Abstract: The compound of formula (1a) wherein p is 1 or 2, R1-R4 are hydrogen atom or the like, and a-d are 1 or 2, or a pharmaceutically acceptable salt thereof, which has an antitumor effect by inhibiting the binding between a MLL fusion protein that is infused with AF4, AF9, or the like, which is a representative fusion partner gene causing MLL leukemia, and menin.

Abstract: A method for producing an HSL protein with increased catalytic activity to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner is disclosed. A method for producing a plant with increased resistance to a 4-HPPD inhibitor using the method for producing the HSL protein is also disclosed. It has been revealed that, by mutating position 140 to a basic amino acid in an HSL protein, the catalytic activity of the protein to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner can be increased, and an activity of the protein to decompose the inhibitor can be increased.

Abstract: In order to provide: a method for producing an HSL protein with increased catalytic activity to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner; and a method for producing a plant with increased resistance to a 4-HPPD inhibitor using the method for producing the HSL protein, it has been revealed that, by mutating position 140 to a basic amino acid in an HSL protein, the catalytic activity of the protein to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner can be increased, and an activity of the protein to decompose the inhibitor can be increased.

Abstract: In a friction pad assembly for a disc brake, a plurality of lining assemblies supported on a guide plate are pressed to a disc rotor. The lining assembly includes a friction material and a back plate portion. A plate fitting portion of the lining assembly is inserted and equipped to a guide hole portion, and braking torque is transmitted from the plate fitting portion to the guide plate. A plurality of link plates applying pressing force from a torque receiving plate to the lining assembly are provided between the torque receiving plate and the back plate portion adhered to the guide plate. A damping layer sandwiched between inner surfaces of the torque receiving plate is provided on back surface sides of the link plates.

Abstract: A friction pad assembly for a disc brake is provided. A lining assembly includes a friction material which is pressed against a disc rotor during braking and a back plate which is fixed to a back surface of the friction material, and the back plate includes a plate fitting part swingably fitted to a guide hole provided in a guide plate. The plate fitting part is fitted into the guide hole such that a braking torque acting when the friction material is pressed against the disc rotor is transmitted from the plate fitting part to the guide plate. A rotation regulator regulating a rotation of the lining assembly is integrally formed on a torque receiving plate fixed to the guide plate.

Abstract: A disc brake (11) includes: a floating caliper (13) including a base portion (25) slidably supported by an upper guide pin (31) supported by a support (23), a piston side pressing arm (39) and an opposite piston side pressing arm (41); a pair of brake pads (17); a drive piston (15) provided on the piston side pressing arm (39); a caliper return mechanism (22) for elastically biasing the base portion disposed on an end portion of the guide pin (31) to the side opposite to the drive piston side; and an inner circumferential side washer (44) disposed on both sides in an axial direction of the rubber ring (21) elastically supporting the upper guide pin (31) in a radial direction to restrict an inner circumferential portion of the rubber ring (21) from bending deformation along an axial direction of the upper guide pin (31).

Abstract: In a disc brake apparatus, a parallelism maintaining control mechanism for pressing lining surfaces of pads against a disc rotor in parallel includes a pressure plate which is brought into abutment with a pad holding member, a link arm having a fixing shaft projecting from a caliper body in parallel to a side surface of a disc rotor, a moving shaft disposed in parallel to the fixing shaft and pivotally supporting the pressure plate, joint members which connect the fixing shaft and the moving shaft in parallel to each other and a connecting shaft for pivotally connecting the joint members to each other, and a spring member for pressing the pressure plate against the pad holding member.

Abstract: A disc brake (11) includes: a floating caliper (13) including a base portion (25) slidably supported by an upper guide pin (31) supported by a support (23), a piston side pressing arm (39) and an opposite piston side pressing arm (41); a pair of brake pads (17); a drive piston (15) provided on the piston side pressing arm (39); a caliper return mechanism (22) for elastically biasing the base portion disposed on an end portion of the guide pin (31) to the side opposite to the drive piston side; and an inner circumferential side washer (44) disposed on both sides in an axial direction of the rubber ring (21) elastically supporting the upper guide pin (31) in a radial direction to restrict an inner circumferential portion of the rubber ring (21) from bending deformation along an axial direction of the upper guide pin (31).

Abstract: In order to provide: a method for producing an HSL protein with increased catalytic activity to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner; and a method for producing a plant with increased resistance to a 4-HPPD inhibitor using the method for producing the HSL protein, it has been revealed that, by mutating position 140 to a basic amino acid in an HSL protein, the catalytic activity of the protein to oxidize a 4-HPPD inhibitor in a 2-oxoglutarate-dependent manner can be increased, and an activity of the protein to decompose the inhibitor can be increased.

Abstract: By a QTL analysis and so forth using 4-HPPD inhibitor-susceptible rice and 4-HPPD inhibitor-resistant rice, a hypothetical gene (HIS1 gene) of an iron/ascorbate-dependent oxidoreductase gene located on a short arm of chromosome 2 of rice has been identified as a 4-HPPD inhibitor-resistance gene. Further, it has also been revealed that a homologous gene (HSL1 gene) of the HIS1 gene is located on chromosome 6 of rice. Furthermore, it has been found out that utilizations of these genes make it possible to efficiently produce a plant having increased resistance or susceptibility to a 4-HPPD inhibitor and to efficiently determine whether a plant has resistance or susceptibility to a 4-HPPD inhibitor.

Abstract: In a friction pad assembly for a disc brake, a plurality of lining assemblies supported on a guide plate are pressed to a disc rotor. The lining assembly includes a friction material and a back plate portion. A plate fitting portion of the lining assembly is inserted and equipped to a guide hole portion, and braking torque is transmitted from the plate fitting portion to the guide plate. A plurality of link plates applying pressing force from a torque receiving plate to the lining assembly are provided between the torque receiving plate and the back plate portion adhered to the guide plate. A damping layer sandwiched between inner surfaces of the torque receiving plate is provided on back surface sides of the link plates.

Abstract: In a disc brake apparatus, a parallelism maintaining control mechanism for pressing lining surfaces of pads against a disc rotor in parallel includes a pressure plate which is brought into abutment with a pad holding member, a link arm having a fixing shaft projecting from a caliper body in parallel to a side surface of a disc rotor, a moving shaft disposed in parallel to the fixing shaft and pivotally supporting the pressure plate, joint members which connect the fixing shaft and the moving shaft in parallel to each other and a connecting shaft for pivotally connecting the joint members to each other, and a spring member for pressing the pressure plate against the pad holding member.

Abstract: A disk brake includes a floating caliper, a pair of brake pads, a driving piston and a caliper return mechanism. The floating caliper includes a base portion which is slidably supported via a guide pin to a support and a pair of pressing arms which extend from the base portion to pinch a disk rotor. The brake pads are provided in tip portions of the pressing arms so as to face side surfaces of the disk rotor. The driving piston is provided on one of the pressing arms so as to drive one of the brake pads toward one of the side surfaces. The caliper return mechanism is arranged in at least one of both end portions of the guide pin on a side opposite to the driving piston side so as to elastically bias the base portion to the side opposite to the driving piston side.

Abstract: A disk brake includes a floating caliper, a pair of brake pads, a driving piston and a caliper return mechanism. The floating caliper includes a base portion which is slidably supported via a guide pin to a support and a pair of pressing arms which extend from the base portion to pinch a disk rotor. The brake pads are provided in tip portions of the pressing arms so as to face side surfaces of the disk rotor. The driving piston is provided on one of the pressing arms so as to drive one of the brake pads toward one of the side surfaces. The caliper return mechanism is arranged in at least one of both end portions of the guide pin on a side opposite to the driving piston side so as to elastically bias the base portion to the side opposite to the driving piston side.

Abstract: By a QTL analysis and so forth using 4-HPPD inhibitor-susceptible rice and 4-HPPD inhibitor-resistant rice, a hypothetical gene (HIS1 gene) of an iron/ascorbate-dependent oxidoreductase gene located on a short arm of chromosome 2 of rice has been identified as a 4-HPPD inhibitor-resistance gene. Further, it has also been revealed that a homologous gene (HSL1 gene) of the HIS1 gene is located on chromosome 6 of rice. Furthermore, it has been found out that utilizations of these genes make it possible to efficiently produce a plant having increased resistance or susceptibility to a 4-HPPD inhibitor and to efficiently determine whether a plant has resistance or susceptibility to a 4-HPPD inhibitor.

Abstract: An outboard motor in which exhaust of an engine is emitted into water via an exhaust passage. The outboard motor comprises a throttle valve connected to an air intake port of the engine via an air intake manifold, a control motor for driving the throttle valve to open and close, and a controller for controlling the control motor. The controller controls the control motor such that the throttle valve fully closes when a determination is made that reverse rotation is occurring in the engine. The exhaust passage is communicated with the air intake manifold via a communication passage. A communication valve which opens only when reverse rotation is occurring in the engine is located at a portion where the communication passage and the air intake manifold connect.

Abstract: The mold commutator of the present invention comprises a plurality of commutator segments made of copper or copper alloy and circumferentially arranged, a plurality of spark absorbing elements, disposed between adjacent commutator segments, with paired parallel surfaces respectively having electrodes thereon, and a resin mold portion which integrates these portions into one piece. The spark absorbing element is electrically connected to the commutator segment via the electrode, and spark voltage generated at the commutator segment is absorbed by current flowing between the electrodes.

Abstract: A motor stator is disclosed. Each of a first phase, second phase and third phase of three-phase winding has multiple toroidal coils and crossover wires connecting the coils. The crossover wire of the first phase runs inside the second phase coil and the third phase coil. The crossover wire of the second phase runs over the first phase coil with a guide by guide posts and runs inside the third phase coil. The crossover wire of the third phase runs over the first phase coil and the second phase coil with a guide by the guide posts.

Abstract: An outboard motor in which exhaust of an engine is emitted into water via an exhaust passage. The outboard motor comprises a throttle valve connected to an air intake port of the engine via an air intake manifold, a control motor for driving the throttle valve to open and close, and a controller for controlling the control motor. The controller controls the control motor such that the throttle valve fully closes when a determination is made that reverse rotation is occurring in the engine. The exhaust passage is communicated with the air intake manifold via a communication passage. A communication valve which opens only when reverse rotation is occurring in the engine is located at a portion where the communication passage and the air intake manifold connect.

Abstract: A motor stator is disclosed. Each of a first phase, second phase and third phase of three-phase winding has multiple toroidal coils and crossover wires connecting the coils. The crossover wire of the first phase runs inside the second phase coil and the third phase coil. The crossover wire of the second phase runs over the first phase coil with a guide by guide posts and runs inside the third phase coil. The crossover wire of the third phase runs over the first phase coil and the second phase coil with a guide by the guide posts.