Patents by Inventor Akiko Kawasaki

Akiko Kawasaki has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 10966911
    Abstract: To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.
    Type: Grant
    Filed: February 10, 2017
    Date of Patent: April 6, 2021
    Assignee: Kao Corporation
    Inventors: Daiki Murase, Akira Hachiya, Naoki Oya, Kei Takano, Akiko Kawasaki, Keigo Kawabata
  • Publication number: 20190053994
    Abstract: To provide an inhibitor of melanin decomposition, which inhibits decomposition of melanin in keratinocytes to accelerate accumulation of melanin in skin and hair. An inhibitor of melanin decomposition in keratinocytes, comprising at least one selected from the group consisting of a plant extract containing berberine or a salt thereof, berberine or a salt thereof, proguanil or a salt thereof and phenformin or a salt thereof, as an active ingredient.
    Type: Application
    Filed: February 10, 2017
    Publication date: February 21, 2019
    Applicant: KAO CORPORATION
    Inventors: Daiki MURASE, Akira HACHIYA, Naoki OYA, Kei TAKANO, Akiko KAWASAKI, Keigo KAWABATA
  • Patent number: 10064800
    Abstract: A transglutaminase activator containing at least one kind selected from the group consisting of an extract from Justicia procumbens, an extract from Peristrophe japonica, and a compound represented by Formula (1), as an active ingredient: wherein R1 and R2 represent a hydrogen atom, a hydroxyl group, or an alkoxy group having 1 to 4 carbon atoms; R3 represents a hydrogen atom, or a group for forming a methylenedioxy group by bonding with R2; R4 and R5 represent a hydrogen atom, or a group for forming a methylenedioxy group by bonding with each other; R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.
    Type: Grant
    Filed: August 29, 2013
    Date of Patent: September 4, 2018
    Assignee: Kao Corporation
    Inventors: Junko Ishikawa, Shino Mitsunaga, Shi Chen, Akiko Kawasaki, Yoshiya Sugai, Yoshie Shimotoyodome, Naoki Oya
  • Patent number: 9603833
    Abstract: The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: February 25, 2015
    Date of Patent: March 28, 2017
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Tatsuya Matsukawa, Kazuhiro Masuzaki, Akiko Kawasaki, Akiko Akasaka, Yosuke Kawai
  • Patent number: 9486488
    Abstract: Provided are a very safe skin whitening agent, melanin production inhibitor, and dopa oxidase activity inhibitor. Use of kitsunenomago or an organic solvent extract thereof to inhibit the dopa oxidase activity.
    Type: Grant
    Filed: July 18, 2012
    Date of Patent: November 8, 2016
    Assignee: Kao Corporation
    Inventors: Akiko Kawasaki, Mamiko Kikuchi
  • Patent number: 9408969
    Abstract: Provided is an anesthetic solution-filled cartridge-type electric dental syringe, wherein the plunger has been shortened but the plunger can nevertheless be extended to the distance necessary to evacuate the anesthetic solution from the cartridge. The syringe comprises: an extension tube into which a plunger is movably inserted, the extension tube being movably disposed in the through hole of a support block and having racks formed in the side surface thereof that are coordinated with the racks of the plunger; and a means for the plunger to draw the extension tube to engage the racks of the extension tube with a pinion when the plunger reaches the middle of the distance corresponding to the anesthetic solution accommodation length of the cartridge. By the engagement of the racks of the extension tube with the pinion, the plunger moves together with the extension tube for the remainder of the distance corresponding to the anesthetic solution accommodation length of the cartridge.
    Type: Grant
    Filed: December 27, 2010
    Date of Patent: August 9, 2016
    Assignee: Showa Yakuhin Kako Co., Ltd.
    Inventors: Fumio Tanaka, Mitsuhiro Haraguchi, Yoshihiko Kawasaki, Mutsumi Shibuya, Renji Hayashi, Yoshinori Kato, Akiko Kawasaki
  • Patent number: 9339454
    Abstract: The invention provides a method for inhibiting dopa oxidase activity, for inhibiting melanin production, or for whitening skin using haguro-so or an organic solvent extract thereof, or a compound of formula (I):
    Type: Grant
    Filed: January 20, 2012
    Date of Patent: May 17, 2016
    Assignee: Kao Corporation
    Inventors: Mamiko Kikuchi, Daiki Murase, Mitsuru Sugiyama, Akiko Kawasaki
  • Publication number: 20150238404
    Abstract: A transglutaminase activator containing at least one kind selected from the group consisting of an extract from Justicia procumbens, an extract from Peristrophe japonica, and a compound represented by Formula (1), as an active ingredient: wherein R1 and R2 represent a hydrogen atom, a hydroxyl group, or an alkoxy group having 1 to 4 carbon atoms; R3 represents a hydrogen atom, or a group for forming a methylenedioxy group by bonding with R2; R4 and R5 represent a hydrogen atom, or a group for forming a methylenedioxy group by bonding with each other; R6 represents a hydrogen atom, a hydroxyl group, an alkoxy group having 1 to 5 carbon atoms, an acyloxy group having 1 to 4 carbon atoms, or a specific sugar residue.
    Type: Application
    Filed: August 29, 2013
    Publication date: August 27, 2015
    Applicant: Kao Corporation
    Inventors: Junko Ishikawa, Shino Mitsunaga, Shi Chen, Akiko Kawasaki, Yoshiya Sugai, Yoshie Shimotoyodome, Naoki Oya
  • Publication number: 20150166525
    Abstract: The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: February 25, 2015
    Publication date: June 18, 2015
    Inventors: Tatsuya MATSUKAWA, Kazuhiro MASUZAKI, Akiko KAWASAKI, Akiko AKASAKA, Yosuke KAWAI
  • Patent number: 8999989
    Abstract: The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: May 29, 2009
    Date of Patent: April 7, 2015
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Tatsuya Matsukawa, Kazuhiro Masuzaki, Akiko Kawasaki, Akiko Akasaka, Yosuke Kawai
  • Patent number: 8840585
    Abstract: A motorized syringe for use with two types of dental anesthetic solution-filled cartridges, having a plunger plug in the 1.8 ml cartridge pushed by a push rod by a length required to push a plunger plug in the 1.0 ml cartridge. The syringe includes a cartridge holder for use with 1.0 ml and 1.8 ml cartridges, the push rod having a 1.0 ml position and a 1.8 ml position drawn back from the 1.0 ml position so that push rod movement can end at a common terminal position for both, a sleeve adapted to receive the push rod rear end when pushed back from the common terminal position, and to be not interfered with by the push rod's rear end when it is in the 1.0 ml position, the sleeve being pushed rearward with the push rod's rear end when pushed back to the 1.8 ml position.
    Type: Grant
    Filed: April 12, 2011
    Date of Patent: September 23, 2014
    Assignee: Showa Yakuhin Kako Co., Ltd.
    Inventors: Fumio Tanaka, Mitsuhiro Haraguchi, Mutsumi Shibuya, Renji Hayashi, Yoshinori Kato, Akiko Kawasaki
  • Publication number: 20140219940
    Abstract: Provided are a very safe skin whitening agent, melanin production inhibitor, and dopa oxidase activity inhibitor. Use of kitsunenomago or an organic solvent extract thereof to inhibit the dopa oxidase activity.
    Type: Application
    Filed: July 18, 2012
    Publication date: August 7, 2014
    Applicant: KAO CORPORATION
    Inventors: Akiko Kawasaki, Mamiko Kikuchi
  • Publication number: 20140011158
    Abstract: Provided is an anesthetic solution-filled cartridge-type electric dental syringe, wherein the plunger has been shortened but the plunger can nevertheless be extended to the distance necessary to evacuate the anesthetic solution from the cartridge. The syringe comprises: an extension tube (11) into which a plunger (5) is movably inserted, the extension tube being movably disposed in the through hole (14) of a support block (13) and having racks (15, 15) formed in the side surface thereof that are coordinated with the racks (9) of the plunger; and a means for the plunger to draw the extension tube to engage the racks (15, 15) of the extension tube with a pinion (21) when the plunger reaches the middle of the distance corresponding to the anesthetic solution accommodation length of the cartridge.
    Type: Application
    Filed: December 27, 2010
    Publication date: January 9, 2014
    Applicant: SHOWA YAKUHIN KAKO CO., LTD.
    Inventor: Akiko Kawasaki
  • Publication number: 20130295207
    Abstract: Use of haguro-so or an organic solvent extract thereof, or a compound represented by the following formula (I) or a salt thereof, for inhibiting a dopa oxidase activity, for inhibiting melanin production, or for whitening the skin; in the formula (I), R1 and R2, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R1 and R2 together form a methylenedioxy group; R3 and R4, being the same or different, each represent a hydroxyl group, or a C1-4 linear or branched alkoxy group, or R3 and R4 together form a methylenedioxy group; R5 represents a hydrogen atom, a hydroxyl group, a C1-5 linear or branched alkoxy group, a C1-4 acyl group, or a sugar residue selected from the group consisting of (D-apio-?-D-furanosyl)oxy, (?-D-glucopyranosyl)oxy, (3-O,4-O-dimethyl-D-xylopyranosyl)oxy, (2-O,3-O,4-O-trimethyl-?-D-xylopyranosyl)oxy, and (3-O-methyl-?-D-glucopyranosyl)oxy; R6 and R7 are each a hydrogen atom and R8 and R9 together represent an oxygen atom, or R8 and R9
    Type: Application
    Filed: January 20, 2012
    Publication date: November 7, 2013
    Applicant: KAO CORPORATION
    Inventors: Mamiko Kikuchi, Daiki Murase, Mitsuru Sugiyama, Akiko Kawasaki
  • Patent number: 8507690
    Abstract: The invention provides a thiazole derivative useful as a VAP-1 inhibitor, as well as a pharmaceutical agent for the prophylaxis or treatment of VAP-1 associated diseases and the like, a method of inhibiting VAP-1 in a subject, and a method for the prophylaxis or treatment of VAP-1 associated disease in a subject. The thiazole derivative is a compound represented by the formula (I): R1—NH—X—Y—Z wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Grant
    Filed: January 30, 2009
    Date of Patent: August 13, 2013
    Assignee: R-Tech Ueno, Ltd.
    Inventors: Tatsuya Matsukawa, Kazuhiro Masuzaki, Yosuke Kawai, Akiko Kawasaki, Akiko Akasaka, Makoto Takewaki
  • Publication number: 20110117038
    Abstract: A dopa oxidase inhibitor, a skin-lightening agent and an external preparation for skin; comprising an extract of at least one plant selected from the group consisting of Melia toosendan Sieb. et Zucc., Amomum tsao-ka Crevost et Lemaire. Senecio gracilis and Veratrum nigrum L., or a compound represented by the following Formula (1), as an active ingredient: wherein R represents an acyl group having 1 to 5 carbon atom(s).
    Type: Application
    Filed: November 4, 2010
    Publication date: May 19, 2011
    Applicant: Kao Corporation
    Inventors: Akiko KAWASAKI, Mitsuru Sugiyama, Yasuko Amano
  • Publication number: 20110059957
    Abstract: The present invention provides a novel benzene derivative or thiophene derivative useful as a VAP-1 inhibitor, or a medicament for the prophylaxis or treatment of a VAP-1 associated disease and the like, namely, a compound represented by the formula (I): wherein each symbol is as defined in the present specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: May 29, 2009
    Publication date: March 10, 2011
    Applicant: R-TECH UENO, LTD.
    Inventors: Tatsuya Matsukawa, Kazuhiro Masuzaki, Akiko Kawasaki, Akiko Akasaka, Yosuke Kawai
  • Publication number: 20110015240
    Abstract: The invention provides a thiazole derivative useful as a VAP-1 inhibitor, as well as a pharmaceutical agent for the prophylaxis or treatment of VAP-1 associated diseases and the like, a method of inhibiting VAP-1 in a subject, and a method for the prophylaxis or treatment of VAP-1 associated disease in a subject. The thiazole derivative is a compound represented by the formula (I): R1—NH—X—Y—Z wherein each symbol is as defined in the specification, or a pharmaceutically acceptable salt thereof.
    Type: Application
    Filed: January 30, 2009
    Publication date: January 20, 2011
    Applicant: R-TECH UENO, LTD.
    Inventors: Tatsuya Matsukawa, Kazuhiro Masuzaki, Yosuke Kawai, Akiko Kawasaki, Akiko Akasaka, Makoto Takewaki