Abstract: In a plating method for mounting a tubular workpiece having openings at both ends in an axial direction thereof on a power feeding clip and immersing the tubular workpiece in a circulated plating solution to plate the tubular workpiece, the mounting of the tubular workpiece on the power feeding clip is performed by inserting the power feeding clip into the tubular workpiece from one of the openings of the tubular workpiece. The power feeding clip is configured by a folded metal plate, and includes a plurality of elastic contact pieces that can elastically contact the inner surface of the tubular workpiece to hold the tubular workpiece and supply power to the tubular workpiece, and a restraining part that is located inside the tubular workpiece and restrains flow of the plating solution in the axial direction.

Abstract: Resin molded body includes an uneven structure surface that exhibits liquid repellency by having a plurality of recesses and a plurality of projections alternately arranged in a predetermined direction in a planar form. Each of the projections includes a base portion and a distal end portion that is larger than the base portion.

Abstract: A compound of formula (7) is provided wherein L4 is a linking group selected from the group consisting of: provided that an asterisk (*) indicates the position bonding to the nitrogen atom of the carbazolyl group, R6 to R13 are independently a hydrogen atom, or a phenyl group, Ar17 is an unsubstituted phenylphenyl group, and Ar18 is a phenylphenyl group which may be substituted by a phenyl group or a naphthyl group, or a phenyl group which may be substituted by a naphthyl group.

Abstract: In a plating method for mounting a tubular workpiece having openings at both ends in an axial direction thereof on a power feeding clip and immersing the tubular workpiece in a circulated plating solution to plate the tubular workpiece, the mounting of the tubular workpiece on the power feeding clip is performed by inserting the power feeding clip into the tubular workpiece from one of the openings of the tubular workpiece. The power feeding clip is configured by a folded metal plate, and includes a plurality of elastic contact pieces that can elastically contact the inner surface of the tubular workpiece to hold the tubular workpiece and supply power to the tubular workpiece, and a restraining part that is located inside the tubular workpiece and restrains flow of the plating solution in the axial direction.

Abstract: The present invention aims at establishing a novel therapy for facioscapulohumeral muscular dystrophy. An oligonucleotide or a pharmaceutically acceptable salt thereof, wherein the oligonucleotide comprises an oligonucleotide of 15-30 bases consisting of a nucleotide sequence complementary to the region of nucleotide Nos. 502-556 or 578-612 of DUX4-fl mRNA consisting of the nucleotide sequence as shown in SEQ ID NO: 1; the 5? and/or 3? end of the oligonucleotide may be chemically modified; and the oligonucleotide is capable of switching the splice form of the DUX4 gene from DUX4-fl to DUX4-s. A pharmaceutical drug comprising the above oligonucleotide or a pharmaceutically acceptable salt thereof (e.g. therapeutic for facioscapulohumeral muscular dystrophy).

Abstract: There is provided a method for manufacturing a three-dimensional shaped object by a continuous formation of a plurality of solidified layers through a light beam irradiation, the three-dimensional shaped object being provided with a hollow portion in an interior of the shaped object. The manufacturing method performs the formation of the solidified layer by irradiating a raw material with a light beam at the time of suppling the raw material, thereby allowing a sintering of the raw material or a melting and subsequent solidification of the raw material. In particular, a solidified foundation portion is provided as a part of the three-dimensional shaped object, the solidified foundation portion being used for a platform for a formation of a subsequent layer provided as the solidified layer. An orientation of the solidified foundation portion is changed prior to the formation of the subsequent solidified layer.

Abstract: The present invention provides a compound having excellent histone acetyl transferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

Abstract: There is provided a more efficient method for manufacturing a three-dimensional shaped object. The method of the present invention comprises a successive formation of a plurality of solidified layers through a light beam irradiation, wherein the solidified layers are provided by a hybrid of combined systems of an after irradiation system and a simultaneous irradiation system, the after irradiation system being such that the light beam irradiation is performed after a formation of a powder layer, the simultaneous irradiation system being such that the light beam irradiation is performed while a raw material is supplied.

Abstract: A compound of formula (7) is provided wherein L4 is a linking group selected from the group consisting of: provided that an asterisk (*) indicates the position bonding to the nitrogen atom of the carbazolyl group, R6 to R13 are independently a hydrogen atom, or a phenyl group, Ar17 is an unsubstituted phenylphenyl group, and Ar18 is a phenylphenyl group which may be substituted by a phenyl group or a naphthyl group, or a phenyl group which may be substituted by a naphthyl group.

Abstract: A compound of formula (9) is provided. wherein, B1 and B2 are a methyl group, Z1 and Z2 are a hydrogen atom, X1 is an N-carbazolyl group, X2 is a —NAr21?Ar22? group, Ar21? is a 2-phenylphenyl group, a 3-phenylphenyl group, or a 4-phenylphenyl group, and Ar22? is a 1-naphthyl group, a 2-naphthyl group, a 2-phenylphenyl group, a 3-phenylphenyl group, a 4-phenylphenyl group, a 2-fluorenyl group, a 9,9-dimethyl-2-fluorenyl group or a phenanthryl group. Also provided is an organic electroluminescent device comprising a compound of formula (9).

Abstract: An organic electroluminescent device including: an anode, a cathode, an emitting layer formed of an organic compound and interposed between the cathode and the anode, and two or more layers provided in a hole-injecting/hole-transporting region between the anode and the emitting layer; of the layers which are provided in the hole-injecting/hole-transporting region, a layer which is in contact with the emitting layer containing a compound represented by the formula (1); and of the layers which are provided in the hole-injecting/hole-transporting region, a layer which is interposed between the anode and the layer which is in contact with the emitting layer containing an amine derivative represented by the formula (2).

Abstract: The present invention provides a compound having excellent histone acetyl transferase inhibitory activity against EP300 and/or CREBBP, or a pharmacologically acceptable salt thereof. The compound is represented by the following formula (1) or a pharmacologically acceptable salt thereof: wherein ring Q1, ring Q2, R1, R2, R3 and R4 respectively have the same meanings as defined in the specification.

Abstract: A compound of formula (9) is provided. wherein, B1 and B2 are a methyl group, Z1 and Z2 are a hydrogen atom, X1 is an N-carbazolyl group, X2 is a —NAr21?Ar22? group, Ar21? is a 2-phenylphenyl group, a 3-phenylphenyl group, or a 4-phenylphenyl group, and Ar22? is a 1-naphthyl group, a 2-naphthyl group, a 2-phenylphenyl group, a 3-phenylphenyl group, a 4-phenylphenyl group, a 2-fluorenyl group, a 9,9-dimethyl-2-fluorenyl group or a phenanthryl group. Also provided is an organic electroluminescent device comprising a compound of formula (9).

Abstract: There is provided a method for manufacturing a three-dimensional shaped object by alternate repetition of a powder-layer forming and a solidified-layer forming, including: (i) forming a solidified layer by irradiating a predetermined portion of a powder layer with a light beam, thereby allowing a sintering of the powder in the predetermined portion or a melting and subsequent solidification of the powder; and (ii) forming another solidified layer by newly forming a powder layer on the formed solidified layer, followed by an irradiation of a predetermined portion of the newly formed powder layer with the light beam. The plurality of the solidified portions of the powder layers overlap each other, and after a formation of a first solidified portion, at least both main edge regions of the first solidified portion are irradiated with the light beam.

Abstract: A method for manufacturing a three-dimensional shaped object by alternate repetition of a powder-layer forming and a solidified-layer forming, the repetition comprising: (i) forming a solidified layer by irradiating a predetermined portion of a powder layer with a light beam, thereby allowing a sintering of the powder in the predetermined portion or a melting and subsequent solidification of the powder, and (ii) forming another solidified layer by newly forming a powder layer on the formed solidified layer, followed by an irradiation of a predetermined portion of the newly formed powder layer with the light beam, wherein a removal of a mobile foreign material is performed prior to at least one time-formation of the solidified layer, the mobile foreign material existing in an upper surface region of a latest formed solidified layer.

Abstract: The objective of the present invention is to provide nucleic acid therapeutics which exhibits more excellent effect and which shows a substantivity for a prolonged period to suppress an expression of ?-synuclein. The oligonucleotide or a pharmacologically acceptable salt thereof according to the present invention is characterized in comprising at least one 2?-O,4?-C-ethylene nucleoside, wherein the oligonucleotide can hybridize with ?-synuclein gene, has an activity to suppress an expression of the ?-synuclein gene, and is complementary to the ?-synuclein gene, 5? end of the oligonucleotide is a nucleotide complementary to the specific nucleotide, the oligonucleotide is complementary to at least a part of SEQ ID NO: 1, and the oligonucleotide has a length of 13 or more and 15 or less nucleotides.

Abstract: There is provided a method for manufacturing a three-dimensional shaped object by a continuous formation of a plurality of solidified layers through a light beam irradiation, the three-dimensional shaped object being provided with a hollow portion in an interior of the shaped object. The manufacturing method performs the formation of the solidified layer by irradiating a raw material with a light beam at the time of suppling the raw material, thereby allowing a sintering of the raw material or a melting and subsequent solidification of the raw material. In particular, a solidified foundation portion is provided as a part of the three-dimensional shaped object, the solidified foundation portion being used for a platform for a formation of a subsequent layer provided as the solidified layer. An orientation of the solidified foundation portion is changed prior to the formation of the subsequent solidified layer.

Abstract: The application relates to a method for manufacturing a three-dimensional shaped object by alternate repetition of a powder-layer forming and a solidified-layer forming, the repetition including: (i) forming a solidified layer by irradiating a predetermined portion of a powder layer with a light beam; and (ii) forming another solidified layer by forming a new powder layer on the formed solidified layer, and irradiating a predetermined portion of the newly formed powder layer with the light beam. A main beam and a sub beam are used as the light beam. The predetermined portion is irradiated with the sub beam prior to an irradiation of the predetermined portion with the main beam, the main beam having an irradiation energy density that melts the predetermined portion of the powder layer and the solidified layer located below the predetermined portion, the sub beam having an irradiation energy density that melts only the predetermined portion.

Abstract: In order to provide a manufacturing method for a three-dimensional shaped object which is capable of obtaining a higher accurate three-dimensional shaped object, there is provided that a method for manufacturing a three-dimensional shaped object by alternate repetition of a powder-layer forming and a solidified-layer forming, the repetition comprising: (i) forming a solidified layer by irradiating a predetermined portion of a powder layer with a light beam, thereby allowing a sintering of the powder in the predetermined portion or a melting and subsequent solidification of the powder; and (ii) forming another solidified layer by forming a new powder layer on the formed solidified layer, followed by irradiation of a predetermined portion of the newly formed powder layer with the light beam, further comprising performing a monitoring for an appearance property of an irradiated spot upon a formation of the solidified layer, the irradiated spot being irradiated with the light beam.

Abstract: An organic electroluminescent device including: an anode, a cathode, an emitting layer formed of an organic compound and interposed between the cathode and the anode, and two or more layers provided in a hole-injecting/hole-transporting region between the anode and the emitting layer; of the layers which are provided in the hole-injecting/hole-transporting region, a layer which is in contact with the emitting layer containing a compound represented by the formula (1); and of the layers which are provided in the hole-injecting/hole-transporting region, a layer which is interposed between the anode and the layer which is in contact with the emitting layer containing an amine derivative represented by the formula (2).