer receives a first voltage reference, and controls slopes of a rising edge and a falling edge to generate a second voltage reference. The first operational amplifier receives an output feedback voltage and a reference voltage, and performs an operational amplification to obtain a compensation voltage. When the first voltage reference has the falling edge, the reference voltage is coupled to the first voltage reference through a first switch, and the second voltage reference is coupled to an output voltage through a second switch. When the first voltage reference has the rising edge, the reference voltage is coupled to the second voltage reference through a third switch.

Abstract: An inductive current simulation circuit of a switching circuit, an inductive current simulation method of the switching circuit, and a switched-mode power supply are provided. The inductive current simulation method includes the following steps: based on an error amplification circuit, performing, by the error amplification circuit, an error amplification on a first sampling signal representing a current of a synchronous rectifier and a second sampling signal representing an inductive current simulation signal when the synchronous rectifier is turned on to obtain an error amplification signal; and reconstructing an inductive current according to the error amplification signal when the synchronous rectifier is turned on and a first current when a main power transistor is turned on to obtain the inductive current simulation signal.

Abstract: Disclosed is a switch protection circuit and a power converter, configured to set upper and lower limit-value current signals which can be adjusted along with an input voltage, so that instantaneous power of a main power switch can be prevented from being too high, and the main power switch can always be operated within a safe operating range, thereby solving the problem that the power converter is easy to be damaged in applications under a high-current circumstance.

Abstract: A system and a method for an integrated test on a primary-secondary pole-mounted breaker. The method includes: establishing an electrical connection between the system and the primary-secondary pole-mounted breaker; establishing a communication connection between the system and the primary-secondary pole-mounted breaker; applying, by the system, a voltage signal and a current signal to the primary-secondary pole-mounted breaker through the electrical connection, to generate a voltage and a current on the primary-secondary pole-mounted breaker; collecting, by the system, signals of the voltage and the current fed back from the primary-secondary pole-mounted breaker through the communication connection; performing, by the system, an integrated accuracy test and an integrated protection test; outputting a test result of the accuracy test and a test result of the integrated protection test to the industrial control machine, to generate the test report.

Abstract: A control method of a switching circuit, a control circuit of the switching circuit and the switching circuit are provided. The control circuit includes a slope buffer and a first operational amplifier. The slope buffer receives a first voltage reference, and controls slopes of a rising edge and a falling edge to generate a second voltage reference. The first operational amplifier receives an output feedback voltage and a reference voltage, and performs an operational amplification to obtain a compensation voltage. When the first voltage reference has the falling edge, the reference voltage is coupled to the first voltage reference through a first switch, and the second voltage reference is coupled to an output voltage through a second switch. When the first voltage reference has the rising edge, the reference voltage is coupled to the second voltage reference through a third switch.

Abstract: An inductive current simulation circuit of a switching circuit, an inductive current simulation method of the switching circuit, and a switched-mode power supply are provided. The inductive current simulation method includes the following steps: based on an error amplification circuit, performing, by the error amplification circuit, an error amplification on a first sampling signal representing a current of a synchronous rectifier and a second sampling signal representing an inductive current simulation signal when the synchronous rectifier is turned on to obtain an error amplification signal; and reconstructing an inductive current according to the error amplification signal when the synchronous rectifier is turned on and a first current when a main power transistor is turned on to obtain the inductive current simulation signal.

Abstract: A control method and a control circuit for a switching power supply circuit and the switching power supply circuit. The switching power supply circuit includes a main switching transistor, a synchronous rectifier and an inductive element. When a switching signal indicates that the synchronous rectifier is turned from on to off, and the main switching transistor is turned from off to on, a gate voltage of the synchronous rectifier is pulled down to be lower than a threshold voltage of the synchronous rectifier and higher than a zero voltage by using a resistor-capacitor delay effect and timing is started. When a gate voltage of the main switching transistor is detected to rise to a first voltage or the timing reaches a first time, the gate voltage of the synchronous rectifier is pulled down to the zero voltage.

Abstract: A receiver optical subassembly includes an optical receiving housing, and a first optical receiver, a second optical receiver, and a first glass are packaged in the optical receiving housing. The first glass is disposed obliquely relative to an optical receiving direction, and includes a light incident surface and a light emergent surface. The first optical receiver and the second optical receiver are opposite to the light emergent surface of the first glass. A first light splitting film is disposed on the light emergent surface of the first glass. A first reflective film is disposed on the light emergent surface of the first glass. The first light splitting film can transmit an optical signal of a first wavelength and reflect an optical signal of a second wavelength.

Abstract: A control method and a control circuit for a switching power supply circuit and the switching power supply circuit. The switching power supply circuit includes a main switching transistor, a synchronous rectifier and an inductive element. When a switching signal indicates that the synchronous rectifier is turned from on to off, and the main switching transistor is turned from off to on, a gate voltage of the synchronous rectifier is pulled down to be lower than a threshold voltage of the synchronous rectifier and higher than a zero voltage by using a resistor-capacitor delay effect and timing is started. When a gate voltage of the main switching transistor is detected to rise to a first voltage or the timing reaches a first time, the gate voltage of the synchronous rectifier is pulled down to the zero voltage.

Abstract: Adiponectin-expressing thymocytes and compositions comprising the thymocytes are provided. Methods are provided for using the adiponectin-expressing thymocytes for metabolic regulation and treatment of hyperproliferative diseases.

Abstract: A power device driving method and a driving circuit for a switching circuit having a main switching transistor, a synchronous rectifier, and an inductive element. When a switching signal indicates that the synchronous rectifier is turned from on to off and the main switching transistor is turned from off to on, a gate voltage of the synchronous rectifier is pulled down to be lower than a threshold voltage of the synchronous rectifier and higher than zero voltage by a body effect of a MOS transistor, and timing is started. When detecting that a gate voltage of the main switching transistor rises to a first voltage or the timing reaches a first time, the gate voltage of the synchronous rectifier is pulled down to the zero voltage.

Abstract: A system and a method for an integrated test on a primary-secondary pole-mounted breaker. The method includes: establishing an electrical connection between the system and the primary-secondary pole-mounted breaker; establishing a communication connection between the system and the primary-secondary pole-mounted breaker; applying, by the system, a voltage signal and a current signal to the primary-secondary pole-mounted breaker through the electrical connection, to generate a voltage and a current on the primary-secondary pole-mounted breaker; collecting, by the system, signals of the voltage and the current fed back from the primary-secondary pole-mounted breaker through the communication connection; performing, by the system, an integrated accuracy test and an integrated protection test; outputting a test result of the accuracy test and a test result of the integrated protection test to the industrial control machine, to generate the test report.

Abstract: The invention provides the use of non-polyaminated lipocalin-2 and/or polyaminated lipocalin-2 as biomarkers for cardiometabolic disease as well as antibodies, assays and devices related to these biomarkers.