Patents by Inventor Akihide Hibara

Akihide Hibara has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210341488
    Abstract: A fluorescence polarization immunoassay that uses a fluorescent labeling substance in which a single domain antibody is labeled with a fluorescent dye. A fluorescent labeling substance obtained by labeling a single domain antibody, such as a VHH antibody or a vNAR antibody, having a binding ability to a target substance with a fluorescent dye is used. The fluorescence polarization immunoassay includes a binding step for binding the fluorescent labeling substance to a target substance; and a measuring step for measuring a change in the fluorescence polarization of the fluorescent labeling substance to which the target substance is bound.
    Type: Application
    Filed: April 27, 2021
    Publication date: November 4, 2021
    Applicants: TOHOKU UNIVERSITY, Tianma Japan, Ltd., NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Mao Fukuyama, Akihide Hibara, Ayuko Imai, Koji Shigemura, Manabu Tokeshi
  • Patent number: 9719927
    Abstract: An excitation light source emits excitation light to a target sample. An image sensor includes pixels arranged one-dimensionally or two-dimensionally, and receives measurement light from the sample according to the excitation light. A polarization selector arranged between the sample and image sensor includes pixels arranged one-dimensionally or two-dimensionally. Each pixel receives a corresponding portion of the measurement light, selects light having a polarization direction that corresponds to a driving signal applied to the pixels, and supplies this light to the image sensor. A measurement control unit supplies the cyclic driving signal having a first period T1, and acquires data I1, I2, I3, and I4 from each pixel of the image sensor for each exposure time segment T2=T1/4 obtained by dividing the first period T1 by 4.
    Type: Grant
    Filed: May 8, 2015
    Date of Patent: August 1, 2017
    Assignees: TOHOKU UNIVERSITY, NATIONAL UNIVERSITY CORPORATION HOKKAIDO UNIVERSITY
    Inventors: Akihide Hibara, Manabu Tokeshi, Osamu Wakao
  • Publication number: 20170074796
    Abstract: An excitation light source emits excitation light to a target sample. An image sensor includes pixels arranged one-dimensionally or two-dimensionally, and receives measurement light from the sample according to the excitation light. A polarization selector arranged between the sample and image sensor includes pixels arranged one-dimensionally or two-dimensionally. Each pixel receives a corresponding portion of the measurement light, selects light having a polarization direction that corresponds to a driving signal applied to the pixels, and supplies this light to the image sensor. A measurement control unit supplies the cyclic driving signal having a first period T1 and acquires data I1, I2, I3, and I4 from each pixel of the image sensor for each exposure time segment T2=T1/4 obtained by dividing the first period T1 by 4.
    Type: Application
    Filed: May 8, 2015
    Publication date: March 16, 2017
    Inventors: Akihide HIBARA, Manabu TOKESHI, Osamu WAKAO
  • Publication number: 20100060981
    Abstract: An objective of the present invention is to provide a circular dichroism thermal lens microscope apparatus capable of identifying and quantifying optically active samples in ultra-trace amounts, and which has a higher sensitivity than conventional apparatuses. The objective is achieved by a circular dichroism thermal lens microscope apparatus which beams excitation light and detection light into an optical microscope, where the detection light enters a thermal lens formed by irradiating a sample with the excitation light, and a substance in a sample is detected by determining the diffusion of the detection light by the thermal lens, and where the excitation light is modulated by a phase-modulation element, so as to identify or quantify an optical isomer.
    Type: Application
    Filed: February 10, 2006
    Publication date: March 11, 2010
    Applicants: Kanagawa Academy of Science and Technology, Institute of Microchemical Technology, The University of Tokyo
    Inventors: Masayo Yamauchi, Akihide Hibara, Takehiko Kitamori, Kazuma Mawatari, Manabu Tokeshi
  • Patent number: 7402439
    Abstract: An integrated structure of multilayer flow microchannel, which comprises a plurality of microchannels in which parallel multilayer flow that involves the interface of fluids is formed, arranged on various positions of a substrate, wherein each of the multilayer flow microchannels is communicated with another multilayer flow microchannel. A plurality of unit operations can be carried out continuously with high efficiency on a microchip, enabling high-degree microanalysis or precise chemical synthesis using the highly integrated structure of multilayer flow microchannel.
    Type: Grant
    Filed: July 10, 2002
    Date of Patent: July 22, 2008
    Assignee: Kanagawa Academy of Science and Technology
    Inventors: Takehiko Kitamori, Manabu Tokeshi, Akihide Hibara
  • Publication number: 20080123088
    Abstract: There are provided a microchemical system capable of acquiring a highly accurate TLM output value and a method for calculating TLM output thereof. A microchemical system 1 comprises: a microchemical chip having a channel with a depth t in which a sample flows; an exciting light source 13 adapted to irradiate the sample with an exciting light through an objective lens 10 with a numerical aperture NA; a detecting light source 14 adapted to irradiate the sample with a detecting light coaxially with the exciting light through the objective lens 10; and a PD adapted to receive a transmitted light when the detecting light transmits the sample before and after formation of a thermal lens 12. When a TLM output is calculated in the microchemical system 1 on the basis of a received light amount of the PD, the depth t (?m) is set to the range of 75?t?300, the numerical aperture NA is set to the range of 0.04?NA?0.
    Type: Application
    Filed: November 16, 2007
    Publication date: May 29, 2008
    Applicant: Nippon Sheet Glass Company, Limited
    Inventors: Masatoshi Nara, Ryo Anraku, Takahiro Asai, Jun Yamaguchi, Akihiko Hattori, Takehiko Kitamori, Manabu Tokeshi, Akihide Hibara, Kazuma Mawatari
  • Patent number: 7079315
    Abstract: A small and portable microscope for ultramicroanalysis has an excellent spatial resolution and fixed position analyzing ability. The microscope has at least a part of an excitation light source, a part of a probe light source and a part of a thermal lens microscope optical system arranged integrally in a device body. The device body also includes an analyzing cell and substrates supporting the analyzing cell.
    Type: Grant
    Filed: May 2, 2005
    Date of Patent: July 18, 2006
    Assignee: Kanagawa Academy of Science and Technology
    Inventors: Takehiko Kitamori, Akihide Hibara, Manabu Tokeshi
  • Publication number: 20050190439
    Abstract: A small and portable microscope for ultramicroanalysis having an excellent spatial resolution and a fixed position analyzing ability in which at least a part of an excitation light source (3), a part of a probe light source (4) and a part of a thermal lens microscope optical system are arranged integrally in a device body comprising an analyzing cell (1) and substrates (2A), (2B) supporting the analyzing cell (1).
    Type: Application
    Filed: May 2, 2005
    Publication date: September 1, 2005
    Inventors: Takehiko Kitamori, Akihide Hibara, Manabu Tokeshi
  • Publication number: 20040219078
    Abstract: An integrated structure of multilayer flow microchannel, which comprises a plurality of microchannels in which parallel multilayer flow that involves the interface of fluids is formed, arranged on various positions of a substrate, wherein each of the multilayer flow microchannels is communicated with another multilayer flow microchannel. A plurality of unit operations can be carried out continuously with high efficiency on a microchip, enabling high-degree microanalysis or precise chemical synthesis using the highly integrated structure of multilayer flow microchannel.
    Type: Application
    Filed: June 15, 2004
    Publication date: November 4, 2004
    Inventors: Takehiko Kitamori, Manabu Tokeshi, Akihide Hibara
  • Publication number: 20040021935
    Abstract: A small and portable microscope for ultramicroanalysis having an excellent spatial resolution and a fixed position analyzing ability in which at least a part of an excitation light source (3), a part of a probe light source (4) and a part of a thermal lens microscope optical system are arranged integrally in a device body comprising an analyzing cell (1) and substrates (2A), (2B) supporting the analyzing cell (1).
    Type: Application
    Filed: July 1, 2003
    Publication date: February 5, 2004
    Inventors: Takehiko Kitamori, Akihide Hibara, Manabu Tokeshi