Abstract: A guide wire includes a first wire disposed on the distal side, and a second wire disposed on the proximal side and made from a material having an elastic modulus larger than that of the first wire. The first wire and the second wire are joined to each other by welding. The second wire has, in the vicinity of the welded portion, a small cross-sectional area portion having a cross-sectional area smaller than that of a proximal end portion of the first wire. The outer diameter of the small cross-sectional area portion is gradually reduced in the direction toward the distal end. The first wire may be made from a superelastic alloy, whereas the second wire may be made from a stainless steel. The first wire and the second wire may be welded to each other by a butt resistance welding process. Since the change in rigidity of the guide wire becomes smooth in the longitudinal direction, the operationality and kink resistance of the guide wire are improved.

Abstract: A guide wire includes a first wire disposed on the distal side, and a second wire disposed on the proximal side and made from a material having an elastic modulus larger than that of the first wire. The first wire and the second wire are joined to each other by welding. The second wire has, in the vicinity of the welded portion, a small cross-sectional area portion having a cross-sectional area smaller than that of a proximal end portion of the first wire. The outer diameter of the small cross-sectional area portion is gradually reduced in the direction toward the distal end. The first wire and the second wire may be welded to each other by a butt resistance welding process. Since the change in rigidity of the guide wire becomes smooth in the longitudinal direction, the operationality and kink resistance of the guide wire are improved.

Abstract: A guide wire includes a first wire disposed on the distal side of the guide wire and a second wire disposed on the proximal side. The second wire has an elastic modulus larger than the first wire. The first wire is joined to the second wire at a welded portion by welding. A coil is disposed on the distal side of the first wire. A cover layer is formed on the outer peripheral surface of the wire member in such a manner as to cover at least the welded portion. The cover layer is made from a material capable of reducing the friction of the cover layer, for example, a fluorocarbon resin or a hydrophilic material, to thereby improve the sliding performance of the guide wire. Such a guide wire is excellent in operationality and kink resistance.

Abstract: A guide wire includes a first wire disposed on the distal side, and a second wire disposed on the proximal side and made from a material having an elastic modulus larger than that of the first wire. The first wire and the second wire are joined to each other by welding. The second wire has, in the vicinity of the welded portion, a small cross-sectional area portion having a cross-sectional area smaller than that of a proximal end portion of the first wire. The outer diameter of the small cross-sectional area portion is gradually reduced in the direction toward the distal end. The first wire may be made from a superelastic alloy, whereas the second wire may be made from a stainless steel. The first wire and the second wire may be welded to each other by a butt resistance welding process. Since the change in rigidity of the guide wire becomes smooth in the longitudinal direction, the operationality and kink resistance of the guide wire are improved.

Abstract: A guide wire includes a first wire disposed on the distal side, and a second wire disposed on the proximal side and made from a material having an elastic modulus larger than that of the first wire. The first wire and the second wire are joined to each other by welding. The second wire has, in the vicinity of the welded portion, a small cross-sectional area portion having a cross-sectional area smaller than that of a proximal end portion of the first wire. The outer diameter of the small cross-sectional area portion is gradually reduced in the direction toward the distal end. The first wire and the second wire may be welded to each other by a butt resistance welding process. Since the change in rigidity of the guide wire becomes smooth in the longitudinal direction, the operationality and kink resistance of the guide wire are improved.

Abstract: A guide wire includes a core possessing a distal end part and a proximal end part, a distal covering layer covering the distal end part of the core, and a proximal covering layer covering the proximal end part of the core. The proximal covering layer includes a first layer that covers the surface of the core, and a second layer that partly covers the surface of the first layer. The first layer has a first part which is not covered by the second layer and a second part which is covered by the second layer, and the surface of the second part is tightly surrounded by the proximal end of the distal covering layer.

Abstract: A guide wire includes a first wire disposed on the distal side of the guide wire and a second wire disposed on the proximal side. The second wire has an elastic modulus larger than the first wire. The first wire is joined to the second wire at a welded portion by welding. A coil is disposed on the distal side of the first wire. A cover layer is formed on the outer peripheral surface of the wire member in such a manner as to cover at least the welded portion. The cover layer is made from a material capable of reducing the friction of the cover layer, for example, a fluorocarbon resin or a hydrophilic material, to thereby improve the sliding performance of the guide wire. Such a guide wire is excellent in operationality and kink resistance.

Abstract: A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.

Abstract: A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.

Abstract: A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.

Abstract: A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.

Abstract: A guide wire includes a first wire disposed on the distal side of the guide wire and a second wire disposed on the proximal side. The second wire has an elastic modulus larger than the first wire. The first wire is joined to the second wire at a welded portion by welding. A coil is disposed on the distal side of the first wire. A cover layer is formed on the outer peripheral surface of the wire member in such a manner as to cover at least the welded portion. The cover layer is made from a material capable of reducing the friction of the cover layer, for example, a fluorocarbon resin or a hydrophilic material, to thereby improve the sliding performance of the guide wire. Such a guide wire is excellent in operationality and kink resistance.

Abstract: A guide wire includes a first wire disposed on the distal side of the guide wire and a second wire disposed on the proximal side. The second wire has an elastic modulus larger than the first wire. The first wire is joined to the second wire at a welded portion by welding. A coil is disposed on the distal side of the first wire. A cover layer is formed on the outer peripheral surface of the wire member in such a manner as to cover at least the welded portion. The cover layer is made from a material capable of reducing the friction of the cover layer, for example, a fluorocarbon resin or a hydrophilic material, to thereby improve the sliding performance of the guide wire. Such a guide wire is excellent in operationality and kink resistance.

Abstract: A medical guide wire includes a core wire having a distal portion, and a cover portion formed of a resin for covering at least the distal portion of the core wire, and is provided with a distal shape portion having a curved portion, wherein the distal portion of the core wire includes a tapered portion continuously varied in outside diameter, and a distal flexible portion provided on the distal side of the tapered portion, and the wire diameter variation rate at the tapered portion is 40 to 55%.

Abstract: A guide wire includes a first wire disposed on the distal side of the guide wire and a second wire disposed on the proximal side from the first wire. The first wire and the second wire are joined to each other by welding. A welded portion formed by welding has a projection projecting in the outer peripheral direction. The height of the projection may be in a range of 0.001 to 0.3 mm. The first wire may be made from a superelastic alloy, and the second wire be made from a stainless steel. The first wire and the second wire are welded to each other by a butt resistance welding process. Such a guide wire has a high joining strength between the first wire and the second wire, to thereby improve the operationality.

Abstract: A method of making a guide wire involves butting a connection end face at a proximal end of a first wire against a connection end face at a distal end of a second wire while applying voltage and a pressing force to weld together the first and second wires at a welded portion. The welded portion forms a projection that projects outwardly in an outer peripheral direction relative to portions of the first and second wire adjacent the projection. The outer dimension of the projection at the welded portion is adjusted so that upon completing adjusting the outer dimension of the projection the projection still projects outwardly in the outer peripheral direction relative to the portions of the first and second wire adjacent the projection.

Abstract: A guide wire includes a core possessing a distal end part and a proximal end part, a distal covering layer covering the distal end part of the core, and a proximal covering layer covering the proximal end part of the core. The proximal covering layer includes a first layer that covers the surface of the core, and a second layer that partly covers the surface of the first layer. The first layer has a first part which is not covered by the second layer and a second part which is covered by the second layer, and the surface of the second part is tightly surrounded by the proximal end of the distal covering layer.

Abstract: A guide wire includes a wire member having a first wire disposed on the distal side of the guide wire, and a second wire disposed on the proximal side from the first wire. The second wire is made from a material having an elastic modulus larger than that of the first wire. For example, the first wire is made from a superelastic alloy, and the second wire is made from a stainless steel. The first wire is joined to the second wire at a welded portion by welding. A coil is disposed on the distal side from the first wire. A cover layer is formed on the outer peripheral surface of the wire member in such a manner as to cover at least the welded portion. The cover layer is made from a material capable of reducing the friction of the cover layer, for example, a fluorocarbon resin or a hydrophilic material, to thereby improve the sliding performance of the guide wire. Such a guide wire is excellent in operationality and kink resistance.

Abstract: A guide wire includes a wire body and a coil provided so as to cover the distal side of the wire body. The wire body has a first wire disposed on the distal side, a second wire disposed on the proximal side from the first wire, and a third wire disposed on the proximal side from the second wire. The first wire is made from a reshapable metal material such as a stainless steel. The second wire is made from a pseudo-elastic alloy such as a Ni-Ti alloy. The third wire is made from a material having an elastic modulus larger than that of a material for forming the second wire. The first wire and the second wire are joined to each other by welding, and similarly the second wire and the third wire are joined to each other by welding.

Abstract: A guide wire includes a wire member having a first wire disposed on the distal side of the guide wire, and a second wire disposed on the proximal side from the first wire. The second wire is made from a material having an elastic modulus larger than that of the first wire. For example, the first wire is made from a superelastic alloy, and the second wire is made from a stainless steel. The first wire is joined to the second wire at a welded portion by welding. A coil is disposed on the distal side from the first wire. A cover layer is formed on the outer peripheral surface of the wire member in such a manner as to cover at least the welded portion. The cover layer is made from a material capable of reducing the friction of the cover layer, for example, a fluorocarbon resin or a hydrophilic material, to thereby improve the sliding performance of the guide wire. Such a guide wire is excellent in operationality and kink resistance.