Patents by Inventor Akihiro Higuchi

Akihiro Higuchi has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20210277206
    Abstract: The purpose of the present invention is to provide a cellulose acetate excellent in transparency, and a molded article of the cellulose acetate. In the cellulose acetate, an acetylation degree is 52% or more and 59% or less, and a content of low-molecular-weight components having a molecular weight of not more than ¼ of a peak top molecular weight in a molecular weight distribution measured by gel permeation chromatography of cellulose acetate is 12% or less.
    Type: Application
    Filed: January 17, 2018
    Publication date: September 9, 2021
    Applicant: DAICEL CORPORATION
    Inventors: Ikuhiro SUZUKI, Yuya ASHIDA, Akihiro HIGUCHI
  • Patent number: 11107597
    Abstract: A cask includes a cask body, an outer cylinder, a plurality of fins, and a plurality of neutron shields. The cask body has a tubular shape around a central axis and is capable of housing fuel assemblies. The outer cylinder has a tubular shape surrounding the cask body. The fins are aligned in a circumferential direction in a tubular space formed between the cask body and the outer cylinder, and connect an outer peripheral surface of the cask body and an inner peripheral surface of the outer cylinder to divide the tubular space into a plurality of divided spaces. The neutron shields contain a neutron shielding material with which the divided spaces are filled. Each neutron shield includes a void portion extending in the axial direction along the central axis. Accordingly, it is possible to reduce stress that may be exerted on the outer cylinder or other components by thermal expansion of the neutron shielding material when the fuel assemblies are housed in the cask.
    Type: Grant
    Filed: July 25, 2018
    Date of Patent: August 31, 2021
    Assignee: HITACHI ZOSEN CORPORATION
    Inventors: Akira Higuchi, Kenta Hamada, Hiroyuki Morita, Akihiro Shin
  • Patent number: 11066484
    Abstract: Provided is cellulose acetate with which a hollow fiber membrane having excellent salt rejection and water permeability can be produced. The cellulose acetate, in which a total content of calcium and magnesium is 2.8 to 3.5 ?mol/g; a 6 percent viscosity is 40 to 80 mPa·s; a degree of filtration Kw is 35 g?1 or less; a molecular weight distribution Mw/Mn is 3.00 or less; and a degree of acetylation is 61.3 to 62.3%.
    Type: Grant
    Filed: January 12, 2016
    Date of Patent: July 20, 2021
    Assignee: DAICEL CORPORATION
    Inventors: Naohiro Oyamada, Akihiro Higuchi
  • Patent number: 10927189
    Abstract: The purpose of the present invention is to provide a cellulose acetate which can be used to obtain an optical film having a very small amount of bright spot foreign matters, with excellent production efficiency, even when cellulose containing a small amount of hemicellulose components and having a high degree of crystallinity is used as a raw material. A cellulose acetate in which a content ratio by mole of mannose units to a sum of xylose units, mannose units and glucose units, which are sugar chain components, is 0.04 mol % or less, and a filtration index K measured by the following measurement method is 30 mL?1 or less. (Measurement method) The cellulose acetate is dissolved in a mixed solvent containing methylene chloride and methanol at a weight ratio of methylene chloride/methanol of 9/1 to obtain a solution with a solid concentration of 16% by weight. The temperature of the solution is adjusted to 25° C.
    Type: Grant
    Filed: August 21, 2017
    Date of Patent: February 23, 2021
    Assignee: DAICEL CORPORATION
    Inventors: Maiko Tsuda, Akihiro Higuchi
  • Patent number: 10875932
    Abstract: Provided is a cellulose acetate powder that makes it possible to reduce the formation of spotty patches on a formed article of the cellulose acetate and prevent lowering of the production process passability of the formed article. A cellulose acetate powder includes cellulose acetate having an acetylation degree of 53 to 56% and a 6% viscosity of 30 to 200 mPa·s. In the cellulose acetate powder, a cumulative pore volume is not less than 0.200 ml/g; a proportion of particles having a particle diameter of not less than 500 ?m is not higher than 40%; and an angle of repose is not greater than 51°.
    Type: Grant
    Filed: February 26, 2015
    Date of Patent: December 29, 2020
    Assignee: DAICEL CORPORATION
    Inventors: Akihiro Higuchi, Takehiro Matsumoto
  • Publication number: 20200262933
    Abstract: Provided is cellulose acetate with which a hollow fiber membrane having excellent salt rejection and water permeability can be produced. The cellulose acetate, in which a total content of calcium and magnesium is 2.8 to 3.5 ?mol/g; a 6 percent viscosity is 40 to 80 mPa?s; a degree of filtration Kw is 35 g?1 or less; a molecular weight distribution Mw/Mn is 3.00 or less; and a degree of acetylation is 61.3 to 62.3%.
    Type: Application
    Filed: January 12, 2016
    Publication date: August 20, 2020
    Applicant: DAICEL CORPORATION
    Inventors: Naohiro OYAMADA, Akihiro HIGUCHI
  • Publication number: 20190389976
    Abstract: The purpose of the present invention is to provide cellulose acetate with which it is possible to obtain a molded article containing cellulose acetate having a small amount of lumps. Cellulose acetate having an acetylation degree of 52% or more and 59% or less, and an acetone-insoluble substance content of 0.04 wt % or less.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 26, 2019
    Applicant: DAICEL CORPORATION
    Inventors: Yuya ASHIDA, Ikuhiro SUZUKI, Akihiro HIGUCHI
  • Publication number: 20190389977
    Abstract: The purpose of the present invention is to provide cellulose acetate excellent in transparency. The method for producing cellulose acetate flakes includes the steps of (a) generating a cellulose acetate dope by reacting cellulose with acetic anhydride in a presence of an acid catalyst and an acetic acid solvent; (b) hydrolyzing the generated cellulose acetate to adjust an acetylation degree to 52% or more and 59% or less; (c) precipitating the adjusted cellulose acetate in a presence of water; (d) forming the cellulose acetate obtained by precipitation into a slurry by dispersing the cellulose acetate in a mixed solvent including a solvent having a solubility parameter ? of 8 to 13 and a solvent having a solubility parameter ? of 14 or more; and (e) separating the cellulose acetate from the slurry to form the cellulose acetate into flakes, the mixed solvent containing 30% by weight or more and 70% by weight or less of the solvent having a solubility parameter ? of 8 to 13.
    Type: Application
    Filed: January 17, 2018
    Publication date: December 26, 2019
    Applicant: DAICEL CORPORATION
    Inventors: Ikuhiro SUZUKI, Yuya ASHIDA, Akihiro HIGUCHI
  • Publication number: 20190218312
    Abstract: The purpose of the present invention is to provide a cellulose acetate which can be used to obtain an optical film having a very small amount of bright spot foreign matters, with excellent production efficiency, even when cellulose containing a small amount of hemicellulose components and having a high degree of crystallinity is used as a raw material. A cellulose acetate in which a content ratio by mole of mannose units to a sum of xylose units, mannose units and glucose units, which are sugar chain components, is 0.04 mol % or less, and a filtration index K measured by the following measurement method is 30 mL?1 or less. (Measurement method) The cellulose acetate is dissolved in a mixed solvent containing methylene chloride and methanol at a weight ratio of methylene chloride/methanol of 9/1 to obtain a solution with a solid concentration of 16% by weight. The temperature of the solution is adjusted to 25° C.
    Type: Application
    Filed: August 21, 2017
    Publication date: July 18, 2019
    Applicant: DAICEL CORPORATION
    Inventors: Maiko TSUDA, Akihiro HIGUCHI
  • Patent number: 9968566
    Abstract: A pharmaceutical composition for prophylaxis and/or treatment of a corneal and conjunctival disease or presbyopia, the composition containing a compound represented by Formula (I), or a salt thereof or a prodrug thereof as an active ingredient, wherein m and n are each independently an integer of 0 to 5; m+n?1; and each aromatic ring of the compound represented by Formula (I) may be substituted.
    Type: Grant
    Filed: August 26, 2015
    Date of Patent: May 15, 2018
    Assignee: KEIO UNIVERSITY
    Inventors: Akihiro Higuchi, Kazuo Tsubota, Kiyoshi Fukuhara
  • Publication number: 20180037670
    Abstract: Provided is a cellulose acetate powder that makes it possible to reduce the formation of spotty patches on a formed article of the cellulose acetate and prevent lowering of the production process passability of the formed article. A cellulose acetate powder includes cellulose acetate having an acetylation degree of 53 to 56% and a 6% viscosity of 30 to 200 mPa·s. In the cellulose acetate powder, a cumulative pore volume is not less than 0.200 ml/g; a proportion of particles having a particle diameter of not less than 500 ?m is not higher than 40%; and an angle of repose is not greater than 51°.
    Type: Application
    Filed: February 26, 2015
    Publication date: February 8, 2018
    Applicant: DAICEL CORPORATION
    Inventors: Akihiro HIGUCHI, Takehiro MATSUMOTO
  • Publication number: 20170246122
    Abstract: A pharmaceutical composition for prophylaxis and/or treatment of a corneal and conjunctival disease or presbyopia, the composition containing a compound represented by Formula (I), or a salt thereof or a prodrug thereof as an active ingredient, wherein m and n are each independently an integer of 0 to 5; m+n?1; and each aromatic ring of the compound represented by Formula (I) may be substituted.
    Type: Application
    Filed: August 26, 2015
    Publication date: August 31, 2017
    Applicant: KEIO UNIVERSITY
    Inventors: Akihiro HIGUCHI, Kazuo TSUBOTA, Kiyoshi FUKUHARA
  • Publication number: 20140080765
    Abstract: The present invention provides: a novel metalloprotein, i.e., selenium-lactoferrin; and a process for producing the metalloprotein. Selenium-lactoferrin according to the present invention can be produced suitably by adding a selenium salt to a solution containing lactoferrin and/or apolactoferrin and then subjecting the resultant mixed solution to dialysis or ultrafiltration. Selenium-lactoferrin according to the present invention has an excellent therapeutic effect on corneal and conjunctival diseases, and is suitable for mass production on an industrial scale.
    Type: Application
    Filed: May 18, 2012
    Publication date: March 20, 2014
    Applicants: KOWA COMPANY, LTD., KEIO UNIVERSITY
    Inventors: Akihiro Higuchi, Hiroyoshi Inoue, Kazuo Tsubota
  • Patent number: 8133990
    Abstract: Disclosed is a cellulose diacetate comprising a 6-position highly acetylated cellulose diacetate having a 6-percent viscosity of 40 to 600 mPa·s, and having a total degree of acetyl substitution of DSt and a degree of acetyl substitution at the 6-position of DS6, wherein DSt and DS6 satisfy following Conditions (1) and (2): 2.0?DSt<2.6??(1) 0.400?(DS6/DSt)?0.531?0.088×DSt??(2) The cellulose diacetate is usable typically as a starting material for cellulose acylates of different acyl groups, which have a high total degree of acyl substitution, have superior optical properties, and usable typically as photographic materials and optical materials.
    Type: Grant
    Filed: December 23, 2008
    Date of Patent: March 13, 2012
    Assignee: Daicel Chemical Industries, Ltd.
    Inventor: Akihiro Higuchi
  • Patent number: 7745615
    Abstract: Cellulose ester and film thereof useful for remarkably improving optical properties, e.g., optical isotropy. The cellulose ester has a degree of substitution from 2.90 to 2.965, a total of degrees of substitution at 2- and 3-positions ?1.97, and a half height width of chemical composition expressed in degree of substitution of ?0.09. The cellulose ester maybe produced by (i) acylating a cellulose with an acylating agent in the presence of a sulfuric acid catalyst, and (ii) hydrolyzing the acylated product in the presence of a sulfuric acid catalyst, wherein the acylation carried out with 1.40 to 2.0 molar equivalents of the acylating agent relative to 1 mol of a hydroxyl group in the cellulose in the presence of 6.5 to 9.5 parts by weight of the sulfuric acid catalyst relative to 100 parts by weight of the cellulose in the acylating step (i).
    Type: Grant
    Filed: September 21, 2005
    Date of Patent: June 29, 2010
    Assignee: Daicel Chemical Industries, Ltd.
    Inventors: Shu Shimamoto, Akihiro Higuchi
  • Publication number: 20090171079
    Abstract: Disclosed is a cellulose diacetate comprising a 6-position highly acetylated cellulose diacetate having a 6-percent viscosity of 40 to 600 mPa·s, and having a total degree of acetyl substitution of DSt and a degree of acetyl substitution at the 6-position of DS6, wherein DSt and DS6 satisfy following Conditions (1) and (2): 2.0?DSt<2.6 ??(1) 0.400?(DS6/DSt)?0.531?0.088×DSt ??(2) The cellulose diacetate is usable typically as a starting material for cellulose acylates of different acyl groups, which have a high total degree of acyl substitution, have superior optical properties, and usable typically as photographic materials and optical materials.
    Type: Application
    Filed: December 23, 2008
    Publication date: July 2, 2009
    Inventor: Akihiro HIGUCHI
  • Publication number: 20090043088
    Abstract: A cellulose ester and film thereof useful for remarkably improving optical properties such as optical isotropy are provided. The cellulose ester is adjusted so that the degree of substitution is from 2.90 to 2.965, the total of degrees of substitution at 2- and 3-positions is not less than 1.97, and the half height width of chemical composition expressed in degree of substitution is not more than 0.09. Such a cellulose ester maybe produced by a method for producing a cellulose ester, which comprises (i) an acylating step for acylating a cellulose with an acylating agent in the presence of a sulfuric acid catalyst, and (ii) a hydrolyzing step for hydrolyzing the acylated product in the presence of a sulfuric acid catalyst, and in which the acylation carried out with from 1.40 to 2.0 molar equivalents of the acylating agent relative to 1 mol of a hydroxyl group in the cellulose in the presence of 6.5 to 9.
    Type: Application
    Filed: September 21, 2005
    Publication date: February 12, 2009
    Applicant: DAICEL CHEMICAL INDUSTRIES, LTD.
    Inventors: Shu Shimamoto, Akihiro Higuchi
  • Patent number: 6916869
    Abstract: An acrylic resin plastisol coating compound which comprises containing therein acrylic resin particles and a self-crosslinking blocked isocyanate prepolymer having blocked isocyanate group and hydroxyl group in the molecule. It is superior in storage stability and workability and gives a coating film with good adhesion and chipping resistance.
    Type: Grant
    Filed: June 10, 2003
    Date of Patent: July 12, 2005
    Assignees: Asahi Rubber Co., Ltd., Toyota Jidosha Kabushiki Kaisha
    Inventors: Hirofumi Eto, Osamu Sakai, Akihiro Higuchi, Ayumi Takata, Yutaka Ohashi
  • Patent number: 6852687
    Abstract: The present invention relates to a method for treating a subject having a condition or disease involving apoptosis, which comprises administering an effective amount of albumin to the subject. The apoptosis inhibiting activity of albumin can be increased by administering a cell growth factor such as epidermal growth factor, transforming growth factor, fibroblast growth factor, hepatocyte growth factor, insulin-like growth factor, platelet-derived growth factor and nerve growth factor and/or vitamin A together with albumin.
    Type: Grant
    Filed: April 26, 2002
    Date of Patent: February 8, 2005
    Assignees: Sucampo AG
    Inventors: Kazuo Tsubota, Akihiro Higuchi
  • Publication number: 20030232908
    Abstract: An acrylic resin plastisol coating compound which comprises containing therein acrylic resin particles and a self-crosslinking blocked isocyanate prepolymer having blocked isocyanate group and hydroxyl group in the molecule. It is superior in storage stability and workability and gives a coating film with good adhesion and chipping resistance.
    Type: Application
    Filed: June 10, 2003
    Publication date: December 18, 2003
    Applicants: ASAHI RUBBER CO., LTD., TOYOTA JIDOSHA KABUSHIKI KAISHA
    Inventors: Hirofumi Eto, Osamu Sakai, Akihiro Higuchi, Ayumi Takata, Yutaka Ohashi