Abstract: Some aspects include acquisition of a first plurality of projection images of a volume using a megavoltage x-ray source, each of the first plurality of projection images associated with a respective one of a first plurality of locations of the megavoltage x-ray source, acquisition of a second plurality of projection images of the volume using a kilovoltage x-ray source, each of the second plurality of projection images associated with a respective one of a second plurality of locations of the kilovoltage x-ray source, and performance of digital tomosynthesis reconstruction to generate a three-dimensional image of the volume based on the first plurality of projection images and the second plurality of projection images. The first axis may be perpendicular to the second axis.

Abstract: A system includes acquisition of a three-dimensional computed tomography image of a patient volume at a computed tomography scanner, acquisition of projection images of the patient volume located at an isocenter of a linear accelerator, and determination of a transformation between a coordinate system of the linear accelerator and a coordinate system of the three-dimensional computed tomography image based on the projection images.

Abstract: A system includes acquisition of a three-dimensional computed tomography image of a patient volume at a computed tomography scanner, acquisition of projection images of the patient volume located at an isocenter of a linear accelerator, and determination of a transformation between a coordinate system of the linear accelerator and a coordinate system of the three-dimensional computed tomography image based on the projection images.

Abstract: Some aspects include acquisition of a first plurality of projection images of a volume using a megavoltage x-ray source, each of the first plurality of projection images associated with a respective one of a first plurality of locations of the megavoltage x-ray source, acquisition of a second plurality of projection images of the volume using a kilovoltage x-ray source, each of the second plurality of projection images associated with a respective one of a second plurality of locations of the kilovoltage x-ray source, and performance of digital tomosynthesis reconstruction to generate a three-dimensional image of the volume based on the first plurality of projection images and the second plurality of projection images. The first axis may be perpendicular to the second axis.

Abstract: Some aspects include acquisition of a first plurality of projection images of a volume using a megavoltage x-ray source, each of the first plurality of projection images associated with a respective one of a first plurality of locations of the megavoltage x-ray source, acquisition of a second plurality of projection images of the volume using a kilovoltage x-ray source, each of the second plurality of projection images associated with a respective one of a second plurality of locations of the kilovoltage x-ray source, and performance of digital tomosynthesis reconstruction to generate a three-dimensional image of the volume based on the first plurality of projection images and the second plurality of projection images. The first axis may be perpendicular to the second axis.

Abstract: Some embodiments include determination of a first projection image of a phantom based on first imaging geometry parameters associated with a first radiation-based imaging system and on a virtual model of the phantom, acquisition of a second projection image of the phantom based on radiation emitted from the first radiation-based imaging system, the phantom located at a first position and determination of a difference between the first projection image and the second projection image. Second imaging geometry parameters are determined based on the first imaging geometry parameters and the difference between the first projection image and the second projection image, a third projection image of the phantom is determined based on the second imaging geometry parameters and on the virtual model of the phantom, and a fourth projection image of the phantom located at the first position is acquired based on radiation emitted from the first radiation-based imaging system.

Abstract: Some embodiments include determination of a first projection image of a phantom based on first imaging geometry parameters associated with a first radiation-based imaging system and on a virtual model of the phantom, acquisition of a second projection image of the phantom based on radiation emitted from the first radiation-based imaging system, the phantom located at a first position, and determination of a difference between the first projection image and the second projection image. Second imaging geometry parameters are determined based on the first imaging geometry parameters and the difference between the first projection image and the second projection image, a third projection image of the phantom is determined based on the second imaging geometry parameters and on the virtual model of the phantom, and a fourth projection image of the phantom located at the first position is acquired based on radiation emitted from the first radiation-based imaging system.

Abstract: Some aspects include acquisition of a first plurality of projection images of a volume using a megavoltage x-ray source, each of the first plurality of projection images associated with a respective one of a first plurality of locations of the megavoltage x-ray source, acquisition of a second plurality of projection images of the volume using a kilovoltage x-ray source, each of the second plurality of projection images associated with a respective one of a second plurality of locations of the kilovoltage x-ray source, and performance of digital tomosynthesis reconstruction to generate a three-dimensional image of the volume based on the first plurality of projection images and the second plurality of projection images. The first axis may be perpendicular to the second axis.